Reduxin® (Reduxin)

Reduxine dị n'ụdị capsules: nha Nke 2, acha anụnụ anụnụ na acha anụnụ anụnụ, ihe ndị ahụ na-acha ọcha ma ọ bụ na-acha ntụ ntụ na-acha odo odo (10 nke ọ bụla na blisters, na ngwungwu 3 ma ọ bụ 6 ngwugwu).

Bekee arụ ọrụ (na 1 Capsule):

• Microcrystalline cellulose - 158.5 mg ma ọ bụ 153.5 mg,
• Sibutramine hydrochloride monohydrate - 10 mg ma ọ bụ 15 mg.

Ngwa inye aka: steetite calcium.

Ngwakọta nke akpukpo ahihia: gelatin, dye titanium dioxide, ihe eji acha anụnụ anụnụ edo edo, acha uhie uhie azorubine (capsules 10 mg).

Ihe ngbanwe

• Ọbara ọbara na - achịkwaghị achịkwa (ọbara mgbali elu karịa 145/90 mm Hg)
• Ọrịa obi, ọrịa obi akwara ọrịa obi, ọrịa obi, ọrịa obi na-adịghị ala ala, ọrịa obi akwara na -akpata, tachycardia, ọrịa akwara (ọrịa mberede ụbụrụ, ọrịa strok),
• Ọria akụrụ siri ike yana akwara ozi,
• Akọrọ ndị ọzọ
• Ọrịa ụbụrụ
• Nsogbu iri nri (bulimia nervosa ma ọ bụ anorexia),
• Benign prostatic hyperplasia
• Ọnụnọ nke ihe na - akpata oke ibu (hypothyroidism, wdg),
• Thyrotoxicosis,
• Mkpuchi mmechi nke Angle,
• Ọgwụ ọgwụ, mmanya ma ọ bụ ị drugụ ọgwụ,
• Pheochromocytoma,
• N'otu oge eji antipsychotics, antidepressants na ọgwụ ndị ọzọ na-eme ihe na sistemụ akwara,
• Mkpesa iji ma ọ bụ nchịkwa maka izu 2 tupu nchịkwa nke Reduxine ka monoamine oxidase inhibitors (dịka ọmụmaatụ, ephedrine, ethylamphetamine, fenfluramine, phentermine, dexfenfluramine),
• Ojiji nke ọgwụ ndị ọzọ iji belata oke ahụ mmadụ, yana ọgwụ nwere tryptophan yana edepụtara maka nsogbu ihi ụra.
• Undermụaka n’agbata afọ 18,
• Ime na lactation
• O mere agadi karịa afọ 65,
• Ntinye obi na akụkụ nke ọgwụ ọ bụla.

Ikwu (were ọgwụ jiri ịkpachapụ anya):

• Ọbara ọbara (akụrụngwa ma chịkwaa),
• Ọrịa na-adịghị ala ala,
• Akụkọ ihe mere eme nke arrhythmias,
• Ọrịa akwara ọbara na - arịa ọrịa (gụnyere akụkọ ihe mere eme)
• Imezi akụrụngwa na / ma ọ bụ ọrụ imeju nke ogo na nwayọ,
• Cholelithiasis,
• Akuko banyere esemokwu na nke moto.
• Ọrịa Neurological, gụnyere ọdịdọ na nlọghachi uche (gụnyere akụkọ ihe mere eme).

Usoro onunu ogwu na nhazi

A na-eralomi capsuine caplules otu ugboro n'ụbọchị, tupu nri ma ọ bụ n'oge nri. A loda Capsule ahụ dum ma jiri mmiri ma ọ bụ mmiri ọzọ sachaa ya.

Emebere ogwu a n’otu n’otu dabere na ịnagide ọgwụ yana ịdị n’otu ọgwụ. Usoro izizi na-abụkarị 10 mg. Ọ bụrụ na ọgwụ anabataghị nke ọma, ị nwere ike ịmalite were 5 mg.

Site na mbelata nke ahụ ya site na ihe na-erughị 5% n'oge ọnwa mbụ nke ọgwụgwọ, a na-abawanye ọgwụ nke ọgwụ ahụ ruo 15 mg kwa ụbọchị. N'ime ndị ọrịa dara ida 5% ma ọ bụ karịa nke mbido mbụ ha n'ime ọnwa 3, a kwụsịrị ọgwụgwọ. Agaghị aga n'ihu usoro ọgwụgwọ ahụ ọbụlagodi na, mgbe oke oke, onye ọrịa ahụ gbakwunye 3 n'arọ ma ọ bụ karịa.

Oge ngụkọta nke usoro ọgwụgwọ ragela adịghị ihe karịrị afọ 2, ebe ọ bụ na enweghị data na nchekwa yana arụmọrụ nke ọgwụ nwere ọgwụgwọ ogologo.

A na-eme ọgwụgwọ n'okpuru nlekọta nke dọkịta nwere ahụmịhe bara uru n'ịlụso oke ibu ọgụ. A na-atụ aro ka ọgwụgwọ ahụ gbakwunye ya na mmega ahụ na nri.

Ndị na-ahụ maka ọgwụ

Mlọ ọgwụ

Reduxin ® bu nkwadebe ejikọtara ọnụ nke omume ya bụ nke mebere ya.

Sibutramine bụ prodrug ma na-arụkwa ọrụ ya na vivo n'ihi metabolites (amines nke mbụ na nke abụọ) na-egbochi ịmaliteghachi nke monoamines (serotonin, norepinephrine na dopamine). Mmụba nke ọdịnaya nke neurotransmitters na synapses na-eme ka ọrụ nke etiti 5-HT-serotonin na ndị na-anabata adrenergic, nke na-eme ka mmụba nke satiety na mbelata nri chọrọ, yana mmụba nke mmepụta ihe ọkụ. Na-eme ka beta rụọ ọrụ na-enweghị uche₃-adrenoreceptors, sibutramine eme ihe na aja aja adipose. Mbelata nke ahụ mmadụ na-esonye na mmụba na ịta plasma nke HDL na mbelata ọnụ ọgụgụ triglycerides, cholesterol mkpokọta, LDL na uric acid. Sibutramine na metabolites ya adịghị emetụta ntọhapụ nke monoamines, egbochikwa MAO, nwee mmekọrịta dị ala maka ọnụ ọgụgụ buru ibu nke ndị na-anabata neurotransmitter, gụnyere serotonin (5-HT)₁5-NT_1A5-NT_1B5-NT_2C), adrenergic (beta₁-, beta₂-, beta₃-, alfa₁-, alfa₂-), dopamine (D₁, D₂), muscarinic, histamine (N₁), benzodiazepine na ndị na-anabata glutamate (NMDA).

MCC Ọ bụ ihe dị na enterosorbent, nwere ihe anwansi na arụmọrụ nhụghị ọnụ. Ọ na - ejikọ ma kpochapụ microorganisms dị iche iche, ngwaahịa nke ọrụ ha dị mkpa, toxins nke exogenous na endogenous nature, allergens, xenobiotics, yana ngafe nke ụfọdụ metabolic ngwaahịa na metabolites maka mmepe nke toxicosis endogenous.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gachara, a na-ewere ngwa ngwa site na nri diges dịkarịa ala 77%. N'ime ụzọ izizi site na imeju, ọ na-eme biotransformation n'okpuru mmetụta nke CYP3A 4 isoenzyme na nguzobe nke metabolites abụọ na - arụ ọrụ - monodesmethylsibutramine (M1) na didesmethylsibutramine (M2). Mgbe otu ọgwụ were 15 mg C_max n'ọbara plasma ọbara, M1 bụ 4 ng / ml (3.2 –4.8 ng / ml), M2 bụ 6.4 ng / ml (5.6-7.2 ng / ml). C_max enwetara mgbe awa 1.2 gachara (sibutramine), awa 3-4 (M1 na M2). Iri Udi riri nri C_max metabolites na 30% ma nwekwuo oge iru ya site na awa 3 na-enweghị ịgbanwe AUC. A na-ekesa ya ngwa ngwa na akwa akwa. Nkwukọrịta na protein bụ 97 (sibutramine) na 94% (M1 na M2). C_ss A na - ebute metabolites na - arụ ọrụ n'ime plasma ọbara n'ime ụbọchị 4 mgbe mmalite nke iji ihe dị ka ugboro 2 na - etinye uche gị na plasma ọbara. Ndi_1/2 sibutramine - awa 1.1, M1 - awa iri na anọ, awa M2 - awa 16. Ọrụ metabolites na - arụ ọrụ na - anọrọ hydroxylation na conjugation na nguzobe metabolites na - adịghị arụ ọrụ, nke akụrụ na - apụkarị.

Ndị otu ọrịa pụrụ iche

Paul Ugbua enwere oke data agwaghị egosi ịdị adị nke oke ọgwụ dị na ụlọ ọrụ ọgwụ na ụmụ nwoke na ụmụ nwanyị.

Agadi. Pharmacokinetics na ndị agadi nwere ahụike (nkezi afọ - afọ 70) yiri nke ahụ na ndị na-eto eto.

Odida ntaramahụhụ. Mwepu mmerụ ahụ anaghị emetụta AUC nke metabolites M1 na M2 na-arụ ọrụ, ma e wezụga maka metabolite M2 n'ime ndị ọrịa nwere ọdịda akwara ọdịda na-ada usoro nyocha.

Imeju imeju. N'ime ndị ọrịa nwere ọrịa imeju na-agafeghị oke mgbe otu ọgwụ nke sibutramine AUC, metabolites na-arụ ọrụ M1 na M2 dị 24% karịa ndị nwere ahụ ike.

Ime na lactation

Yabụ na ugbu a, enwebeghị ọnụọgụ ọmụmụ zuru ezu gbasara nchekwa nke mmetụta sibutramine na nwa ebu n’afọ, ọgwụ a na - egbochi ime n’oge amụ nwa.

Mụ nwanyị ndị toro ogo kwesịrị iji ọgwụ mgbochi ọgwụ mgbe ha na-a Reduụ ihe a na-ebutere ya.

Emebiwo ya aru ike iji ya Choroxin.

Nsonaazụ

Ọtụtụ mgbe, nsonaazụ na-apụta na mmalite nke ọgwụgwọ (n'ime izu anọ mbụ). Udiri ha na oge ha ga na-ebelata ka oge na-aga. Mmetụta ndị na-adịkarị nwayọọ ma na-atụgharị. A na-egosi nsonaazụ ndị ọzọ, dabere na nsonaazụ na akwara ndị dị na usoro a: oge ​​mgbe (≥10%), ọtụtụ mgbe (≥1%, mana sistemụ akwara Central: oge niile - akpịrị ịkpọ nkụ na ehighị ụra nke ukwuu, ọtụtụ mgbe - isi ọwụwa, ọgbụgbọ, ụjọ, paresthesia, yana mgbanwe uto.

Site na CCC: ọtụtụ mgbe - tachycardia, palpitations, ọbara mgbali elu, vasodilation.

A na-ahụta ịrị elu nke ọbara mgbali elu na izu ike site na 1-3 mm Hg. na mmụba dị elu na ọnụego obi site na 3-7 kụrụ / min. N'ọnọdụ ụfọdụ, ọpụpụ mgbakwunye dịkwuo elu na ọbara mgbali elu na ọnya obi. Ederede mgbanwe dị iche iche dị ala na ọbara ọgbụgba na ọria ihu na mmalite ọgwụgwọ (n'ime izu anọ 4-8).

Ojiji Symbol ® nyere ndị ọrịa nwere ọbara mgbali elu: lee “Contraindications” na “Ntuziaka Pụrụ Iche”.

Site na nri digestive: Ọtụtụ mgbe - enweghị agụụ na afọ ntachi, ọtụtụ mgbe - ọgbụgbọ na nkụda mmụọ nke hemorrhoid. Site n'ịkpa afọ n'oge afọ, ịkwesịrị ịhapụ ọrụ mkpochapụ nke eriri afọ. Ọ bụrụ na afọ ntachi mere, kwụsị ị andụ ọgwụ mgbu.

Na akpukpo ahu: ọtụtụ mgbe - ịba ụba aja.

N'ọnọdụ ndị dịpụrụ adịpụ, a kọwara ihe ndị dị egwu dị egwu a na-achọghị n'oge ọgwụgwọ na nwanne: dysmenorrhea, edema, flu-like syndrome, itching nke anụ ahụ, azụ mgbu, afọ, ịrị elu nke agụụ, akpịrị ịkpọ nkụ, rhinitis, ịda mba, ụra, nchekasị mmetụta uche, nchekasị, oke iwe, ụjọ, nnukwu nephritis interstitial nephritis, ọbara ọgbụgba, Shenlein-Genoch purpura (ọbara ọgbụgba na anụ ahụ), nkwarụ, thrombocytopenia, mmụba dị mkpirikpi na ọrụ nke enzymes imeju na ọbara.

N'ime usoro ọmụmụ banyere ahịa, a kọwara mmeghachi omume ọjọọ ndị ọzọ, nke usoro sistem nyere n'okpuru:

Site na CCC: atrial fibrillation.

Si dịghịzi usoro: mmeghachi omume hypersensitivity (site na rashes na-agba na akpụkpọ ahụ na urticaria ruo angioedema (edere Quincke) na anaphylaxis).

Ọrịa uche: psychosis, steeti echiche igbu onwe ya, igbu onwe ya na oke ara. Ọ bụrụ n'ụdị ọnọdụ a emee, a ga-akwụsị ị drugụ ọgwụ ahụ.

Si ụjọ usoro: mgbakasị ahụ, obere ncheta obere oge.

Site n'akụkụ akụkụ ahụ nke ọhụụ: ọhụhụ (ọhụhụ n'anya).

Site na nri digestive: afọ ọsịsa, vomiting.

Na akpụkpọ anụ ahụ alopecia.

Site na akụrụ na eriri afọ: njigide urinary.

Site na usoro omumu: Ọrịa ejaculation / orgia, enweghi ike, enweghi nsogbu nwoke, ọbara ọgbụgba.

Mmekorita

Ndị na-egbochi ịkpụzi microsomal, gụnyere ndị na-egbochi CYP3A 4 isoenzyme (gụnyere ketoconazole, erythromycin, cyclosporine) na-abawanye ụba plasma nke sibutramine metabolites na-abawanye na ọnụego obi na mmụba na-enweghị atụ na oge etiti QT.

Rifampicin, ọgwụ mgbochi macrolide, phenytoin, carbamazepine, phenobarbital na dexamethasone nwere ike ime ka metabolism nke sibutramine mee ngwa ngwa. Ojiji nke ọtụtụ ọgwụ na-eme ka ihe serotonin dị na plasma ọbara n’otu oge nwere ike ibute mmepe nke nnukwu mmekọrịta. N'ọnọdụ ndị a na-adịghị ahụkebe, site na iji ọgwụ ahụ a na-akpọ Reduxin ® na SSRI (ọgwụ maka ọgwụgwọ nke ịda mba), ụfọdụ ọgwụ maka ọgwụgwọ migraine (sumatriptan, dihydroergotamine), analgesics (pentazocine, pethidine, fentanyl) ma ọ bụ ọgwụ antitussive (dextromethorphan) nwere ike ịmalite. ọrịa serotonin.

Sibutramine anaghị emetụta nsonaazụ ọgwụ mgbochi.

Site na nhazi nke sibutramine na mmanya n’otu oge, enweghị mmụba na mmetụta ọjọọ nke mmanya. Agbanyeghị, mmanya anaghị etinye ọnụ na usoro nri eji atụ aro mgbe ị na-ewere sibutramine.

Site n'otu oge iji ọgwụ ọgwụ ndị ọzọ na sibutramine na-emetụta hemostasis ma ọ bụ ọrụ platelet, ohere nke ọbara ọgbụgba na-abawanye.

Mmekorita ọgwụ ya na ojiji nke sibutramine n'otu oge na ọgwụ nke na-abawanye ọbara mgbali elu na obi gị ugbu a aghọtachaghị. Otu ọgwụ a gụnyere decongestants, antitussive, oyi na ọgwụ mgbochi, nke gụnyere ephedrine ma ọ bụ pseudoephedrine. Yabụ, n'ihe gbasara imepụta ọgwụ ndị a n'otu oge na sibutramine, a ga-akpachara anya. Mkpokọta ojiji nke sibutramine na ọgwụ iji belata oke ahụ, ime ihe na akwara isi, ma ọ bụ ọgwụ maka ọgwụgwọ nke nsogbu uche.

Usoro onunu ogwu na nhazi

N'ime Otu ugboro n'ụbọchị, n'ụtụtụ, na-enweghị a cheụ ma na-a plentyụ ọtụtụ mmiri mmiri (otu iko mmiri). Enwere ike ị drugụ ọgwụ ahụ na afọ efu ma jikọta ya na nri.

A na-etinye dose ahụ iche iche, dabere na ịnabata ya na nrụpụta ọgwụ Usoro akwadoro ịmalite bụ 10 mg / ụbọchị. Ọ bụrụ na n’ime izu anọ site na nmalite ọgwụgwọ, mmụba dị n’arụghị ihe na-erughị 2 n'arọ, mgbe ahụ dose ahụ na-abawanye ruo 15 mg / ụbọchị.

Ọgwụ ọgwụgwọ Obinichibidoro ịgaghị ọnwa 3 n’ebe ndị ọrịa anaghị anabata ọgwụ ike nke ọma, i.e. nke n’ime ọnwa atọ a gwochara ọgwụgwọ na-adabaghị n’iwe n’arụ site na 5% site na ngosipụta izizi. Agaghị aga n'ihu ọgwụgwọ ma ọ bụrụ na, na usoro ọgwụgwọ ọzọ mgbe ọ nwesịrị ịdị na-agbasa ahụ, ịdị arọ nke onye ọrịa ahụ na-abawanye 3 n'arọ ma ọ bụ karịa.

Ogologo oge ọgwụgwọ agaghị agafe afọ 1, ebe ọ bụ na maka ogologo oge ị na-ewere sibutramine, arụmọrụ yana nchekwa nchekwa adịghị.

Ekwesịrị ịgwọ ya na Reduxine ® yana njikọ yana nri na mmega ahụ n'okpuru nlekọta nke dibịa nwere ahụmịhe bara uru n'ịgwọ oke ibu.

Dodoụbiga ya ókè

Ọrịa enwere obere ihe akaebe banyere ị ofụbiga mmanya ókè nke sibutramine. Mmeghachi omume kachasị njọ na-emetụtakarị ịdoụbiga mmanya ókè bụ tachycardia, ọbara mgbali elu, isi ọwụwa, dizziness. Onye ọrịa ahụ kwesịrị ịgwa onye nlekọta nlekọta ahụike ya ma ọ bụrụ na echere na ị doụfere ya oke.

Ọgwụgwọ: Enweghị ọgwụgwọ ọ bụla ma ọ bụ ọgwụ mgbochi a kapịrị ọnụ. Ọ dị mkpa iji mepụta usoro izugbe: iji hụ na iku ume n'efu, nyochaa ọnọdụ nke CVS, yana kwa, ọ bụrụ na ọ dị mkpa, mepụta usoro ọgwụgwọ Symptomatic. Nhazi oge nke carbon a na-eme ka ọ rụọ ọrụ, yana ịba n'ime eriri afọ, nwere ike belata oriri nke sibutramine n'ime ahụ. Ndị ọrịa nwere ọbara mgbali elu na tachycardia ka enyere ọgwụ mgbochi beta. E guzobeghị ịdị irè nke diuresis ma ọ bụ ọrịa metụtara akụrụngwa.

Ntụziaka pụrụ iche

Ekwesịrị ịgwọ ya na Reduxine ® dị ka akụkụ nke usoro ọgwụgwọ dị omimi maka ịbelata oke n'okpuru nlekọta nke dibịa nwere ahụmịhe bara uru n'ịgwọ oke ibu.

Usoro ọgwụgwọ mgbagwoju anya gụnyere ma mgbanwe nri na etu esi ebi ndụ, yana mmụba na mmega ahụ.

Akụkụ dị mkpa nke usoro ọgwụgwọ ahụ bụ ịmepụta ihe ga - eme tupu mgbanwe a na - agbanwe agbanwe na omume iri nri na ndụ, nke dị mkpa iji nọgide na-enwe mbelata nke anụ ahụ mgbe a kwụsịrị ọgwụgwọ ọgwụ. Dịka akụkụ nke usoro ọgwụgwọ ahụ na Reduxin ®, ọ dị mkpa ka ndị ọrịa gbanwee ụdị ndụ ha na omume ha nke na mgbe ha mechara ọgwụgwọ, ha na-ahụ na enwere mmebe ahụ na-ebute arụmọrụ.

Ndị ọrịa kwesịrị ịghọta nke ọma na ịhapụ ime ihe ndị a chọrọ ga-eduga n'ịba ụba na ibu ahụ na ugboro ugboro na dọkịta na-aga.

N'ime ndị ọrịa na-ewere Reduxin ®, ọ dị mkpa iji tụọ ọkwa nke ọbara mgbali elu na obi obi. N'ime ọnwa atọ mbụ ọgwụgwọ, a ga-enyocha parampat ndị a kwa izu abụọ, ma kwa ọnwa. Ọ bụrụ na n’oge nleta abụọ na-abawanye na ọnụego obi na izu ike ≥10 gbagwojuru / min ma ọ bụ CAD / DBP ≥10 mm Hg achọpụtara. , ị ga-akwụsịkwa ọgwụgwọ. Ndị ọrịa nwere ọbara mgbali elu, n'ime ha, na-emegide usoro ọgwụgwọ antihypertensive, mgbali ọbara dị elu karịa 145/90 mm Hg. , ekwesịrị iji akara a rụọ ọrụ nke ọma ma ọ dị mkpa, na obere oge. Ndị ọrịa nọ n’ọbara mgbede ugboro abụọ n’oge ana -echi ya karịrị ogo nke 1-2/90 mm Hg. , ekwesịrị ịkagbu ọgwụgwọ na Fataxine ((lee. “Nsonaazụ”).

N'ime ndị ọrịa nwere ọrịa ihi ụra, ọ dị mkpa iji nlezianya nyochaa ọbara mgbali.

Ntinye uche pụrụ iche na-achọ n’otu oge ọgwụ nke na-abawanye oge QT. Ọgwụ ndị a gụnyere ọgwụ mgbochi histamine H.₁ndị na-anabata ihe (astemizole, terfenadine), ọgwụ antiarrhythmic nke na-abawanye etiti oge QT (amiodarone, quinidine, flecainide, mexiletine, propafenone, sotalol), eriri afọ motility stimulator cisapride, pimozide, sertindole na tricyclic antide. Nke a metụtakwara ọnọdụ ndị nwere ike ibute mmụba na oge etiti QT (hypokalemia na hypomagnesemia - lee “Mmekọrịta”).

Ọdịiche dị n'etiti ihe na-egbochi MAO na-egbochi (gụnyere furazolidone, procarbazine, selegiline) yana ọgwụ Reduxin ® kwesịrị ịdịkarịa ala izu abụọ.

Agbanyeghi na onwebebeghi njikọ n'etiti iwelataadanxin ® na mmepe nke ọbara ọgbụgba na -akpata, ka o sina dị, nyere ohere a maara nke ọma maka ndị otu a ọgwụ, na nlele ahụike mgbe niile, a ga-akwụ ụgwọ nlebara anya dịka mgbaàmà dịka dyspnea na-aga n’ihu (ọdịda iku ume), obi mgbu na ọzịza nke ụkwụ. .

Ọ bụrụ n ’ịwụda otu ọgwụ nke Reduxin ®, ịgaghị a doseụ okpukpu abụọ nke ọgwụ na ọgwụ ọzọ, a na-atụ aro ka ị gaa n’ihu ị takeụ ọgwụ ahụ dịka usoro enyere gị ike.

Ogologo oge ị na-ewere Reduxin ® agaghị agafe afọ 1.

N'iji ojiji nke sibutramine na SSRI ndị ọzọ, enwere ohere dị n'ọbara. N'ime ndị ọrịa nwere ọbara ọgbụgba, yana ị drugsụ ọgwụ ọjọọ metụtara ọrịa hemostasis ma ọ bụ ọrụ platelet, ekwesịrị iji akọ mee ihe.

Ọ bụ ezie na data ụlọ ọgwụ na ọgwụ riri ahụ na sibutramine adịghị, ọ kwesịrị ịchọpụta ma enwere okwu banyere ị drugụ ọgwụ ọ inụ historyụ nke akụkọ onye ọrịa ahụ ma toaa ntị na akara ndị nwere ike ị ofụ ọgwụ ọjọọ.

Sibutramine bụ ndepụta nke ihe ndị nwere ike, nke Iwu nke Gọọmentị Russia kwadoro na December 29, 2007 Nke 964.

Mmetụta ikike ịkwọ ụgbọala na usoro. Ibelata Discoxine ® nwere ike belata ike gị ịnya ụgbọ ala na iji rụọ ọrụ. N’oge a na-eji ọgwụ xinrexin ®, a ga-akpachara anya mgbe ị na-anya ụgbọ ala ma na-eme ihe ndị ọzọ nwere ike dị ize ndụ chọrọ mmụba uche na ọsọ nke mmeghachi omume psychomotor.

Emeputa

LLC "Ozone". 445351, Russia, Samara Mpaghara, Zhigulevsk, ul. Aja, 11.

Tel./fax: (84862) 3-41-09.

Federal State Unitary Enterprise “Moscow Endocrine Plant”. 109052, Moscow, abụrụ. Novokhokhlovskaya, 25.

Tel./fax: (495) 678-00-50 / 911-42-10.

Adreesị na akara ekwentị nke nzukọ enyere maka kọntaktị (mkpesa na mkpesa): LLC KWES RR R RUS. 105005, Russia, Moscow, ul. Polytovaya Malaya, 2/2, p. 1, pom. 1, ime ụlọ 2.

Tẹm: (495) 640-25-28.

Mkparịta ụka ọgwụ ọjọọ

Erythromycin, ketoconazole na cyclosporine na-eme ka mkpụkọ plasma nke sibutramine metabolites na-abawanye na ọnụego obi na-agbatịkwu ogologo oge nke oge QT.

Phenytoin, rifampicin, phenobarbital, carbamazepine, dexamethasone, na ọgwụ mgbochi macrolide nwere ike ime ka metabolism metabolism dịkwuo ike.

Iji otu oge iji ọgwụ nyocha (pethidine, pentazocine, fentanyl), ọgwụ ụfọdụ maka ọgwụgwọ migraine (dihydroergotamine, sumatriptan), ọgwụ antitussive (dextromethorphan) na ọgwụ maka ọgwụgwọ nke ịda mba, n'ọnọdụ ndị na-adịghị ahụkebe, mmepe nke serotonin syndrome nwere ike.

Reduxin anaghị emetụta mmetụta mgbochi ọgwụ a na-aralụ nke ọnụ.

Site na nchịkwa nke oge a na ethanol, enwebeghị mmụba nke mmetụta ọjọọ nke ikpeazụ ahụ. Agbanyeghị, mmanya na-egbu egbu anaghị emegide oke usoro nri akwadoro n'oge ọgwụgwọ.

Ihe ngosi maka ojiji

Edere Choxin maka ibu ibu n’ihu ọnọdụ ndị a:

• Ebu oke ibu na aru nke aru (BMI) nke 27 n'arọ / m 2 ma obu karie ya na ihe ndi ozo di egwu jikọtara ya na oke obara (nke bu insulin-non-insulin-delllius dyslipoproteinemia),
• Oké ibu na BMI nke 30 n'arọ / m 2 ma ọ bụ karịa.

Ntuziaka maka ojiji nke Reduxin: usoro na usoro onunu ogwu

Ekwesịrị iji ọnụ na-a Reduụ ya ọgwụ ọnụ otu ugboro n'ụbọchị, n'ụtụtụ, na-elo ihe niile dị n'ime mmiri ma na-a themụ ya nke ọma, na afọ na-enweghị isi ma ọ bụ n'oge nri.

Usoro akwadoro ịmalite bụ 10 mg. Ọ bụrụ n’ime izu anọ ọ gaghị ekwe omume imebelata ịdị arọ nke anụ ahụ dịkarịa ala 5%, a na-abawanye ọgwụ kwa ụbọchị ruo 15 mg.

Oge ngụkọta ọgwụgwọ agaghị agafe afọ abụọ (n'ihi ụkọ data na nchekwa na arụmọrụ nke iji ogologo oge) nke sibutramine.

Ọ bụrụ n’agbata ọnwa atọ na-ebelata mbelata nke ahụ gị, ọ dịkarịa ala 5% n’ime ibu mbụ, a na-akagbu mbelata. Agaghị aga n'ihu na ọgwụgwọ ahụ ma ọ bụrụ na, na ijikwa ọgwụ ọzọ, onye ọrịa na-agbakwunye kilogram 3 ma ọ bụ karịa.