Etu esi eji ọgwụ Liprimar 10 mee ihe?

A na-ekepụta Liprimar n'ụdị mbadamba ụrọ nke ihe mkpuchi fim: ọcha, elliptical, na ọkpọkọ - isi ọcha, kanyere na akụkụ abụọ dabere na usoro onunu ogwu - “10” na “PD 155” / “20” na “PD 156” / “ 40 ”na“ PD 157 ”/“ 80 ”na“ PD 158 ”(10 na 20 mg nke ọ bụla - pcs 10. N'ime blisters, 3 na blisters abụọ na igbe kaadi, pcs 7. Iko katoonu, 40 na 80 mg nke ọ bụla - pọọsụ 10 n'ime blisters, blisters 10 na ngwungwu kaadiboodu, pcs 7 na blisters, 2 ma ọ bụ 4 blisters na ngwungwu kaadiboodu).

Ngwakọta nke mbadamba 1 gụnyere:

• Ngwakọta ọrụ: atorvastatin - 10, 20, 40 ma ọ bụ 80 mg (n'ụdị nnu nke calcium),
• Ihe ntinye aka: carbonateate - 33/66/132/264 mg, microcrystalline cellulose - 60/120/240/480 mg, lactose monohydrate - 32.8 / 65.61 / 131.22 / 262.44 mg, croscarmellose sodium - 9/18/36/72 mg, polysorbate 80 - 0.6 / 1.2 / 2.4 / 4.8 mg, hyprolose - 3/6/12/24 mg, magnesium stearate - 0.75 / 1.5 / 3/6 mg,
• Uwe mkpuchi: Opadry ọcha YS-1-7040 (hypromellose - 66,12%, polyethylene glycol - 18,9%, titanium dioxide - 13.08%, talc - 1.9%) - 4.47 / 8.94 / 17 , 88 / 35.76 mg, emulsion nke simethicone (simethicone - 30%, steuric emulsifier - 0.075%, sorbic acid, mmiri) - 0.03 / 0.06 / 0.12 / 0.24 mg, candelilla wax - 0, 08 / 0.16 / 0.32 / 0 mg.

Mlọ ọgwụ

Atorvastatin bụ ihe na - egbochi asọmpi HMG-CoA reductase, nke bụ enzyme isi nke na - agbanwe 3-hydroxy-3-methylglutaryl-CoA mevalonate, ihe ga - ebido steroid, gụnyere kọlestrọl. Liprimar na-ezo aka na ndị na-ewetalata ume nke ihe sịntetik sitere.

Ojiji nke atorvastatin na ndị ọrịa nwere dyslipidemia agwakọta, ụdị hypercholesterolemia, yana heterozygous na hyzycholesterolemia homozygous na-eduga ná mbelata ọbara plasma nke triglycerides (TG), oke njupụta lipoprotein cholesterol (ChL-VLLL) Dipoprotein obere cholesterol (cholesterol-LDL) na obere cholesterol (cholesterol). Ọzọkwa, mgbe ị na-ewere Liprimar, ịba ụba nke nnukwu protein lipoprotein cholesterol (HDL-C) na-abawanye.

Atorvastatin na-egbochi mmepụta cholesterol n'ime imeju, na-egbochi HMG-CoA reductase, ma na-abawanye ọnụ ọgụgụ nke ndị na-anabata heDatic LDL na mpụga mkpụrụ ndụ, nke na-eduga n'ịba ụba na catabolism nke LDL-C ma na-emekwa ka mbelata ọkwa cholesterol na LDL-C na plasma.

Liprimar na-ebelata ọnụ ọgụgụ nke LDL ma gbochie nguzobe nke LDL-C, na-eduga n'ịba ụba na nkwụsi ike na ọrụ nke ndị na-anabata LDL, gbakotara ntụgharị ihu dị mma nke ntụpọ LDL, ma na-ebelata ọkwa nke LDL cholesterol na ndị ọrịa nwere ụdị hyzycholesterolemia hyredcholesterolemia na-eguzogide ịdị na-arịa ya. ọgwụgwọ na ọgwụ ndị ọzọ na-ebelata ọgwụ.

Mgbe ewere ya na oke nke 1080 mg, atorvastatin belata mkpokọta nke TG site na 14-33%, apo-B site na 34-50%, cholesterol-LDL site na 41-61% na cholesterol site na 30-65%. Nsonaazụ ọgwụgwọ ahụ bụ otu ihe n'ime ndị ọrịa nwere ụdị hypercholesterolemia, heterozygous familial hypercholesterolemia na hyperlipidemia agwakọta, gụnyere ndị ọrịa nwere ụdị shuga 2.

N'ime ndị ọrịa nwere hypertriglyceridemia dịpụrụ adịpụ, Liprimara na-arụ ọrụ na-ebelata ọkwa nke TG, apo-B, cholesterol-VLDL, cholesterol-LDL na cholesterol zuru oke ma na-abawanye ọkwa cholesterol-HDL. N'ime ndị ọrịa nwere ọrịa dysbetalipoproteinemia, mgbe ị na-ewere Liprimar, nsonaazụ nke etiti lipoprotein cholesterol (cholesterol-lowering steroids) na-ebelata.

N'ime ndị ọrịa nwere hyperlipoproteinemia ụdị IIa na IIb, dịka Fredrikon si kọọ maka ọgwụgwọ atorvastatin (ọnụọgụ 1080 mg), ntinye nke HDL-C na-abawanye na nkezi site na 5.1-8.7% ma e jiri ya tụnyere uru mbụ, mmetụta a adịghị bụ ọgwụ dabere. Oke nke cholesterol-LDL / cholesterol-HDL na cholesterol-cholesterol-HDL bụ mbelata nke ukwuu (mbelata ihe a na-ekpebi site na dose nke Liprimar ewere) site na 37-55% na 29-444%, n'otu n'otu. Atorvastatin na ọgwụ nke 80 mg nwere ike belata ihe ize ndụ nke ịmalite nsogbu ischemic ma belata ọnwụ site na 16% mgbe ọ gachara usoro ọgwụgwọ nke izu 16, yana ihe ize ndụ nke ịmaliteghachi ụlọ ọgwụ metụtara angina pectoris, nke a na-esochi ihe ịrịba ama nke ischemia myocardial, na-ebelata 26% dị ka nyocha , enwere mbelata n'ịdị njọ nke mgbaàmà nke ischemia myocardial isimesia n’oge ọgwụgwọ ọgwụ na-akụda ike ngwa ngwa (MIRACL). N'ime ndị ọrịa nwere ọkwa dị iche iche nke LDL-C, ndị ọrịa enweghị angina na infarction myocardial na-enweghị ebugharị Q, na agbanyeghị nwoke (nwoke na nwanyị) na afọ (okenye na okenye karịa afọ 65), na-ewere atorvastatin na-ebelata oke ohere nsogbu ischemic na ọnwụ. Mbelata uche nke LDL-C na plasma na-egosi njikọta ka mma na ọgwụ Liprimar karịa itinye uche ya na mpaghara ọbara ọbara. Ekwesịrị ịhọrọ dose ahụ na-eburu n'uche mmetụta na-adakarị.

A na-edekọ mmetụta ọgwụgwọ Liprimar izu 2 mgbe mmalite nke ọgwụgwọ, rute elu mgbe izu anọ gasịrị ma nọgide na-agbaso usoro ọgwụgwọ.

N'ime ndị ọrịa nwere ọbara mgbali elu, yana ihe atọ ma ọ bụ karịa n'ihe ọ bụla, ịorụ atorvastatin na ọgwụ 10 mg na-ebelata ihe ize ndụ nke ịmalite nkụchi obi na-adịghị egbu egbu ma e jiri ya tụnyere placebo. Nsonaazụ nke ọmụmụ Anglo-Scandinavia na nyocha nke nsonaazụ nke ọrịa obi (ASCOT-LLA), dịka nke nchịkwa nke Liprimar na dose 10 mg na-ebelata ohere nke ụfọdụ nsogbu dịka ndị a:

• ọrịa strok (anaghị egbu / egbu) - site na 26%,
• nsonye ọbara (ọrịa obi na - adịghị egbu egbu na ọrịa obi, yana ọnwụ) - site na 36%,
• nsogbu gbasara akwara gbasara oke - 29%,
• nsogbu gbasara akwara na usoro ịtụgharị uche - site na 20%.

Dabere na nsonaazụ nke nnyocha nke nchịkwa nke atorvastatin maka ụdị ọrịa shuga mellitus nke 2 (CARDS), ojiji nke Liprimar na ndị ọrịa nwere ọrịa a na-ebelata ihe ize ndụ nke ọrịa obi n'agbanyeghị afọ na okike ma ọ bụ itinye uche nke LDL-C dị ka ndị a:

• ọrịa strok (anaghị egbu egbu / egbu egbu) - site na 48%,
• Ischemia na-adịghị egbu mgbu, nke na-adịghị egbu egbu (nke na-egbu egbu) myocardial infarction - site na 42%,
• isi nsogbu obi (ọrịa strok, usoro ịmụgharị, ọrịa ụkwara ume ọkụ na-adịghị ala ala, enweghi ike ọ bụla ma ọ bụ nke myocardial infarction, percutaneous transluminal coronary angioplasty, ọnwụ n'ihi oke iwe nke akwara obi, ọrịa obi na akwara grafting, angina pectoris na-anaghị akwụ ụgwọ) - site 37.

Nnyocha nke nsonaazụ ahụike hypolipPs siri ike na mmepe azụ nke akwara azụ atherosclerosis (REVERSAL) gosiri na ndị ọrịa nwere ọrịa obi na-ewere atorvastatin na mkpụrụ ọgwụ kwa ụbọchị nke 80 mg na -ebelata mbelata nke oke atheroma site na 0.4% mgbe ọnwa 1.8 gasịrị.

Nlekọta nke atorvastatin na ọgwụ kwa ụbọchị nke 80 mg nwere ike belata ihe ize ndụ nke ọrịa strok na-adịghị egbu egbu (nke na-egbu egbu) na ndị ọrịa merụrụ ọrịa trensient ischemic ọgụ ma ọ bụ ọrịa strok na-enweghị akụkọ banyere ọrịa obi obi ma e jiri ya tụnyere placebo dabere na nsonaazụ nke ihe omumu ihe omumu ihe banyere iku ume na mbelata nke cholesterol. (SPARCL). Nke a na-ebelata oke ihe ọghọm nsogbu ọrịa obi yana mkpa maka usoro nyochaghachi. Mbelata ihe ize ndụ nke nsogbu nke akwara obi n'oge ọgwụgwọ na atorvastatin ka a hụrụ na ndị ọrịa niile, ewezuga nke gụnyere ndị ọrịa nwere isi ọwụwa ma ọ bụ ugboro ugboro.

N'ime ndị ọrịa nwere ọrịa obi, ị Liụ ọgwụ Liprimar na ọgwụ nke 80 mg ma e jiri ya na 10 mg budata belata ihe egwu nke nsogbu dịka ndị a (dabere na nsonaazụ nke ọmụmụ nke usoro ọgwụgwọ TNT iji nweta ebumnuche mkpụrụ ndụ ọhụụ):

• akwukwo angina pectoris edeputara - site na 10.9%,
• Ọrịa obi (ọrịa obi na-adịghị egbu egbu na ọrịa obi, yana ọnwụ) - site na 8.7%,
• akwara akwara ịwa ahụ ma ọ bụ usoro ịmụgharị ọzọ - site na 13.4%,
• infarction myocardial na-adịghị egbu egbu, nke usoro ahụ kpatara - site na 4.9%,
• idobe ụlọ ọgwụ metụtara ọrịa mkpọchi obi - site na 2.4%,
• ọrịa ọnya na - egbu egbu (nke na - egbu egbu) - site na 2.3%.

Weputara udi ya na ihe mebere ya

Ọgwụ a dị na mbadamba mkpuchi-osisi. Ngalaba usoro onodu ogwu nwere ihe dika 10 mg nke calcium atorvastatin dika ihe na aru oru. Maka ọsọ nke nnabata na ụba bioavailability, mbadamba nkume nwere ihe ndị ọzọ:

• microcrystalline cellulose,
• stereta magnesium,
• mmiri ara ehi shuga
• Hyprolose
• sodium croscarmellose,
• carbon dioxide.

Ihe mejupụtara mbadamba ihe ndị ahụ bụ microcrystalline cellulose, magnesium stearate, shuga mmiri ara ehi, hyprolose, croscarmellose sodium, kabon kalsium.

Ajuju nke ihe nkiri a nwere ihe eji emechi anwansara, hypromellose, polyethylene glycol, talc, simethicone, titanium dioxide. Na mbadamba ọcha nke elliptical udi kanyere “PD 155” na dose nke ihe eji arụ ọrụ.

Omume ọgwụ

Liprimar bụ ndị otu ọgwụ ọgwụ na-egbusi ike. Atorvastatin na-arụ ọrụ bụ ihe na-ahọrọ ihe mgbochi HMG-CoA, nnukwu enzyme dị mkpa maka mgbanwe nke 3-hydroxy-3-methylglutaryl coenzyme n'ime mevalonate.

Na ọnụnọ nke ụdị hypercholesterolemia (cholesterol mụbara), ngwakọta dyslipidemia, Liprimara na-arụ ọrụ ga-enyere aka belata mkpokọta plasma nke mkpokọta cholesterol (Ch), apolipoprotein B, VLDL na LDL (lipoproteins dị ala) na obere nke triglycerides. Atorvastatin na-ebute mmụba dị elu lipoprotein (HDL)

Uzo ihe eji eme ya bu ihe mgbochi nke oru HMG-CoA reductase na mgbochi nke cholesterol na hepatocytes.

Atorvastatin nwere ike ịbawanye ọnụ ọgụgụ nke ndị na-anabata mkpụrụ ndụ lipoprotein dị ala na mpụta nke mkpụrụ ndụ imeju, nke na-eduga n'ịba ụba na mbibi nke LDL.

Ogwu ahụ nwere ike mee ka ọnụ ọgụgụ nke ndị na - anata mkpo lipoprotein dị ntakịrị nke dị n’elu elu nke imeju akwara.

Akụrụngwa na-arụ ọrụ na-ebelata njikọta LDL cholesterol na ọnụọgụ nke lipoproteins na-emerụ ahụ, n'ihi nke enwere mmụba na ọrụ nke ndị na-anabata LDL. N'ime ndị ọrịa nwere ụdị hypercholesterolemia nke homozygous na-eguzogide ihe nke ọgwụ Lipid, belata LDL. A na-ahụ mmetụta ọgwụgwọ ahụ n'ime izu abụọ mgbe mmalite nke ọgwụ ọgwụ. Edere nsonaazụ kachasị mgbe ọnwa gasịrị ọgwụgwọ Liprimar.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gasịrị, mbadamba nkume ndị ahụ anaghị agbaze n'okpuru ọrụ hydrochloric acid n'ime afọ, na-adaba na jejunum proximal. N’akụkụ akụkụ nke ihe digestive, membrane ihe nkiri ahụ na-enyocha hydrolysis.

Mbadamba ụrọ ahụ mebiri emebi, nri na ọgwụ na-amalite ịdọrọ microvilli pụrụ iche.

Atorvastatin na-abanye n'ọbara ọbara site na mgbidi eriri afọ, ebe ọ na-eru ọkwa kachasị nke plasma n'ime awa 1-2. N'ime ụmụ nwanyị, ntinye uche nke ihe dị n'ọrụ dị pasenti 20 karịa nke ụmụ nwoke.

Mgbe nchịkwa ọnụ gasịrị, mbadamba nkume ndị ahụ anaghị agbaze n'okpuru ọrụ hydrochloric acid na afọ.Liprimar 10 na-abanye n'ọbara ọbara site na mgbidi eriri afọ.
Ngwakọta ọgwụ ahụ na-arụ ọrụ na-ejikọ ya na albumin site na 98%, ọ bụ ya mere na ịba ọcha n'anya adịghị arụ ọrụ.

Bioavailability ruru 14-30%. Ihe ngosipụta dị ala na-akpata ya n'ihi parietal metabolism nke atorvastatin na akpụkpọ anụ mucous nke eriri afọ na mgbanwe na mkpụrụ ndụ akwara site na isoenzyme nke cytochrome CYP3A4. Ihe dị n’ime ya na-ejikọ albumin site na 98%, nke mere na hemodialysis anaghị arụ ọrụ. Iwepu ọkara ndụ na-erute awa iri na anọ. Mmetụta ọgwụgwọ ahụ na-adịgide ruo awa 20-30. Site na sistemụ urinary, atorvastatin na-ahapụ ahụ ahụ nwayọ - na mmamịrị, mgbe ọ gbasasịrị otu ọgwụ, naanị 2% nke dose ahụ ka achọtara.

Ihe ngosi maka ojiji

A na-eji ọgwụ ahụ eme ihe na ahụike iji gwọọ:

• isi hypercholesterolemia nke ọrịa e ketara eketa ma ghara inweta ya,
• mụbara endogenous etoju nke triglycerides na-eguzogide ọgwụ ọgwụ,
• hereditary homozygous hypercholesterolemia na ịdị ala nke nri nri yana usoro ọgwụgwọ ndị ọzọ na-abụghị ọgwụ.
• ụdị jikọtara hyperlipidemia.

Edere ọgwụ ahụ ka ọ bụrụ ihe mgbochi maka ọrịa obi na ndị ọrịa na-enweghị ihe ịrịba ama nke ọrịa obi, ma o nwere ihe ndị dị ize ndụ: ịka nká, omume ọjọọ, ọbara mgbali elu, ọrịa shuga mellitus. Ndị otu ahụ nwere nsogbu gụnyere hypercholesterolemia yana oke HDL.

Edere ọgwụ ahụ dịka ọgwụ mgbochi maka ọrịa obi.

A na-eji ọgwụ ahụ eme ihe dị ka mgbakwunye na ọgwụgwọ nri maka mmepe nke dysbetalipoproteinemia. A na-eji Liprimar eme ihe iji gbochie mmepe nke nsogbu na ndị ọrịa nwere ischemia myocardial iji belata ihe egwu ọnwụ, nkụchi obi, ọrịa strok na ụlọ ọgwụ maka angina pectoris.

Ihe ngbanwe

• Ọrịa imeju na-arụ ọrụ ma ọ bụ mmụba n'ọbara nke transaminases (karịa ugboro atọ ma e jiri ya tụnyere oke nke ụkpụrụ) nke etiology amaghi.
• Afọ ruru afọ iri na asatọ (n'ihi ezughi oke ụlọ nyocha banyere nchekwa na arụ ọrụ nke Liprimar maka ndị ọgbọ a),
• Ime na lactation
• Ejiri ọgwụ mgbochi.

Ikwu (Liprimar kwesịrị iji nlezianya depụta ya):

• Abuse abuseụbiga mmanya ókè
• Ihe ngosiputa nke akuko banyere oria imeju.

N'oge usoro ọgwụgwọ, ụmụ nwanyị nke afọ omumu kwesịrị iji ụzọ mgbochi ime.

Ntuziaka maka iji Liprimar: usoro na usoro onunu ogwu

Tupu iji Liprimar, ọ dị mkpa ịnwale iji nweta hypercholesterolemia site na enyemaka nke nri, mmega ahụ na oke ibu na ndị ọrịa nwere oke ibu, yana ọgwụgwọ maka ọrịa na-akpata ya.

Mgbe ị na-ede ọgwụ ahụ, a ga-adụ onye ọrịa ọdụ ka ọ gbasoo usoro hypocholesterolemic usoro n'oge usoro mmụta ahụ dum.

A na-ewere Liprimar n'ọnụ, oge 1 kwa ụbọchị, n'agbanyeghị nri nri na oge ụbọchị.

Dabere na ọdịnaya mbụ nke LDL-C, ebumnuche ọgwụgwọ na nzaghachi nke onye ahụ, dose ahụ nwere ike ịdị iche site na 10 mg ruo 80 mg (kachasị).

Na mbido ọgwụgwọ na / ma ọ bụ n'oge mmụba nke ọgwụ kwa izu 2-4, ọ dị mkpa ijikwa ọdịnaya egbugbere ọnụ na plasma ma, na-ekwekọ na nke a, na-ebu mmezi dose.

Maka ọtụtụ ndị ọrịa, ọgwụ Liprimar kwa ụbọchị yana hyperlipidemia agwakọta na hypercholesterolemia bụ 10 mg. Dịka iwu, a na-egosipụta mmetụta ọgwụgwọ ahụ ụbọchị iri na anọ, na-erute otu ọnwa. Site na usoro ọgwụgwọ ogologo oge, mmetụta ahụ na-adịgide.

Na hyzycholesterolemia homozygous familialia, a na-enye Liprimar ọgwụ kwa ụbọchị nke 80 mg.

N'ime ndị ọrịa nwere oke ịba ọcha n'anya, a na-ebelata ọgwụ ọgwụ ahụ n'okpuru nleba anya ọrụ nke aspartate aminotransferase na alanine aminotransferase.

Pairrụ ọrụ akụrụkaghị arụ ọrụ adịghị emetụta ntinye uche nke atorvastatin na plasma ọbara ma ọ bụ ogo nke mbelata ọdịnaya nke LDL-C, yabụ, ndị ọrịa dị otú a achọghị ndozi nke dose.

Site na nchịkwa nke oge a na cyclosporine, oke ọgwụ Liprimar bụ 10 mg.

Nsonaazụ

Dịka iwu, a na-anabata Liprimar nke ọma, nsogbu na-apụta na-adịte aka ma dịkwa nro.

N'oge usoro ọgwụgwọ, mmetụta ndị ọzọ na-esote nwere ike ịmalite (≥1% - ọtụtụ mgbe, ≤1% - ugboro ugboro):

• Sistemụ akwara Central: ọtụtụ mgbe - isi ọwụwa, nsogbu ehighị ụra, ọrịa asthenic, ugboro ugboro - neuropathy akụkụ, ọgbụgbọ, ọrịa, paresthesia, amnesia, hypesthesia,
• Usoro nri: oge ​​niile - afọ ntachi, dyspepsia, ọgbụgbọ, mgbu nke afọ, afọ ọsịsa, flatulence, ugboro ugboro - anorexia, vomiting, pancreatitis, hepatitis, cholestatic jaundice,
• Usoro akwara: mgbe mgbe - myalgia, ugboro ugboro - myopathy, azụ mgbu, olu mgbu, ogbu na nkwonkwo, myositis, rhabdomyolysis,
• Sistem Hematopoietic: nwa oge - thrombocytopenia,
• Metabolism: ugboro ugboro - hyperglycemia, hypoglycemia, ụba etoju nke serine creatine phosphokinase,
• Mmeghachi omume nfụkasị: na - adịghị ala ala - akpịrịkpa nke necrolysis na-egbu egbu (nrịanrịa nke Lyell), ọnya anụ ahụ, urticaria, pruritus, ihe ọkụ ọkụ, mmeghachi omume anaphylactic, erythema multiforme exudative (gụnyere ọrịa Stevens-Johnson syndrome),
• Ndị ọzọ: ike ọgwụgwụ oge, ike ọgwụgwụ, ọgụ na-agwụ ike, oke ibu, tinnitus, mgbu obi, ọdịda akwara nke ukwuu, alopecia.

Dodoụbiga ya ókè

Ihe nrịba ama nke oke onorvastatin na-abawanye na nsonaazụ ya.

Ọ bụrụ na ọ dị mkpa, a na-atụ aro ọgwụgwọ ọrịa, ileba anya na ọrụ nkeineine phosphokinase na ule ọrụ imeju oge niile. Ebe ọ bụ na ihe dị n’ime ya na-arụ ọrụ n’ime usoro nke ijikọ protin plasma, a na-ele ojiji nke hemodialysis anya maka ya enweghị isi.

Amaghị ọgwụ mgbochi nke atorvastatin amabeghị.

Ntụziaka pụrụ iche

Mgbe etinyere Liprimar, mmụba dị ala na serum nke alanine aminotransferase na aspartate aminotransferase, mmụba na-abawanye na ọkwa ọbara nke ọrịa hepatic transminases (na enweghị mmepe nke jaundice ma ọ bụ ngosipụta ndị ọzọ). Site na mbelata nke ọgwụ, iwepụ ọgwụ (obere oge ma ọ bụ zuru ezu), ọrụ nke transpeases hepatic na-alaghachikarị ọkwa mbụ. N'ọtụtụ oge, ndị ọrịa nwere ike ịga n'ihu na usoro ọgwụgwọ na obere belata na-enweghị nsonaazụ ọria.

A ga-enyocha ndị na-egosi ọrụ imeju tupu ọgwụgwọ, izu isii na iri na abụọ ka mmalite nke Liprimar ma ọ bụ mgbe mmụba na-abawanye, yana n'oge usoro ọgwụgwọ.

A kagbuola ọgwụ ahụ yana mmụba dị ukwuu na ọrụ nke creatine phosphokinase, n'ihu ọnụnọ myopathy na-enyo enyo ma ọ bụ gosipụtara. Mgbe ị na-edepụta Liprimar n'otu oge na immunosuppressants, fibrates, erythromycin, ọgwụ antifungal (ọgwụ azole) ma ọ bụ nicotinic acid na usoro hypolipPs, ekwesịrị iburu n'uche na nke a na-abawanye ohere nke ịmalite myopathy. Nyochaa ọnọdụ onye ọrịa oge niile dị mkpa iji chọpụta adịghị ike ma ọ bụ ihe mgbu, karịsịa n'oge ọnwa mbụ nke ọgwụgwọ yana n'oge oge ị andụ ọgwụ ọ bụla. Ọ bụrụ na ọ dị mkpa iji duzie ọgwụ ngwakọta, ọ dị mkpa ịtụle ohere nke iji ọgwụ ndị a na mbido mbụ na usoro mmezi.

Mgbe ị na-etinye Liprimar, a kọwapụtala ikpe ndị gbasara rhabdomyolysis na oke gbasara akụrụ oke n'ihi myoglobinuria. Ọ bụrụ na enwere ihe ịrịba ama nke myopathy enwere ike ma ọ bụ ọnụnọ nke ihe ndị dị ize ndụ maka ọdịda akwara n'ihi rhabdomyolysis (dịka ọmụmaatụ, na nnukwu ọrịa ọrịa, akwara hypotension, trauma, metabolic, endocrine na nsogbu ụbụrụ na enweghị nchịkwa, nnukwu ịwa ahụ), a na-atụ aro ka ịkagbu ọgwụgwọ ahụ kpamkpam ma ọ bụ kwụsịtụ ya nwa oge. .

Ọ bụrụ na ị na-enwe adịghị ike a na-akọwaghị ma ọ bụ mgbu mgbu, ọ bụrụ na ahụ ọkụ na ọnya na-eso ha, ị kwesịrị ịkpọtụrụ ọkachamara.

Mmetụta ikike ịkwọ ụgbọala na usoro dị mgbagwoju anya

Enweghị ihe omuma banyere mmetụta nke Liprimar na ikike ịkwọ ụgbọ ala ma rụọ ụdị ọrụ egwu nwere ike ịchọrọ ịbawanye ụba na mmeghachi omume psychomotor ozugbo. Agbanyeghị, na enwere ike ịmị ọnya, a ga-akpachara anya mgbe ị na-eme ihe ndị a dị n'elu.

Ime na lactation

N'oge usoro ọgwụgwọ, ụmụ nwanyị afọ imu Liprimar kwesịrị iji ọgwụ mgbochi ndị a pụrụ ịdabere na ha. Ebumnuche nke ọgwụ a contraindicated na ndị ọrịa na-adịghị echebe site na ime. Enwere ihe omuma banyere nsogbu nwatakiri ịba ama mgbe intrauterine kpughere HMG-CoA reductase inhibitors (statins) na nwa ebu n’afọ. Ihe omumu banyere anumanu gosiputara ihe ojoo n’agba.

Ọ bụ ihe a na-anabataghị ịkọpụta Liprimar nye ndị nne na-enye nwa ara, ebe ọ bụ na enweghị ozi a pụrụ ịdabere na ya banyere nbanye nke atorvastatin n'ime mmiri ara. Ọ bụrụ na ọ dị mkpa iji ọgwụ mee ihe n’oge a na-enye nwa ara, kwesịrị ịkagbu nwa ara, iji zere mmụba nke mmetụta ndị na-adịghị mma na ụmụ ọhụrụ.

Jiri na nwata

Na omume ụmụaka, Liprimar bụ contraindicated maka ọgwụgwọ nke ụmụaka na ndị na-eto eto na-erubeghị afọ 18, n'ihi enweghị data na-adakarị na arụmọrụ na nchekwa nke usoro ọgwụgwọ na ọgbọ a. Ihe dị iche bụ ọgwụgwọ heterozygous familial hypercholesterolemia, nke na-egosi ojiji nke atorvastatin na ụmụaka site na afọ 10.

Na arụ ọrụ imeju

A machibidoro ya ị theụ ọgwụ ahụ maka ndị ọrịa nwere ọrịa imeju na-arụ ọrụ, yana mmụba nke ọrụ hepatic transaminases nke amaghị ama na plasma ọbara karịa ugboro atọ ma e jiri ya tụnyere oke nke ụkpụrụ ahụ.

N'iji nlezianya, Liprimar ka enyere ndị ọrịa nwere akụkọ banyere ọrịa imeju yana / ma ọ bụ ndị na-a alcoholụbiga mmanya ókè.

Jiri na agadi

Mgbe ị na-eji Liprimar na ndị ọrịa merela agadi, ọ nweghị ọdịiche n'ihe nchekwa yana arụmọrụ atụnyere ọnụọgụ ndị mmadụ ka amata, ya mere, ọ dịghị mkpa maka idozi dose.

Ebe ọ bụ na ịbawanye n'ihe ize ndụ nke rhabdomyolysis mgbe ọ dị afọ 70, ekwesịrị iji nlezianya mee Liprimar.

Mkparịta ụka ọgwụ ọjọọ

Site n'otu oge iji Liprimar na ọgwụ ụfọdụ, mmetụta ndị a nwere ike ime:

• Cyclosporin, fibrates, erythromycin, clarithromycin, ọgwụ antifungal (ọgwụ azole) na acid nicotinic na usoro hypolipPs: ohere dị elu nke myopathy,
• CYP3A4 isoenzyme inhibitors: ụba plasma nwere nke atorvastatin,
• Ndị na-egbochi OATP1B1 (dịka ọmụmaatụ, cyclosporine): ụba bioavailability nke atorvastatin,
• Erythromycin, clarithromycin, CYP3A4 inhibitors, diltiazem, ihe ọpeụpeụ mkpụrụ osisi: ụba plasma ịta nke atorvastatin,
• Itraconazole: mmụba na AUC (mkpokọta plasma nke ihe) nke atorvastatin,
• Indocers nke cytochrome CYP3A4 isoenzyme: mbelata mkpokọta atorvastatin na plasma ọbara,
• Colestipol: mbelata nke mkpokọta nke atorvastatin na plasma, na -eme ka ihe omimi nke ogwugwo nke ogwu karie nke ha n’otu n’otu,
• Digoxin: mmụba na ịta ya mgbe ị na-ewere Liprimar na oke onunu (ọ dị mkpa iji nyochaa ọnọdụ ndị ọrịa),
• Ihe mgbochi oral nwere norethisterone na ethinyl estradiol: ụba AUC nke ihe ndị a.

Ihe analogues nke Liprimar bu: Atorvastatin, Atorvastatin-Teva, Atoris, Liptonorm, Torvakard, Atorvoks, Tribestan, Krestor.

Nyocha na Liprimar

A na-enyekarị ọgwụ a maka ndị ọrịa na-arịa ọrịa dị iche iche na arụ ọrụ nke akụrụngwa obi. Enwere nyocha dị iche iche banyere Liprimar, karịchaa, ọtụtụ ndị ọrịa na-akọ nrụpụta ọgwụgwọ dị elu. Agbanyeghị, ụfọdụ ndị ọrịa anaghị aghọta nke ọma etu esi a theụ ọgwụ ahụ n'ihi nkọwa ezughi ezu nke usoro ọgwụgwọ dọkịta nwere. Ya mere, ha na-anwa iji aka ha họrọ ma ọ bụ dozigharị ọnụọgụ nke atorvastatin, nke na-eduga n'ọdịdị nsonaazụ ndị na-adịghị mma (nhụcha ọnya na ọnya ahụ, ịcha ọbara, wdg).

Ndị ọkachamara na-atụle Liprimar bụ otu n'ime ọgwụ kachasị dị irè nke enyere ọ bụrụhaala na a na-ahụ nyocha usoro ọnụọgụ na oge usoro ahụ. Ha na-adụkwa ọdụ n'oge ọgwụgwọ iji mee mmega ahụ a na-ahụ anya, soro nri ma mee nyocha ọbara oge niile.

Uzo esi ewere Liprimar 10

Mbadamba ụrọ ka edobere maka nchịkwa ọnụ, n'agbanyeghị oge ụbọchị ma ọ bụ nri. A na-eme ọgwụgwọ ọgwụ ọjọọ naanị na adịghị ike nke hypocholesterolemic nri, usoro ịbelata oke megide ihe ndabere nke oke ibu gabigara ókè, mmega ahụ. Ọ bụrụ na mmụba nke cholesterol bụ ihe kpatara ọrịa a na-akpata, tupu i jiri Liprimar eme ihe, ịkwesịrị ịgbalị iwepụ usoro pathologies bụ isi. N'ime usoro ọgwụgwọ ọgwụ dum, ị ga-agbaso nri pụrụ iche.

Ọgwụ ọgwụ na Liprimar 10 ka a na-eme bụ naanị na adịghị ike nke nri hypocholesterolemic.

Usoro ubochi kwa ubochi bu 10-80 mg maka ijiri otu ma emeghari ya dabere na oru LDL-C na iweta nsonaazu ogwu.

Ihe kacha anabata ike ị nweta bụ 80 mg.

N'oge ọgwụgwọ Liprimar, ọ dị mkpa iji nyochaa ịta ụbụrụ plasma nke lipids kwa izu 2-4 ọ bụla, mgbe nke a gasịrị, ịchọrọ ịkpọtụrụ dọkịta gị banyere mgbanwe mgbanwe usoro ọgwụgwọ.

Iji kpochapụ ụdị hyperlipidemia, ọ dị mkpa iji 10 mg otu ugboro kwa ụbọchị, ebe hyzychous hereditary hypercholesterolemia chọrọ ọgwụgwọ ọgwụgwọ kachasị nke 80 mg. N'okwu nke abụọ, a na-ebelata ọkwa cholesterol site na 20-45%.

Na-a drugụ ọgwụ maka ọrịa shuga

Ndị ọrịa nwere ọrịa shuga kwesịrị ịkpachara anya mgbe hypercholesterolemia mere. Ndị dị otú ahụ nọ n'ihe ize ndụ nke ibute ọrịa obi. A na-eji liprimar eme ihe dị ka ihe na-egbochi infarction myocardial. O were usoro dibia bekee kpebie usoro onodu a dabere n’otu ọkwa cholesterol.

Ndị ọrịa nwere ọrịa shuga kwesịrị ịkpachara anya mgbe hypercholesterolemia mere.

Sistemụ akwara Central

Mmeghachi omume na-adịghị mma na mmebi nke usoro akwara ozi dịka:

• ehighi ura
• izugbe oria
• ọrịa asthenic
• isi ọwụwa na ọnya afọ,
• mbelata na mfu nke uche,
• sistemụ akwara azụ,
• amnesia.

Site na sistem iku ume

Dyspnea nwere ike ime.

Site n'igosipụta mmeghachi omume anaphylactic, rashes na anụ ahụ, redness, itching, exryative erythema, necrosis nke subcutaneous fatịlaịza nwere ike iputa. N'ọnọdụ siri ike, ụbụrụ Quincke na ụzụ anaphylactic.

Na ọgwụ ọgwụ a na-ajụ ajụjụ nwere ike ịkpalite ọdịdị nke rashes na anụahụ.

Mmanya ndakọrịta

Ọgwụ ekwesịghị ị mixedụ mmanya. Mmanya ethyl na-egbochi usoro ụjọ ahụ, usoro akụrụngwa na usoro ọbara, yabụ belata ike hypocholesterolemic Liprimar. Ihe gbasara nke puru iche banyere oghe eji akpo atherosclerotic na mgbidi akwara obara na-abawanye.

Ọgwụ ekwesịghị ị mixedụ mmanya.

A naghị atụ aro maka nchịkọta

N'ihi ihe egwu nke ọrịa neuromuscular, a na-akwadoghị njikwa nsogbu nke Liprimar na:

• Ọgwụ nje cyclosporin
• usoro nicotinic acid,
• Erythromycin
• ọgwụ antifungal
• fibrates.

Agaghị akwado nchịkwa nke Liprimar na Erythromycin.

Njikọ ọgwụ ndị dị otú a nwere ike ibute myopathy.

Jiri nlezianya

A na-atụ aro ịkpachara anya mgbe ị na-eji Liprimar na ọgwụ ndị ọzọ:

• Atorvastatin nwere ike ịbawanye AUC nke mgbochi igbochi ọnụ site na 20-30%, dabere na homonụ ndị dị na nhazi ahụ.
• Atorvastatin nwere usoro onunu ogwu nke 40 mg na ngwongwo 240 nke Diltiazem na-eduga na mmụba na mkpokọta plasma nke atorvastatin n'ọbara. Mgbe ị na-ewere 200 mg nke Itraconazole na 20-40 mg nke Liprimar, a hụrụ mmụba na AUC nke atorvastatin.
• Rifampicin na-ebelata ọkwa plasma nke atorvastatin.
• Colestipol na-ebute mbelata nke ọgwụ na-agbada Plasma cholesterol.
• Na nkwonkwo ngwakọta na digoxin, itinye uche nke ikpeazụ na-abawanye site na 20%.

Ihe ọ juiceụpeụ mkpụrụ osisi grepu na-egbochi ihe cytochrome isoenzyme CYP3A4, nke mere na mgbe ị na-eji ihe karịrị 1.2 lita ihe ọrusụrusụ citrus kwa ụbọchị, plasma ịta nke atorvastatin na-abawanye. A na-ahụ mmetụta yiri nke ahụ mgbe ị na-ewere ndị na - egbochi CYP3A4 (Ritonavir, Ketoconazole).

A machibidoro Liprimar iji ụmụ nwanyị dị ime 10.

Jiri n'oge ime na lactation

Amachibidoro iji ọgwụ a maka ụmụ nwanyị dị ime, dịka enwere nsogbu nke imebi ezi anụ ahụ na akwara n'oge uto nke afọ. Enweghị data banyere ike nke Liprimar ịbanye na mgbochi hematoplacental.

N'oge ọgwụgwọ ọgwụ, a ga-akagbu inye ara.

Ihe ọgwụ ọgwụ nwere mmetụta yiri ya na-agụnye:

A na-eme mgbanwe mgbe emechara nyocha ahụike.

Vidiyo nkwado "Liprimar" nkuzi LiprimarEzizi

Usoro onunu ogwu na nhazi

Tupu ịkọwa Liprimar, ọ dị mkpa iji nweta njikwa nke hypercholesterolemia site n'ịgwọ ọrịa na-akpata, yana usoro ndị ọzọ na-abụghị ọgwụ ọgwụ (nri, mmega ahụ na oke ibu na ndị ọrịa nwere oke ibu).

N'oge ọgwụgwọ ọgwụ, a na-atụ aro onye ọrịa ka ọ gbasoo usoro hypocholesterolemic.

A na-ezube Liprimar maka nchịkwa ọnụ, n'agbanyeghị oge ụbọchị ma ọ bụ nri.

Ọgwụ dịgasị iche site na 10 ruo 80 mg otu ugboro n'ụbọchị. A na-eme nhọrọ ntụrụndụ na-eburu n'uche ihe mbụ dị na lipoprotein cholesterol ọdịnaya (LDL-C), mmetụta onye ọ bụla na ebumnuche ọgwụgwọ. Oke kachasị kwa ụbọchị bụ 80 mg otu ugboro.

Na mbido ọgwụgwọ, yana iji usoro onunu ogwu na-abawanye, ọ dị mkpa iji chọpụta ntughari nke lipids na plasma kwa izu 2-4 niile, ma na-eburu n'uche data nke enwetara, dozie ọnụọgụ.

Site na hyperlipidemia agwakọta na hypocholesterolemia agwakọta, ọgwụ Liprimar maka ọtụtụ ndị ọrịa bụ 10 mg otu ugboro n'ụbọchị. A na-egosiputa ọgwụgwọ ahụ n’izu abụọ mbụ ma rute ihe kachasị ruo izu anọ nke ọgwụgwọ. Site na usoro ọgwụgwọ ogologo oge, mmetụta ahụ na-adịgide.

Maka ndị ọrịa nwere hypercholesterolemia homozygous familial, a na-enye Liprimar iwu na 80 mg otu ugboro kwa ụbọchị (a na-ebelata ọkwa LDL-C site na 18-45%).

Ọ bụrụ na arụ ọrụ ezighi ezi na-eme agadi na ndị agadi, a chọghị ịmegharị dose.

Na mmebi imeju, a na-ebelata dose ahụ n'okpuru nleba anya ọrụ nke enzymes alanine aminotransferase na aspartate aminotransferase.

Site na iji cyclosporine na-eme n'otu oge, dose nke Liprimar ekwesịghị gafere 10 mg kwa ụbọchị.