Insulin weputara uzo abuo

Nkwado insulin na-emekọ ihe, bụ analog nke insulin. Mkpesa Biphasic nke mejupụtara insulin asulu so 30 (30%) yana kristal nke proulinine propartine (70%). Nlekọta insulin nwetara site na teknụzụ DNA nke ọzọ na-eji ụdị Saccharomyces cerevisiae, n'ụdị insulin ahụ, amino acid na-anọchi ọnọdụ B28 ejiri aspartic acid dochie.

Ọgwụ Farmacology

Biphosic insulin na-emekọ ihe ọnụ na ndị na-anabata ya nke akpụkpọ ahụ cytoplasmic nke ahụ ma mepụta insulin-receptor na-akpali usoro intracellular, gụnyere njikọ nke ọtụtụ isi enzymes (hexokinase, pyruvate kinase, glycogen synthetase). Mbelata nke mkpokọta glucose na ọbara bụ n'ihi mmụba na njem nke akwara umeji ya, mmụba dị elu site na akwara ọkpụkpụ na anụ ahụ adipose, yana mbelata nke mmụpụta nke glucose na imeju. Ọ nwere otu ọrụ ahụ ka insulin mmadụ si yie na molar. Igha nkpuru nke amino acid n’eburu n’onodu B28 ya na aspartic acid na –ebelata udiri umu irighiri ihe wee kee okpukpo ahu nke ogwu, bu nke a na - ahu n’ime insulin nke mmadu nwere. N'akụkụ a, a na-enweta insulin aspart na abụba dị n'okpuru ala karịa ngwa ngwa insulin na-adị n'ime insulin nke mmadụ. A na-etinye insulin aspart protamine ogologo oge. Mgbe sc nchịkwa, mmetụta ahụ na-amalite mgbe minit 10-20 gasịrị, nsonaazụ kachasị mgbe ọ rụchara awa iri anọ na anọ, oge a ga-eme ihe ruru awa iri abụọ na anọ (dabere na dose, ebe nchịkwa, ọbara ọgbụgba siri ike, ahụ ọkụ na ọkwa nke mmega ahụ).

Mgbe s / na dose nke 0.2 U / kg body body T_max - Nkeji 60 Ind jikọtara protein ndị dị ala dị ala (0-9%). Ọgwụ insulin insulin na-alaghachi na mbụ mgbe awa 15-18 gachara.

Ime na lactation

Iji oge ime ime ga-ekwe omume ma ọ bụrụ na atụ anya ọgwụgwọ gafere ihe egwu dị na nwa ebu n’afọ (emebeghị nnyocha zuru oke ma na-achịkwa ike). Amabeghị ma insulin aspart biphasic nwere ike ị nweta nsị ma ọ bụrụ na ejiri ya n'oge ime yana ma ya emetụta ikike ịmụ nwa.

N'oge oge ọ ga-ekwe omume ịtụrụ ime, na oge ya niile, ọ dị mkpa iji nlezianya nyochaa ọnọdụ ndị ọrịa nwere ọrịa mellitus ma lelee ọkwa nke glucose n'ọbara. Mkpa insulin, dị ka a na-achị, na-ebelata na ọkara nke mbụ wee jiri nwayọọ nwayọọ na-abawanye na nke abụọ na nke atọ nke afọ ime.

N'oge ịmụ nwa na ozugbo ha gbasịrị, mkpa insulin nwere ike ibelata nke ukwuu, mana ọ na - alaghachi ọsọ ọsọ na ọkwa ahụ nke dị tupu afọ ime.

Amabeghị ma ọgwụ ọ banye na mmiri ara. N'oge a na-enye nwa ara, enwere ike inwe mkpa maka idozigharị dose.

Insulin aspart biphasic: Nsonaazụ

Njehie na adịghị mma (na mmalite ọgwụgwọ), mmeghachi ahụ nfụkasị mpaghara (hyperemia, ọria, itching nke anụ ahụ na ntụtụ), mmeghachi omume nfụkasị ahụ (ọnya ọnya, itching, ịba ụba ọsụsọ, ọrụ eriri afọ, ike iku ume, tachycardia, mbelata ọbara mgbali, angioedema) edema), lipodystrophy na ntaneti.

Mmekorita

Abali insulin aspart bụ nke ọgwụ ekwekọghị na ọgwụgwọ nke ọgwụ ndị ọzọ. A na - eme ka mmetụta hypoglycemic dị elu site na ọgwụ ọgwụ hypoglycemic ọgwụ, sulfanilamides, MAO inhibitors (gụnyere furazolidone, procarbazine, selegiline), ndị na-egbochi carbonic anhydrase, ndị na-egbochi ACE, ọgwụ anabolic (gụnyere stanozolol, oxandrolone, metroprotinol na tetroproton , nnupụisi, fibrates, fluoxetine, ketoconazole, mebendazole, theophylline, cyclophosphamide, fenfluramine, pyridoxine, quinidine, quinine, chloroquine, ethanol na ethanol nwere ọgwụ. Hypoglycemic mmetụta nke isi glucocorticoids, glucagon, ibu hormone, thyroid homonụ, estrogens, progestogens (atụ onu gbochie afọ), thiazide diuretics, CCB, heparin, sulfinpyrazone, sympathomimetics (dị ka epinephrine, salbutamol, terbutaline), isoniazid, phenothiazine nkwekọrịta, danazol, tricyclics, diazoxide, morphine, nicotine, phenytoin.

Beta-blockers, clonidine, nnu nke lithium, reserpine, salicylates, pentamidine - nwere ike ịkwalite ma mee ka ike hypoglycemic dị na insulin.

Biphosic insulin aspart: Usoro ugwọ na nhazi

P / c, ozugbo nri, ma ọ bụrụ na ọ dị mkpa - ozugbo nri. A na-eme ntụtụ ahụ n'apata ụkwụ ma ọ bụ n'azu ime, ma ọ bụ n'ubu ma ọ bụ n'ikpere. Okwesiri igbanwe ebe igba ogwu di n'etiti mpaghara anatomical (igbochi mmepe nke lipodystrophy). Okpomoku nke mmanu insulin kwesiri ino na okpomoku.

Ọ bụ dọkịta ga-ekpebi ọ̀tụ̀tụ̀ insulin aspart biphasic n'otu n'otu n'okwu nke ọ bụla, dabere n'ọbara glucose n'ọbara. Ná nkezi, kwa ụbọchị bụ 0.5-1 nkeji / n'arọ ahu aro. Site na iguzogide insulin (dịka ọmụmaatụ, n'ibu oke ibu), enwere ike ịbawanyewanye mkpa insulin kwa ụbọchị, yana ndị ọrịa nwere insulin insogenous insulin nke mmiri ọgwụ.

Nchedo nchekwa

Abụọ n'ime insulin ngalaba abụọ agaghị enwe ike iv. Ọgwụ ezughi oke ma ọ bụ ịkwụsị ọgwụgwọ (karịchaa ụdị ọrịa shuga 1) nwere ike ibute mmepe nke hyperglycemia ma ọ bụ ketoacidosis mamịrị. Dịka iwu, hyperglycemia gosipụtara onwe ya nke nta nke nta ọtụtụ awa ma ọ bụ ụbọchị (akara nke hyperglycemia: ọgbụgbọ, ọgbụgbọ, ura, redness na akọrọ nke anụ ahụ, akpọnwụ akpịrị, mmụba mmụba, akpịrị ịkpọ nkụ na agụụ, ọdịdị nke isi acetone na ikuku na-agwụ ike), na enweghị ọgwụgwọ kwesịrị ekwesị nwere ike ibute ọnwụ.

Mgbe ha kwusịrị metabolism metabolism, dịka ọmụmaatụ, n'oge ọgwụgwọ insulin kpụ ọkụ n'ọnụ, ndị ọrịa nwere ike ịnwe mgbaàmà nke ebumnuche hypoglycemia, nke e kwesịrị ịgwa ndị ọrịa banyere ya. N'ime ndị ọrịa nwere ọrịa metabolic kachasị mma, nsogbu nke ọrịa shuga na-ebute ma emesịa ma jiri nwayọ nwayọ. N'akụkụ a, a na-atụ aro ka ọ rụọ ọrụ ndị kachasị maka njikwa metabolic, gụnyere ilele ọkwa glucose dị n'ọbara.

Ekwesịrị iji insulin nkebi abụọ mee ihe na njikọta nri. Ọ dị mkpa iburu n'uche oke ọsọ nke mmalite nke nsonaazụ na ọgwụgwọ ndị ọrịa nwere ọrịa concomitant ma ọ bụ ị takingụ ọgwụ ọjọọ nke na-ebelata oriri. Ọnụnọ ọrịa na-efe efe, ọkachasị na-efe efe, mkpa ịba insulin na-abawanye. Alrụ ọrụ akụrụ na - ma ọ bụ ọrụ imeju nwere ike iduga n'ịbelata insulin chọrọ. Izere nri ma ọ bụ mgbatị ahụ na-enweghị nhazi nwere ike iduga mmepe nke hypoglycemia.

Site na mmepe nke hypoglycemia ma ọ bụ hyperglycemia, mbelata nke itinye uche na ọsọ ọsọ ga-ekwe omume, nke nwere ike ịdị ize ndụ mgbe ị na-anya ụgbọ ala ma ọ bụ na-eji igwe na arụ ọrụ. A dụrụ ndị ọrịa ọdụ ka ha mee ihe iji gbochie mmepe nke hypoglycemia na hyperglycemia. Nke a dị ezigbo mkpa maka ndị ọrịa na-enweghị ma ọ bụ belata ihe mgbaàmà nke ihe ndị na - ebilite hypoglycemia ma ọ bụ na - ata ahụhụ site na ọrịa hypoglycemia ugboro ugboro.

Aha Azụmaahịa

NovoMix 30 Penfill: nkwusioru maka usoro ochichi nke subcutaneous 100 PIECES / ml, Novo Nordisk (Denmark)

NovoMix 30 FlexPen: nkwusioru maka usoro ochichi nke subcutaneous 100 PIECES / ml, Novo Nordisk (Denmark)

NovoMix 50 FlexPen: nkwusioru maka usoro ochichi nke subcutaneous 100 PIECES / ml, Novo Nordisk (Denmark)

NovoMix 70 FlexPen: nkwusioru maka usoro ochichi nke subcutaneous 100 PIECES / ml, Novo Nordisk (Denmark)

Omume ọgwụ

Ọ na - emekọ ihe n'etiti ndị na - anabata ya nke mkpụrụ ndụ cytoplasmic nke mkpụrụ ndụ ma mepụta ogige insulin-receptor na-akpali usoro intracellular, gụnyere njikọ nke ọtụtụ isi enzymes (hexokinase, pyruvate kinase, glycogen synthetase). Mbelata nke mkpokọta glucose na ọbara bụ n'ihi mmụba na njem nke akwara umeji ya, mmụba dị elu site na akwara ọkpụkpụ na anụ ahụ adipose, yana mbelata nke mmụpụta nke glucose na imeju. Ọ nwere otu ọrụ ahụ ka insulin mmadụ si yie na molar. Igha nkpuru nke amino acid n’eburu n’onodu B28 ya na aspartic acid na –ebelata udiri umu irighiri ihe wee kee okpukpo ahu nke ogwu, bu nke a na - ahu n’ime insulin nke mmadu nwere. N'akụkụ a, a na-enweta insulin aspart na abụba dị n'okpuru ala karịa ngwa ngwa insulin na-adị n'ime insulin nke mmadụ. A na-etinye insulin aspart protamine ogologo oge. Mgbe sc nchịkwa, mmetụta ahụ na-amalite mgbe minit 10-20 gasịrị, nsonaazụ kachasị mgbe ọ rụchara awa iri anọ na anọ, oge a ga-eme ihe ruru awa iri abụọ na anọ (dabere na dose, ebe nchịkwa, ọbara ọgbụgba siri ike, ahụ ọkụ na ọkwa nke mmega ahụ). Mgbe s / na dose nke 0.2 U / kg body body Tmax - 60 nkeji Ind jikọtara protein ndị dị ala dị ala (0-9%). Ọgwụ insulin insulin na-alaghachi na mbụ mgbe awa 15-18 gachara.

Njirimara nke insulin asap biphasic

Nkwado insulin na-emekọ ihe, bụ analog nke insulin. Mkpesa Biphasic nke mejupụtara insulin asulu so 30 (30%) yana kristal nke proulinine propartine (70%). Ntanari insulin nwetara site na iji teknụzụ DNA jikọtara ọnụ site na iji nje Saccharomyces cerevisiae, n'ime molekul meputara insulin, a na - eji aspartic acid dochie proton amino acid nke no n’ogo B28.

Nsonaazụ nke ihe insulin aspart biphasic

Dodoụbiga ya ókè

Ọrịa hypoglycemia - ọsụsọ "oyi", pallor nke anụ ahụ, ụjọ, ụjọ, nchekasị, ike ọgwụgwụ pụrụ iche, adịghị ike, mgbakasị ahụ, anya isi, ọgbụgba, agụụ siri ike, nkwarụ anya nke nwa oge, isi ọwụwa, ọgbụgbọ, tachycardia, cramps, nsogbu akwara ozi. Coma.

Ọgwụgwọ: onye ọrịa ahụ nwere ike ịkwụsị obere hypoglycemia site na ị gluụ glucose, shuga ma ọ bụ nri nwere carbohydrate. N'ọnọdụ siri ike - na / na 40% dextrose መፍትሄ, na / m, s / c - glucagon. Mgbe ọ nwetasịrị onwe ya, a na-atụ aro onye ọrịa ka ọ rie nri nwere carbohydrate iji gbochie ịmaliteghachi hypoglycemia.

Ihe ị ga - eme ga - eme ka insulin na - ebe ike mmadụ

Can nweghị ike ịbanye iv. Ọgwụ ezughi oke ma ọ bụ ịkwụsị ọgwụgwọ (karịchaa ụdị ọrịa shuga 1) nwere ike ibute mmepe nke hyperglycemia ma ọ bụ ketoacidosis mamịrị. Dịka iwu, hyperglycemia gosipụtara onwe ya nke nta nke nta ọtụtụ awa ma ọ bụ ụbọchị (akara nke hyperglycemia: ọgbụgbọ, ọgbụgbọ, ura, redness na akọrọ nke anụ ahụ, akpọnwụ akpịrị, mmụba mmụba, akpịrị ịkpọ nkụ na agụụ, ọdịdị nke isi acetone na ikuku na-agwụ ike), na enweghị ọgwụgwọ kwesịrị ekwesị nwere ike ibute ọnwụ.

Ekwesịrị iji ọgwụ a mee ihe kpọmkwem na ntinye nri. Ọ dị mkpa iburu n'uche ọnụọgụ dị elu nke mmalite nke nsonaazụ na ọgwụgwọ ndị ọrịa nwere ọrịa concomitant ma ọ bụ ị takingụ ọgwụ ọjọọ nke na-ebelata oriri. Ọnụnọ ọrịa na-efe efe, ọkachasị na-efe efe, mkpa ịba insulin na-abawanye. Alrụ ọrụ akụrụ na - ma ọ bụ ọrụ imeju nwere ike iduga n'ịbelata insulin chọrọ. Izere nri ma ọ bụ mgbatị ahụ na-enweghị nhazi nwere ike iduga mmepe nke hypoglycemia.

Ekwesịrị ịbufe onye ọrịa na ụdị insulin ọhụụ ma ọ bụ ịkwadebe insulin nke onye nrụpụta ọzọ n'okpuru nlekọta ahụike siri ike, enwere ike ịchọ ndozi dose. Ọ bụrụ na ọ dị mkpa, enwere ike ịmeghari doti na ọgwụ mbụ ma ọ bụ n'izu mbụ ma ọ bụ ọnwa ọgwụgwọ. Enwere ike ịgbanwe mgbanwe ị doseụ ọgwụ nwere ike ịgbanwe yana ị inụ nri ya na ịba ụba na-emega ahụ. Mgbatị ahụ ozugbo ị rie nri nwere ike ịbawanye ohere ị nwere hypoglycemia.

Ciplekpụrụ nke ịrụ ọrụ

Ọgwụ a na - ekekọta ndị na - anabata insulin na anụ ahụ adipose na akwara. A na-ebelata ọ̀tụ̀tụ̀ glucose dị n’ọbara n’ihi eziokwu ahụ bụ́ na akwara ndị ọzọ nwere ike imeju glucose nke ọma karịa, ọ na-aka mma ịba n’ime sel, ebe ọnụego ya guzobere n’imeju, n’ụzọ megidere, na-eji nwayọ nwayọ. Usoro nke abụba abụba dị n’ahụ na-eme ka ọ sie ike ma na-eme ka njikọta ihe eke protein dị n’ọrụ.

Omume nke ọgwụ ahụ na-amalite mgbe nkeji 10-20 gasịrị, a na-ahụkwa itinye uche ya kachasị na ọbara mgbe awa 1-3 gasịrị (nke a bụ ugboro 2 ngwa ngwa ma e jiri ya tụnyere hormone nke mmadụ na-emebu). A na-ere insulin dị otu a n'okpuru aha ahia NovoRapid (ma e wezụga ya, enwere insulin nwere usoro abụọ, nke dị iche na otu ya).

Nnukwu insulin

Biphasic insulin aspart nwere otu ụkpụrụ nke mmetụta ọgwụ ọgwụ na ahụ. Ihe dị iche bụ na o nwere insulin na-adị mkpụmkpụ (n'ezie we kewa) yana homonụ na-arụ ọrụ (protamine-insulin aspart). Oke nke insulins ndị a na ọgwụ dị ka ndị a: 30% bụ homonụ na-eme ngwa ngwa ma 70% bụ ụdị dị ogologo.

Mmetụta mbụ nke ọgwụ na-amalite n'ụzọ nkịtị ozugbo nchịkwa (n'ime nkeji 10), na 70% nke ọgwụ ndị ọzọ na -emepụta ntinye insulin n'okpuru anụahụ. A na-ewepụta ya nwayọ nwayọ ma rụọ ọrụ na nkezi ruo awa 24.

Enwekwara usoro ọgwụgwọ eji etinye insulin (aspart) na nwa obere ihe na-arụ ọrụ ogologo oge (degludec). Aha azụmahịa ya bụ Ryzodeg. Enterbanye na ngwa a, dị ka insulin jikọtara ọnụ, ị nwere ike naanị subcutaneously, na-agbanwe mpaghara maka injections (iji gbochie mmepe nke lipodystrophy). Ogologo oge ọgwụ a na agba nke abụọ ruru ụbọchị 2 ruo 3.

Ọ bụrụ na onye ọrịa ahụ chọrọ ịgbanye ụdị homonụ dị iche iche, mgbe ahụ ikekwe ọ ga-aka adịrị ya mma ka ọ were ọgwụ mgbochi abụọ. Nke a na-ebelata ọnụ ọgụgụ nke injections ma na-enyere aka ijikwa glycemia nke ọma. Mana naanị endocrinologist nwere ike ịhọrọ ọgwụgwọ kachasị mma dabere na nsonaazụ nyocha na data nyocha ebumnuche.

Uru na ọghọm ya

Insulin aspart (biphasic na otu-usoro) dị iche na insulin mmadụ nkịtị. N'ọnọdụ ụfọdụ, a na-eji aspartic acid (nke a makwaara dị ka aspartate) dochie proino amino acid. Naanị nke a na - eme ka Njirimara homonụ ahụ ghara ịdị mma ma ọ bụ n ’ụzọ ọ bụla anaghị emetụta nnabata ya dị mma, yana ọrụ yana oke adịghị mma. N'ihi mgbanwe a, ọgwụ a na-amalite ime ngwa ngwa karịa analogues ya.

Nke ọghọm dị na ọgwụ nwere ụdị insulin a, ọ ga - ekwe omume ịchọpụta, ọ bụ ezie na ọ naghị adịkarị, mana ọ ka nwere ike inwe mmetụta ọ bụla.

Ha nwere ike igosipụta onwe ha n’ụdị:

ọzịza na ọnya na ntụtụ ahụ,
lipodystrophy,
akpukpo aru
akpụkpọ akọrọ,
mmeghachi omume nfụkasị.

Ihe ngbanwe

Ihe mgbochi maka iji ọgwụ ahụ bụ ekweghị ibe nọrọ, ihe nfụkasị ume na shuga dị ala (hypoglycemia). Enwebeghịkwa ọmụmụ ọmụmụ a na-achịkwa banyere ojiji nke insulin a n'oge ime nwa na ara. Nnwale anụmanụ dị n'oge a egosila na n'ọtụtụ ọgwụ agafereghị ihe a tụrụ aro ya, ọgwụ ahụ na-emetụta ahụ n’otu ụzọ insulin mmadụ si arụ ọrụ.

N'otu oge ahụ, mgbe ụmụ nwanyị aferela gafere 4-8 ugboro n'ime ụmụ anụmanụ, a hụrụ ime ọpụpụ na mbido afọ, mmepe nke ajọ ọrịa afọ na nsogbu na ịmịpụta na ọkwa nke ime.

Amabeghị ma ọgwụ a na-abanye na mmiri ara ara, yabụ akwadoghị ụmụ nwanyị inye ụmụ ara ara n'oge a na-agwọ ya. Ọ bụrụ na onye ọrịa ahụ kwesịrị ịgbanye insulin n'oge afọ ime, a na-ahọrọ ọgwụ ahụ site na ntụnyere na uru nne ya yana ihe ọghọm nke nwa ebu n’afọ.

Dịka iwu, na mmalite nke ịtụrụ ime, mkpa insulin na-ebelata nke ọma, na oge nke abụọ na nke atọ, enwere ike ịchọrọ ọgwụ ọzọ. Na ọrịa shuga, ọrịa a anaghị eji ya. N'ọnọdụ ọ bụla, ọ bụghị naanị endocrinologist, kamakwa onye na-ahụ maka nwanyi na - ahụkarị nwanyị ga - edegara nwanyị dị ime ọgwụ ọgwụgwọ yiri nke ahụ.

Hormonedị homonụ a n'ọtụtụ oge ndị ọrịa na-anabata ya nke ọma, ọ na - esite na mgbe ọ na - ebute nsonaazụ ya.

Otutu ogwu di iche-iche nke nwere aha ahia di iche na-adabere na ya na enyere gi aka ịhọrọ udiri oge nke ogwu igba onye obia n’otu n’otu. Mgbe ị na-a withụ ọgwụ a, ọ dị mkpa ịgbaso usoro dọkịta nyere gị ndụmọdụ ka ọ ghara ichefu maka nri, mmega ahụ yana ibi ndụ dị mma.

Mpempe mwepụta

Nkwụsị nkwanye d / na 100 IU / ml 3 ml Nke 5

Ihe omuma ndi di na peeji a ị na-eleputa bu n’ihi ihe omuma nke ihe omuma, n’oru adighi kwa ogwu nke onwe. Ebumnuche a bu iji mee ka ndi okacha mara ahuike mara ihe banyere otutu ogwu, si otu a bulie ogo oru ha. Iji ọgwụ ọjọọ eme ihe "Insulin emere uzo abuo" na-agbadokarị maka inye gị ndụmọdụ maka ịmụrụ anya, yana ndụmọdụ ya gbasara usoro iji ya na usoro ị doụ ọgwụ ọgwụ ị họọrọ siri dị.

Inulin-abuo nke abuo

Enwetara nkwadebe ahụ site na teknụzụ pụrụ iche nke DNA site na iji Saccharomyces cerevisiae straine, nke eji dochie amline acid na aspartic acid. Ojiji nke ọgwụ a nwere ike ịkwụ ụgwọ maka ọrịa shuga mellitus (DM), belata ohere nke ọrịa a kapịrị ọnụ, ma ọ bụ gbuo oge na-enweghị atụ ha na ndị nwere akụkọ ntolite.

Ngwakọta na ụdị ntọhapụ

Ihe na - arụ ọrụ n'ime ọgwụ ahụ (insulin Aspart) bụ insulin gbanwetụrụ ikike mmadụ nwere nke usoro ultrashort. Onye na-ahụ maka hypoglycemic dị ka usoro nke abụọ (insulin Aspart na kristal protamine) na-ahụ maka nchịkwa subcutaneous na intravenous. Na mgbakwunye na akụrụngwa nọ n'ọrụ, ihe mejupụtara ọgwụ ahụ gụnyere ihe inyeaka. Lee okpokoro dị n'okpuru maka nkọwa ndị ọzọ.

Sodium hydrogen phosphate dihydrate

Sodium hydroxide 2M

Hydrochloric acid 2M

Ngwongwo ogwu

Ihe dị n'ime ọgwụ ahụ na - eso ndị na - anabata ọgwụ cytoplasmic nke mkpụrụ ndụ, na - akpụkọta ụdị nnabata insulin, nke na - akpali njikọta nke ọtụtụ enzymes dị mkpa. Nsonaazụ nke ọgwụ ahụ bụ n'ihi mmụba na ntinye nke glucose site na anụ ahụ, yana mbelata ọrụ glycogenic nke imeju.

Dochie amino acid n'ọnọdụ B28 na aspartic acid na -ebelata ebumnuche nke ụmụ irighiri ihe ịkpụkọta ọghọm ọgwụ nke soluble nke ọgwụ ahụ, nke akọwapụtara na ụdị okike nke homonụ ahụ. N'ihi nke a, nnabata Insulin Aspart sitere na abụba dị n'okpuru ala na-apụta ngwa ngwa karịa mmadụ. Mgbe ịgba ọgwụ ahụ gasịrị, nsonaazụ hypoglycemia na-amalite n'ime minit 15-20, ruru ogo ya mgbe awa 1-3 gachara, mgbe awa 5-6 gasịrị, mmịpụta glucose na-alaghachi na ọkwa mbụ ya.

Ihe ngosi maka ojiji

Edebere insulin Aspart maka ọrịa shuga riri nne. N'ime ụdị ọrịa shuga 2, a na-eji ọgwụ ahụ eme ihe mgbe onye ọrịa kwụsịrị inwe mmetụta nke ndị na-anabata insulin na ọnụ ọgụgụ ndị na-arịa ọrịa hypoglycemic n'ọnụ n'oge usoro ọgwụgwọ. Na mgbakwunye, a na-atụ aro ngwaahịa ọgwụ ahụ maka ndị mmadụ, na mgbakwunye na ọrịa na-akpata ọrịa (ọrịa shuga), na-enwe ọnọdụ ịmụrụ ọrịa.

Ntụziaka maka ojiji

Ofzọ eji ọgwụ ahụ eme ihe bụ ọgwụ ntụtụ. Amachibidoro injection intramuscular. A na-enye ọgwụ insulin infusions dị ụkọ maka ihe ngosi pụrụ iche. Ekwesịrị ịnye ọgwụ ahụ n'ime mgbidi nke apata, apata ụkwụ ma ọ bụ ala. Nwere ike iji analọg mmadụ na-eme insulin ma tupu i rie nri. A na-agbakọ ọ̀tụ̀tụ̀ ọgwụ ahụ n’otu n’otu maka onye ọrịa ọ bụla.

Site na arụ ọrụ akụrụma ma ọ bụ ọrụ imeju, mkpa maka homonụ na-ebelata, ebe ya na ọrịa na-efe efe ọ na-abawanye, nke chọrọ mmezi insulin Asọmbigharị nke kwekọrọ. Mmetụta nke ọgwụ a na nri, yabụ, ọ bara uru ịtụle oke ọnụọgụ nke nsonaazụ ya na ndị ọrịa na-a drugsụ ọgwụ ike nke na-ebelata oriri. Mgbe ha kwusịrị metabolism metabolism, ndị ọrịa nwere ike ịnwe mgbaàmà nke hypoglycemia ha, na-achọ nchịkwa ozugbo nke ihe ngwọta nke glucose ma ọ bụ shuga dị n'ime.

Ntụziaka pụrụ iche

N'ime ntuziaka maka ojiji, a kọọrọ na usoro ezughị ezu ma ọ bụ nkwụsị nke ọgwụgwọ ọrịa shuga nwere ike ibute hyperglycemia, ketoacidosis. Ojiji insulin Aspart na oge ụfọdụ chọrọ ịrị elu na ọnụ ọgụgụ nke inje nke ndị ọrụ hypoglycemic na-emebu. N'oge ịgwọ ọrịa shuga na ọgwụ a, akpachara anya kwesịrị ịkpachara anya mgbe ị na-anya ụgbọ ala ma na-eme ihe ndị ọzọ dị ize ndụ nke chọrọ mmụba nke uche na ọsọ nke mmeghachi omume psychomotor.

Mkparịta ụka ọgwụ ọjọọ

Insulin Aspart ekweghi ọgwụ gwọọ ọgwụ ogwu ndi ozo. A na-eme ka emereme nke ọgwụ ahụ site na ọgwụ ọnụ hypoglycemic nke ọgwụ, MA inhibitors, ACE inhibitors, carbonic anhydrase, sulfonamides, steroid anabolic, tetracyclines, ethanol nwere ọgwụ. Ihe mgbochi oral, thiazide diuretics, heparin, tricyclic antidepressants, morphine, nicotine na-egbochi mmetụta hypoglycemic nke homonụ nke abụọ. N'okpuru mmetụta nke salicylates na reserpine, enwere ike ịhụ mmụba ma na-akụda ọrụ nke ọgwụ ahụ.

Mmetụta akụkụ na ị andụbiga mmanya ókè

Na-ekpe ikpe site na nyocha, na mmalite ọgwụgwọ nke ọgwụ a na-ekwu okwu, imebi ntụgharị uche na-apụtakarị, nke kachasị maka oge adịghị adị. Ikekwe mmepe nke mmeghachi omume nfụkasị mpaghara na ụdị hyperemia, itching nke anụ ahụ na ntụtụ ahụ, ọnya, ọzịza. N'ọnọdụ ndị a na-adịghị ahụkebe, a na-ahụta mmetụta ndị ọzọ: angioedema, wedata ọbara mgbali elu, tachycardia, iku ume. Na-emegide ihe dị na usoro insulin Aspart, usoro ọgwụgwọ ndị a nwere ike ime:

hypoglycemia,
ogwe
hypoglycemic coma,
nnukwu ihe mgbu neuropathy,
okwu adighi ike
ịda mba
obi mgbawa nke ọrịa mamịrị retinopathy,
amata aja aja.

Usoro ire na ebe nchekwa

Ndụ nchekwa nke ngwaahịa a bụ ọnwa 30 site na ụbọchị a rụpụtara. A ga-egbochi insulin Aspart pụọ na ikpughe oke ọkụ na ọkụ. Chekwaa homonụ na-agbanwe mkpụrụ ndụ ihe ọkụkụ na 2-8ºC. Ndị ọgwụ na-ere ọgwụ ahụ naanị site na ndenye ọgwụ.

Mgbe ojiji nke homonụ nke gbanwere agba abụọ nwere ike ọ gaghị ekwe omume n'ihi ntinye nke ihe ya ma ọ bụ mkpa ọgwụ dị ọnụ ala, ndị dọkịta depụtara ọgwụ yiri Insulin Aspart. Taa, a na-enye ndị na-azụ ahịa nnukwu nhọrọ nke ndị na - ahụ ike hypoglycemic, mana, ịhọrọ nke a ma ọ bụ ọgwụ ahụ, a ga-ahọrọ ndị na-emepụta USA, Japan na Western Europe. N'ọnọdụ ka ukwuu, edepụtara analogues ndị a:

NovoRapid Flexpen,
NovoLog,
NovoRapid Penfill.

Ọnụ maka insulin Aspart

Onu ogugu ego nke ogwu n’ulo ogwu na Moscow bu ihe dika 1700-1800 p. kwa 3 ml nke hypoglycemic ngwọta. Nyere na ịgwọ ọrịa shuga na insulin gbanwere mkpụrụ ndụ chọrọ nnukwu ego mmefu, ọ gaghị abụ nke kachasị ị toa ntị na akụrụngwa pụrụ iche nke Intanet, ebe ọnụahịa ọgwụ dị ala karịa ka ekwuru na ụlọ ahịa ọgwụ.

Olga, dị afọ 48. Ejiri m Insulin Aspart mgbe m chọpụtara na ọgwụ ịgwọ ọrịa shuga kwụsịrị ọrụ. Wasbọchị ọ bụla nke ọgwụ a ka dọkịta dere. Dabere na nkwenye ndị ị natara, m webatara 5 usoro nke edozi tupu nri ọ bụla. N'ihi ọgwụ a, enyere m aka ịhazi ọkwa glucose na obere oge.

Andrey, afọ 50. Ruo afọ atọ, enwere m ọrịa shuga rụrụ arụ. Ọgwụ, nri, ndụ ike emeghị ka ibelata shuga n'ọbara, ya mere, agara m gbanwee ọgwụgwọ hormone. Dọkịta ahụ jiri insulin Aspart nye ya ndụmọdụ. A gbanyere m ọgwụ ntụ 20 ọgwụ kwa ụbọchị maka otu ọnwa, emesịa ọnọdụ ahụ kwụsiri ike.

Elena, 56 afọ m ji insulin Aspart otu afọ ugbu a, Ekwesịrị m ikweta, ahụ dị m mma. Tupu nke a, enwere m adịghị ike oge niile, mgbu akwara. N'oge m na-ewebata nkeji iri na ọgwụ ọgwụ iri na ụbọchị. N'otu oge ahụ, ana m eleru anya mgbanwe ọ bụla na ụdị ndụ m na-ebi, na-adabere na nke m na-ahazi usoro ị dailyụ ọgwụ kwa ụbọchị.

Banyere ọgwụ

Edere ya iwu iji belata mkpokọta nke dextrose na plasma.

Mbelata glucose na-amalite site na imeziwanye nnabata ya site na anụ ahụ. Ọgwụ na-agbadata ọnụego shuga na imeju ma na - eme ka mkpụrụ ndụ dị abata.

Edere otu usoro maka ndị ọrịa nwere ọrịa shuga 1.

A na-enyekwa insulin asapum biphasic maka ụdị shuga 2, ma ọ bụrụ na enwere nguzogide ndị na-emegide antidiedi.

Ọrụ nke ndị nnọchi anya otu dị mkpụmkpụ. Ọ na - apụta nkeji 10-20 ka ngwa gachara. Ogologo oge nke ikpughe ruo awa 5.

Ihe abuo abuo - rue ubochi. Mmetụta ọgwụgwọ ahụ na-apụta mgbe nkeji iri gasịchara, n'ihi na ọ nwere homonụ dị mkpụmkpụ ma na-ajụ.

Njirimara ngwa

A machiri insulin Bifaxicum na Aspart n'ime ndị ọrịa na-erubeghị afọ isii. Emebeghị nnyocha banyere mmetụta ọgwụ ahụ nwere n'ahụ ahụ ụmụaka. Ndị dọkịta amaghị etu ọgwụ ga-esi metụta ọnọdụ nwatakịrị niile.

Anyị na-enye ndị na-agụ saịtị anyị ego nlele

Amachibidoro ị duringụ ọgwụ n’oge a na-enye ọgwụ mgbochi. Anabatara iji ya ma ọ bụrụ na ihe ize ndụ dị na nwatakịrị erughị uru nne ya.

Maka ndị ọrịa agadi, ọ dị mkpa ịgbanwe ọgwụ a. Mgbanwe ndị metụtara afọ na ahu nwere ike ibute ahụike adịghị mma. Ebe ọ bụ na arụ ọrụ nke akwara dị n’ime, arụ ọrụ ọgwụ hypoglycemic na-aka njọ ọnọdụ ahụ.

Mmekọrịta na ọgwụ ndị ọzọ

Ọgwụ ndị na -eme ka shuga dị n'ọbara, nke a na-ewere ọnụ, na-akwalite ọrụ nke mmiri a na-arụ ọrụ. A naghị atụ aro ọgwụ ndị dị otú ahụ. Hypoglycemia na-etolite, ọnọdụ e ji mgbadalata glucose na-agbadata ụkpụrụ dị mma.

Anabolic steroid, Ketoconazole, Pyridoxine na ọgwụ ndị ọzọ dabere na ethanol na tetracyclines, nke a na-ejikwa otu oge na ọgwụ hypoglycemic a, na-ebute mbelata nke ọma na glucose ọbara.

Ihe mgbochi oral, heparin na antidepressants eji na ọrịa shuga mellitus belata ihe mgbaàmà nke oke iwe nwere ike belata nsonaazụ nke ọgwụ.