Desmopressin - ntuziaka maka ojiji

Nkọwa nke metụtara 30.07.2015

• Aha Latin: Desmopressinum
• Koodu ATX: H01BA02
• Usoro kemịkal: C₄₆H₆₄Nd₁₄O₁₂S₂
• Koodu CAS: 16679-58-6

Njirimara kemịkal

Desmopressin bụ analog sịntetik homonụ vasopressin antidiuretic, nke ụmụ mgbe ochie na-eme pituitary gland. Enwetara ihe ahụ site na iji ihe megharia obere molekulu. vasopressin:1-ọnya cysteine na nnọchi 8-l-arginineugbu a na mbụ molekul na 8-D-arginine.

Ngwá ọrụ nwere mmetụta dị ala na akwara akwara akwara nke akwara vaskụla na akụkụ ahụ, mana ọ mgbochi mmetụta duretic kwuputara ike nke ukwuu.

Pharmacodynamics na pharmacokinetics

Ume ahụ na-arụ ọrụ Ndị na-anabata Vasopressin V2nke dị na anụ ahụ epithelial tubules jikọtara ọnụ na n’ime Na-arịgo loops nke Henle, nke a na - eduga n'ịbawanyewanye na usoro nke ịbanye mmiri ọzọ n'ime arịa ọbara, na - akpali akpali Ihe coagulation 8.

Mmetụta antiduretic nke ọgwụ ahụ na-enweta site na subcutaneous, intravenous na intramuscular management, na nrụnye ọgwụ na imi.

Nkeji ọkara ndụ nke homonụzụ nkeji = 75 nkeji. Agbanyeghị, enwere ike ịchọpụta ihe zuru oke nke ihe ahụ na ahụ n'ime awa 8-20, mgbe nchịkwa gasịrị. Egoputara na oria di iche-iche polyuria pụọ n'anya ugboro abụọ iji ngwaahịa ahụ. Nlekọta ọgbụgba n’ime adịghị arụ ọrụ nke ọma karịa nchịkwa nke intranasal.

Na ndị ọrịa na- hemophilia na ọrịa ọrịa Wrebrandt mgbe otu ntụtụ nke 0.4 μg nke ọgwụ kwa 1 n'arọ nke ịdị arọ, 8 ihe coagulationna-abawanye site ugboro 3-4. Mmetụta ọgwụ ahụ na-amalite ịpụta mgbe ọkara otu elekere ma rute uru kachasị ya n'ime ọkara na ọkara - awa 2.

Ọzọkwa, mgbe ị na-a theụ ọgwụ ahụ, a na-achọpụta mmụba ngwa ngwa na mkpo plasma plasminogenmana n’otu oge larịị fibrinolysis na-ahụ otu ihe ahụ.

Ihe mejupụtara ya bụ mejupụtara na akwara nke imeju. Cleavage na-eme mebie akwa metụtara enzyme transhydrogenases. Ọgwụ nwere mmamịrị agbanwe agbanwe ma ọ bụ n'ụdị metabolites na-adịghị arụ ọrụ. Desmopressin nwere nsí dị ala, ọ dịghị teratogenic ma obu Njirimara mutagenic.

Mpempe mwepụta

A na-emepụta ọgwụ ahụ n'ọtụtụ nsụgharị. Tupu ịhọrọ ụdị, ịkwesịrị ịgakwuru dọkịta gị ka ị chọta nke ziri ezi maka ọgwụgwọ nke ọrịa ahụ.

A na-emezi ihe ngwọta maka injection ka intramuscularly, intravenously, subcutaneously.

Ọgwụ dị n'ụdị ọcha, mbadamba gburugburu. N'akụkụ ya, ihe e dere “D1” ma ọ bụ “D2”. Na warawara nke abụọ. Na mgbakwunye na akụrụngwa na-arụ ọrụ, desmopressin, ihe mejupụtara ahụ gụnyere magnesium stearate, stachi nduku, povidone-K30, lactose monohydrate.

Ọgwụ dị n'ụdị ọcha, mbadamba gburugburu.

Ngwurugwu Nasal bụ mmiri mmiri na-enweghị agba. Ndị pụrụ iche bụ chlorobutanol, sodium chloride, mmiri, hydrochloric acid. Usoro onunu ogwu 0.1 mg kwa 1 ml.

Ọ bụ mmiri doro anya. Ejiri ya na karamaiche pụrụ iche na onye na-enye ihe. Ndị pụrụ iche bụ ọgwụ sorbate potassium, mmiri, hydrochloric acid, sodium chloride.

Mlọ ọgwụ

Ọkara ọkara nke homonụsị nke arụ bụ 75 nkeji. Ma n'otu oge ahụ, ọgwụ ahụ nwere oke ụkpụrụ dị elu ka enwere ike ịhụ ya n'ime ahụ ruo awa 8-20 mgbe ejiri ya. E kpughere ya na ihe iriba ama nke polyuria na-apụ n'anya mgbe ị 2-3ụ ọgwụ ọjọọ 2-3. N'okwu a, ịgba irighiri irighiri ọbara na-adị irè karịa nchịkwa nke intranasal.

N'ime ndị nwere ọrịa ọrịa Wellebrand, yana hemophilia nwere otu nchịkwa nke 0.4 μg / n'arọ nke ihe ahụ, a na-achọpụta mmụba nke ugboro 3-4 ugboro 8 nke ọbara coagulation. Ọgwụ na-amalite ime ihe dị ka nkeji iri atọ site na oge ejiri ya wee ruo ogo kachasị elu mgbe awa 1.5-2 gasịrị.

N'otu oge ahụ, iji ọgwụ ahụ eme ihe na-eduga n'ịba ụba ngwa ngwa na ụkpụrụ nke plasminogen, ọ bụ ezie na ihe ngosi nke fibrinolysis ka dị otu.

Ọgwụ a na-eme metabolism n’ime akwara anụ ahụ. Ihe a na-ejikọ akwa akwa bụ nke enzyme transhydrogenase.

Mwepu nke ihe na-agbanweghi agbanwe ma ọ bụ ngwaahịa metabolic na-adịghị arụ ọrụ na-apụta na mmamịrị.

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Ihe ngbanwe

• polydipsia nke akparamaagwa ma obu mmuo,
• ọnụnọ nke ọrịa anuria,
• plasma hypoosmolality,
• mmiri na-ejide n'ime ahụ,
• ọnụnọ nke nkụda obi na mkpa ọgwụ diuretic,
• azịza nke nfụkasị ọgwụ.

Amachibidoro ịnye ọgwụ ahụ intravenlong na ọrịa von Willebrand-Dian nke subtype 2b, yana mgbakwunye na angina na-akwụghị chịm.

Usoro onunu ogwu na nhazi

Mpekere kwesịrị iwere ya ọnụ, mgbe awa ole na ole gachara ị rie nri (ha na-ejikọ otu oge, na-eme ka ike gwụ ọgwụ, nke ga-eduga n'ịbelata ịdị irè ya). Ndi dọkịta doziri nha ijere na oge ọgwụgwọ.

Ndị nwere ụdị ọrịa shuga mellitus kwesịrị ibido 0.1 mg nke ihe ahụ ugboro 1-3 n'ụbọchị. Mgbe nke a gasiri, odi nkpa ịhota otu, na-eburu n’uche banyere mbadamba ihe, na ntachi obi ya site n’aka onye ọrịa. Na nkezi, usoro onunu ogwu bụ 0.1-0.2 mg, ewere ya ugboro 1-3 n’ụbọchị.

Ogo nke ọgwụ ọgwụ oke ohere ga-akwado ya kwa ụbọchị bụ 1.2 mg.

Na enweghi mgbakwunye abalị, ha na - ebubata 0.2 mg nke ihe dị n'ime n'abalị. Ọ bụrụ na mmetụta ahụ ezughi oke, akụkụ ahụ okpukpu abụọ ka 0.4 mg. Mgbe ị na-eme ọgwụgwọ, ịkwesịrị ịmachi ịmịnye mmiri na ọkara nke abụọ nke ụbọchị. Ná nkezi, usoro ọgwụgwọ na-aga n'ihu dị ụbọchị 90. N'iburu n'uche onyonyo onyonyo a, dọkịta nwere ike ịgbatị ahụ (oge ụfọdụ, tupu ịgbatị ọgwụgwọ ahụ, a na-akagbu ọgwụ ahụ maka ụbọchị 7, na mgbe ahụ, na-eburu n'uche ozi ụlọ ọgwụ natara mgbe ịhapụ ọgwụ, ha na-ekpebi ma onye ọrịa ahụ kwesịrị ịga n'ihu na usoro ahụ).

Ndị okenye, ya na ụdị polyuria na-eme n'abalị, na-adịkarị mkpa ị 0ụ 0.1 mg nke ọgwụ ahụ n'abalị. N'ibighi nsonaazụ ọgwụgwọ, ọ ga-ekwe omume okpukpu abụọ nke ọgwụ - iji 0.2 mg. N'okpuru nlekọta nke dibịa, usoro ọgwụgwọ ahụ nwere ike ịga n'ihu na-abawanye ma ọ bụrụ na ọ dị mkpa. Na enweghị ihe ịrịba ama nke mmelite mgbe ọnwa 1 nke iji ọgwụ ọjọọ eme ihe, a ga-akwụsị ọgwụgwọ.

A na-eji ifesa intranasal mee ihe na 10-40 mcg / ụbọchị, nke a na-ekesa n'ọtụtụ dịgasị iche. Agedmụaka dịkarịa ala ọnwa atọ ma ọ dịkarịa afọ 12 kwesịrị ịhazigharị kwa ụbọchị, nke dị na microgram 5-30.

Usoro onyonyo nke Desmopressin maka iv, s / c, yana kwa / m injections bụ 1-4 mcg / day (maka ndị okenye). A na-ahapụ ụmụaka ka ha banye 0.4-2 microgram nke ọgwụ kwa ụbọchị.

Ọ bụrụ na enweghị nsonaazụ mgbe izu nke 1 nke ọgwụgwọ gasịrị, ọ dị mkpa iji dozie kwa ụbọchị. Ka ịhọrọ usoro ọgwụgwọ dị mma ọ ga - ewe oge dị ukwuu - n'ime izu ole na ole.

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Dodoụbiga ya ókè

Isonisonụ ọgwụ ọgwụ na-eme ka njigide mmiri na mmepe nke akara hyponatremia.

N'okwu ndị a, achọrọ ya inye ọgwụ isotonic intravenic ma ọ bụ ọgwụ hypertonic nke sodium chloride, ma depụta onye ọrịa ahụ diuretic (furosemide).

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Mmekọrịta na ọgwụ ndị ọzọ

Njikọ ya na dopamine, ọkachasị na oke ọnụọgụ dị elu, nwere ike belata nsonaazụ pressor.

Indomethacin na-emetụta ike mmetụta ọgwụ ike nke Desmopressin na-egosipụta.

Nchikota nke ogwu na carbon lithium na-eduga na mbelata ihe ogwugwu ya.

Ekwesịrị ịkpachara anya iji jikọta ọgwụ na ọgwụ ndị na-abawanye njọ nke ntọhapụ nke homonụ antidiuretic: dị ka carbamazepine na chlorpromazine, phenylephrine na tricyclics, na epinephrine. Nchikota di otua puru ime ogwu vasopressor nke ogwu.

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Ngwa maka ụmụaka

Ọ ga-ahazigharị oge nri ụmụaka na-erubeghị afọ iri na abụọ.

N'ime ụmụ ọhụrụ ruo afọ 1, ị withụbiga ihe mmanya ókè nwere ike iduga mmepe nke ihe ọdịdọ - n'ihe metụtara mmetụta iwe ọgwụ ahụ nwere na NS.

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Ihe analogues nke ihe ahu bu nkwadebe Vazomirin, Minirin na Emosint nwere Presinex, na mgbakwunye Adiuretin, Desmopressin acetate, Nourem na Nativa, Apo-Desmopressin na Adiuretin SD.

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Desmopressin na-enweta nyocha dị mma na ọgwụgwọ nke nocturnal enuresis na ụmụaka, n'agbanyeghị na achọpụtara na mmetụta nke iji ya adịghị etolite ozugbo, mana mgbe ọtụtụ izu gasịrị. N'otu oge, ihe ndị a na-ekwu na-anabata ọgwụ ahụ nke ọma.

Enwere nyocha banyere arụmọrụ dị mma nke ọgwụ na ọrịa shuga nke ọdịdị shuga - ojiji ya na-eme ka ọnọdụ onye ọrịa dị mma, na-ebelata akara nke ọrịa ahụ.

Usoro nke ime ihe

Ihe na-arụ ọrụ bụ ihe eji emegharị mmadụ anya nke mmiri ọgwụ vasopressin. Mgbe ọgwụ ahụ batara n’ahụ, a na-eme ka ndị na-anabata ndị pụrụ iche rụọ ọrụ, n’ihi nke a na-eme ka usoro ịbanye mmiri ọzọ sikwuo ike. Igha ọbara na-emeziwanye.

N'ime ndị ọrịa nwere haemophilia, ọgwụ ahụ na-abawanye ihe coagulation 8 site na ugboro 3-4. Enwere mmụba n'ọnụ ọgụgụ plasminogen na plasma ọbara.

Nlekọta intraven na-enye gị ohere ịnweta nsonaazụ ngwa ngwa.

Ọgwụ ahụ na - eme ka ịmịnye ọbara.

Jiri nlezianya

Bụrụ na imebi nguzo mmiri, mmiri nke eriri afọ, ọrịa nke akwara obi ma ọ bụ akụrụ, ihe ọghọm nke mgbali intracranial, a kwesịrị ịkpachara anya n'oge ọgwụgwọ. A na-ahụta onye na - egbochi afọ ime ihe karịrị afọ 65.

Usoro ọgwụgwọ na nchịkwa na-adabere na ọrịa ahụ, njirimara nke onye ọrịa. Ekwesịrị ịhọrọ ha na dọkịta. Shouldkwesịrị ịmara onwe gị na ntuziaka maka ojiji.

Usoro izizi maka nrịpụta nke imi, ịgba na-adị site na 10 ruo 40 mcg kwa ụbọchị. Ekwesịrị iwere ya ọtụtụ oge. Undermụaka na-erubeghị afọ iri na abụọ ga-achọ ndozi. Maka ha, a na-ahọrọ micro 5-25 n'ime ụbọchị.

Site na ntinye nke injections maka ndi okenye, usoro ogwu a sitere na 1 ruo 4 microgram kwa kilogram nke aru. Na nwata, ekwesịrị iji micrograg 0.4 - 1-2 microgram.

Ọ bụrụ na ọgwụgwọ ewetaghị nsonaazụ a tụrụ anya ya n'ime otu izu, ọ ga-edozikwa usoro ọgwụgwọ ahụ.

Ọ bụrụ na ọgwụgwọ ewetaghị nsonaazụ a tụrụ anya ya n'ime otu izu, ọ ga-edozikwa usoro ọgwụgwọ ahụ.

Nsonaazụ

Dizziness, isi ọwụwa, ọgba aghara ga-ekwe omume. N’oge na-adịghị anya, ndị ọrịa adaba na mmiri. Ikpa ahụ nwere ike ịba ụba, rhinitis nwere ike ime. N'ebe ụfọdụ ndị ọrịa, akpụkpọ ahụ mucous nke imi na-aza. Vom, ọgbụgbọ, na afọ mgbu ga-ekwe omume.

Ọbara ọbara nwere ike ịrị elu ma ọ bụ ibelata. Mgbe ụfọdụ oliguria, ọkụ na-acha ọkụ, mmeghachi omume nfụkasị ahụ na-apụta. Hyponatremia nwere ike ime. Mgbe ị na-eji inje, ihe mgbu nwere ike ịmara na ebe ịgba ahụ.

Ọ bụrụ na eji ọgwụ a gwọọ ụmụaka na-erubeghị ọnwa iri na abụọ, ihe ọdịdọ ga-ekwe omume.

Ihe ngosi maka ojiji

Ekwesiri iji Desmopressin maka nchoputa na ọgwụgwọ nke ọrịa shuga dị n'etiti insipidus.

Na mgbakwunye, akara dị iche iche maka usoro onunu ogwu:

• mbadamba ụrọ: ụmụaka karịrị afọ 5 - isi sekọndịrị enuresis, ndị okenye - ọgwụgwọ ụbụrụ nke nocturnal polyuria,
• nzere gbara ya ma ọ bụ imi imu ya: ule nyocha maka ikike ịta akụrụ,
• ọnya nasal: nnukwu polyuria nke mkpụrụ ndụ ihe omimi, kpatara ọrịa ma ọ bụ ntinye aka na sistemụ akwara, trauma.

Mmanya ndakọrịta

A naghị atụ aro ị alcoholụ mmanya na-egbu egbu n'oge ọgwụgwọ, n'ihi na ọ na-eme ka ọgwụ ghara ịba uru.

Ogwu ahu nwere otutu nmekorita. Analogs bụ mbadamba Minirin, Nativa, Adiuretin, Presayneks sprays, Vasomirin. A na-ejikwa Desmopressin Acetate. Enwere capsules ndị ọzọ, mbadamba na ihe ngwọta nwere akụrụngwa antidiuretic. Ikekwe iji usoro ọgwụgwọ ndị mmadụ.

Minirin bụ analog nke Desmopressin.

Usoro onunu ogwu na nhazi

Ana eburu mbadamba ndị ahụ ọnụ, mgbe ụfọdụ ka e risịrị nri.

• Central na-arịa insipidus: usoro mbụ bụ 0.1 mg 1-3 ugboro n'ụbọchị maka ụmụaka na ndị okenye. Na-esote, ahọrọ homonụ ahụ na-eburu n'uche mmeghachi omume ụlọ ọrụ nke ya, ọ nwere ike ịdị site na 0.2 mg ruo 1.2 mg kwa ụbọchị,
• isi nocturnal enuresis: ọgwụ mbụ bụ 0.2 mg n'oge ụra, na enweghị mmetụta ọgwụgwọ zuru oke, enwere ike ịbawanye ya gaa na 0.4 mg. Ọ dị mkpa amachibido ị fluidụ mmiri na mgbede. Ọga ahụ were ụbọchị 90. Mgbe ezumike ụbọchị asaa gasịrị, enwere ike ịmaliteghachi ọgwụ na-adabere n'ihe akaebe banyere ọgwụ,
• nocturnal polyuria n'ime ndị okenye: ọgwụ mbụ bụ 0.1 mg n'oge ụra, n'oge enweghị mmetụta achọrọ, ọ na-abawanye kwa ụbọchị 0.1 site na 0.1 mg ruo mgbe a ga-enweta ọgwụ na-enye nsonaazụ kachasị mma.

Ọ bụrụ na enweghị nzaghachi ọgwụgwọ zuru oke mgbe ụbọchị 30 nke ọgwụgwọ gasịrị, a ga-akwụsị ọgwụ ahụ.

Usoro onunu ogwu imu ume

Ejiri mmanu ahu site na nchịkwa intranasal, otu pịa na dosing ngwaọrụ kwekọrọ 0.01 mg nke ọgwụ.

N'ime nlekọta ụmụaka, ekwesịrị ịme usoro n'okpuru nlekọta nke ndị okenye.

A na-ekpebi ogo kachasị mma site na nhọrọ nke onye ọ bụla.

• Central insipidus nke ọrịa shuga: ndị okenye - 0.01-0.04 mg, ụmụaka - 0.01-0.02 mg kwa ụbọchị. A na-eme usoro ahụ otu ugboro ma ọ bụ kewaa ọgwụ etinyere n'ime ụzọ abụọ,
• Nnwale ịta akụrụ: ndị okenye - 0.04 mg, ụmụaka karịrị 1 afọ - 0.01-0.02 mg, ụmụaka na-erubeghị afọ 1 - 0.01 mg. Mgbe ọ gbasachara, onye ọrịa ahụ kwesịrị ime ka eriri akpa ahụ, n'ime elekere asatọ na-esote, a na-ewere sọks abụọ nke mmamịrị iji mụọ osmolality ya. Mkpokọta olu mmiri onye ọrịa na-egbu n'oge ule (1 awa tupu ọmụmụ ihe ahụ na oge awa asatọ na-esote) ekwesịghị gafere 500 ml. Ọ bụrụ na ntụpọ osmolality dị n'okpuru 800 mOsm / kg n'ime ndị okenye yana 600 mOsm / kg n'ime ụmụaka, a na-emeghachi ule ahụ. Mgbe ikwenye imebi ikike ịta akụrụ, a ga-achọ nyocha ọzọ.

Nasal dara

A na-etisa mmiri mpe mpe mpekere site na ịbanye n'akụkụ imi ya, wee na-eme mpụta isi ya na mpụta ya n'akụkụ.

Ngosipụta nke ọgwụgwọ ọgwụgwọ na-apụta n'ime nkeji 30 mgbe etinyere ọgwụ a.

• ọrịa shuga na insipidus sitere na isi etiti: ndị okenye - 0.01-0.04 mg (2-8 tụlee), ụmụaka - 0.005-0.02 mg (1-4 tụlee) kwa ụbọchị. A na-a drugụ ọgwụ ahụ otu ugboro, ma ọ bụ na-ekewa ụbọchị kwa ụbọchị gaa na 2-3 injections. Dọkịta na-edepụta usoro na oge dị n'etiti nchịkwa dị iche iche, na-eburu n'uche mmetụta onye ọrịa nwere ọgwụ ahụ,
• acdị siri ike nke Central polyuria: 0.01 mg nke ọ bụla. Ekwesịrị inyocha nsịkọ dị n'ime mmiri na elele kwa elekere rue oge zuru oke. N'ime awa 3-5, lelee osmolarity nke plasma na mmamịrị, ịta nke sodium n'ọbara.
• nyocha nke ike ịta akụrụ: ndị okenye - 0.015 mg, ụmụaka gbara afọ 1 - 0.01-0.015 mg. Mgbe ịbubachara ọgwụ ahụ, achọrọ eriri afọ. Mgbe ahụ a na-anakọta samfba mmamịrị iji chọpụta osmolarity, a na-emeghachi usoro ahụ ugboro anọ na oge dị ka elekere 1. Ọ bụrụ na akpịrị na-akpọ nkụ, a na-ahapụ ya ka ọ were ihe karịrị 200 ml mmiri mmiri maka oge ahụ dum (elekere 1 tupu ọmụmụ ihe ahụ na n'ime elekere asatọ na-esote) nke ọmụmụ ahụ.

Ntụziaka pụrụ iche

Ekwesighi iji Desmopressin mee ihe na ndị ọrịa nwere ọrịa nje ma ọ bụ mgbe ha na-a drugsụ ọgwụ nwere ike ibute njigide mmiri na ahụ na nsogbu elekịkịkị.

Ndị ọrịa nwere isi elekere mbụ na-ele anya 1 awa tupu na n'ime awa 8 mgbe ị drugụsịrị ọgwụ ahụ kwesiri iwelata oriri mmiri - nke a ga-ebelata ihe egwu nke nsonaazụ ya.

Ojiji nke Desmopressin maka ọgwụgwọ nke ọrịa ehihie na-akpata ụmụaka na ndị ọrịa na-eto eto na-ebute ihe egwu nke ọrịa ụbụrụ.

Ndị ọrịa nwere polyuria site na lita 2.8 ruo 3 na obere ọkwa sodium plasma dị ala nwere nnukwu nsogbu nke nsonaazụ ya.

N'iburu oke nlezianya anya, a na-atụ aro ka ị drugụ ọgwụ ahụ na ndị ọrịa karịa afọ 65 n'ihi nnukwu ihe ize ndụ nke njigide mmiri, mmepe nke hyponatremia na mmetụta ndị ọzọ na-achọghị. Ekwesịrị inye onye ọrịa ahụ njikwa steeti na oge niile (tupu ọgwụgwọ, mgbe ụbọchị atọ nke ọgwụgwọ na mgbe mmụba ọ bụla) mkpebi nke ọkwa sodium na plasma ọbara.

Ọ bụrụ na ahụ ọkụ, ọnya na-arịa ma ọ bụ eriri afọ, a ga-akwụsị ị theụ ọgwụ ahụ.

Iji gbochie hyponatremia, a na-atụ aro ka ọmụmụ ihe ugboro ugboro iji chọpụta ọkwa nke sodium na plasma ọbara, karịsịa mgbe ị na-ejikọ mbadamba nkume na tricyclic antidepressants, serotonin inhibitors, chlorpromazine, carbamazepine, ọgwụ ndị ọzọ na-akpata ọrịa nke enweghị nzuzo nke homonụ antidiuretic, yana yana ọgwụ mgbochi-enweghị ọgwụ. NSAIDs).

Nchọpụta na ọgwụgwọ nke urinary incontinence, nocturia na / ma ọ bụ dysuria, ọrịa urinary tract, eriri afọ ma ọ bụ prostate tumor, decompensated diabetes mellitus, polydipsia, na ahoụrụma kwesịrị ịmalite tupu eji Desmopressin.

N'ime ụmụaka na-erubeghị afọ 1, ule ga-ekpebi ike mkpesa ike akụrụ ga-eme bụ naanị n'ụlọ ọgwụ.

Mgbe emechara nnwale nyocha, a na-ahapụ onye ọrịa ọ toụ mmiri site na oke nke na-eme ka akpịrị kpọọ nkụ.

Enweghị ike ịkọwa ọgwụ onunu ogwu nye ụmụaka ma ọ bụrụ na ọgwụ achọrọ maka ọgwụgwọ dị n'okpuru 0.01 mg.

Ọmụmụ ihe banyere ike ịta akụrụ nke nwere ụmụ nwatakịrị na-erubeghị afọ 1 ka a ga-eme n'ọnọdụ dị iche, ebe ọ bụ na n'oge nke a, a na-ebelata ike ịta akụrụ. Usoro a kwesịrị ịrụ site na dibia neurologist. Ogologo oke ịba ụba n’ime ụmụ ọhụrụ nwere ike ime ka ahụ iwe nke usoro ụjọ ahụ, ya na mmepe nke ihe ọdịdọ. N'oge nnabata mmamịrị, achọrọ mkpochapu mmiri ara ehi.

Ebe ọ bụ na enwere nnukwu rhinitis, nnabata nke tụlee adịghịzi emebi emebi, a na-atụ aro iji ọgwụ ahụ n'ime.

Site na insipidus nke ọrịa shuga nke isi mmalite, nchịkwa intranasal nke desmopressin na-abawanye ohere nke ibute ọrịa hyponatremia.

Mkparịta ụka ọgwụ ọjọọ

Site n'otu oge eji Desmopressin:

• indomethacin nwere ike ibute mmụba na desmopressin na-enweghị ịba ụba oge ya,
• tetracycline, glibutide, norepinephrine, nkwadebe lithium na-ebelata mmetụta antidiuretic nke ọgwụ,
• ndị na - ahụ maka hypertensive na - eme ka mmetụta ha ka mma
• nhọrọ ndị na-egbochi serotonin inhibitors, ọgwụ tricyclic antidepressants, carbamazepine, chlorpromazine nwere ike ibute ọrịa nke homonụ antidiuretic na-ezighi ezi, ụba antidiuretic mmetụta nke desmopressin, ịba ụba nke njigide mmiri na mmepe nke hyponatremia,
• NSAIDs na-abawanye ihe ize ndụ nke njigide mmiri n'ime ahụ, ihe omume nke hyponatremia,
• dimethicone belata absorption nke ọgwụ,
• loperamide na ọgwụ ndị ọzọ na-agbada peristalsis nwere ike ime ka ọkwa plasma nke desmopressin jiri ugboro atọ wee belata ohere nke njigide mmiri na hyponatremia.

Analogs nke Desmopressin bụ: mbadamba - Minirin, Nativa, Nourem, ịgba - Apo-Desmopressin, Presineks, Minirin, Vasomirin.

Mmekorita

Ojiji eji emejuputa atumatu, karisia na otutu onunu dopamine nwere ike ịkwalite mmetụta nrụpụta.

Indomethacin nwere ike imetụta ịdị ukwuu nke ikpughe Desmopressin na ahụ.

Ka ị na-a medicationụ ọgwụ carbonate lithium, a na-ebelata nsonaazụ ya na antidiuretic.

N'iji nlezianya, ihe ahụ kwesịrị ijikọ ya na ọgwụ na-abawanye ntọhapụ. antidiuretic homonụ: chlorpromazine, carbamazepine, ọgwụ mgbochi tricyclic, phenylephrine, epinephrine. Nchikota a nwere ike ibute mmụba na vasopressor nke Desmopressin.

Omume ọgwụ

Desmopressin bụ analogue nke ọgwụ arginine-vasopressin nwere eke nke nwere mmetụta antidiuretic.

E jiri ya tụnyere vasopressin, ọ nwere mmetụta na-adịchaghị mma na akwara dị mma nke arịa ọbara na akwara dị n'ime, nke a bụ n'ihi mgbanwe na nhazi nke mọlọtọ desmopressin ma e jiri ya tụnyere eke vasopressin eke - mmebi nke 1-cysteine ​​na dochie 8-L-arginine na D-arginine.

Na-abawanye permeability nke epithelium nke akụkụ nke distal nke tubules agbakọtara maka mmiri ma mee ka njigide ya dịkwuo elu. Ojiji nke Desmopressin na Central na-arịa ọrịa shuga na-eduga n'ịbelata mmamịrị ọnụ na mmụba mmamịrị ọnụ na mbelata osimesila plasma ọbara. Nke a na - eduga n'ịbelata oge mmesịrị ahụ yana Mbelata polyuria nocturnal.

Mmetụta antidiuretic kachasị na-apụta mgbe ejiri ọnụ mee ya - mgbe awa 4-7 gasịrị. Mmetụta antidiuretic mgbe a na-eji ọnụ ya mee ihe na 0.1-0.2 mg - ruo awa 8, na nha 0.4 mg - ruo awa 12.

Ide mmiri

• Jụọ onye ọkachamara n'ihe banyere akwara ajụjụ
• Zụta ọgwụ
• Lelee ụlọ ọrụ

Phardị ọgwụ ọgwụ

Onye nrụpụta ahụ na-emepụta ọgwụ ahụ n'ọtụtụ ọgwụ ọgwụ, otu n'ime:

1. Nasal dara, nke bụ mmiri doro anya, na enweghị agba. Makọtara na karama eji eji ihe mbadamba, nke ọ bụla nwere 5 ml nke ọgwụ.
2. N'ịgwọ Nasal "Desmopressin". Ọ bụ mmiri doro anya na-enweghị agba. Achịkọtara n'ime karama ejiri mee iko gbara ọchịchịrị ma nwee ngwaọrụ pụrụ iche maka ịgba. Kọọm ọ bụla na-ejide dosu 50.
3. Ọgwụ Ha na-acha ọcha na agba, n’otu akụkụ bụ ihe egwu. Makọtara na akpa polyethylene nke 28, 30, 90 iberibe, ma ọ bụ na ngwugwu ọnya 10, 30 iberibe.

A naghị egosi ntuziaka maka ojiji nke "Desmopressin" analogues. Anyị ga-atụle ha n'okpuru.

Nrụ ọrụ dị n’ime mbadamba ụrọ na ọsụsọ imi bụ desmopressin acetate, n’ime idebe - desmopressin. N'ime imepụta mbadamba, a na-eji ihe inyeaka dịka magnesium stearate, stachione-K30, lactose monohydrate na-eji.

Ihe ntinye aka na ntan bu: mmiri di ocha, hydrochloric acid, sodium chloride, sorbate potassium.

Dika eji ihe ndi ozo na imeputa mmiri: mmiri di ọcha, hydrochloric acid, sodium chloride, chlorobutanol.

Ihe analogues nke mbadamba Desmopressin na ịgba anaghị esiri ike ịtụtụrụ, mana dibịa na-aga kwesịrị ime nke a.

Mmetụta ọjọọ sitere na iji ọgwụ

Na-emegide usoro iji mmiri tụlee, ịgba na mbadamba Desmopressin, onye ọrịa ahụ nwere ike ịmalite mmeghachi omume na-adịghị mma, n'ihe metụtara nke a na-atụ aro ịgbasochi doses nke dọkịta nyere. Ọtụtụ mgbe na ọgwụgwọ ọgwụ apụta:

• Mgbu na ntụtụ ebe.
• Mmebi nke lacrimation.
• Allergic conjunctivitis.
• Na ebili mmiri.
• Ihe nrịba ama n’ahụ.
• Ife Chukwu.
• Colic intestinal.
• Vomiting
• Ihe mgbu.
• Ahụ erughị ala
• Okpokoro na ndabere nke njigide mmiri nwere n'ahụ.
• Hyponatremia.
• Oliguria.
• Mmụba ma ọ bụ ibelata ọbara mgbali elu ma ọ bụrụ na enyere ọgwụ a ngwa ngwa intravenfully.
• Okpokoro nke oghere mucous na oghere imi.
• Hypoosmolality.
• Rhinitis.
• Iwetara uru.
• Ọnwụ nke mmụọ.
• Mgbagha.
• Dizziness.
• Isi ọwụwa.
• Coma

Ọ bụrụ na mmeghachi omume ojoo ọ bụla mere, ọ dị mkpa ịgwa dọkịta gị. Ntụziaka a gosipụtara na a ga-eji ya mee ihe. Analogs nke Desmopressin nwere mmetụta ndị ọzọ yiri ya.

Iji ogwu ogwu: otu esi eme ya

Usoro ọgwụgwọ na usoro ọgwụgwọ nke onye ọrịa ọ bụla ka dọkịta kpebiri n’otu n’otu.

Mgbe ị na-eji ụdị ọgwụ ọgwụ intranasal, a na-egosipụta nchịkwa ruru 40 mgk nke ọgwụ kwa ụbọchị. Ekwesịrị ka ekenye dose ahụ egosipụtara n’ọtụtụ ngwa. Na ọgwụgwọ ụmụaka, ọ dị mkpa idozigharị dose, ebe ọ bụ na-ejikarị 3 μg kwa ụbọchị na-ejikarị.

Ọ bụrụ na etinyere nchịkwa ọgwụ ahụ intramuscularly, intravenously, subcutaneously, mgbe ahụ, ndị ọrịa toro eto kwesịrị iji 4 μg kwa ụbọchị, ụmụaka - ruo 2 μg.

Ọ bụrụ na enweghị ọgwụgwọ ọgwụgwọ kwa izu iji ọgwụ ahụ, ị ​​ga-agakwuru dọkịta iji dozie dose ahụ. Ọ na-ewekarị ọtụtụ izu iji họrọ usoro ọgwụgwọ dị mma.

Ọnọdụ nchekwa maka ọgwụ

Chekwaa ọgwụ ahụ n'ebe ụmụaka anaghị enweta ya, yana ọnọdụ okpomọkụ nke anaghị agafe ogo 30.

Debe ọgwụ ahụ ka ụmụaka ghara iru ya.

Ime na lactation

Emebeghị nnyocha omumu ihe omimi ma ghasasie ike na nchekwa nke desmopressin n’oge di ime na n’ara nwa. Ọ bụrụ na ọ dị mkpa iji desmopressin na ụdị ndị ọrịa a, uru nke atụ anya ọgwụgwọ maka nne yana ihe nwere ike ibute nwa ebu n’afọ ma ọ bụ nwa.

Nkwadebe nke nwere DESMOPRESSIN (DESMOPRESSIN)

• APO-DESMOPRESSINE (gọziere imi). 10 mcg / 1 dose: fl. 2,5 ml (doses 25) ma ọ bụ 5 ml (doses 50) • ngwọta EMOSINT (EMOSINT) d / injection. 4 μg / 0,5 ml: amp. 10 PC. • MINIRIN® (MINIRIN) taabụ. sublingual 120 mcg: 10, 30 ma ọ bụ 100 PC. • MINIRIN® (MINIRIN) taabụ. 200 mcg: 30 PC. • MINIRIN® (MINIRIN) taabụ.

100 mcg: 30 PC. • EMOSINT (EMOSINT) maka ntụtụ. 40 mcg / 1 ml: amp. 10 pcs. • DESMOPRESSIN (DESMOPRESSIN) ọgwụ ọwara imu mịrị amị 10 mcg / 1: vial. 50 doses na dosing. • Ngwaọrụ MINIRIN® (MINIRIN) nasal dosing spray. 10 mcg / 1 dose: fl. 2,5 ml (doses 25) ma ọ bụ 5 ml (50 doses) • taabụ MINIRIN® (MINIRIN).

240 mcg sublingual: 10, 30 ma ọ bụ 100 nkeji • PRESINEX (nasal dosing spray). 10 mcg / 1 dose: fl. 60 onunu ogwu • EMOSINT (EMOSINT) d d injection. 20 mcg / 1 ml: amp. 10 pcs. • DESMOPRESSIN (ọsụsọ nke ala) 100 mcg / 1 ml: vial. 5 ml

• MINIRIN® (MINIRIN) taabụ.

sublingual 60 mcg: 10, 30, ma ọ bụ 100 PC.