Espa Lipon (600 mg

Dabere na ntuziaka maka Espa-Lipon, ọgwụ nwere detoxification, hypoglycemic, hypocholesterolemic na hepatoprotective, na-ekere òkè na nhazi nke metabolism. Thioctic acid, nke bụ akụkụ nke Espa-Lipon, na-etinye aka na mmeghachi nke oxidative nke alfa-keto acid na pyruvic acid, na-eme ka ọrụ imeju dịkwuo mma, ma na-akpali metabolism.

Site na okike a na-eme, thioctic acid yiri vitamin nke otu B. Espa-Lipon na-enyere aka iwelie glycogen na sel imeju, belata oke glucose n'ọbara, ma merie mmebi nke ike nke mkpụrụ ndụ na ịba ụba nke insulin. Ọgwụ na - enyere aka iwepụ nsí n’ahụ, na - echebe akwara imeju ka mmadụ ghara ibute ihe ndị na - egbu egbu, na - echekwa anụ ahụ ma ọ bụrụ na ọ bụ nnu nwere nnukwu ọla.

Mmetụta neuroprotective nke Espa-Lipon bụ igbochi peroxidation egbugbere ọnụ nke anụ ahụ, na-eme ka ọbara na -akpata ma na-eme ka usoro nke iduzi akwara ozi site na sel.

Akingnweta ọgwụ ahụ na ndị ọrịa nwere ọrịa neuropathy, dịka nyocha nke Espa-Lipon, na-akpalite ọdịdị nke ọnụ ọgụgụ bara ụba macroergic na akwara.

Mgbe a na -ekwu ya ọnụ, Espa-Lipon dị mma ma na-agbadata ngwa ngwa site na nri diges, yana otu oge ị ofụ ọgwụ ahụ na nri na-ebelata ọsọ na ogo nke ọgwụ a.

Metabolization nke thioctic acid bụ nke a na-ebu site na conjugation na oxidation nke n'agbụ ndị dị n'akụkụ. Espa-Lipon nọ n'ọrụ ka ewepụrụ na mmamịrị n'ụdị metabolites. Ọkara ndụ nke ọgwụ ahụ site na plasma ọbara bụ nkeji 10-20.

Espa-Lipon nwere “ihe mbugharị mbụ” site na imeju - ya bụ, akụrụngwa nke ọgwụ ahụ na-agbadata ntakịrị n'okpuru onye na-agbachitere ihe okike site na ihe ndị si mba ọzọ na-abanye ahụ.

Mpempe usoro onunu ogwu

Na-echebara echiche maka ngbanye infusion 600 mg / 24 ml

24 ml na 1 ml nke ọgwụ nwere

ike ihe: acid a na-akpọ thioctic acid na 24 ml-600.0 mg na 1 ml-25.0 mg

n'imeonye inyeakase bekeea: ethylenediamine, mmiri maka ịgba ntụtụ.

Pipe mmiri na-acha ọbara ọbara site na ìhè edo edo ruo odo akwụkwọ ndụ akwụkwọ ndụ.

Ngwongwo ogwu

Mlọ ọgwụ

Egwu. Site na nchịkwa intravenous, oge ị ga-erute ịta plasma kachasị bụ nkeji iri ruo 11-11, oge kachasị bụ 25-38 μg / ml, mpaghara dị n'okpuru oge ịta ahụ bụ ihe dịka 5 hg h / ml. Bioavailability bụ 100%.

Metabolism: Thioctic acid na-arịa “ụzọ mbụ” site na imeju.

Nkesa: olu nke nkesa dị ihe dịka 450 ml / n'arọ.

Dradọrọ: Site na akụrụ (threctic acid) na metabolites ya na-apụ n'anya. Oge iwepu ọkara ndụ bụ nkeji iri abụọ na ise. Mkpochapụ plasma bụ nkeji iri na isii.

Mlọ ọgwụ

Espa-lipon - antioxidant endogenous (na - egbochi radicals), bụ nke a na - eme n'ime ahụ site na iji ọgwụ ụrọ oxidative decarboxylation nke alpha-keto acid. Dị ka coenzyme nke mitochondrial multienzyme ogige, ọ na-esonye na oxarative decarboxylation nke pyruvic acid na alfa-keto acid. Ọ na - enyere aka belata mkpụkọ glucose na ọbara ma mee ka mgbakwunye glycogen na imeju, yana imeri nguzogide insulin. Site na okike nke ndu ogwu ndu, o di nso na vitamin B sonyere n’usoro nke mmanu mmanu na mmanu mmanu, na - akpali cholesterol metabolism, na - eme ka oru umeju di elu, na - ebelata oke mmebi nke endogenous na toxins. Ọ na - eme ka akwara ozi trophic dịkwuo elu.

Mlọ ọgwụ

Thioctic acid — antioxidant, nke edobere n’ime ahụ site na decarboxylation nke alpha-keto acids. Ọ nwere mmetụta yiri nke ahụ B vitamin. Ọ na-ekere òkè na metabolism ike, na-edozi Lipid (cholesterol metabolism) na metabolism metabolism. Ntughari lipotropicna mmetụta ngbanwe. Mmetụta na metabolism metabolism na-akpata mmụba glycogenimeju na ibelata glucosen’ime ọbara.

Ọ na - eme ka trophism nke neurons dịkwuo mma, ebe ọ na - agbakọ na ha ma belata ọdịnaya nke radicals na ọrụ imeju n'efu (yana usoro ọgwụgwọ).

Ntughari ịbelata ike, hypoglycemic, hepatoprotectivena mmetụta hypocholesterolemic.

Usoro onunu ogwu na nhazi

Na mbido ọgwụgwọ, a na-edozi ọgwụ ahụ parenterally. E mesịa, mgbe ha na-eme ọgwụgwọ mmezi, ha na-agbanwe ị toụ ọgwụ ahụ n'ime.

Na-echebara echiche maka ngwọta maka infusion:

A na-achịkwa ọgwụ ahụ intravenly n'ụdị nke infusions mgbe mbido mbu na 200-250 ml nke ngwọta sotum chloride isotonic.

Na ụdị siri ike nke polyneuropathy mamịrị a na-a drugụ ọgwụ ahụ otu ugboro kwa ụbọchị n'ime mkpụmkpụ nke 24 ml nke ọgwụ a na ngwongwo isotonic sodium chloride (nke kwekọrọ na 600 mg nke thioctic acid kwa ụbọchị). Ogologo oge nke infusion 30 nkeji. Oge oge ịgba ọgwụ bụ ụbọchị 5-28.

Ekwesịrị ịchekwa azịza infusion kwadebere n'ọchịchịrị ma jiri ya ruo awa 6 mgbe nkwadebe gasịrị. N'oge infusion kwesịrị kechie karama na ọchịchịrị akwụkwọ. Na-esote, ikwesiri ịgbanye na ọgwụgwọ mmezi n'ụdị mbadamba ụrọ na ọkara nke 400-600 mg kwa ụbọchị. Ogologo oge ọgwụgwọ na mbadamba bụ ọnwa 3.

N'ọnọdụ ụfọdụ, ị takingụ ọgwụ ahụ na-agụnye iji ogologo oge, oge dọkịta ga-ekpebi oge ọ ga-ekpebi oge ahụ.

Nsonaazụ

- rashes na anụ ahụ, urticaria, itching

- Usoro mmeghachi omume nfụkasị (usoro anaphylactic)

ọgbụgbọ, vomiting, mgbanwe na uto

-eche banyere ọbara ọgbụgba, agamị ọbara ọgbụgba

dysfunction platelet

-enweta ogo shuga (n'ihi mmụba glucose dị mma), nwere ike ibute ọgbụgba, ọrịa anya dị iche iche, mmụba dị elu.

- isi ọwụwa (ịgafe na oge), mgbali intracranial mụbara, ịda mbà iku ume (mgbe nchịkwa intravenous ngwa ngwa)

Mkparịta ụka ọgwụ ọjọọ

Site na iji Espa-Lipon na-ejikọ ya na insulin na ọgwụ antidiedi, a na-enwekwu ike hypoglycemic nke ikpeazụ.

Thioctic acid na-akpụ akpụ ogige nwere ike ịnwụ na ụmụ irighiri shuga (dịka ọmụmaatụ, ihe ngwọta nke levulose).

Ngwakọta infusion ekwekọghị na ngwọta glucose, ngwọta Ringer, yana ngwọta nwere ike ịmekọrịta n'etiti SH-otu ma ọ bụ kpaghasị àkwà mmiri.

Thioctic acid (dị ka ihe ngwọta maka infusion) belata nsonaazụ nke cisplatin.

A naghị atụ aro ka a na - ejikwa ya maka iron, magnesium, ngwaahịa mmiri ara ehi na - agagharị tupu (awa 6-8 tupu nchịkwa ọgwụ).

Ntụziaka pụrụ iche

Mgbe ị na-eme ọgwụgwọ Espa-Lipon na ndị ọrịa nwere ọrịa mellitus, ọkachasị na mmalite nke ọgwụgwọ, itinye oge niile (dịka ndụmọdụ dọkịta ahụ si dị) nlebara anya ịbanye n'ọbara glucose ọbara dị mkpa. N'ọnọdụ ụfọdụ, achọrọ mbelata hypeglycemic elekọta mmadụ chọrọ.

N'oge ọgwụgwọ, ọ dị mkpa iji zere ị alcoholụ mmanya na-aba n'anya kpamkpam, ebe ọ bụ na ike ọgwụgwọ thioctic acid esighi ike.

A na-emezi ihe ngwọta maka infusion na ntinye, ya bụ n'ime izu 2-4 n'ime mmalite ọgwụgwọ.

Maka nchịkwa intravenous, a na-agwakọta ihe dị na espaule Lipa 600 mg ampoule na 250 ml nke 0.9% sodium chloride solution, n'ụdị infusion obere oge ọ dịkarịa ala minit 30.

N'ihi nnukwu fotoensitivity nke ihe na-arụ ọrụ, a ga-akwadebe ihe na-akpata infusion ozugbo nchịkwa, a ga-ewepụ ampoules na nkwakọ ngwaahịa naanị ozugbo tupu ejiri ya, a ga-eji akwụkwọ gbara ọchịchịrị kpuchiri vial ahụ n'oge infusion. Ndụ shelf nke ihe a kwadebere maka mgbe ejiri dilution ya na isotonic sodium chloride solution bụ ihe kachasị ka awa 6 mgbe echekwara ya n'ebe gbara ọchịchịrị.

Ime na lactation

N'ihi enweghị ahụmịhe banyere iji ọgwụ ahụ, edeghị Espa-Lipon maka ụmụ nwanyị dị ime.

A naghị atụ aro ka ị theụọ ọgwụ ahụ n'oge a na-enye nwa ara, ebe ọ nweghị data ọ bụla banyere ọgwụ ịreụ mmiri ara ara.

Mmetụta n'ịnyịnya ụgbọ ala ma ọ bụ igwe nwere ike ịdị ize ndụ

N’enye nsogbu ndị ọ ga - ekwe omume (nkwusi, nkụda mmụọ, anya mmiri), a ga - akpachara anya mgbe ị na - anya ụgbọala ma ọ bụ na - arụ ọrụ igwe na - akpụ akpụ

Dodoụbiga ya ókè

Ọrịa isi ọwụwa, ọgbụgbọ, ọgbụgbọ.

Dodoụbiga mmanya ókè nwere ike ime ka ngosipụta ụlọ ọgwụ nke oke egbu egbu ya na mgbanwe na sistemụ akwara na-emetụta ya (ntụgharị psychomotor na nkwarụ), lactic acidosis, hypoglycemia, na mmepe nke DIC.

Ọgwụgwọ: usoro ọgwụgwọ symptomatic, ọ bụrụ na ọ dị mkpa - ọgwụgwọ anticonvulsant, na - ebido ichebe ọrụ nke akụkụ ahụ dị mkpa. Enweghị ọgwụ mgbochi akọwapụtara.

Mpempe akwụkwọ Mpempe akwụkwọ

Esparma GmbH, Seepark 7, 39116 Magdeburg, Germany

Adreesị nke nzukọ ahụ nke na-anabata ndị na-azụ ahịa banyere ogo ngwaahịa dị na Republic of Kazakhstan

Lọ ọrụ nnọchite anya nke Pharma Garant GmbH

Zhibek Zholy 64, off.305 Almaty, Kazakhstan, 050002

Ihe ngosi maka iji Espa-Lipona

Dịka ntuziaka ahụ si dị, Espa-Lipon ka enyere iwu maka ọnọdụ ndị ọrịa:

• Polyneuropathies (gụnyere ọrịa shuga na etiologies).
• Ọrịa imeju (gụnyere ọrịa ịba ọcha n'anya),
• Mmanya na-egbu egbu ma ọ bụ nke na-emetụta nsị na nnu nke nnukwu ọla, olu, wdg.

Ọzọkwa, ọgwụ dị irè megide atherosclerosis, eji maka ọgwụgwọ na mgbochi nke ọrịa akwara.

Ihe ngbanwe

Edebere Espa-Lipon maka ndị ọrịa na-arịa ị alcoholụ mmanya na-egbu egbu, ọrịa glucose-galactose malabsorption, yana ndị nwere ụkọ lactase.

N'iji nlezianya mee ihe, a na-akwado iji Espa-Lipon maka ndị ọrịa nwere ọrịa mellitus - yana ntụgharị nke mmachi nke dose nke ndị ọrụ hypoglycemic. Shouldmụaka ekwesịghị ị Esụ ọgwụ Espa-Lipon maka ụmụaka na-erubeghị afọ 18 - n'ihi enweghị data na nchekwa nke iji ọgwụ maka ụdị ndị ọrịa a. Ọ bụrụ na enwere ihe ngosi dị mkpa, mmadụ nke afọ a nwere ike ị drugụ ọgwụ a dabere na ndụmọdụ dọkịta, na-eburu n'uche usoro ị takingụ ọgwụ ahụ.

Ekwenyebeghị nchekwa zuru oke nke Espa-Lipon maka ahụike nke nwa ebu n'afọ mgbe ị theụ ọgwụ n'oge afọ ime egosipụtaghị. Ọ bụrụ na ọ dị mkpa ịgwọ nwanyị na Espa-Lipon n'oge a na-enye nwa, ọ dị mkpa iji dozie okwu banyere ịhapụ nwa ọhụrụ nwa nwa site na ara.

Mkparịta ụka ọgwụ ọjọọ

Nlekọta oge nke Espa-Lipon nwere ọgwụ ọgwụ hypoglycemic ọnụ na insulin nwere ike ịkpalite mmụba na hypoglycemic mmetụta - mmụba na uche nke akwara anụ ahụ na - emewanye insulin.

Ojiji nke Espa-Lipon dika ntuziaka ya tinyere mmanya ethyl si belata ọrụ nke thioctic acid. N’oge ịgwọ ọgwụ ahụ, a na-atụ aro ka ọ hapụ ị productsụ ngwaahịa nwere ethanol na ihe ọholicụholicụ na-aba n’anya.

Na mgbakwunye, a na-ahụ ọrụ nke thioctic acid n'ihe gbasara iji jikọtara ọnụ nke metal, ya mere, ojiji nke Espa-Lipon n'otu oge yana ọgwụ nwere iron, calcium, magnesium ion ga-ekwe omume na oge elekere abụọ n'etiti ọgwụ.

Iburu Espa-Lipon na cisplatin belatara nrụpụta nke ọgwụ.

Espa-Lipon, ntuziaka maka ojiji (Usoro na usoro onunu ogwu)

Ọtụtụ mgbe, ọgwụgwọ na-amalite site na iv infusus, na-esochi ịgbanye na mbadamba Espa-Lipon. A na-ewere mbadamba okwu ọnụ, na-enweghị ita, nkeji 30 tupu nri 1 oge kwa ụbọchị. Kwa ụbọchị nke 600 mg. Onwa ato Dika dọkịta nyere ya, enwere ike ị drugụ ọgwụ ahụ ogologo oge.

Na ọrịa shuga njikwa chọrọ glucosen’ime ọbara. N'oge ọgwụgwọ, anaghị ekwe ya mmanyanke na - eme ka mmetụta ọgwụ ahụ pụta.

Mmekorita

A na-achọpụta mmụba na hypoglycemic mmetụta mgbe ejiri ya insulin ma ọ bụ ọgwụ hypoglycemic ọgwụ.

Belatara arụmọrụ Cisplatin n'oge atọrọ na thioctic acid.

Ethanolna-ebelata mmetụta nke ọgwụ ahụ.

Enwetara mmetụta mgbochi mbufụt GKS.

N'ihi ya, ọ ga-ekeji ọla nhazi ígwè enweghị ike ikenye ya n'otu oge. N'ikuku banyere ọgwụ ndị a ka ekesara (awa 2).

Espa Lipon na-eme nyocha

Enweghị ọtụtụ nyocha banyere iji ọgwụ a, n'ihi na Espa-Lipon adịkarịghị eji ọgwụ monotherapy. Ọtụtụ mgbe enwere nyocha banyere etu esi eme ya polyneuropathy na-arịa ọrịa mamịrị. Ndị ọrịa rịbara ama na nnabata ogologo nyere aka wepu mgbu n'ime ụkwụ na ụkwụ, na-enwu ọkụ, "ọsụsọ", akwara mgbu ma weghachite uche na-efu.

Na Ọrịa imeju na-egbu egbu ọgwụ a nyere aka mee ka mmiri ọgwụ onye ọzọ dị ọcha ma wepụsịa ọrịa dyspeptik. Egosipụta nkwalite ndị ọrịa site na nyocha (ịdị ka usoro nke mmega ahụ si dị transaminase) na mmetụta dị mma nke ihe ịrịba ama nke ultrasound.

Enwere ihe akaebe mgbe ejiri Espa-Lipon n'ụzọ gara nke ọma na usoro ọgwụgwọ dị mgbagwoju anya atherosclerosis.

N'okwu niile, ọgwụgwọ malitere site na nchịkwa draịva (10-20 ụmụ nwanyị) na ọnọdụ ụlọ ọgwụ, mgbe ahụ ndị ọrịa weere ụdị mbadamba mbadamba, oge ụfọdụ kwa ụbọchị bụ 1800 mg (3 mbadamba 3).

Nke mmetụta dị n’akụkụ, a na-ama ọgbụgbọ na obi mgbawa mgbe ị na-a pụ ọgwụ thrombophlebitis yana nchịkwa intraven.

Aha:

Espa-Lipon (ihe ngwọta maka ntụtụ) (Espa-Lipon)

Otu ampoule nke Espa-Lipon 300 nwere:
Ethylene bisatsan-salts nke alfa lipoic acid (na usoro nke alfa lipoic acid) - 300 mg,
Ndị ọkachamara: mmiri maka ịgba ọgwụ mgbochi.

Ampoule 1 nke Espa-Lipon 600 nwere:
Ethylene bisatsan-salts nke alfa lipoic acid (na usoro nke alfa lipoic acid) - 600 mg,
Ndị ọkachamara: mmiri maka ịgba ọgwụ mgbochi.

Ime

N'oge a, enweghị data ndị a pụrụ ịdabere na ya banyere nchekwa nke ọgwụ Espa-Lipon n'oge afọ ime. Onye dibia bekee puru ime ogwu ogwu n’oge o di ime ya ma o buru na uru nne a choro gafee na nsogbu nke nwa a.
Ọ bụrụ na ọ dị mkpa iji ọgwụ ahụ n'oge a na-enye nwa ara, ọ dị mkpa ka gị na dọkịta gị gaa kpebie nkwụsị nke ị ofụ ara.

Ọnọdụ nchekwa

A na-atụ aro ọgwụ a ka echekwa ya n'ebe ọkpọka naanị site na ìhè anyanwụ na okpomọkụ nke ogo 15 ruo 25 Celsius. Alfa lipoic acid nwere ọnụnọ dị elu, yabụ ekwesịrị iwepụ ampoule ahụ ozugbo ọ bụla tupu ejiri ya.
Ndụ nchekwa nke ọgwụ ahụ bụ afọ 3.
Nwere ike ịchekwa infusion መፍትሄ nwere ike ịchekwa n'ebe gbara ọchịchịrị maka ihe na-erughị awa 6.