Glucovans: ntuziaka maka ojiji > Ọgwụgwọ na mgbochi

1 otu mbadamba ihe mkpuchi fim nwere:

Usoro onunu ogwu 2,5 mg + 500 mg:

Ngwaọrụ nọ n'ọrụ: glibenclamide - 2.5 mg, metformin hydrochloride - 500 mg.

Core: croscarmellose sodium - 14.0 mg, povidone K 30 - 20,0 mg, cellulose

microcrystalline - 56.5 mg, magnesium stearate - 7.0 mg.

Shell: opadry OY-L-24808 pink - 12.0 mg: lactose monohydrate - 36,0%,

15cP hypromellose - 28,0%, titanium dioxide - 24.39%, macrogol - 10,00%, ọla edo na-acha odo odo - 1.30%, iron iron oxide - 0.3%, black iron oxide - 0.010%, mmiri dị ọcha. - qs

Usoro onunu ogwu 5 mg + 500 mg:

Ngwaọrụ nọ n'ọrụ: glibenclamide - 5 mg, metformin hydrochloride - 500 mg.

Nucleus: sodium croscarmellose - 14.0 mg, povidone K 30 - 20.0 mg, microcrystalline cellulose - 54.0 mg, magnesium stearate - 7.0 mg.

Shell: Opadry 31-F-22700 odo - 12.0 mg: lactose monohydrate - 36,0%, hypromellose 15 cP - 28,0%, titanium dioxide - 20.42%, macrogol - 10.00%, acha odo odo quinoline - 3.00%, odo oxide edo edo - 2,50%, iron oxide red - 0.08%, mmiri dị ọcha - qs.

Usoro onunu ogwu 2,5 mg + 500 mg: biconvex gbara okpu kapiri nke eji ese ya, ihe eji enyo enyo kpuchie ya na “2.5” n’otu akuku.

5 mg + 500 mg usoro onyonyo: mbadamba ihe mkpuchi biconvex nke nwere ihe nkiri
acha odo odo, nke etinyere ya "5" n'otu akụkụ.

Omume ọgwụ

Glucovans® bụ ngwongwo abụọ nke ọgwụ hypoglycemic nke otu ọgwụ dị iche iche: metformin na glibenclamide.

Metformin bụ otu nke biguanides ma belata ọdịnaya nke basal na postprandial glucose n'ọbara plasma. Metformin anaghị akpali insulin na ya mere ọ bute hypoglycemia. O nwere usoro ihe omume atọ:

- na - ebelata mmepụta nke glucose site na umeji site na igbochi gluconeogenesis na glycogenolysis,

- na-abawanye uche nke ndị na - anabata ihe na - eme insulin, ike na ojiji nke glucose site na mkpụrụ ndụ na akwara.

- na-egbu oge ịmịnye glucose na eriri afọ.

Metformin na glibenclamide nwere usoro ọrụ dị iche iche, mana jikọtara ọrụ hypoglycemic ọrụ ibe ha. Njikọ nke ndị na - arụ ọrụ hypoglycemic abụọ nwere mmetụta mmekọrịta na ibelata glucose.

Mlọ ọgwụ

Glibenclamide. Mgbe a na -ekwu ya n’onu, iwere si akwara gbasara ihe karịrị 95%. Glibenclamide, nke bụ akụkụ nke ọgwụ Glucovans® bụ micronized. Oke ruru na plasma erutela n’ihe dịka awa anọ, olu nke nkesa dị ihe dịka 10 lita. Nkwukọrịta na protein protein bụ 99%. Ọ fọrọ nke nta ka ọ bụrụ metabolized n'ime imeju na ịmalite nke metabolites abụọ na-adịghị arụ ọrụ, nke

site na akụrụ (40%) yana bile (60%). Iwepu ọkara ndụ bụ site na awa anọ ruo na iri na otu. Mgbe nchịkwa ọnụ gasịrị, a na-etinye metformin na eriri afọ ahụ nke ọma, oke omimi na plasma na-eru n'ime awa 2.5. Ihe dị ka 20-30% nke metformin na-apụ apụ site na eriri afọ na-agbanweghị. Ezigbo bioavailability sitere na 50 ruo 60%.

A na-ekesa Metformin ngwa ngwa na anụ ahụ, ihe fọrọ nke nta ka ọ bụrụ na ọ nweghị ihe nchebe protein. Ọ bụ metadolized ruo obere adịghị ike ma kpụrụ ya akụrụ. Nkebi ọkara ndụ bụ ọkara 6.5. N'ihe banyere ọrụ akụrụ na-emebi emebi, mkpụchapu akwara na-adalata, dịka ikike nhichapụ nke creatinine, ebe mkpochapu ọkara ndụ na-abawanye, nke na-eduga n'ịbawanye ụba nke metformin na plasma ọbara. Nchikota nke metformin na glibenclamide n’otu usoro onodu ogwu nwere otu bioavailability dika mgbe ewere mbadamba ihe dika metformin ma obu glibenclamide n’onwe ya. Mmetụta bioavailability nke metformin yana yana glibenclamide anaghị emetụta nri oriri, yana bioavailability nke glibenclamide. Agbanyeghị, ogo oriri glibenclamide na-abawanye site na nri ị na-eri.

Ihe ngosi maka ojiji

Diabetesdị shuga 2 n'ime ndị okenye:

na adighi ike nke usoro nri, mmega ahụ na monotherapy gara aga na usoro metformin ma ọ bụ usoro sulfonylurea,

iji dochie ọgwụ gara aga site na iji ọgwụ abụọ (metformin na sulfonylurea derivative) na ndị ọrịa nwere ọkwa glycemia kwụ chịm ma chịkwaa nke ọma.

Ihe ngbanwe

hypersensitivity na metformin, glibenclamide ma ọ bụ ihe ndị ọzọ na-eme ka sulfonylurea, yana ihe inyeaka, ụdị shuga 1 nke ọrịa mellitus,

ọrịa mamịrị ketoacidosis, precca mamịrị, ọrịa shuga, akụrụ gbasara akwara ma ọ bụ ịrụ ọrụ ezinaụlọ (mwepụta nke na-erughị 60 ml / min),

ọnọdụ ọjọọ nke nwere ike ibute mgbanwe na ọrụ akụrụ: akpịrị ịkpọ nkụ, ọrịa na-efe efe, ujo, intravascular management nke ayodiin nwere ihe dị iche (lee "Ntuziaka Pụrụ Iche"),

ọrịa ma ọ bụ ọrịa na-adịghị ala ala nke na-esonyere hypoxia anụ ahụ: obi ma ọ bụ akụkụ okuku ume, ndaba na myocardial infarction, ujo, ọdịda imeju, porphyria,

tụụrụ ime, oge ị na-a breastụ ara, ojiji nke miconazole, nnukwu ịwa ahụ,

egbu egbu egbu, ịxụbiga mmanya ókè, lactic acidosis (gụnyere akụkọ ihe mere eme)

rube isi na obere kalori (na-erughị calorie 1000 / ụbọchị),

A naghị atụ aro ka iji ọgwụ ahụ mee ihe na ndị mmadụ karịa afọ 60 bụ ndị na-arụ ọrụ anụ ahụ dị arọ, nke ejikọtara ya na oke ihe ize ndụ nke ịmalite ọrịa lactic acidosis n'ime ha.

Glucovans® nwere lactose, yabụ akwadoghị iji ya maka ndị ọrịa nwere ọrịa hereditary ejikọtara na enweghị nkwekọrịta galactose, ụkọ lactase ma ọ bụ glucose-galactose malabsorption syndrome.

Ime na lactation

Ihe ogwu ahu n’emeghari ime. E kwesịrị ịdọ onye ọrịa ahụ ndụmọdụ na oge ọgwụgwọ ya na Glucovans®, ọ dị mkpa ịgwa dọkịta ahụ maka ịtụrụ ime na mmalite nke ịtụrụ ime. Mgbe ị na-eme atụmatụ ịtụrụ ime, yana n’ihe gbasara afọ ime n’oge ịcoụ ọgwụ Glucovans®, ekwesịrị ịkwụsị ọgwụ a ma mekwaa ọgwụ insulin. A na-egbochi Glucovans® n'ime ara ara, ebe ọdịghị ihe akaebe na-egosi na ọ nwere ike ịbanye na mmiri ara.

Usoro onunu ogwu na nhazi

Mkpebi ọgwụ a ka dọkịta kpebiri n’otu n’otu n’otu n’arụrụ onye ọrịa ọ bụla, dabere n’ọkpụkpụ glycemia.

Ọgwụ izizi bụ 1 mbadamba ọgwụ ọgwụ Glucovans® 2.5 mg + 500 mg ma ọ bụ Glucovans® 5 mg + 500 mg otu ugboro n'ụbọchị. Iji zere hypoglycemia, usoro mbụ ekwesịghị ịgụta kwa ụbọchị nke glibenclamide (ma ọ bụ nha nha nke ọgwụ sulfonylurea ọzọ e meburu) ma ọ bụ metformin, ma ọ bụrụ na ejiri ya mee ihe dị ka usoro ọgwụgwọ mbụ. A na-atụ aro ka ọnụọgụ ahụ rịa elu karịa 5 mg nke glibenclamide + 500 mg nke metformin kwa ụbọchị izu abụọ ma ọ bụ karịa iji nweta nchịkwa glucose ọbara zuru oke.

Ntinye ogwu eji agwughari ya na metformin na glibenclamide: dose mbụ agaghị agafe kwa ụbọchị nke glibenclamide (ma ọ bụ ihe nha nke nke ọzọ nkwadebe sulfonylurea) na metformin ewere na mbụ. Kwa izu abụọ ma ọ bụ karịa mgbe ịmalite ọgwụgwọ, a na-edozi dose ahụ dabere na ogo nke glycemia.

Oke kachasị kwa ụbọchị bụ mbadamba 4 nke ọgwụ Glucovans® 5 mg + 500 mg ma ọ bụ mbadamba 6 nke ọgwụ Glucovans® 2.5 mg + 500 mg.

Usoro usoro usoro onunu ogwu dabere na ebumnuche mmadụ:

Maka onunu ogwu nke 2.5 mg + 500 mg na 5 mg + 500 mg

• Otu ugboro n'ụbọchị, n'ụtụtụ n'oge nri ụtụtụ, na-edobe mbadamba 1 kwa ụbọchị.

• Ugboro abụọ n'ụbọchị, n'ụtụtụ na ná mgbede, na -eme mbadamba 2 ma ọ bụ 4 kwa ụbọchị.

Maka usoro onunu ogwu nke 2.5 mg + 500 mg

• Ugboro atọ n'ụbọchị, n'ụtụtụ, n'ehihie, na mgbede, yana mbadamba 3, 5 ma ọ bụ 6 kwa ụbọchị.

Maka usoro onunu ogwu nke 5 mg + 500 mg

• Ugboro atọ n'ụbọchị, n'ụtụtụ, n'ehihie na mgbede, na-edobe mbadamba mbadamba 3 kwa ụbọchị.

E kwesịrị iji nri dị mbadamba. Iri nri ọ bụla nwere carbohydrate kwesịrị ịgbakwunye ya, iji gbochie ọrịa hypoglycemia.

A na-ahọrọ ọ̀gwụ nke ọgwụ ahụ dabere na steeti ọrụ arụmọrụ. Ọgwụ nke mbụ ekwesịghị ịfe 1 mbadamba ọgwụ ọgwụ Glucovans® 2.5 mg + 500 mg. Ntụle oge niile maka ọrụ gbasara akụrụ dị mkpa.

A naghị akwado Glucovans® maka ụmụaka.

Dodoụbiga ya ókè

N'ihe banyere oke ịdoụbiga mmanya ókè, mmepe nke hypoglycemia ga-ekwe omume n'ihi ọnụnọ nke ọgwụ sulfonylurea na mejupụtara ọgwụ ahụ (lee "Ntuziaka Pụrụ Iche").

Enwere ike idozi ntakịrị ihe mgbaàmà hypoglycemia na-enweghị ume na ngosipụta akwara ozi site na ị immediateụ shuga ozugbo. Ọ dị mkpa iji megharia dose na / ma ọ bụ gbanwee nri. Ọnọdụ mmeghachi omume hypoglycemic siri ike na ndị ọrịa nwere ọrịa shuga, yana coma, paroxysm, ma ọ bụ nsogbu ndị ọzọ metụtara akwara, chọrọ nlekọta ahụike mberede. Nlekọta intravense nke ọgwụgwọ dextrose dị mkpa ozugbo achọpụtara ma ọ bụ enyo enyo nke hypoglycemia, tupu ụlọ ọgwụ onye ọrịa. Mgbe ọ nwetasịrị, ọ dị mkpa inye onye ọrịa ahụ nri nwere nnukwu carbohydrates na-adị ngwa ngwa (iji zere ịmalite ịmalite hypoglycemia).

Do overụbiga mmanya ókè ma ọ bụ ọnụnọ nke ihe ndị dị ize ndụ nwere ike ịkpasu mmepe nke lactic acidosis, ebe ọ bụ na metformin bụ akụkụ nke ọgwụ ahụ

Lactic acidosis bụ ọnọdụ chọrọ nlekọta ahụike mberede, ọgwụgwọ nke lactic acidosis kwesịrị ịrụ n'ụlọ ọgwụ. Treatmentzọ ọgwụgwọ kachasị dị irè maka iwepu lactate na metformin bụ hemodialysis.

Mkpochasị Plasma glibenclamide nwere ike ịbawanye na ndị ọrịa nwere ọrịa imeju. Ebe ọ bụ na glibenclamide nwere njikọ chiri anya na protein ndị dị n'ọbara, a naghị ewepụ ọgwụ ahụ n'oge usoro ọgwụgwọ.

Mmekọrịta na ọgwụ ndị ọzọ

Bozentan na glibenclamide na-abawanye ohere nke hepatotoxicity. A na-atụ aro ka ị zere ị theseụ ọgwụ ndị a n'otu oge. Mmetụta hypoglycemic nke glibenclamide nwekwara ike ibelata.

Metformin metụtara

Mmanya na-egbu egbu: Ihe ize ndụ nke imepụta lactic acidosis na-abawanye site n'ị intoụbiga mmanya ókè, karịsịa n'ihe banyere agụụ, ma ọ bụ nri na-edozi ahụ, ma ọ bụ imeju imeju. N'oge ọgwụgwọ ya na Glucovans®, a ga-ezere mmanya na ọgwụ nwere mmanya.

Ejikọtara ya na iji ọgwụ hypoglycemic niile

Chlorpromazine: na usoro onyonyo dị elu (100 mg / ụbọchị) na-akpata mmụba nke glycemia (na -ebelata mwepụta insulin).

Ihe ị ga - akpachara anya: ị kwesịrị ịdọ onye ọrịa aka na ntị ka ọ dị mkpa inyocha onwe glucose ọbara, ọ bụrụ na ọ dị mkpa,

dozie dose nke hypoglycemic n'ụlọnga n'oge otu oge nke ihe antipsychotic na mgbe ịkwụsị ya iji.

Glucocorticosteroids (GCS) na tetracosactide: mmụba nke glucose ọbara, oge ụfọdụ yana ketosis na-eso (GCS na-ebute mbelata nnabata glucose).

Ihe ị ga - echebara: kwesịrị ịdọ onye ọrịa aka na ntị banyere mkpa ọ dị ịchekwa glucose ọbara, ọ bụrụ na ọ dị mkpa, ekwesịrị ịhazigharị ọgwụ nke hypoglycemic nnọkọ n'oge otu oge nke GCS na mgbe ịkwụsị ya.

Danazole nwere mmetụta hyperglycemic. Ọ bụrụ na ọgwụgwọ na danazol dị mkpa na mgbe a kwụsịrị nke ikpeazụ, ọ ga-adị mkpa ịgbanwetụ ọgwụ Glucovans® n'okpuru nchịkwa glycemia.

Zr-adrenergic agonists: n'ihi mkpali nke ndị na-anabata pr-adrenergic na-eme ka ịbawanye ụba nke glucose n'ọbara.

Ihe ị ga - elebara anya: ọ dị mkpa ịdọ onye ọrịa aka na ime ka ịchịkwa ọdịnaya glucose ọbara, ị nwere ike weghachite ọgwụ insulin.

Diuretics: mmụba nke glucose ọbara.

Ihe ị ga --eme: a ga-adọ onye ọrịa aka na ntị banyere mkpa ọ dị ịchebe glucose ọbara, mmezi nke onye na - ahụ maka hypoglycemic n'oge a na - eme ya na oge ọ ga - enwe ike ịchọ ọgwụ ha.

Ndị na - egbochi ihe ndị na - egbochi enzyme enzyme (ACE) (captopril, enalapril): iji ọgwụ ndị na - egbochi ACE na - enyere aka belata glucose ọbara. Ọ bụrụ na ọ dị mkpa, ekwesịrị ịhazigharị ọgwụ Glucovans during n'oge a na-ejikọ ya na ndị na-egbochi ACE ma kwụsịchaa ojiji ha.

Metformin metụtara

Diuretics: Lactic acidosis nke na - eme mgbe a na - ewere Metformin na ọdịda akụrụngwa arụpụtara site na diuretics, ọkachasị akwara loop.

Ejikọtara ya na iji glibenclamide

Ihe mgbochi Z-adrenergic, clonidine, reserpine, guanethidine na sympathomimetics na-ekpuchi ụfọdụ ihe mgbaàmà hypoglycemia: palpitations na tachycardia, ọtụtụ ndị na - ahọrọ beta-blockers na - eme ka ọnụnọ na ogo nke hypoglycemia sie ike. E kwesiri ịdọ onye ọrịa aka na ntị gbasara mkpa ọ dị ịchebe glucose ọbara, ọkachasị na mmalite ọgwụgwọ.

Fluconazole: Mmụba na ọkara ndụ nke glibenclamide yana omume enwere ike ịpụta na hypoglycemia. Ekwesịrị ịdọ onye ọrịa aka na ntị banyere mkpa ọ dị ịchekwa glucose na ọbara, ọ nwere ike ịdị mkpa iji dozie ọnụọgụ ọgwụ hypoglycemic n'oge otu oge ọgwụgwọ na fluconazole na mgbe ịkwụsị iji ya.

Ejikọtara ya na iji glibenclamide

Desmopressin: Glucovans® nwere ike belata mmetụta antidiuretic nke desmopressin.

Ọgwụ antibacterial sitere na otu nke sulfanilamides, fluoroquinolones, anticoagulants (counarineri), MAO inhibitors, chloramphenicol, pentoxifylline, ọgwụ na-ebelata mkpụrụ ndụ nke fibrates, na-enupụ isi - ihe ize ndụ nke hypoglycemia site na iji glibenclamide.

Njirimara ngwa

Na-emegide usoro ọgwụgwọ na Glucovans®, ọ dị mkpa iji nyochaa ọkwa nke glucose na-ebu ọnụ mgbe ọ bụla erichara nri.

Lactic acidosis bụ ihe na-adịghị ahụkebe, mana njọ (ọnwu dị elu na-enweghị ọgwụgwọ mberede) mgbagha nke nwere ike ịdakwasị n'ihi oke metformin. Ọrịa lactic acidosis na ndị ọrịa mesoro metformin mere tumadi na ndị ọrịa nwere ọrịa mellitus nwere nnukwu akụrụ.

Ekwesịrị ịtụle ihe ndị ọzọ metụtara ihe egwu, dịka ọrịa shuga na-achịkwa nke ọma, ketosis, ibu ọnụ ogologo oge, ị alcoholụbiga mmanya ókè, ọdịda imeju, na ọnọdụ ọ bụla metụtara hypoxia siri ike.

E kwesịrị ịtụle ihe ize ndụ nke ịmalite lactic acidosis mgbe akara ndị na-enweghị aha dịka ọnya akwara na-esochi ọnya dyspeptik, mgbu afọ na oke ịrịa. N'okwu ndị dị njọ, ume iku ume acidotic, hypoxia, hypothermia, na coma.

Usoro nyocha ụlọ nyocha bụ: pH dị ala ọbara, ntụpọ lactate plasma karịa 5 mmol / l, ụba anionic na oge lactate / pyruvate ruru.

Ebe ọ bụ na Glucovans® nwere glibenclamide, ị takingụ ọgwụ ahụ nwere ihe ize ndụ nke hypoglycemia n'ime onye ọrịa. Nkeji nke nta nke nta nke usoro mgbe mmalite ọgwụgwọ nwere ike igbochi ịda ọrịa hypoglycemia. Enwere ike ịnye ọgwụgwọ a naanị onye ọrịa na-agbaso nri mgbe niile (gụnyere nri ụtụtụ). Ọ dị mkpa na iri nri carbohydrate na-adị kwa ụbọchị, ebe ọ bụ na ihe ize ndụ nke ịmalite hypoglycemia na-abawanye site na nri mbubreyo, ezughị ezu ma ọ bụ na-edozi ahụ ịrateụ mmanya. Mmepe hypoglycemia nwere ike ịbụ nwere nri hypocaloric, mgbe ọ gbasasịrị nnukwu anụ ahụ ma ọ bụ ogologo oge, yana mmanya ma ọ bụ yana ngwakọta nke ndị ọrụ hypoglycemic.

N'ihi mmeghachi omume nkwụghachi ụgwọ nke hypoglycemia, ọsụsọ, ụjọ, tachycardia, ọbara mgbali elu, palpitations, angina pectoris na arrhythmia nwere ike ime. Ihe mgbaàmà nke ikpe-azụ ahụ nwere ike anọghị ma ọ bụrụ na hypoglycemia amalite nwayọ, n'ihe banyere ọrịa akwara autonomic ma ọ bụ mgbe ị na-a betaụ ihe mgbochi-beta, clonidine, reserpine, guanethidine ma ọ bụ sympathomimetik.

Ihe mgbaàmà ndị ọzọ nke hypoglycemia na ndị ọrịa nwere ọrịa shuga nwere ike ịgụnye isi ọwụwa, agụụ, ọgbụgbọ, ọgbụgbọ, ike ọgwụgwụ, nsogbu nke ụra, oke iwe, oke iwe, mkparị, mkparị, nsogbu okwu, ịhụ ọhụụ, ịma jijiji, ahụ mkpọnwụ. na paresthesia, dizzness, delirium, bluls, obi abụọ, amaghị ihe ọ bụla, iku ume, na bradycardia.

Presdebe nlezianya, ịhọrọ dose, na ntuziaka kwesịrị ekwesị maka onye ọrịa dị mkpa iji belata ihe ize ndụ hypoglycemia. Ọ bụrụ na onye ọrịa ahụ na-echeta ọgụ hypoglycemia, nke siri ike ma ọ bụ jikọtara ya na amaghị akara nke mgbaàmà ahụ, ekwesịrị ịtụle ọgwụgwọ na ndị nnọchite hypoglycemic ndị ọzọ.

Ihe ndị na-enye aka na mmepe nke hypoglycemia:

• of Theụbiga mmanya ókè, ọkachasị n'oge a na-ebu ọnụ,

• Ọjụjụ ma ọ bụ (karịchaa ndị agadi agadi) enweghị ike ka ya na dọkịta wee nwee ike iso dọkịta wee soro ndụmọdụ ndị akọwapụtara na ntuziaka maka ojiji,

• Oriri na-ezighi ezi, nri oge na-adịghị, ụnwụ nri ma ọ bụ mgbanwe nri,

• enweghi ike n’etiti mmega ahụ na oriri carbohydrate,

• Ọrịa imeju siri ike,

• doụ ọgwụ Glucovans® ọgwụ ọjọọ,

• Nsogbu endocrine ahọrọ: ụbụrụ ọrụ thyroid,

pituitary na adrenal glands,

• administrationmekota ọgwụ ọgwụ n'otu oge.

Mgbaaka na imeju imeju

Pharmacokinetics na / ma ọ bụ pharmacodynamics nwere ike ịdị iche na ndị ọrịa nwere nkwarụ hepatic ma ọ bụ oke akụrụ. Ọrịa hypoglycemia nke na-adị na ndị ọrịa dị otú ahụ nwere ike ịgbatị oge, nke a ga-ebido ịmalite ọgwụgwọ kwesịrị ekwesị.

Ọrịa Gluu Ọtọ

N'ọnọdụ ịwa ahụ ma ọ bụ ihe ọzọ kpatara ọgbụgba shuga, a na-atụ aro ka ịgbanwere ọgwụ insulin na nwa oge. Ihe mgbaàmà nke hyperglycemia bụ urination ugboro ugboro, akpịrị ịkpọ nkụ, akpụkpọ akpọnwụ.

Oge awa 48 tupu ọgwụgwọ ịwa ahụ emebere ma ọ bụ nchịkwa mgbochi nke ihe na-enye rediopaque ọgwụ, a ga-akwụsị ọgwụ Glucovans®. A na-atụ aro ịmaliteghachi ọgwụgwọ ka awa 48 gachara, naanị mgbe enyochala ọrụ ezumike ma chọpụta dịka ihe nkịtị.

Ebe ọ bụ na akụrụngwa mepụtara metformin, na mgbe nke a gachara, ọ dị mkpa iji chọpụta kọwaa nke creatinine na / ma ọ bụ ihe mejupụtara ya: ọ dịkarịa ala otu ugboro n'afọ na ndị ọrịa nwere ọrụ mkpo nkịtị, yana ugboro 2-4 kwa afọ na ndị ọrịa agadi. , yana ndị ọrịa nwere ikike imebi ya site na oke nke kwesịrị.

A na-atụ aro oke nlezianya na ọnọdụ ebe enwere ike ịnwe mmekpa ahụ akụrụ, dịka ọmụmaatụ, na ndị ọrịa agadi, ma ọ bụ na mmalite nke usoro ọgwụgwọ antihypertensive, ojiji nke diuretics ma ọ bụ ọgwụ mgbochi mkpali (NSAIDs).

Cakpachara anya

Onye ọrịa ga-agwa dọkịta banyere mpụta nke ọrịa bronchopulmonary ma ọ bụ ọrịa na-efe efe nke akụkụ akụkụ ahụ.

Mmetụta ikike ịkwọ ụgbọ ala ma jiri usoro rụọ ọrụ

Ekwesịrị ịgwa ndị ọrịa banyere ihe ize ndụ hypoglycemia ma kwesịrị ilezi anya mgbe ha na-anya ma na-arụ ọrụ na-achọkarị mmụba uche na ọsọ nke mmeghachi omume psychomotor.