Rosuvastatin sz > Ọgwụ

Na-akwadokwa ọkwa shuga ruo ogologo oge
Weghachi weghachi ọgwụ insulin

Ndị na-agụ akwụkwọ anyị ejirila Aterol belata cholesterol. Thehụ ihe ndị ama ama n’ahịa a, anyị kpebiri inyefe ya n’aka gị.

Rosuvastatin SZ (North Star) so na otu nke statins nwere mmetụta na-ebelata.

A na-eji ọgwụ ahụ eme ihe n'ụzọ dị irè maka ọrịa ndị metụtara metabolism na-akpata nkwarụ, yana maka mgbochi ụfọdụ ọrịa obi. Enwere ike ịchọta nkọwa ndị ọzọ gbasara ọgwụ ahụ na ihe a.

Na ahịa ọgwụ, ị nwere ike ịchọta ọtụtụ ọgwụ nwere ihe rosuvastatin dị ike, n'okpuru ụdị dị iche iche. Rosuvastatin SZ bụ nke onye na - emepụta ụlọ bụ Severnaya Zvezda mepụtara.

Otu mbadamba ụrọ nwere 5,10,10, 20 ma ọ bụ 40 mg calcium rosuvastatin. Isi ya gụnyere shuga mmiri ara ehi, povidone, sodium stearyl fumarate, primellose, MCC, aerosil na calcium hydrophosphate dihydrate. Mbadamba ụrọ Rosuvastatin SZ bụ biconvex, nwere okirikiri ma kpuchie ya na mpempe pink.

Akụkụ nọ n'ọrụ bụ ihe na-egbochi HMG-CoA reductase. Ebumnuche ya bụ ịbawanye ọnụ ọgụgụ enzymes hepatic LDL, mee ka nkwalite nke LDL belata ma belata ọnụ ọgụgụ ha.

N'ihi iji ọgwụ ahụ eme ihe, onye ọrịa ahụ na-ahụ maka ibelata cholesterol nke "ọjọọ" ma bulie itinye uche nke "ihe ọma". Enwere ike ịhụ ezigbo mmetụta ugbua ụbọchị 7 mgbe mmalite nke ọgwụgwọ, ma mgbe ụbọchị 14 gasịrị ọ ga-ekwe omume nweta 90% nke mmetụta kachasị. Mgbe mkpụrụ ụbọchị iri abụọ na asatọ gachara, mkpụrụ ndụ na -emeghachi uru ọcha, ma mesịa chọọ ọgwụgwọ mmezi.

A na-ahụ ọdịnaya kachasị elu nke rosuvastatin 5 awa mgbe nchịkwa ọnụ.

Ihe fọrọ nke nta ka ọ bụrụ 90% nke ihe na-arụ ọrụ na-ejikọ ya na albumin. Nwepu ya n’arụ n’arụ n’arụọ ya.

Ihe ngosi na contraindications maka ojiji

Edere Rosuvastatin-SZ maka metabolism lipa na-egbochi ya na mgbochi nke ọrịa obi.

Dịka iwu, iji mbadamba nkume ndị a chọrọ ịgbaso nri hypocholesterol na mmega ahụ.

Mpempe akwụkwọ ntụziaka a nwere ihe ngosi ndị a maka ojiji:

izizi, ezinaụlọ ezumike ma ọ bụ hypercholesterolemia agwakọta (dị ka mgbakwunye na usoro ọgwụgwọ abụghị ọgwụ),
hypertriglyceridemia (IV) dị ka mgbakwunye na nri pụrụ iche,
atherosclerosis (igbochi ichebe akwa nke cholesterol ma mezie ogo nke cholesterol na LDL).
igbochi ọnya afọ, nwughari akwara na nkụchi obi (ọ bụrụ na enwere ihe dịka ịka nká, ogo nke protein C-reactive, sịga, mkpụrụ ndụ ihe nketa na ọbara mgbali elu).

Dọkịta machibidoro ị theụ ọgwụ Rosuvastatin SZ 10mg, 20mg na 40mg ọ bụrụ na ọ chọpụta na onye ọrịa:

Onwe onye n’onwe ya na ihe mejuputara.
Okpu gbasara akụrụngwa siri ike (ya na QC; Ntuziaka maka iji ọgwụ eme ihe

E kwesịrị iji iko mmiri ọ .ụ swallowụ rie mbadamba. Ana ewere ha n'agbanyeghị nri n'oge ọ bụla n'ụbọchị.

Tupu ịmalite na n'oge ọgwụgwọ ọgwụ, onye ọrịa ahụ na-ajụ ngwaahịa ndị dị ka ntinye (akụrụ, ụbụrụ), yolks, anụ ezi, mmanu abuba, nri ndi ozo abuba, ihe eji esi nri, achicha achicha na uto.

Dọkịta na-ekpebi usoro ị theụ ọgwụ ahụ dabere na ọkwa cholesterol, ebumnuche ọgwụgwọ yana njiri mara onye ọrịa ahụ.

Mkpụrụ mbụ nke rosuvastatin bụ 5-10 mg kwa ụbọchị. Ọ bụrụ na ọ gaghị ekwe omume iru nsonaazụ achọrọ, a na-amụba usoro ọgwụ ahụ ruo 20 mg n'okpuru nlekọta siri ike nke ọkachamara. Ọ dịkwa mkpa iji nlezianya na-elele 40 mg nke ọgwụ ahụ, mgbe a chọpụtara onye ọrịa na-arịa ọrịa hypercholesterolemia na oke ohere nke nsogbu obi.

-28bọchị 14-28 mgbe mmalite nke ọgwụ ọgwụ, ọ dị mkpa iji nyochaa metabolism lipid.

Ọ dịghị mkpa ịhazigharị ọgwụ ole ọ toụrụ ọgwụ ahụ nye ndị ọrịa agadi na ndị na-arịa oruru ezinaụlọ. Site na polyformism mkpụrụ ndụ, ebumnuche nke myopathy ma ọ bụ nke agbụrụ Mongoloid, dose nke ihe na-egbu egbu ekwesịghị ịfe 20 mg.

Usoro nchekwa okpomọkụ nke ịchekwa nkwakọ ngwaahịa ọgwụ adịghị ihe karịrị ogo 25 Celsius. Ndụ shelf bụ afọ 3. Debe nkwakọ ngwaahịa ebe echekwara na mmiri na anwụ.

Mmetụta Ọkụ na Nnwekọrịta

A kọwara ntụpọ mmetụta niile ọ bụla enwere ike ị whenụ mgbe ị na-eji ọgwụ ahụ na ntuziaka maka ojiji.

Dịka iwu, mmetụta ndị ọzọ na-akpata mgbe ị na-a thisụ ọgwụ a dị ụkọ.

N'agbanyeghị ọdịdị nke mmeghachi omume na-adịghị mma, ha dị nwayọọ ma na-aga n'onwe ha.

Ntuziaka maka ojiji, usoro ndị a ka egosipụtara:

Usoro endocrine: mmepe nke ọrịa mellitus na-abụghị insulin na-adabere (ụdị 2).
Sistemụ immune: Quincke edema na mmeghachi hyperensitivity ndị ọzọ.
CNS: dizziness na migraine.
Usoro ure: proteinuria.
Ọkpụkpụ akwara: ọrịa dyspeptik, mgbu epigastric.
Usoro akwara: myalgia, myositis, myopathy, rhabdomyolysis.
Akpukpo ahu: itching, hives, na ihe nro.
Usoro biliary: pancreatitis, nnukwu ọrụ nke transminases hepatic.
Ihe ngosi nke ulo-akwukwo: hyperglycemia, elu nke bilirubin, alkaline phosphatase, oru GGT, adighi aru oru thyroid.

N'ihi nyocha azụmaahịa, a na-achọpụta mmeghachi omume na-adịghị mma:

thrombocytopenia
ọrịa jaundice na ịba ọcha n'anya
Stevens-Johnson ọrịa
ncheta
isi ike,
ọrịa mamịrị polyneuropathy,
gynecomastia
hematuria
mkpụmkpụ ume na akpịrị kpọrọ nkụ,
arthralgia.

N'ọnọdụ ụfọdụ, iji Rosuvastatin SZ na ọgwụ ndị ọzọ nwere ike ibute nsonaazụ na-enweghị atụ. N'okpuru bụ atụmatụ nke usoro nlekọta ọgwụ a n'otu oge na-ajụ ndị ọzọ:

Na-ebugharị ndị na - egbochi protein - mmụba nke ohere myopathy na mmụba na ego nke rosuvastatin.
Ihe mgbochi nje HIV - ekpughere ekpughe nke ihe arụ ọrụ.
Cyclosporine - mmụba nke ọkwa nke rosuvastatin site na ihe karịrị ugboro asaa.
Gemfibrozil, fenofibrate na fibrates ndị ọzọ, nicotinic acid - ihe dị elu nke ihe na-arụ ọrụ na ihe ize ndụ nke myopathy.
Erythromycin na antacids nwere aluminom na magnesium hydroxide - mbelata ihe ndị dị na rosuvastatin.
Ezetimibe - mmụba na ntinye nke mpaghara arụ ọrụ.

Iji gbochie mmepe nke mmeghachi omume na-adịghị mma n'ihi otu oge nke ọgwụ na-ekwekọghị ekwekọ, ọ dị mkpa ịgwa dọkịta banyere ọrịa niile na-agakọ.

Ọnụahịa, nyocha na analogues

Ebe ọ bụ ọgwụ Rosuvastatin na-emepụta ụlọ ọgwụ ụlọ ọgwụ "North Star", ọnụahịa ya adịghị elu. Nwere ike ịzụta ọgwụ n'ụlọ ahịa ọgwụ ọ bụla na obodo.

Ọnụahịa nke otu ngwugwu nwere mbadamba 30 nke 5 mg nke ọ bụla bụ 190 rubles, 10 mg nke ọ bụla bụ 320 rubles, 20 mg nke ọ bụla bụ 400 rubles, na 40 mg nke ọ bụla bụ 740 rubles.

N'etiti ndị ọrịa na ndị dọkịta, ị nwere ike ịchọta ọtụtụ nyocha dị mma banyere ọgwụ. Nnukwu gbakwunyere bụ ụgwọ ọnụ na-akwụ ụgwọ ma nwee mmetụta ọgwụgwọ dị ike. Ka o sina dị, mgbe ụfọdụ enwere nyocha na-adịghị mma nke metụtara ọnụnọ nke nsonaazụ.

Eugene: “Achọpụtara m mmebi nke metabolism lipid ogologo oge gara aga. Anwalere m ọtụtụ ọgwụ. Na mbu were Liprimar, ma kwụsị, n'ihi ọnụ ahịa ya buru ibu. Ma kwa afọ, ana m eme ndị na-eme mkpọtụ iji na-ata arịa ụbụrụ. Dọkịta ahụ nyere m iwu Krestor, mana ọzọ esighị na ọgwụ na-adịghị ọnụ ala. Achọtara m n’otu n’otu n’otu, aha ya bụ Rosuvastatin SZ. M ka na-a takingụ ọgwụ ndị a, ana m enwe ọ greatụ, kọlestrọl m alọghachila nkịtị. ”

Tatyana: “N'oge ọkọchị, cholesterol dị elu ruru 10, mgbe ụkpụrụ dị 5.8. Ọ chigharịkwuuru onye na-agwọ ọrịa, o nyekwara m iwu Rosuvastatin. Dọkịta ahụ kwuru na ọgwụ a anaghị eme ihe ngwa ngwa imeju. Ana m ewere Rosuvastatin SZ ugbu a, na ụkpụrụ, ihe niile dị mma, mana enwere otu “mana” - isi ọwụwa na-eche mgbe ụfọdụ. ”

A na-ahụ rosuvastatin na-arụ ọrụ dị n'ime ọgwụ n'ọtụtụ ọgwụ ndị ndị nrụpụta dị iche iche mepụtara. Mmeghari gunyere:

Akorta,
Crestor
Mertenil
Rosart,
Ro statin
Rosistark,
Rosuvastatin Canon,
Roxer
Rustor.

Site na ịba ọcha n'anya nke rosuvastatin, dọkịta na-ahọrọ analogue dị mma, i.e. onye na - arụ ọrụ nke nwere ihe ọzọ na - arụ ọrụ na - arụ ọrụ, mana ọ na --emepụta otu mmetụta Lipid dị ala. N'ime ụlọ ahịa ọgwụ ị nwere ike ịzụta ụdị ọgwụ a:

Isi ihe na ọgwụgwọ nke cholesterol dị elu bụ ịgbaso ndụmọdụ niile nke ndị ọkachamara na-abịa, soro usoro nri ma na-ebi ndụ dị mma. Yabụ, ọ ga-ekwe omume ịchịkwa ọrịa ahụ ma gbochie nsogbu dị iche iche.

A kọwara Rosuvastatin SZ ọgwụ ahụ n'ụzọ zuru ezu na vidiyo dị n'isiokwu a.

Na-akwadokwa ọkwa shuga ruo ogologo oge
Weghachi weghachi ọgwụ insulin

Nyocha banyere ọgwụ na-ebelata cholesterol ọbara

Cholesterol dị elu nke ọbara bụ otu n'ime ihe na-akpata ọrịa obi. Cholesterol bụ abụba dị oke abụba, nke bụ isi mepụtara ya na imeju (ihe dịka 80%) ma akụkụ na-esokwa nri (ihe dịka 20%). Ọ na - enye antioxidants ahụ, na - ekere òkè na mmepụta nke steroid homonụ na bile acids, na - achịkwa ọrụ nke usoro ụjọ ahụ, ọ dị mkpa na owuwu sel.

Nke nta nke nta, cholesterol na - agbakọ n'ime ahụ ma debe mgbidi ahụ vaskụla n'ụdị nke oghere atherosclerotic. N'ihi ya, akwara nke arịa ahụ, mgbasa ọbara na - aghọ ihe siri ike, nfe oxygen na nri nke anụ ahụ na akwara, tinyere ụbụrụ na akwara obi. Nke a bụ otu ischemia, infarction na myocardial si amalite.

Cholesterol na-abanye n'ọbara dị ka ọgwụ na protein a na-akpọ lipoproteins. Nke ikpeazụ bụ nke ụdị HDL abụọ (nnukwu njupụta) na LDL (njupụta dị ala). Nke mbu bu cholesterol. LDL na-emerụ ahụ, ọ bụ ngafe ya nke dị ize ndụ maka ahụ.

Needsnye kwesịrị ịillsụ ọgwụ maka cholesterol?

Ndị dọkịta nwere echiche dị iche iche maka ị ofụ ọgwụ ọjọọ, ọtụtụ kwenyere na n'ihi ọnụ ọgụgụ dị ukwuu nke nsonaazụ ya, ekwenyeghị ojiji ha iji ihe ọ bụla. Tupu ịmalite ị suchụ ọgwụ ndị dị otú a, ịkwesịrị ịgbalị iji nweta nsonaazụ ahụ site na enyemaka nke nri, ịhapụ omume ndị na-adịghị mma, mmega ahụ. Agbanyeghị, n'ọnọdụ ụfọdụ, ị suchụ ụdị ọgwụ ahụ dị mkpa. Otu a gụnyere ndị nwere ọrịa obi na akwara, yana ischemia nwere nnukwu nkụchi obi, na -echekarị ihe nketa na cholesterol dị elu, ndị nwere nkụchi ma ọ bụ ọrịa strok.

Ọgwụ cholesterol

A na-eji ọgwụgwọ eme ihe site na iji ọgwụ ọjọọ nke ìgwè abụọ: statins na fibrates. Iji mee ka cholesterol dị ala, a na-ejikarị statins. Taa, ọ bụ ụzọ kachasị dị irè. Ihe ha mere bụ na ha na-egbochi imepụta cholesterol ọjọọ site na ibelata enzymes ndị dị mkpa maka nke a. Ya mere, ha na - egbochi imepụta iberibe ikuku na atherosclerotic na mgbochi nke arịa ọbara, nke pụtara na ha belata ihe egwu nke ọrịa obi na ọrịa vaskụla.

Statins bụ ọgwụ na-ebelata cholesterol dị njọ ma na-abawanye mma. Mgbe ha gachara, ọkwa nke izugbe na-ada site na 35-45 pasent, na ọkwa nke ndị ọjọọ - pasent 40-60.

You kwesịrị ịmara na ọgwụ ndị a nwere ọtụtụ mmetụta dị na ya, yabụ ịkwesịrị ị were ya naanị n'okpuru nlekọta ndị dọkịta. Statins na-emetụta ọtụtụ sistemụ, ebe nsogbu nwere ike apụtaghị ozugbo usoro nchịkwa, mana mgbe oge ụfọdụ gasịrị. Otu n'ime nsogbu ndị dị na ya bụ:

anya ntughari
nsogbu ịrahụ ụra
isi ọwụwa
ncheta
parasthesia
amnesia
nkuchi obi
afọ ọsịsa ma ọ bụ afọ ntachi,
ọgbụgbọ
ịba ọcha n'anya
anya cataract
pancreatitis
olu mgbu
Ihe nfụkasị ahụ n ’ụdị rashes na itching,
mgbago ọgụgharị,
imebi arụmọrụ,
nsogbu metabolic.

Atụmatụ ime, oge ime na inye ụmụ ara,
ụmụaka na-erubeghị afọ 18
ọrịa imeju
ọrịa akụrụ
ọrịa thyroid
mmadu anabataghi ya.

Statins na ụdị ha

Ekepụtara ha dabere na ihe eji arụ ọrụ nke na - egbochi mmepụta cholesterol. Na emume mbụ, ihe a bụ lovastatin. Ka oge na-aga, ọgwụ pụtara na fluvastafin, simvastain na pravastain. Ọgwụ ọhụụ nwere rosuvastatin na atorvastatin nwere mmetụta akpọpụtara, belata LDL na ọbara ma mụbaa cholesterol dị mma. Ọ bụrụ na ọgwụ nwere lovastine belata LDL site na 25%, mgbe ahụ ọgbọ ọhụrụ nke mbadamba nkume nwere rosuvastine - site na 55%.

Statins bụ ọgwụ ndị a:

Ndị na-agụ akwụkwọ anyị ejirila Aterol belata cholesterol. Thehụ ihe ndị ama ama n’ahịa a, anyị kpebiri inyefe ya n’aka gị.

ya na lovastatin - “Choletar”, “Cardiostatin”,
ya na simvastatin - “Vazilip”, “Ariescore”, “Sinkard”, “Simvastol”, “Zokor”,
ya na Furevastatin - “Leskol Forte”,
ya na atorvastatin - “Tulip”, “Liptonorm”, “Atoris”, “Liprimar”, “Canon”, “Liprimar”,
ya na rosuvastatin - “Roxer”, “Mertenil”, “Tavastor”, “Crestor”, “Rosulip”.

Ihe ikwesiri ima banyere statins?

A na-eburu ha ogologo oge na nlekọta nlekọta ahụ ike.
A na-emepụta cholesterol n'abalị, yabụ ịkwesịrị ị were ọgwụ ọgwụ a na mgbede.
Ọ bụrụ na ị nwere adịghị ike na mgbu, ị kwesịrị ịkpọtụrụ dọkịta gị ozugbo.
N'iji nlezianya debe ya, ndị mmadụ ka a na-enye ya n'aka ọnya isi na ọkwa ọ bụla.
Mụ nwanyị nke afọ omumu kwesịrị iji ọgwụ mgbochi ma na-ewere statins.
N'oge ọgwụgwọ, a ga-eme nyocha ọbara iji chọpụta arụmọrụ nke ọgwụgwọ yana ịchọpụta nsonaazụ ọgwụ.

Otu ọgwụ ọgwụ ndị ọzọ na-ebelata cholesterol bụ ihe dị iche iche nke fibroic acid. Ọgwụ ndị a adịchaghị arụ ọrụ megide LDL karịa statins. Ha na-abawanye HDL na ọkwa dị ala nke abụba na-anọpụ iche, ma ọ bụ triglycerides. Na mkpokọta, cholesterol na-ebelata 15%, ebe a na-ewusi mgbidi vaskụla ike.

Ọgwụ ndị a so n’otu a:

Mmetụta dị n'akụkụ gụnyere:

akpukpo aru
emeghari udiri nri,
myopathy
allergies
mmepe nke pancreatitis,
ụba nke enzymes imeju,
mmepe nke thrombosis.

Mmechi

Ọgwụ ọgwụgwọ nke cholesterol dị elu nwere ọtụtụ nsonaazụ ndị nwere ike imetụta ahụike na ojiji ogologo oge. Ndị dọkịta ekweghị banyere nhọpụta nke ọgwụ ndị dị otú ahụ. Menmụ nwoke na-eto eto (rue afọ 35) na ụmụ nwanyị toro afọ ịmụ nwa na-adịghị enwe ike ibute ọrịa obi na-adụ ọdụ ka ha belata cholesterol ha n’agwọghị ọgwụ, ya bụ, ịgbanwe ụdị nri ha na-ebi. Agbanyeghị, enweghị ike inye mbadamba nkume mgbe niile. Ọ dị mkpa icheta na ha kwesịrị iwere ya naanị ka dọkịta si duzie ya. Na mgbakwunye na ị medicationsụ ọgwụ, ịkwesịrị ịgbanwe ụdị ndụ ị na-ebi, ya bụ, soro usoro nri, mmega ahụ, ewepu ise anwụrụ.

Rosuvastatin - ngosipụta maka ojiji

Kedu ihe eji eme rosuvastatin? Ndepụta ọrịa na ọnọdụ dị obere:

Hypercholesterolemia (ụdị IIa, gụnyere famileal heterozygous hypercholesterolemia) ma ọ bụ hypercholesterolemia agwakọta (ụdị IIb) dị ka mgbakwunye na nri,
Ezinaụlọ hyzycholesterolemia dị ka mgbakwunye nri,
Ọria akwara, akụkụ ụbụrụ ma ọ bụ akwara atherosclerosis, akwara akwara
Atherosclerosis nke akwara akwara nke ala ala, tinyere oria Lerish, obara mgbali elu, ya na otutu protein nke C-reactive na akuko ezinulo,
Hypertriglyceridemia (ụdị nke IV dịka Fredrickson),
Ọgwụ nke infarction na ụbụrụ nke myocardial, na-amalite site na oge oke,
Mgbochi infarction myocardial na ọrịa strok.

Dịka ị pụrụ ịhụ, ịkwesighi iji Rosuvastatin dịka mbadamba cholesterol nke ị nwere ike iji na aka gị.

Usoro usoro usoro - esi ewe rosuvastatin?

Ejiri ọnụ mmiri rosuvastatin mbadamba Rosuvastatin. Usoro akwadoro ịmalite maka ndị okenye bụ 1 mbadamba rosuvastatin 10 - 1 oge kwa ụbọchị.

Dabere na nsonaazụ nyocha ndị ahụ, enwere ike ịbawanye usoro onunu ogwu ka 20 mg mgbe izu anọ gasịrị (ọ bụghị na mbụ).

Increbawanye dose ahụ gaa na 40 mg nke rosuvastatin ga-ekwe omume naanị na ndị ọrịa nwere nnukwu hypercholesterolemia na nnukwu nsogbu nke ọrịa obi (ọkachasị ndị ọrịa nwere ezinụlọ hypercholesterolemia) na obere ọgwụgwọ ọgwụgwọ na ọnụọgụ 20 mg, yana n'okpuru nyocha ahụike.

Mgbochi pathologies nke CCC
N'ime nyocha nke mmetụta mgbochi rosuvastatin, a na-eji dose 20 mg / ụbọchị mee ihe. Ekwesịrị itinye ya n’uche - nmalite ịmalite kwesịrị ịdị obere ma nyekwa ya ike iburu n’uche banyere ndị ọrịa site na 5 ruo 10 mg / ụbọchị.

Njirimara

Maka ndị ọrịa sitere na afọ 70, a na-enye ọgwụgwọ na rosuvastatin na usoro mbido 5 mg / ụbọchị. Ọ bụ dọkịta ga-emegharị sịnịma ahụ, ma ọ bụrụ na ọ dị mkpa, na-eburu ego nke cholesterol na ohere nke ọrịa pathologies nke akụrụngwa obi.

Mgbe ị na-eji rosuvastatin na ọgwụ nke 40 mg, a na-atụ aro ka nyochaa ndị na-egosi ọrụ gbasara akụrụ. Mgbakwunye contraindications na rosuvastatin ga-ekwe omume.
N'ọtụtụ oge, proteinuria na-ebelata ma ọ bụ na-apụ n'anya n'oge ọgwụgwọ ma ọ pụtaghị na ọrịa ma ọ bụ nwee ọrịa akụrụ dị.

N'ime ndị ọrịa nwere hypercholesterolemia n'ihi hypothyroidism ma ọ bụ ọrịa nephrotic, a ga-ebu ụzọ gwọọ ọrịa nke isi tupu ọgwụgwọ ya na rosuvastatin.

Nchịkọta nyocha niile: 27 Dee nyocha

Enwere m cholesterol 6,17 - enyere m mbadamba rosuvastatin ndị a, mana mgbe m na-agụ ntuziaka ndị ahụ, enwere contraindications dị iche iche nke na ọ na-atụ ụjọ ịmalite iwere ya. Eleghi anya ọ ga-etili n'oge tupu m a choụ ọgwụ ụdị ọgwụ a.

Elena, buru ụzọ nwaa nri ahụ, ma ọ bụrụ na ịnwalebeghị ya. Rie nri ọzọ ... Satin bụ ebe ikpeazụ.

kedu ihe kacha mma ị ga - eme?

Were dị ka edere ya na ntuziaka maka ojiji, ma ọ bụ dị ka nke dọkịta si nye gị ọgwụ rosuvastatin gosipụtara.

Rosuvastatin amalitela ka dọkịta depụta ya na nso nso a. Nsonaazụ nnwale ahụ ga-egosi ọrụ ya n’oge na-adịghị anya, mana na akwado Rosuvastatin m chọrọ ikwu na ya enweghị mgbaàmà ọjọọ ndị ahụ, dịka site na ụfọdụ ọgwụ ndị ọzọ.

E nwere ihe ọkpụkpọ mebiri emebi n'ọnụ na goosebumps, ọ bụ ezie na 10mg dose bụ nnọọ dubious na ọnụ ọgwụ.

Ejiri m rosuvastatin-s3 40 mg otu afọ gara aga (dọkịta nyere ya iwu) enwere cholesterol dị elu, otu ọnwa mgbe ọ mechara bụrụ ahụ. Ọ dị mkpa iji belata obere.

M na-ewere rosuvastatin-sz, na usoro onunu ogwu nke 10 mg, ma na-enwekwa nsogbu nke ukwuu na nsonaazụ - enwereghị m nsogbu zuru oke na imeju iji nweta cholesterol dị elu, mana enwere m nsogbu n'obi na - enweghị m mma, enwere m cholesterol belatara.

Mgbe ị hụrụ na ntuziaka ahụ nwere ọtụtụ nsonaazụ dị iche iche, nke a na-egosi na a mụọla ọgwụ ahụ n'ụzọ zuru oke ma mụọ ụlọ nyocha nke ọma. Echekwala na ịzụta ọgwụ "ọrụ ebube" ọzọ na obere ntụziaka na ngosipụta "maka ọrịa niile" ga-abụ eziokwu. Azụmaahịa ọgwụ bụ otu n'ime ụwa kachasị mkpa na ekwesịrị 'ịkwalite ya'. Ọ ka m mma ịzụta ụlọ, egosipụtara, na nke kachasị mkpa, Rozuvastatin-SZ họpụtara dọkịta, nke m na-eme kemgbe ọnwa asaa gara aga. N'ihi ya, cholesterol belatara site na 6.9 ruo 5.3. Naanị emela ọgwụ onwe gị - buru ụzọ gaa dọkịta!

Rosuvastatin dị mma maka cholesterol dị elu, mana ọ bụrụ hypercholesterolemia na-agafe agafe, ị nwere ike ịnwe nri na dibicor, yabụ na-ezere mmetụta ogologo oge na-adịghị mma nke statin na ahụ.

Rosuvatin-sz (dị ka ọ dị na foto a) bụ nke kachasị ọnụ maka statins niile. Ekwenyere m - ọ na-arụ ọrụ. Site na nsonaazụ ya - ọgbụgba na ụbọchị mbụ nke nnabata, mgbe ahụ ihe niile gawara. Cholesterol sitere na 7.5 ruo 5.3 n’ime ọnwa 1.5.

Nne nne m na-a roụ rosuvastatin sz, e nyekwara nne m ọgwụ atorvastatin sz, ụjọ anaghị a toụ ya, n'ihi na ọ bụrụ na ị doụghị ya, ihe niile nwere ike ịkwụsị n'ụzọ ọjọọ. Site n'ụzọ, ọgwụ ndị ahụ adịghị ọnụ.

Ọgwụ mara mma, rosuvastatin-sz, ana m akwado site na ihe atụ nke onwe - n’oge ọnwa eji, cholesterol dara site na 8.8 ruo 5.1, na nke a na enweghị nri (echegharịghị, enweghị m ike idebe). M na-ekwukarị na ndị mba ọzọ ka mma, abụghị m onye mbuso agha ma ọ bụ na-abụghị, mana ọ dị ka ọgwụ anyị ka nwere ike ịme, ma ọ dịghị ihe ọzọ anaghị agbagha.

Anọwo m na-akpọ atorvastatin-sz ogologo oge, usoro ọgwụgwọ ahụ abụghị nke buru ibu, mana ọ naghị ekwe ka cholesterol rute na ọnụọgụ dị ize ndụ.

Ekwenyere m na nyocha dị mma banyere rosuvastatin-sz! Kemgbe afọ ise, m na-alụ ọgụ cholesterol, anwara m ihe dị iche iche - ma ndị na-ebubata ya na nke anyị. Ugbu a, n'ezie, ndị mbubata enweghị ike ịkwụ ụgwọ ya ma ọlị, naanị rosuvastatin-sz si n'ụlọ ndị dị mma bata, na nke kachasị mkpa, ọ na-abụkarị n'ụlọ ahịa ọgwụ.

Na 33, n'ụlọ nyocha ahụ, ọ chọpụtara na mberede na cholesterol dị elu! N'ozuzu 8.1, ihe ojoo - 6.7! Nọmba dị egwu. Amalitere m iji rosuvastatin-sz, enwere m egwu na nsogbu ga-esi na ya pụta. Na ahụmịhe m, ọgwụ dị nkịtị, ihe kachasị mkpa bụ na lolesterol lowers.

Anọwo m na-ewere rosuvastatin-sz afọ 3. Mgbe nkụchi obi gasịrị, a họpụtara ha ka ha dịrị ndụ. Enweghị mmetụta ọ bụla, ewezuga na mbu enwere obere nkụwa, cholesterol na-adịgide 4.5-4.8. Obere ọnụahịa ahụ.

Ọmarịcha ọgwụ bụ rosuvastatin. Emere m rosuvastatin-sz, ọ dị ọnụ ala karịa nke ndị ọzọ, mana enwere m ike ịsị na m na-a itụ ya kemgbe ọnwa nke atọ wee dị m mma. Enweghị mmetụta ọ bụla, ọ bụ ezie na aga m agwa gị akụkọ ọjọọ ahụ. Cholesterol belatara site na 8.5 ruo 4.3.

Ọ malitere were rosuvastatin-sz mgbe ọmụmụ abụọ nke oforvastatin - dọkịta ahụ tụrụ aro ịgbanwe ka ọ bụrụ ọgwụ ọhụụ. Cholesterol di nma. Ahụghị m mmetụta ọ na-akpata. Obere ọnụahịa ahụ.

Enwekwara m ike ito rosuvastatin-sz, yana ndị na-ekwu okwu dị n'elu - ọnụ ahịa ahụ masịrị m nke ukwuu, n'ezie achọpụtaghị m ihe dị iche na ọgwụ ndị ọzọ, ndị Russia nabatara ma webata, ha niile na-arụ ọrụ n'otu ụzọ ahụ. Ya mere, ị nwere ike ịhọrọ nkwụ ụgwọ.

E nwere ụzọ ndị mmadụ si arụ ọrụ, mana ha anaghị arụ ọrụ. Ahụ anyị na-arụpụta cholesterol, ma ọ bụ kama ọ kacha. Nwere ike belata ya na akpụ akpụ, dịka ọmụmaatụ, otu rosuvastatin-sz, nke akọwara n’elu. Ofkpụrụ nke ime ihe - ọgwụ na - egbochi mmepụta cholesterol n'ime imeju (nke a bụ nkọwa dị oke egwu, gụọ saịtị profaịlụ). Elegharala ndị dọkịta anya ma ọlị, naanị ha ga-ahọrọ ọgwụgwọ kwesịrị ekwesị.

Ihe na-eme ka ọ dị mfe iwere statins bụ na enwere naanị otu mbadamba ụbọchị. Enweghị m n'aka ma ọ bụrụ na ị nwere kọlestrọl ruru 7 ọ dị mkpa, mana ọ bụrụ na ọ dị elu, mgbe ahụ ọ dị oke mkpa. Atherosclerosis, ọrịa strok na nkụchi obi na-aka njọ karịa ụjọ nke mmetụta pụrụ iche maka imeju na akụrụ. Site n'ụzọ, mgbe nkụchi obi, a na-ahazi akpụrụ akpụ maka ndụ na enweghị ihe ọ bụla, ndị mmadụ na-ebi ndụ obi ụtọ mgbe ọ bụla. M na-emegide ọgwụ ndị dị oke ọnụ, ma ọ bụrụ na enwere ọnụ ala, yana analogues nke ụlọ, yabụ ọ bụrụ na ekenye gị akpụ, chọọ jụọ dọkịta gị banyere rosuvastatin-sz. Na mgbe ahụ a na-ahọpụta obe na tevastors dị iche iche na puku ole na ole kwa ngwungwu, mana enwere otu ihe na 400 rubles.

Gwa m, kedu ihe kwesịrị ịdị n’ọbara cholesterol n’ime agadi, ihe dị ka afọ 67? Kwuru, ụkpụrụ bụ 3.5)

N'oge a, a na-ahụta ụkpụrụ dị ka 4.4 ruo 7.8. Mana odi nma idobe cholesterol na oke ala ya. Iji maa atụ, n’ime ndị gbara afọ 30, usoro iwu si na 3.3 ruo 5.9. Ọ bụrụ na kọlestrọl dị elu, a na-enye ọgwụ akpụ. Dịka ọmụmaatụ, otu rosuvastatin-sz banyere nke ha dere n'elu.

Ana m ewere analogue, rosuvastatin-sz na usoro nke 40 mg, yabụ ọ na-apụta ị were naanị otu mbadamba ụbọchị, nke dị mma. Na ọnụahịa dị ala karịa rosuvastatin dị mbubata.

Ọnwa isii ka ha gbasachara ahụ, ha hụrụ ite ke arịa abụọ ọzọ Rosuvastatin na-ewere oge a dum mg 20. Nke mbụ, gwọọ umeji na akụrụ, azụ, akwara obi, ikekwe nnukwu ọgwụ? Gwa m, ọ dịkarịa ala, onye ọgwụ a gwọrọ. . mgbe ego ole?

Anọwo m na-ewere rosuvastatin ogologo oge, ihe dị ka afọ 4. Anaghị m eme mkpesa banyere cholesterol 5.9-6.2 anaghị ebili n'elu, nrụgide ahụ belatara, ọ na-adịbu 160-170, ugbu a 130-140. N’ọnwa ndị mbụ, a na-ahụkarị mmetụta ahụ kemgbe mkpụmkpụ ume iku ume malitere na mgbatị anụ ahụ na iwe iwe na izu ọ bụla. Na-esote, naanị ọnwa isii ọ bụla, njikwa ọbara.

Ntụziaka maka iji rosuvastatin

Ọgwụ Rosuvastatin (Rosuvastatin) nwere mmetụta dị ala, nwere otu ihe ahụ nọ n'ọrụ. A na-emepụta ọgwụ ahụ site na ọtụtụ ụlọ ọrụ - Russian Canon na North Star, Israel Teva. Eji ọgwụ a gụrụ n'onye ezi omume site na ịba ụba nke lipids na cholesterol n'ime ọbara. Ngwá ọrụ na-eme ka ịta ihe ndị ahụ pụta, na-eweghachi ahụike mmadụ.

Ngwakọta na ụdị ntọhapụ

Rosuvastatin dị naanị n'ụdị mbadamba; enweghị ụdị mgbapụta ọzọ. Njirimara nke ihe mejupụtara:

Gburugburu mbadamba nkume pink dị n'ime ọcha

Theta nke rosuvastatin n'ụdị nnu nke calcium, mg kwa pc.

Red dye carmine, microcrystalline cellulose, triacetin, stgelatinized stachi, magnesium stearate, titanium dioxide, silloon silicon dioxide, hypromellose, lactose monohydrate

Mpempe akwụkwọ 10 PC., 3 ma ọ bụ 6 kwa mkpọ

Pharmacodynamics na pharmacokinetics

Rosuvastatin ọgwụ na-eme ka egbugbere ọnụ dị nro bụ ihe na - egbochi ihe enzyme gamma-glutamyltranspeptidase, na - akwalite ọdịdị mevalonate, ihe na - amalite cholesterol. Ihe na - arụ ọrụ nke ọgwụ ahụ na - arụ ọrụ na imeju, enwere nchịkọta nke cholesterol na catabolism nke lipoproteins nke njupụta ọ bụla. Ọgwụ na-abawanye ọnụọgụ nke ndị na-anabata ya maka nke ikpeazụ na sel nke imeju, na-abawanye nri ha na catabolism, nke na-egbochi mkpokọta lipoproteins dị obere.

Ozugbo n'ime ọbara ahụ, rosuvastatin inhibitor na ebufee efflux na-ebute ntinye kachasị mgbe awa ise gasịrị. Metabolism ya metụtara cytochrome isoenzymes na-apụta na imeju, ọ na - ejikọ ya na albumin site na 90%. Mgbe ekpochasịrị, etolite metabolites n'ime imeju na-arụ ọrụ obere, anaghị emetụta ebugharị nke anion na polypeptides, creatinine na creatine phosphokinase nwechapụ, na chosyerol biosynthesis.

Ihe fọrọ nke nta ka ọ bụrụ ọgwụ dum na ọgwụ ahụ na-ahapụ eriri afọ anaghị agbanwe agbanwe, ihe ndị ọzọ - na akụrụ na mmamịrị. Nkeji ọkara bụ awa 19. Achọpụtaghị ọgwụ ọgwụ ọgwụ nke ihe mejupụtara nke ihe mejupụtara ahụ site na okike, afọ, mana enwere ọdịiche iji ruo na ntinye uche kachasị na ndị nnọchite agbụrụ ndị ọzọ (okpukpu abụọ karịa na Mongoloids na India karịa na Caucasians na Negroids).

Ihe na-arụ ọrụ nke rosuvastatin

Ihe mejupụtara ihe mejupụtara inhibitor na - ebelata cholesterol dị elu, triglycerides, lipoproteins njupụta dị ala, apolipoprotein, na - eme ka mkpokọta lipoproteins dị elu. N'ihi ya, n'ime ndị ọrịa nwere hypercholesterolemia, profaịlụ egbugbere ọnụ na-akawanye mma na ntinye atherogenicity belatara. Mmetụta ọgwụgwọ nke ọgwụ ahụ na-amalite n'ime otu izu, ruru oke site na ọnwa nke ọgwụgwọ. E gosipụtara ọgwụ a maka ndị okenye nwere hypercholesterolemia nwere ma ọ bụ na-enweghị triglyceridemia, na ebumnuche ọnya afọ ma ọ bụ nkụchi obi.

Ihe ngosi maka ojiji

Isi ihe maka iji ọgwụ Rosuvastatin bụ ọrịa ndị metụtara ogo lipid dị elu. Ihe egosi:

hypercholesterolemia bụ isi, gụnyere ụdị ezinụlọ heterozygous, ma ọ bụ hypercholesterolemia agwakọta na nri, mmega ahụ,
Ezigbo ụlọ hypercholesterolemia na nri yana usoro ọgwụgwọ egbugbere ọnụ,
hypertriglyceridemia,
na-ebelata ngba nke atherosclerosis,
mgbochi mbụ nke ọrịa strok, nkụchi obi, ịtụgharị akwara n'enweghị ihe mgbaàmà nke ọrịa obi na-arịa akwara, mana n'ihe egwu nwere ike ibute ya (ime agadi, ọbara mgbali elu, ise anwụrụ, akụkọ gbasara ezinụlọ).

Otu esi ewere rosuvastatin

Mbadamba ụrọ na-ewere ọnụ, jiri mmiri hichaa ya. Enweghị ike ita ata ma ọ bụ gwepịa ha. A na-ewere ọgwụ ahụ n'oge ọ bụla n'ụbọchị, enweghị nri mgbakwunye. Tupu ịmalite ọgwụgwọ, onye ọrịa ahụ ga-agbaso nri nwere mgbochi nke nri nwere abụba na-emerụ ahụ. Ọgwụ nke mbụ maka ndị ọrịa bụ 5 ma ọ bụ 10 mg nke rosuvastatin otu ugboro / ụbọchị. Mgbe izu anọ gachara, usoro ogwu ahụ nwere ike ịbawanye elu.

Ejiri dose rosuvastatin 40 mg nke rosuvastatin na nlezianya, a chọrọ nlebara anya pụrụ iche maka ndị ọrịa dị otú ahụ. Kwa izu 2-4 nke ọgwụgwọ, ndị ọrịa na-enye onyinye ọbara iji chọpụta plọg lipi. Maka ndị ọrịa agadi, a naghị edozi ọgwụ ahụ, ya na ọdịda akwara siri ike, na-ewere mbadamba ihe. Maka oke ahụ ọria ịba ọcha n’anya nwere ike ịgụta 5 mg.

Ntụziaka pụrụ iche

Rosuvastatin na-emetụta ọrụ nke imeju na akụrụ, sistemu ahụ ndị ọzọ, yabụ usoro ntuziaka pụrụ iche so ya na usoro ọgwụgwọ ya. Iwu nke ị takingụ ọgwụ:

Doses dị elu nke ọgwụ nwere ike ime ka protein tialar tubular trensient dị obere. N'oge ọgwụgwọ, o kwesịrị ileba arụmọrụ akụrụ ya anya.
Usoro onunu ogwu kariri 20 mg / ubochi nwere ike ibute myalgia, myopathy, rhabdomyolysis, na ihe ndi ozo na aru oru. Ọ bụrụ na ndị ọrịa nwere ihe ndị dị ize ndụ maka mmepe nke ọrịa ndị dị otú ahụ, a na-enye ọgwụ ahụ ka ọ kpachara anya.
Ọ bụrụ na n’oge ọgwụgwọ onye ọrịa nwere ọrịa mgbu, ike adịghị ike ma ọ bụ akpịrị ịkpọ nkụ n’ihi ọrịa ma ọ bụ ahụ ọkụ, mkpa ọ dị ka ọ gaa dọkịta. Ọnọdụ nke myopathy na-egbochi ogbugba (adịghị ike akwara, ịba ụba enzyme ọrụ) adịkarịghị eme. Iji kpochapụ ihe ịrịba ama na-adịghị mma mgbe nyocha serological, a na-eme ọgwụgwọ immunosuppressive.
Iwere mbadamba rosuvastatin anaghị emetụta mmụba nke akwara ọkpụkpụ.
Ọ bụrụ na hypercholesterolemia kpatara hypothyroidism ma ọ bụ ọrịa nephrotic, mgbe ahụ ị ga-ebu ụzọ kpochapụ ọrịa na-akpata, wee buru Rosuvastatin.
A na-akagbu ọgwụ ahụ na mmụba nke ọrụ hepatic transaminases ugboro atọ.
Ọgwụ ahụ nwere ọgwụ lactose, ya mere a na-egbochi nchịkwa ya n'ihe metụtara enweghị ntinye lactose, ụkọ lactase, glucose-galactose malabsorption.
Ogologo oge ọgwụ statin na-akpata ọrịa ngụgụ, nke a na-egosipụta site na ume iku ume, ụkwara, adịghị ike, na ahụ ọkụ. Ọ bụrụ na achọpụtara mgbaama ndị a, a ga-akwụsị ịgwọ ọrịa ahụ.
N'oge a na-eji ọgwụ ahụ, ọgbụgbọ na adịghị ike nwere ike ime, yabụ, a na-atụ aro ka ịhapụ ịchịkwa usoro na ụgbọ ala.
Mgbe ị na-ede ọgwụ, a ga-atụle polymorphism mkpụrụ ndụ ihe nketa.

N’oge ime ime

Ihe eji eme rosuvastatin egbochi ime ime. Ọ bụrụ na nwanyị ịmụ nwa ga-a ,ụ ọgwụ, mgbe ahụ o kwesịrị iji ụzọ ịtụkwasị obi nke igbochi afọ ime. Mgbe ị na-achọpụta afọ ime, ekwesịrị ịkwụsị ọgwụ ahụ ozugbo.Amabeghị ma ihe ahụ emeghị ka ọpịara ara ara, mana a na-akagbu iji mbadamba oge ara.

Na nwata

A na - ekwekọrịta ojiji nke mbadamba rosuvastatin maka ụmụaka na ndị nọ n'afọ iri na asatọ. Mmachibido iwu dị otú a na-emetụta ọrụ ike nke ọgwụ na imeju, nke nwere ike ibute enweghị ntụgharị ma ọ bụ nnukwu ọrụ na ọrụ nke akụkụ a ma ọ bụ ahụ niile. Nhọpụta nke ọgwụ mgbe afọ iri na asatọ ga-ebu ụzọ gaa nyocha nke dọkịta na nyocha zuru ezu.

Bụrụ na ndị nwere nsogbu gbasara akụrụngwa yana ọrụ ịba ọcha n'anya

A na-egbochi ndị ọrịa nwere nnukwu akụrụ gbasara akwara ọ bụla. A na-amachibido ị dailyụ ọgwụ kwa ụbọchị nke 40 mg nke rosuvastatin maka ndị ọrịa nwere ọdịda akụrụngwa na-agafeghị oke, a na-eji ọgwụ nke 5, 10 na 20 mg doses. N'ihe banyere ọdịda akwara adịghị ike, a ga-eji nlezianya mee ihe 40 mg nke ihe ahụ.

Mkparịta ụka ọgwụ ọjọọ

Ejiri Rosuvastatin gosipụtara na-arụ ọrụ na-arụ ọrụ nke ọgwụ ndị ọzọ. Nchikota na mmekorita enwere ike:

Ngwakọta ọgwụ a na Cyclosporine, ndị na-egbochi nchebe mmadụ na-egbochi immunodeficiency virus (HIV), fibrates na dose nke 40 mg, inducers nke cytochrome substrate amachibidoro.
A na-anabata ngwakọta ọgwụ 5 mg na gemfibrozil, ndị ọrụ hypolipidem, fenofibrate, nicotinic acid, fluconazole, digoxin, ọgwụ nje.
A na-adụ ọdụ iji kpoo rosuvastatin na ezetimibe.
N’agbata mbadamba mbadamba na nkwụsị nke ọgwụ antioxide dabere na aluminom ma ọ bụ magnesium hydroxide, awa abụọ kwesịrị ịgafe, ma ọ bụghị na ịdị irè nke ihe mbụ akwụsịla.
Nchikota nke ogwu na erythromycin na-eme ka ntughari nke rosuvastatin di na ọbara site na ato.
Nchikota nke ogwu na fusidic acid nwere ike iduga mmepe nke rhabdomyolysis.
Ọha nke Rosuvastatin na-edozi mgbe ejikọtara ya na Ritonavir, Atazanavir, Simeprevir, Lopinavir, Clopidogrel, Eltrombopag, Darunavir, Ketoconazole. Njikọ ya na Tipranavir, Dronedarone, Itraconazole, Fosamprenavir, Aleglitazar, Silimarin, Rifampicin, Baikalin chọrọ ihe yiri ya.
Ọgwụ a na - eme ka ọgwụ mgbochi ọgwụ a na - egbochi ọnụ site na homonụ ethinyl estradiol na norgestrel.

10 kwuru

Iji mee ka onye na - ahụ maka ọrịa obi nwee obi ike na onye ọrịa anaghị etolite ọrịa mberede obi - ọrịa coronary syndrome, ọrịa myocardial infarction ma ọ bụ ischemic strok, dọkịta ahụ kwesịrị ilekọta ọkwa nke ngụkọta na cholesterol "ọjọọ", nke gụnyere LDL (low density lipoproteins) ) Na nke a, enyemaka sitere na mba dị iche iche na enyemaka nke European Society of Cardiology na-enyere ya aka.

Ọ na-ekwu na ndị ọrịa nwere nnukwu nsogbu ibute ọrịa obi ha kwesịrị ịgba mbọ hụ na ọkwa LDL erughị 3 mmol kwa otu lita (na -ekere oke), na-erughị 2.5 nwere nkezi na erughị 1.8 mmol / l ya na oke onodu ihe ike (dika ima atu, na onyonya nke obi ma obu ntiria na mbu).

Iji mejuputa ndụmọdụ ndị a siri ike na ndị ọrịa agadi (ọdachi dakwasịrị, n'agbanyeghị 'imegharị ahụ ngwa ngwa, n'agbanyeghị ọrịa ndị ọrịa), ọ dị mkpa ka eme ọtụtụ ihe. Ọ bụrụ na ịgbanwe ọdịdị nri na ụdị ndụ ka dị mfe ime n’oge nwata, mgbe ahụ, onye agadi, na-abụkarị onye na-anọkarị otu ebe, na-ebu oke ibu na ọrịa dị iche iche (ọrịa shuga), na-esikarị ike iji nweta ụkpụrụ ịchọrọ. Yabụ, ọgwụ ndị na-eme ka metabolism abụba dị n'ọrịa ndị dị otú a bụrụ ihe ndabere na ntọala nke igbochi ọrịa vaskụla na nsogbu.

N'ime ọgwụ ndị a, a na-ahụta statins na-egbochi HMG - CoA - reductase enzyme. N'oge anyị enwere ọtụtụ, enwere ọtụtụ ọgbọ nke statins, na arụmọrụ ha dịgasị iche iche. Yabụ, a na-ezo aka na simvastatin (“Vazilip”) na ọgwụ mbụ dị ọnụ ala. Onye nnọchite anya ọgbọ nke abụọ bụ fluvastatin (Leskol), nke atọ - atorvastatin (Liprimar). Ọgwụ kachasị dị irè na nke ọhụụ gụnyere rosuvastatin. Ngwọta a bụ nke akụkụ nke ọgbọ nke anọ, ọgwụ mbụ bidoro n’ahịa ahụ bụ Crestor.

Ugbu a, na ụlọ ahịa ọgwụ Russia ị nwere ike ịzụta ọ bụghị naanị rosuvastatin mbụ, kamakwa ọtụtụ analogues - ihe dị ka ọgwụ iri dị iche iche, na ọ bụrụ na ị gụọ ọnya na-enweghị aha (nke nwere aha azụmaahịa), mgbe ahụ ọnụ ọgụgụ ndị na-emepụta ọgwụ a ga-akarị iri na abụọ. Ahịa ahụ nwere mmetụta dị mkpa na ọ dị mkpa, ọ dịghịkwa onye ga-emepụta ọgwụ na-adịghị ike. Kedu ihe na-eme ka Rosuvastatin nwee mmasị, oleekwa otu o si arụ ọrụ?

Usoro nke rosuvastatin

ọgwụ mbụ na analogues

Dịka e kwuru n’elu, statins niile na - egbochi HMG - CoA - reductase, nke na - arụ ọrụ dị mkpa na kọlụm cholesterol yana akụkụ ya "jọrọ njọ". Mana mkpụrụ ndụ rosuvastatin gbanwere n'ụzọ nke na ọ naghị abụ abụba na abụba, yabụ nwee nnukwu mmekọrịta maka enzyme achọrọ (4 ugboro karịa ihe ndị sitere n'okike nke ahụ). N'ihi nke a, njikọ nke rosuvastatin na onye na-anabata nnabata chọrọ ngwa ngwa, na-agbanwe agbanwe na "si n'aka". N'ihi ya, a na-ebelata mkpokọta mevalonic acid, kọlejirol a na-akwalite imeju.

Mkpụrụ ndụ imeju na-aza nke a na mmụba n'ọnụ ọgụgụ nke ndị na-anabata maka irighiri mmiri cholesterol na akpụkpọ ahụ, "mma" ụmụ irighiri ihe ndị ka mma anapụrụ ma wepụ ha n'ọbara.

Mgbe ị theụsịrị ọgwụ ahụ, ntinye uche kachasị na ọbara na-agbakọta mgbe oge 5 - 5.5 gasịrị otu ọgwụ, yana iji ogologo oge, ịta ahụhụ na-apụta na-apụta 4 awa mgbe ejiri ya. Nke a dị mkpa, ebe ọ bụ na ọtụtụ nnabata ịnabata ya na-adabere na ya. Banyere mwepụ ahụ gị na-agba, ọsọ ọsọ ya esighi na ọgwụ ahụ ọ na-ewe ogologo oge - ruo awa iri abụọ.

Ntuziaka maka usoro na usoro onunu ogwu

Rossuvastatin mbụ ahụ, Krestor, dị ka ihe oyiyi ndị ọzọ niile, dị naanị n'ụdị mbadamba. Enwere onunu ogwu nke 10, 20 na 40 mg. Genfọdụ mkpụrụ ndụ ihe nketa nwere ọbụna usoro ọgwụgwọ dị ala. Yabụ, "Mertenil" nke "Gideon Richter", Hungary, nwere “mmalite” nke 5 mg.

Ohere dị, ị andụ ọgwụ na nri adịghị ejikọ n'ụzọ ọ bụla. Nwere ike iburu Rosuvastatin na afọ efu, n'oge nri ma ọ bụ mgbe nri gasịrị.

Banyere usoro ọgwụgwọ - a họọrọ ya n'otu n'otu, yana ihe ndabere maka ịba ụba nke ọgwụ ahụ bụ ọmụmụ ihe nyocha nke ọkwa nke egbugbere ọnụ ọbara, yana ihe ngosi zuru oke. Ọmụmụ ebe enwere otu ihe pụtara - cholesterol zuru - enweghị isi.

Usoro mbu nke rosuvastatin na-abụkarị 10 mg, mgbe ụfọdụ, na-enwe ntakịrị ihe ize ndụ yana enweghị enweghị oke ibu, a na-atụ aro 5 mg. Allowedmalite usoro onunu ogwu a ka amachara tupu ọnwa agaa. Oke kachasị bụ 40 mg, ma ị nwere ike iwelite ya na ngosipụta a naanị na ndabere nke egosi: nnukwu hypercholesterolemia ma ọ bụ nnukwu ihe egwu. N'ọnọdụ ọ bụla ịkwesịrị ịhọpụta 40 mg nye onye ọrịa malitere ibido statins. Mgbe izu abụọ ma ọ bụ ọnwa nnabata gasịrị, a na-eme nnyocha banyere mkpụrụedemede ọbara na isi ụlọ ọgwụ na usoro mmiri ọgwụ, dọkịta na-ekpebi ụzọ ndị ọzọ maka njikwa onye ọrịa.

Contraindications na nsonaazụ ya

Site na ndenye ọgwụ ziri ezi ma nwee ezi uche, yana ọkachasị na ụkpụrụ nke mmụba nwayọ nwayọ na dose, rosuvastatin egosila nchekwa ya n'ọtụtụ ebe n'ihe gbasara dọkịta. N'ezie, usọ a nwekwara contraindications ya na nsonaazụ na-achọghị ya, bụ nke dabere na ya. Ma rosuvastatin nwere ihe pụrụ iche - ọ bụghị naanị nsonaazụ bụ ọgwụ dabere, kamakwa contraindications. Maka ndị ọrịa nwere ike ị mgụ ọgwụ mg 10 ruo ogologo oge, ọ bụghị mgbe niile ka ọ nwere ike ịbawanye ọgwụ ahụ ruo 20, yana ọbụna karịa karịa 40 mg, dịka ọmụmaatụ, ọgwụ na-agbaso ihe karịrị 5 mg bụ contraindicated maka:

ndị ọrịa nwere ọria imeju na imeju na ụba nke transaminases (cholangitis, ịba ọcha n'anya),
na nnukwu akwara okpu (mwepụ creatinine (CC) erughị 30 ml kwa nkeji),
na myopathy,
ma ọ bụrụ na onye ọrịa ahụ anabata ma ghara ịkagbu cyclosporine,
n’ime ụmụ nwanyị dị ime, ndị nne na-azụ ụmụ na ụmụ ha.

Ihe 40 mg nke rosuvastatin bụ contraindicated, na mgbakwunye ọrịa ndị a dị n'elu, yana n'ọnọdụ ndị a:

na mmezi gbasara akụrụngwa ya na nhụrụpụta creatinine n'okpuru 60 ml kwa nkeji,
n'ihu myxedema na hypothyroidism,
ọnụnọ ọnya anụ ahụ na anamnesis ma ọ bụ na ndị ikwu (myasthenia gravis, myopathy),
ị alcoholụbiga mmanya ókè
Ndị ọrịa Mongoloid (atụmatụ metabolic),
nkwonkwo eji fibrates.

Kwesịrị, ọgwụ na contraindicated na allergies.

Nke nsonaazụ n'akụkụ, isi ọwụwa na mgbu akwara, nchapu anụ ahụ, na ụda olu na-aba ụba bụ ihe a na-ahụkarị. Mgbe ị na-eme ule njikwa, ọkwa nke transaminases na-ebili mgbe ụfọdụ. N'ime ndị ọrịa na-a theụ ọgwụ na mkpesa nke mgbu olu, ọ dị mkpa ịlele ọkwa nke CPK (ebe ọ bụ na mmebi akwara ma ọ bụ rhabdomyolysis ga-ekwe omume).

Na ntuziaka maka iji Rosuvastatin, ngalaba nke ngosipụta pụrụ iche na mmekọrịta dị n'etiti ọgwụ ị ga-atụle tupu ịmalite ọgwụgwọ akọwapụtara nkọwapụta zuru ezu.

Analogs na ihe omumu nke Rosuvastatin

Ugbu a, ọnụ ọgụgụ dị ukwuu nke analogues nke rosuvastatin mbụ ahụ apụtawo na ọnụahịa dị iche iche, yana nyocha dị iche iche, mana otu ntụziaka maka ojiji. Nke a na - enweghị atụ na - egosi ogo dị mma nke ihe eji eme ihe. Enwere ike ịzụta "Crestor" mbụ na "ọnụ akọ": ọnụego nke 0.005 g Nke 28 nwere ike ịzụta maka 1299 rubles, yana mbadamba nkume kachasị nwere 40 mg na otu ego ka ana-ere site na 4475 rubles. Mana onye isi ahụ bụ ngwugwu nke mbadamba 126 nke "Crestor" 10 mg ọ bụla, ọnụ ahịa ya bụ 8920 rubles. N'okwu a, ọnụahịa otu mbadamba bụ 70 rubles.

Ọtụtụ analog dị ọnụ ala karịa: mbadamba ụrọ cansu rosuvastatin sitere na Canonfarm Production nwere ụlọ ọrụ na Schelkovo, Moscow Region, enwere ike ịzụta site na 355 rubles. (10 mg Nke 28). Nwere ezigbo njiri mara "Mertenil" sitere na ụlọ ọrụ "Gedeon Richter" (Hungary) na usoro nke 20 mg, nke bụ nkezi, ị nwere ike ịzụta maka 800 rubles Nke 30, na nkwakọ ngwaahịa ezuru otu ọnwa.

Ihe dị ọnụ ala karịa ọnụahịa zuru oke, rosuvastatin (n'agbanyeghị ọnụ ọgụgụ mbadamba na usoro onunu ogwu) site n'aka FP Obolenskoye - 244 rubles kwa otu 10 mg Nke 28. N'aka ozo, ọnụahịa otu mbadamba mkpụrụ ego dị ọnụ ala bụ 8.7 rubles, nke dị ọnụ ala karịa Mbadamba mbụ ahụ karịa ugboro asatọ.

Na mmechi, achọrọ m ịdọrọ uche gaa ọzọ na ntinye siri ike nke onye ọrịa ahụ na-ewere ụdị nri ọ bụla nke Statin, nke na-eme ka mkpụrụ ndụ belata. Ọ dịkwa mma ifelata, iwepụ omume ọjọọ, yana mgbe ị na-a theụ ọgwụ ahụ - na-enyocha ọkwa nke ọrịa ịba ọcha n'anya na-atụle ma na-eme ka ọ dịkwuo mma.

Mwepụta wepụtara ya na ihe mejupụtara

A na-emepụta ọgwụ ahụ n'ụdị mbadamba ihe eji eme ihe nkiri: biconvex, okirikiri, shei pink, isi ihe dị na ngalaba obe dị ka ocha ma ọ bụ na-acha ọcha (pcs 10. N'ime blisters, na ngwungwu 3 ma ọ bụ 6 ngwugwu, ngwugwu 14. ngwungwu bliri, na ngwungwu 2 ma ọ bụ 4 ngwugwu, pọọsụ 30. n'ime ngwugwu bliri, na ngwugwu kaadi 2, 3 ma ọ bụ 4, pọọsụ 20 ma ọ bụ 90. n'ime karama polymer / ite plastik, na ngwugwu kaadi papa 1 karama / ite, mkpọ nke ọ bụla nwekwara ntuziaka maka iji Rose Vastatin-SZ).

Otu mbadamba 1 nwere:

ihe na-arụ ọrụ: rosuvastatin (n'ụdị calcium rosuvastatin) - 5, 10, 20 ma ọ bụ 40 mg,
ihe ndị ọzọ: calcium hydrogen phosphate dihydrate, lactose monohydrate (shuga mmiri ara ehi), povidone (polyvinylpyrrolidone pere mpe), sodium stearyl fumarate, croscarmellose sodium (primrose), microcrystalline cellulose, colloidal silicon dioxide (aerosil),
mkpuchi ihe nkiri: Opadry II macrogol (polyethylene glycol) 3350, polyvinyl mmanya, akụkụ hydrolyzed, titanium dioxide (E171), talc, soy lecithin (E322), aluminom varnish dabere na dye azorubine, aluminom varnish dabere na dye indigo carmine, aluminom varnish dabere na dye crimson (Ponceau 4R).

Nsonaazụ

Mgbe ị na-eji ọgwụ ọgwụ, mmetụta ndị dị nro, ọ na-apụkarị n'anya nke onwe ha. Mmetụta ọjọọ a na-enwekarị ọgwụ Rosuvastatin bụ:

ọrịa shuga mellitus
isi ọwụwa, nkụda mmụọ, ncheta ihe, neuropathy akụkụ,
afọ ntachi, pancreatitis, ọgbụgbọ, mgbu afọ, ịba ọcha n'anya, afọ ọsịsa,
pruritus, urticaria, ihe ngbu, Stevens-Johnson syndrome,
myalgia, rhabdomyolysis, myopathy, myositis, ogbu na nkwonkwo,
ọrịa asthenic
Okpokoro akpụ akpụ
ihe mgbochi na enweghi nsogbu
proteinuria, hematuria,
mmụba nke ịba ọcha n'anya, glucose, bilirubin (jaundice).
thrombocytopenia
ukwara, ura ume,
gynecomastia
mgbago ọgụgharị,
ịda mba, ehighị ụra nke ọma, ụra abalị,
mmebi nke ọnya afọ nke thyroid, ọrụ mmekọahụ, sistem,
mụbara mkpokọta hemoglobin.

Dodoụbiga ya ókè

Ọ bụrụ n’ị na-ewere ọtụtụ rosuvastatin kwa ụbọchị n’otu oge, ọgwụ ọgwụ ahụ agaghị agbanwe. Mgbaàmà nke ị possibleụbiga ihe ọ possibleụ areụ na-abawanye uru bụ mmetụta ndị ọzọ ọ na-arụ. Onweghi ogwu eji egbu egbu. A na-atụ aro ime ka afọ hichaa afọ, dezie ọgwụgwọ symptomatic site na nkwado nke imeju na akụkụ ndị ọzọ dị mkpa. Hemodilais egosighi ịdị irè.

Rosuvastatin analogs

Nwere ike dochie mbadamba rosuvastatin na nkwadebe nwere otu ma ọ bụ ihe arụ ọrụ bara uru. Ihe analogues nke ogwu gunyere:

Crestor - mbadamba mmiri nwere ike ime ka mmadụ nwee ike ime ya,
Rosart - mbadamba nkume nwere ọgwụ mejupụtara ya maka ọgwụgwọ ọrịa obi.
Roxer - mbadamba sitere na otu nnukwu anụ ọhịa,
Tevastor - mbadamba ụrọ sitere n'otu ihe arụ ọrụ, belata cholesterol ọbara.

Rosuvastatin na Atorvastatin - kedu ihe dị iche

Analogue nke Rosuvastatin - Atorvastatin, etinyere na otu ogwu ogwu nke statins ma enwere ya na okpokoro nwere ihe ndi ozo na-eweda ala. N'adịghị ka ihe a na-ekwu okwu, atorvastatin bụ sọks karịa na abụba, ọ bụghị na plasma ọbara ma ọ bụ mmiri ndị ọzọ, ya mere na-emetụta nhazi nke ụbụrụ, ọ bụghị na mkpụrụ ndụ imeju (hepatocytes).

Ọgwụ Rosuvastatin dị 10% karịa nke Atorvastatin, nke na-enye ya ohere iji ya na ọgwụgwọ ndị ọrịa nwere cholesterol dị elu. Ọzọkwa, onye na-ahụ maka ọrụ ahụ dị irè karị na usoro mgbochi igbochi mkpụrụ ndụ akwara ma nwee mmetụta ọgwụgwọ. Mmetụta ndị ọgwụ ọjọọ ahụ bụ otu, ya mere nhọrọ ọgwụ dị kpam kpam na dọkịta.

Mlọ ọgwụ

Oke ịta nke rosuvastatin (C_max) n'ime plasma ọbara a na-ahụ ihe dị ka awa 5 mgbe nchịkwa ọnụ gachara. Ezigbo bioavailability nke ọgwụ ahụ bụ ihe dị ka 20%, olu nke nkesa (V_d) - ihe dịka 134 lita. Rosuvastatin na - ejikọ protein protein, karịsịa nke albumin, n'ihe dị ka 90%. Ihe ngosipụta nke sistemu (AUC) nke ihe na-arụ ọrụ na-abawanye na oke na nha. Site n'iji ya kwa ụbọchị, njirimara nke ọgwụ anaghị agbanwe agbanwe.

Rosuvastatin bụ metabolized kachasị site na imeju - saịtị bụ isi nke mmepụta cholesterol na mgbanwe metabolism nke LDL-C.A na-agbanye ya na obere obere (ihe dị ka 10%), ihe na-arụ ọrụ bụ ihe na-abụghị isi maka biotransformation site na enzymes nke sistemụ cytochrome P450. Isi isoenzyme na-ahụ maka metabolism nke ihe bụ isoenzyme CYP2C9, isoenzymes CYP2C19, CYP3A4 na CYP2D6 etinyechaghị aka na metabolism. Ihe bụ isi metabolites nke rosuvastatin bụ lactone metabolites na N-desmethylrosuvastatin. Nke ikpeazụ dị ihe dị ka 50% na-arụ ọrụ karịa rosuvastatin. A na-ahụta metabolites metabolic dị ka ọgwụ n’akaghị arụ ọrụ. Ihe karịrị 90% nke ọrụ ọgwụ na-ebelata mgbasa HMG-CoA reductase bụ rosuvastatin na 10% site na metabolites ya.

Ihe dị ka 90% nke rosuvastatin dịpụrụ adịpụ site na eriri afọ n'ụdị agbanweghị (gụnyere ihe ndị na-adọrọ adọrọ na ihe ndị na-adịghị anyụ anyụ), akụrụ na-ewepụ ihe ndị ọzọ. Nkera-ndu (T_1/2) site na plasma dị ihe dị ka awa 19 ma ọ naghị agbanwe agbanwe na ịba ụba. Geometric pụtara plasma doro dị ihe dị ka 50 l / h (ọnụọgụ nke mgbanwe 21.7%). Onye na-ebu ngwakọta nke cholesterol, nke na-arụ ọrụ dị mkpa na mkpochapu hepatic nke ihe a, na-ekere òkè na nkwalite hepatic nke rosuvastatin.

Thezọ ọgwụ pharmacokinetic nke rosuvastatin nọọrọ onwe ya na nwoke na nwanyị onye ọrịa.

Rosuvastatin, dị ka ndị ọzọ na-egbochi HMG-CoA reductase, na-ejikọ ndị na-edozi nchebe, dị ka BCRP (ebugharị efflux) na OATP1B1 (polypeptide nke ebugharị ebugharị mkpụrụ ndụ na-etinye aka na njide nke statins site na mkpụrụ ndụ imeju). Ndị na-ebugharị genotypes ABCG2 (BCRP) s.421AA na SLC01B1 (OATP1B1) s.521CC gosipụtara mmụba na AUC nke rosuvastatin site na oge 2.4 na 1.6, dị iche iche, ma e jiri ya tụnyere ndị na-ebu genotypes ABCG2 c.421CC na SLCO1B1 c.521TT.

Rosuvastatin-SZ, ntuziaka maka ojiji: usoro na usoro onunu ogwu

A na-ewere ọnụ Rosuvastatin-SZ were ọnụ. Mbadamba, ọ bụghị ịzọpịa ma na-ata ata, ga-elo mmiri kpamkpam, were mmiri sachaa ya.

Enwere ike iji onye na-eme ka mmanụ dị nfe bịa n'agbanyeghị agamenyụ nri n’oge ọ bụla n’ụbọchị.

Tupu mmalite nke usoro ahụ, onye ọrịa kwesịrị ịtụgharị gaa na nri oriri zuru oke nke nwere cholesterol dị ala ma sorozie ya na oge dum nke usoro ọgwụgwọ. A na-ahọrọ ọgwụ ahụ n'otu n'otu, na-eburu n'uche usoro ọgwụgwọ nke nchịkwa ọgwụ na ebumnuche nke ọgwụgwọ, yana kwekọrọ na ndụmọdụ ndị dị ugbu a na ọkwa mkpụrụ ndụ.

Maka ndị ọrịa na-ejighị statins mee ihe na mbụ, ma ọ bụ ndị burula ọgwụ ndị ọzọ HMG-CoA reductase inhibitors tupu mmalite nke usoro ahụ, usoro akwadoro mbụ Rosuvastatin-SZ bụ 5/10 mg otu ugboro kwa ụbọchị. A na-ehiwe ọgwụ izizi ahụ, na-eduzi nsonaazụ nke cholesterol ma na-eburu n'uche ohere nke ọrịa obi, yana iyi egwu mmeghachi omume na-adịghị mma. Ọ bụrụ na ọ dị mkpa, mụbaa dose ahụ ka izu anọ gachara.

N'ihi ihe omume nwere ike ibute nsonaazụ n'oge nchịkwa nke 40 mg / ụbọchị, ma e jiri ya na usoro ọgwụgwọ kwa ụbọchị, ọ ga-ekwe omume ịbawanye ọgwụ ahụ ruo 40 mg / ụbọchị (mgbe ị additionalụ ọgwụ ndị ọzọ gafere oge akwadoro maka izu 4) naanị ma ọ bụrụ na enwere nnukwu ogo nke hypercholesterolemia na nnukwu ihe ize ndụ nke ịmalite nsogbu ọrịa obi. Ruo 40 mg / ụbọchị ka edepụtara maka ndị ọrịa nwere hypercholesterolemia familial, ndị na-enwebeghị ike inweta nsonaazụ ọgwụgwọ achọrọ ya na 20 mg / ụbọchị, yana ndị ga-anọ na nlekọta ahụike siri ike. Karịrị nlezianya nlebara anya ahụike dị mkpa na ndị ọrịa na-enweta ọgwụ kwa ụbọchị nke 40 mg nke Rosuvastatin-SZ.

A naghị atụ aro ka ndị ọrịa na-akpọtụrụghị ndị ọkachamara na mbụ ka ha were mbadamba Rosuvastatin-SZ 40 mg.

Izu abuo nke 2-4 mgbe mmalite nke usoro ọgwụgwọ na / ma ọ bụ mmụba na dose ahụ, a ga-ebu ụzọ nyochaa metabolism na, ọ bụrụ na ọ dị mkpa, ekwesịrị idozi dose ahụ.

A naghị akwado ndị na-ebu genotypes c.421AA ma ọ bụ s.521CC iji rosuvastatin-SZ na onunu gafere 20 mg otu ugboro n'ụbọchị.

Na usoro ịmụ akwụkwọ ọgwụ nke rosuvastatin na ndị ọrịa nke agbụrụ dị iche iche, mgbe ndị Japan na ndị China na-a theụ ọgwụ ahụ, ekpughere mmụba nke usoro nke rosuvastatin. Ihe omume a aghaghi iburu n'uche mgbe a na-edegara onye nnochite anya ogwugwu nke agbụrụ Mongoloid. Maka ìgwè ndị ọrịa a nwere ọgwụgwọ na usoro nke 10 na 20 mg, mmadụ kwesịrị ịmalite site na ị 5ụ 5 mg / ụbọchị, mbadamba ụrọ na usoro 40 mg na-egbochi.

Ọbara ndị nwere ọnọdụ togoro nke myopathy Rosuvastatin-SZ ka akwadoro ka ị were ọgwụ izizi nke 5 mg.

Mmetụta ikike ịkwọ ụgbọala na usoro dị mgbagwoju anya

Emebeghị nnyocha iji mụọ nsonaazụ Rosuvastatin-SZ nwere ike ịkwọ ụgbọ ala ma jiri usoro mgbagwoju anya rụọ ọrụ. Mgbe ị na-eme ihe egwu dị egwu, ọ dị mkpa ka ndị ọrịa kpachara anya, n'ihi na akpịrị ịkpọ nkụ nwere ike ịda n'oge ọgwụgwọ.

Ime na lactation

Rosuvastatin-SZ bụ contraindicated na ime na lactation. Womenmụ nwanyị toro afọ ga-eji ọgwụ mgbochi ndị a pụrụ ịdabere na ha.

Ebe ọ bụ na cholesterol na cholesterol biosynthesis ngwaahịa dị ezigbo mkpa maka mmepe nwa ebu n’afọ, ihe ọghọm nke ikpuchi mbelata nke HMG-CoA dị elu karịa uru nke ị Roụ Rosuvastatin-SZ n’ime ụmụ nwanyị dị ime. N'ihe banyere ime n’oge ọgwụgwọ ya ọgwụ, aga-akwụsị nchịkwa ya ozugbo.

Enweghị data na ntinye nke rosuvastatin na mmiri ara, ya mere, n'oge a na-enye nwa ara, ọ dị mkpa ịkwụsị ị Roụ Rosuvastatin-SZ.

Na arụ ọrụ ezumike ọrụ

N'ime ndị ọrịa nwere nsogbu mgbazinye obere azụ ma ọ bụ agafeghị oke, enweghị mgbanwe dị ukwuu n'ọkwa plasma nke rosuvastatin ma ọ bụ N-desmethylrosezuvastatin. Na ọdịda akụrụngwa siri ike, ọkwa nke rosuvastatin dị na plasma ọbara dị ugboro atọ, na N-desmethylrosuvastatin dị okpukpu 9 karịa nke ndị ọrụ afọ ofufo nwere ahụ ike. Ngwakọta plasma nke rosuvastatin dị na ndị ọrịa na-awa n'ọbara dị ihe dịka 50% karịa ndị ọrụ afọ ofufo ahụ siri ike.

Inwe nnabata nke Rosuvastatin-SZ nọ na ọnụnọ nke oke nrụrụ akụrụ (creatinine Cl n'okpuru 30 ml / min).

Maka ndị ọrịa nwere obere akụrụ na-arụ ọrụ nke akụrụngwa (Cl creatinine 30-60 ml / min), iji rosuvastatin-SZ na dose nke 40 mg bụ contraindicated, na dose nke 5, 10 na 20 mg kwesịrị iji nlezianya.

A ga-elebara ndị ọrịa nwere nsogbu izizi obere aha (creatinine Cl karịa 60 ml / min) site na iji 40 mg na-akpachara anya, na-ahụ maka ọrụ gbasara akụrụ. Mgbe ị na-eji ọgwụ ahụ eme ihe na ndị ọrịa nwere obere ọrụ akwara nwere nsogbu, ọgwụ izizi kwesịrị ịbụ 5 mg.

Site na ịrụ ọrụ ọrụ imeju

Na ọnụnọ nke mmebi imeju site na isi 7 na n'okpuru onodu nke Child-Pugh, mmụba na T_1/2 achọpụtaghị rosuvastatin, mmụba na T ka edere na ndị ọrịa abụọ nwere 8 na 9 isi_1/2 ihe na-erughị 2. Enweghị ahụmịhe banyere ojiji Rosuvastatin-SZ n'ime ndị ọrịa ọnọdụ ogo ha dị elu karịa 9 na ọkwa Child-Pugh.

Usoro ọgwụgwọ nke ọgwụ ahụ na-egbochi ndị ọrịa nwere ọrịa imeju na usoro iwe ahụ, gụnyere mmụba na-abawanye na ọrụ ọbara transaminase na mmụba ọ bụla na ọrụ transaminase, ihe karịrị okpukpu atọ karịa VGN. Iji kpachara anya, a na-atụ aro ka e jiri Rosuvastatin-SZ mee ndị ọrịa nwere mmebi imeju. Kpebie akara ngosipụta nke imeju dị mkpa tupu a gwọọ ya na ọnwa 3 mgbe mmalite nke usoro ahụ.

Nyocha banyere Rosuvastatin-SZ

Dabere na nyocha, Rosuvastatin-C3 bụ ọgwụ bara uru dị ala na-eji agwọ hypercholesterolemia, na-ebelata ọganihu nke atherosclerosis ma gbochie nsogbu obi. Mmetụta mbụ nke ọgwụgwọ na-ahụ ọtụtụ ndị ọrịa mgbe izu otu nchịkwa gachara, mmetụta kachasị na ya bụ ọnwa 1 mgbe mmalite nke usoro ahụ. Dabere na nyocha, n'ihi ọrụ nke ọgwụ ahụ, ọkwa nke cholesterol n'ọbara na-ebelata, ọbara mgbali na-akwụsị, ọnọdụ izugbe na-aka mma, mkpụmkpụ ume mgbe mkpịsị ụkwụ belatara. N'oge ọgwụgwọ, n'ọnọdụ ụfọdụ, mmụba nke anụ ahụ na-agbadata n'ihi ojiji nke ọgwụ na nri cholesterol dị ala.

Na ọghọm nke Rosuvastatin-SZ gụnyere ọnụ ọgụgụ buru ibu nke contraindications na mmeghachi omume na-adịghị mma. Na nyocha ụfọdụ, ndị ọrịa na-egosipụta enweghị afọ ojuju maka ọnụ ahịa ọgwụ ahụ, n'ihi na a na-ewerekarị ya ogologo oge, ọnụ ahịa ọgwụ chọrọ maka usoro ọgwụgwọ zuru ezu, n'echiche ha, dị elu.