Ciprofloxacin 250 na mbadamba 500 mg

Nkọwa nke metụtara 20.08.2015

• Aha Latin: Ciprofloxacinum
• Koodu ATX: S03AA07
• Arụ Ọrụ: Ciprofloxacin (Ciprofloxacinum)
• Emeputa: PJSC Farmak, PJSC Teknụzụ, Kyivmedpreparat OJSC (Ukraine), Ozon LLC, Veropharm OJSC, Synthesis OJSC (Russia), C.O. Romlọ ọrụ Rompharm S.R.L. (Romania)

Ntị na anya ida ciprofloxacin nwere ciprofloxacin hydrochloride na ntinye nke 3 mg / ml (n'ihe banyere ihe dị ọcha), Trilon B, chloride benzalkonium, sodium chloride, mmiri dị ọcha.

Na ude mmanụ, ihe dị n'ọrụ dịkwa n’ime mkpo ya nke 3 mg / ml.

Mbadamba Ciprofloxacin: 250, 500 ma ọ bụ 750 mg nke ciprofloxacin, MCC, stachi nduku, ọka ọka, hypromellose, croscarmellose sodium, talc, magnesium stearate, colloidal anhydrous silicon dioxide, macrogol 6000, E171 (titanium dioxide), polysorbate 80.

Ngwunye infusion nwere ihe dị n'ọrụ na mkpo ya 2 mg / ml. Ndị pụrụ iche: sodium chloride, edetate disodium, lactic acid, diluted hydrochloric acidmmiri d / na.

Mlọ ọgwụ

Usoro nke ị theụ ọgwụ ahụ bụ n'ihi ikike nke igbochi DNA gyrase (enzyme nke mkpụrụ ndụ nje) yana njikọ DNA, nkewa na uto nke microorganisms.

Wikipedia na-egosi na, megide ndabere nke iji ọgwụ ahụ eme ihe, mgbochi ndị ọzọ na-abụghị ndị na-egbochi mkpụkọ ahụ adịghị etolite, ọgwụ nje. Nke a na - eme ciprofloxacin nke ukwuu na nje megide nje na - eguzogide ọgwụ. penisilini, ọkụ, tetracycline, cephalosporins ọtutu ndi ọzọ ọgwụ nje.

Ndị kachasị arụ ọrụ megide Gram (-) na Gram (+) aerobes: H. influenzae, N. gonorrhoeae, Salmonella spp., P. aeruginosa, N. meningitidis, E. coli, Shigella spp.

Irè n’ime ọrịa ndị ebutere: eriri staphylococcus (gụnyere ndị na-emepụta penisiliniin), nsogbu ndị dị iche iche enterococcus, legionella, campylobacter, chlamydia, mycoplasma, mycobacteria.

N'ọrụ megide microflora beta-lactamase.

Anaerobes nwere mmetụta dị ala ma ọ bụ na-eguzogide ọgwụ. Ya mere, ndị ọrịa na-agwakọta ọrịa anaerobic na ọrịa aerobic Ekwesịrị itinye nkwado nke ciprofloxacin site na ndenye ọgwụ linksamides ma obu Metronidazole.

Na-eguzogide ọgwụ nje bụ: Ureaplasma urealyticum, faululis nke Streptococcus, Treponema pallidum, Nocardia asteroides.

A na-eji nwayọ nwayọ guzogide microorganisms.

Mlọ ọgwụ

Mgbe ị theụchara ọgwụ ahụ, ọgwụ ya na-abanye ngwa ngwa ma gbasie ike na ngwu ahụ.

Isi na egosiputa ogwu:

• bioavailability - 70%,
• TCmax na plasma ọbara - 1-2 awa mgbe nchịkwa,
• T½ - 4 awa

N'agbata 20 na 40% nke ihe ahụ na-ejikọ protein protein. A na-ekesa Ciprofloxacin nke ọma na ndu mmiri yana anụ ahụ, yana itinye uche ya na anụ ahụ na mmiri nwere ike ịgafe plasma.

Ọ na - agafe na Plasenta rue ọria ọbara, apụrụ iche na mmiri ara, a na-edozikwa ebe nile. N'ime mkpokọtara ọnụọgụ iri were were wepu ka awa iri abụọ na anọ n'ime awa iri abụọ na anọ anaghị agbanwe agbanwe, a na-apịpụ akụkụ nke otu ọgwụ ahụ.

Gini bu ogwu eji n’ile anya nku / ntia?

Na ophthalmology ejiri maka Ọrịa nje na-efe efe nke anya (anya) na ngwa ya, yana yana ọnya afọ keratitis.

Ihe ngosi maka ojiji nke ciprofloxacin na otology: nnukwu nje otitis externa na nnukwu nje otitis media nke etiti ntị na ndị ọrịa na- eriri ọkpọ tympanostomy.

Ihe ngbanwe

Contraindications maka iji sistemụ:

• hypersensitivity
• tụụrụ ime
• lactation
• akpọ akụrụ / imeju akụrụ,
• ihe ngosiputa banyere akuko nke teninitis sitere na iji quinolones.

Idobe anya na ntị na ntị fungal na malitere ịrịa ọrịa nke anya / ntị, na ntachi obi na ciprofloxacin (ma ọ bụ quinolones ndị ọzọ), n'oge ime na lactation.

Maka ụmụaka, mbadamba nkume na ihe ngwọta maka nchịkwa iv nwere ike ịkọwa site na afọ 12, anya na ntị na-ada site na afọ 15.

Nsonaazụ

Ọ nabatara ọgwụ ahụ nke ọma. Kacha mmetụta ndị ọzọ na-arụ ọrụ bụ na / mmeghe na mbido:

• anya ntughari
• ike ọgwụgwụ
• isi ọwụwa
• ịma jijiji
• mkpali.

N'ime akwụkwọ ntuziaka Vidal, a kọrọ na n'ọnọdụ ndị dịpụrụ adịpụ, ndị ọrịa dere:

• ọsụsọ
• ọgba aghara gait
• nsogbu nsogbu nke anya,
• tides,
• ọbara mgbali intracranial,
• ịda mba,
• mmetụta nke ụjọ
• mmebi anya
• flatulence,
• mgbu afọ
• afọ mgbu,
• ọgbụgbọ / ọgbụgba
• afọ ọsịsa,
• ịba ọcha n'anya,
• hepatocyte necrosis,
• tachycardia,
• ọbara mgbali ike(adịkarịghị)
• akpụkpọ anụ?
• Nchapụta nke rashes na anụ ahụ.

Ugwu a na-akaghi aka: bronchospasm, nsogbu anaphylactic, Udeme nke Quincke, arthralgia, petechiae, malignant exudative erythema, vasculitis, Ọrịa Lyell, arịa ọrịa leukemia na thrombocytopenia, eosinophilia, anaemia, hemolytic anaemia, thrombotic ma ọ bụ leukocytosis, mmụba nke plasma nke LDH, bilirubin, alkaline phosphatase, transminases imeju, creatinine.

Ngwa nke ophthalmology so:

• ọtụtụ mgbe - mmetụta nke ahụ erughị ala na / ma ọ bụ ọnụnọ nke ndị si mba ọzọ n'anya, ọdịdị nke ncheta ọcha (na-abụkarị ndị ọrịa nwereọnya afọ keratitis site n'iji nnuputa mmiri mee ihe ugboro ugboro), imeju kristal / flakes, conlayctival overlay na hyperemia, tingling and burn,
• N'onwe m - keratitis/keratopathy, nkuchi ihu, ikpu nke cornea, hypersensitivity mmeghachi omume, lacrimation, belata visual acuity, photophobia, corneal infiltration.

Mmetụta ndị metụtara ya na ọgwụ ma ọ bụ ikekwe metụtara ọgwụ a na-adịkarị nwayọọ, enweghị ihe iyi egwu ma pụọ ​​na ọgwụgwọ.

Na ndị ọrịa na- ọnya afọ keratitis Ngosipụta nke ịcha ọcha adịghị emetụta ọgwụgwọ nke ọrịa ahụ yana paradaịs nke ọhụụ ma kpamkpam na nke ya. Dịka iwu, ọ na-apụta oge site na ụbọchị 1-7 mgbe mmalite nke iji ọgwụ ahụ na-apụ n'anya ozugbo ma ọ bụ n'ime ụbọchị 13 mgbe ọ kwụsịrị.

Ọrịa Neophthalmic mgbe ị na - eji mmiri atugharị: ọdịdị nke aftertaste na - adịghị mma n'ọnụ, n'ọnọdụ dị ụkọ - ọgbụgbọ, dermatitis.

Mgbe ejiri ya mee ihe n’ozi abuo, ihe ndi a kwere omume:

• oge niile - ntipu na nti,
• n'ọnọdụ ụfọdụ - tinnitus, isi ọwụwa, dermatitis.

Ojiji nke ampoules

A na-atụ aro ka ciprofloxacin na ampoules ka a na-enye ya intravenously n'ụdị ọrịrị nke ntapu mmiri. Ọgwụ maka onye okenye bụ 200-800 mg / ụbọchị. Ogologo oge ihe ọmụmụ ahụ dị na 1 izu ruo ụbọchị iri.

Na ọrịa urogenital, nkwonkwo mmebinaọkpọ ma obu Akụkụ ENT A na-etinye onye ọrịa ọrịa ọgwụ 200-400 mg ugboro abụọ n'ụbọchị. Na akụkụ okuku ume na-efe efe, intraperitoneal na-efe efe, ọrịa mbufụt, anụ ahụ dị nro na ọnya anụ ahụ otu uzo eji otu ihe eji eme ya bu 400 mg.

Na akụrụ usoro ịmalite bụ 200 mg, na-esote ya na-emezi ya na-eburu n'uche Clcr.

N'ihe banyere iji ampoules mee ihe na 200 mg, oge infusion bụ nkeji 30, na iwebata ọgwụ na ọgwụ nke 400 mg - 1 awa.

Achọghị inje Ciprofloxacin.

Nhọrọ

Enweghị ọdịiche dị mkpa na otu esi ewere ọgwụ ọjọọ site na ndị nrụpụta dị iche iche: ntuziaka maka ojiji Ciprofloxacin-AKOS yiri ntuziaka na Ciprofloxacin-FPO, Ciprofloxacin-Na-ekwe Nkwa, Vero-Ciprofloxacinma obu Ciprofloxacin-teva.

Maka ụmụaka na ndị nọ n'afọ iri na asatọ, a na-atụ aro ka ọgwụ ahụ naanị ma ọ bụrụ na pathogen na-eguzogide ọgwụ ndị ọzọ.

Dodoụbiga ya ókè

Onweghi ihe mgbaàmà doro anya nwere oke ịdoụ ọgwụ ciprofloxacin. E gosipụtara onye ọrịa ahụ na-aricụ ara, na-a drugsụ ọgwụ ọgwụ emetic, na -emeghachi mmeghachi omume mmamịrị acid, ma na-ewebata nnukwu mmiri. Ekwesịrị ịrụ ọrụ niile ka a na-arụ ọrụ nke sistem na akụkụ ahụ dị mkpa.

Peritoneal dialysis na ịba ọcha n'anya mee ka mkpochapu 10% nke ọgwụ a .ụrụ.

Ọgwụ enweghị ọgwụ mgbochi akọwapụtara.

Mmekorita

Jiri na yana Theophylline na-enye aka na mmụba na ịta plasma na mmụba na T1 / 2 nke ikpeazụ.

Ihe antacids ndị Al / Mg nwere nwere na-enyere aka belata oge aproụkọ nri ciprofloxacin ma si otua belata ntinye uche ya na mmamịrị na ọbara. N’agbata usoro ọgwụ ndị a kwesịrị ịdịgide n ’oge dịkarịa ala 4 awa.

Ciprofloxacin na-akwalite mmetụta ahụ coumarin anticoagulants.

Emebeghị ka mmekọrịta nke ciprofloxacin maka iji nalogy na ophthalmology na ọgwụ ndị ọzọ amụọ.

Ntụziaka pụrụ iche

N'ihi ohere nke nsonaazụ ndị sitere na sistemụ akwara na-esite na ndị ọrịa nwere akụkọ banyere ya, a ga-eji ọgwụ ahụ naanị maka ebumnuche ahụike.

Ejiri Ciprofloxacin jiri nlezianya mee ihe mgbe ị na-agbada ọnụ ụzọ maka ịdị njikere ime mmụọ, Akwụkwụ na-adọ, ụbụrụ mebiri, oke ụbụrụ (Ohere buru ibu nke obara obara na ọrịa strok), na ezigbo imeju akụrụ / arụ ọrụna nká.

N'oge usoro ọgwụgwọ, a na-atụ aro ka ọ ghara ịhapụ UV na radieshon nke anyanwụ na ịba ụba nke mmega ahụ, iji chịkwaa acidity nke mmamịrị na usoro mmanya.

N'ime ndị ọrịa nwere mmezi alkaline nke mmamịrị, edere ikpe ndị ahụ kristalia. Iji zere mmepe ya, ọ bụ ihe a na-anabataghị karịa ịgwọ ọgwụ nke ọgwụ. Na mgbakwunye, onye ọrịa ahụ chọrọ ọ drinkụ drinkụ buru ibu na mmezi nke mmeghachi omume mmamịrị acidic.

Ihe mgbu Tendon na akara ọrịa tenosynovitis bụ ihe nrịbaama maka ịkwụsị ọgwụgwọ, ebe ọ bụ na enwere ike ọ gaghị enwe mmerụ ahụ / mgbaji nke akaị.

Ciprofloxacin nwere ike igbochi ọsọ nke mmeghachi omume psychomotor (ọkachasị megide mmanya mmanya), nke ndị ọrịa kwesịrị iji ngwaọrụ nwere ike ịme ihe na-echeta.

Na mmepe nnukwu afọ ọsịsaga-ekwepseudomembranous colitisn'ihi na ọrịa a bụ contraindication iji ọgwụ.

Ọ bụrụ na ọ dị mkpa, nchịkwa iviki nke barbiturates kwesịrị inyocha ọrụ nke CCC: ọkachasị, ECG, ọnụego obi, ọbara mgbali.

Opdị ophthalmic mmiri nke ọgwụ abụghị maka ọgwụ intraocular.