Angiopril (Angiopril), ntuziaka maka ojiji

Aha mba ofesi - okpokoro isi

Ngwakọta na ụdị ntọhapụ. Ihe nọ n'ọrụ bụ captopril. Mbadamba 0.025 na 0.05 g, 10 PC. na ngwugwu.

Ojiji nke ọgwụ angiopril naanị dị ka dọkịta nyere, a na-enye nkọwa ahụ maka ntụnye!

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Ngwongwo ogwu

Antihypertensive, vasodilator, cardioprotective, natriuretic. Ọ na - egbochi ACE, na - egbochi mgbanwe nke angiotensin nke m na angiotensin nke abụọ ma na - egbochi itinye ume nke vasodilaasị endogenous. A na - egosipụta mmetụta antihypertensive ka oge 15-60 gasịrị mgbe nchịkwa ọnụ gasịrị, ọ kachasị karịa mgbe ọ bụla nkeji 60-90 wee ruo awa 6-12. Ọ na - ebelata oke ọnụ obi, tupu oge na mgbe ebidoro ya n'obi, nrụgide dị na okirikiri pulmonary na iguzogide arịa arịa, na-abawanye mmepụta obi (HR) anaghị agbanwe). Ọ nwere mmetụta cardioprotective. Ngwa ngwa na etinye obi gị dum na ngọngọ diges. Iji okwu abuo mee ihe nke oma, mekwaa ka odiwanye ndu. Ọ na - agafe n'ihe mgbochi nke histohematological, ewezuga BBB, gafere ma banye na mmiri ara. Iwepu ọkara ndụ na-eme awa 2-3. Ọ bụ ọkachasị mma akụrụ.

Ihe ngosi maka ojiji

Ọbara mgbali elu, gụnyere renovascular (dị nwayọ ma ọ bụ agafeghị oke dị ka ọgwụ ịhọrọ nke mbụ, siri ike ma ọ bụrụ na a na-anabata usoro ọkọlọtọ adịghị mma ma ọ bụ na-adịghị anabata), CHF (njikọta ọgwụ), LV dysfunction after a myocardial infarction in a clinically situation situation, ọrịa mamịrị nephropathy with type 2 diabetes mellitus 1 (ya na albuminuria karịa 30 mg / ụbọchị).

Ihe ngbanwe

Akpachapụ anya na captopril ma ọ bụ ndị ọzọ na-egbochi ACE, ịtụrụ ime, lactation (na Russia, anabataghị ọgwụ ahụ maka ojiji ndị mmadụ na-erubeghị afọ 18.) Kpachara anya. Akụkọ banyere ọrịa angioedema n'oge ọgwụgwọ ya na ndị na - egbochi ACE, ihe nketa ma ọ bụ idiopathic angioedema, aortic stenosis, ọrịa ụbụrụ na akwara (gụnyere ụbụrụ ụbụrụ, ọrịa obi obi, akwara coronary insufficiency), ọrịa autoimmune siri ike nke anụ ahụ na - ejikọta ya ( SLE, scleroderma), mgbochi nke ụmị ọkpụkpụ, ọrịa shuga, hyperkalemia, akwara akwara akwara, stenosis nke otu akụrụ akwara, ọnọdụ mgbe ọ gbasesịrị akụrụ, gbasara akụrụ na / ma ọ bụ imeju, nri nwere mmachi Na +, ọnọdụ yana mbelata BCC (gụnyere afọ ọsịsa, ọgbụgbọ), afọ.

Etu esi eji: usoro onunu ogwu na usoro ọgwụgwọ

N'ime, elekere 1 tupu nri, yana ọbara mgbali elu akwara, ọgwụgwọ na-amalite site na iji ọgwụ kachasị dị ala nke 12.5 mg ugboro abụọ kwa ụbọchị (adịkarịghị ugboro 6.25 mg ugboro abụọ n'ụbọchị). Ekwesịrị ị paida ntị na ntinye nke akpa ọgwụ n'oge awa mbụ. Ọ bụrụ na hypotension akwara na-etolite na nke a, a ga-eme ka onye ọrịa kwụrụ na ọnọdụ kwụ ọtọ (ụdị mmeghachi omume nke usoro mbụ ahụ ekwesịghị ịbụ ihe mgbochi na usoro ọgwụgwọ ọzọ). Site na monopherapy captopril, enwere ike ịnweta nsonaazụ dị mma site n'otu oge na-egbochi ị Naụ Na + n'ime ahụ.

Site na usoro ọgwụgwọ, a na-abawanye dose ahụ, ma ọ bụrụ na ọ dị mkpa, mgbe izu 2-4 gasịrị, ka o kwere mee - ruo 50 mg ugboro atọ n'ụbọchị. Na oke ọbara ọgbụgba dị egwu (ọbara mgbali nke 115 mm Hg ma ọ bụ karịa), a na-ejikọkarị ya na ọgwụ ndị ọzọ na-egbochi mmiri, na-ejikarị mgbatị thiazide (hydrochlorothiazide - 25-50 mg / ụbọchị). Enwere ike ịbawanye ọnya ọnya ahụ na ntakịrị oge nke izu 1-2 ruo mgbe ọnụọgụ kachasị n'ọrụ iji na-emeso ọbara mgbali elu ruru.

Ọgwụ mmezi maka “obere nwayị” na ọbara ọgbụgba na-adịghị ala ala (mgbali ọbara - 95-114 mm Hg) bụ 25 mg (oge ụfọdụ 12.5 mg) ugboro abụọ n'ụbọchị.

N'ime ndị ọrịa agadi, ọgwụ izizi bụ 6.25 mg ugboro abụọ kwa ụbọchị.

Bụrụ na nkụda obi, a na - enye ya ya na diuretics na / ma ọ bụ na ngwakọta na digitalis (iji zere ịbelata ọbara mgbali mbụ tupu nchịkwa nke captopril, a na-akagbu akwara ahụ ma ọ bụ belata ọgwụ ahụ). Ọgwụ izizi bụ 6.25 mg ma ọ bụ 12.5 mg ugboro atọ kwa ụbọchị, ma ọ bụrụ na ọ dị mkpa, mụbaa ọ̀ba ahụ ruo 25 mg ugboro atọ n'ụbọchị. Oke kachasị kwa ụbọchị bụ 150 mg.

N'ihe banyere arụ ọrụ LV mgbe ọ nwetasịrị infarction myocardial na ndị ọrịa nọ n'ọnọdụ steeti kwụsiri ike, a ga-ebido kọọtụ isi mmalite ụbọchị 3 ka ọ gbasasịrị infarction myocardial. Ọgwụ izizi bụ 6.25 mg / ụbọchị, mgbe ahụ enwere ike ịbawanye ọgwụ kwa ụbọchị ruo 37.5-75 mg na usoro onyonye 2-3 (dabere na ịnagide ọgwụ ahụ) ruo ihe dịka 150 mg / ụbọchị.

Site na mmepe nke hypotension, ike ịbelata nwere ike ịchọrọ. Mgbalị ndị ọzọ ị ga-eji iji ọgwụ dịkarịsịrị 150 kwa ụbọchị ekwesịrị ịdabere na nnagide nkwado isi.

Na nephropathy na-arịa ọrịa shuga, a na-enye ọgwụ nke 75-150 mg / ụbọchị.

Site n'ọkwa dị oke ala nke nsogbu akụrụngwa nsogbu (CC ma ọ dịkarịa ala 30 ml / min / 1.73 sq.m), enwere ike ịkọwa captopril na ọkara nke 75-100 mg / ụbọchị. Site na ogo ọkwa akpọrọ akpọrọ akpọrọ (CC na-erughị 30 ml / min / 1.73 m), usoro izizi ekwesịghị ịbụ ihe karịrị 12.5 mg / ụbọchị, mgbe ahụ, ọ bụrụ na ọ dị mkpa, a na-eji nwayọọ nwayọọ na-abawanye ọgwụ onwa nke ihe a na-ahụ anya, ma jiri obere karịa. maka ọgwụgwọ nke ọbara mgbali elu, ọgwụ kwa ụbọchị.

Edebere ụmụaka (na Russia ka eji ya eme ihe n'ime ụmụaka) naanị maka ọbara mgbali elu ike (yana enweghị ọgwụgwọ ọzọ) na dose 0.1-0.4 mg / kg 2 ugboro n'ụbọchị.

Newmụ amụrụ ọhụrụ - ọgwụ mbụ nke 0.01 mg / n'arọ 2-3 ugboro n'ụbọchị, ụmụaka toro eto - nmalite nke 0.3 mg / n'arọ ugboro atọ kwa ụbọchị, ọ bụrụ na ọ dị mkpa, mụbaa dose ahụ site na 0.3 mg / kg na oge nke 8-24 awa ruo ntakịrị opekempe nke ọma. .

Omume ọgwụ

Ihe mgbochi ACE. Na-ebelata nguzobe nke angiotensin nke II site na angiotensin I. Mbelata nke ọdịnaya nke angiotensin II na-eduga na mbelata nke mkpirisi aldosterone. N'otu oge ahụ, OPSS, ọbara mgbali, post- na preload na obi na-ebelata. Ọ na-eme ka akwara akwara dị elu karịa akwara. Ọ na-eme ka mbelata bradikinin (otu n'ime mmetụta nke ACE) na mmụba na njikọ nke Pg.

Mmetụta antihypertensive anaghị adabere na ọrụ nke plasma renin, a na-ahụta mbelata ọbara mgbali nkịtị na ọbụna mbelata nke hormone, nke a bụ n'ihi nsonaazụ sistemụ renin-angiotensin. Na-eme ka ọbara na -akpata ọbara na akwara.

Site na iji ogologo oge, ọ na-ebelata ogo nke ọbara mgbali nke myocardium na mgbidi nke akwara ndị dị n'ụdị resistive. Ọ na - eme ka ọkpụkpụ ọbara na ischemic myocardium dị mma. Na-ebelata nchịkọta platelet. Na-enyere aka belata ọdịnaya Na + n'ime ndị ọrịa nwere nkụda obi.

Na usoro nke 50 mg / ụbọchị, ọ na-egosipụta akụrụngwa angioprotective n'ihe metụtara arịa nke microvasculature ma nwee ike belata ọganihu nke ọdịda akwara na-adịghị ala ala na nephroangiopathy mamịrị.

Mbelata ọbara mgbali elu, na ọdịiche na vasodilait (hydralazine, minoxidil, wdg) esonyeghị na tachycardia reflex ma na-eduga n'ịbelata choro oxygen myocardial. Mgbe nkụda obi na-ezuru oke ọ bụla emetụtaghị uru ọbara ọgbụgba bara.

Mbelata ọbara mgbali elu karịa mgbe nchịkwa a na-ekwu okwu dị ka nkeji 60-90 gasịrị. Ogologo oge nke mmetụta hypotensive bụ nke dabere ma rute ụkpụrụ kachasị mma n'ime izu ole na ole.

Nsonaazụ

Site na CCC: tachycardia, ọbara mgbada agbada, orthostatic hypotension.

Site na sistemụ ụjọ: ọgbụgba, isi ọwụwa, ike ọgwụgwụ, asthenia, paresthesia.

Site na sistemụ urinary: proteinuria, ọrụ akwara nwere nsogbu (ịba ụba urea na creatinine n'ime ọbara).

Site n'akụkụ nke mmiri-electrolyte metabolism: hyperkalemia, acidosis.

Site na akụkụ ahụ haemopoietic: neutropenia, anaemia, thrombocytopenia, agranulocytosis.

Mmeghachi omume nfụkasị: angioedema, ịwụfu ọbara n'ọbara nke ihu, ahụ ọkụ, ọnya anụ ahụ (maculopapular, obere oge vesicular ma ọ bụ onye obi ọjọọ), itching, photoensitivity, bronchospasm, ọrịa serum, lymphadenopathy, n'ọnọdụ ndị na-adịghị ahụkebe, ọdịdị nke ọgwụ antiinclear na ọbara.

Site na usoro nri: enweghi uto, uto nri, stomatitis, ọrịa dyspeptik, ọgbụgbọ, mgbu azụ, afọ ntachi ma ọ bụ afọ ọsịsa, mụbara ọrụ nke ọrịa hepatic transaminases, hyperbilirubinemia, ihe ịrịba ama nke mmebi hepatocellular (ịba ọcha n'anya) na cholestasis (n'ọnọdụ ndị na-adịghị ahụkebe), pancreatitis (n'ọnọdụ dịpụrụ adịpụ).

Ndị ọzọ: "akọrọ" ụkwara, na-agafe mgbe ịkwụsị ọgwụ gachara, ọrịa asthenia, ọzịza nke ụkwụ. Mgbaàmà: mbelata nke ọbara mgbali elu, ruo n'ọdịda, infarction myocardial, nnukwu ihe ọria ụbụrụ, ọria ụbụrụ thromboembolic.

Ọgwụ: tinye onye ọrịa ahụ na aka na aka dị elu, usoro iji weghachi ọbara mgbali (mmụba na BCC, gụnyere iv infusion nke 0.9% NaCl ngwọta), ọgwụgwọ Symptomatic. N'ime ndị okenye, ọrịa ịba ọcha n'anya bụ ọrịa, dayaitoneal dialysis anaghị arụ ọrụ.

Ntụziaka pụrụ iche

Tupu ịmalite, yana oge niile mgbe a na-eji captopril, a ga-enyocha ọrụ akụrụ. N'ime ndị ọrịa nwere CHF, a na-eji ha n'okpuru nlekọta ahụike.

Na agbanyeghi ihe eji aru oru ogologo oge nke ihe nlere anya ihe dika 20% nke ndi oria, enwere mmụba na-arịwanye elu na mkpo urea na creatinine na serum ihe kariri 20% ma e jiri ya tụnyere ụkpụrụ ma ọ bụ uru mbụ. Ihe na-erughị 5% nke ndị ọrịa, ọkachasị ndị nwere nnukwu nephropathy, chọrọ ịkwụsị ọgwụgwọ n'ihi mmụba na itinye uche creatinine.

N'ime ndị ọrịa nwere ọbara mgbali elu na akwara ụkwụ, a na-ahụ hypotension arterial hypotension naanị n'ọnọdụ ndị a na-adịghị ahụkebe, ohere nke ịmalite ọnọdụ a na-abawanye site na ụkọ (mmiri) nke mmiri na nnu (dịka ọmụmaatụ, mgbe ọ gbasachara ọgwụgwọ siri ike), na ndị ọrịa nwere ọrịa obi na-adịghị ala ala ma ọ bụ nwee usoro ọgwụgwọ.

Enwere ike belata nbilata nke ọbara mgbali elu site na kagbuo mbido (ụbọchị 4-7) nke diuretic ma ọ bụ site na ịbawanye oriri nke NaCl (ihe dị ka otu izu tupu mmalite nke nchịkwa), ma ọ bụ site na nchịkwa isi mmalite nke ọgwụgwọ obere obere usoro (6.25-12.5 mg / ụbọchị).

N'oge ọgwụgwọ na outpatient, dọọ onye ọrịa aka na ọdịdị ahụ ga-ekwe omume nke mgbaàmà nke ọrịa, na-achọ ka a na-ahụ nyocha ahụike, nyocha na ụlọ nyocha. N'ime ọnwa atọ mbụ nke ọgwụgwọ, a na-enyocha ọnụọgụ ọbara nke leukocytes kwa ọnwa (nke dị n'okpuru - otu ugboro n'ọnwa atọ), na ndị ọrịa nwere ọrịa autoimmune na ọnwa atọ mbụ - izu abụọ ọ bụla, mgbe ahụ - ọnwa 2 ọ bụla. Ọ bụrụ na ọnụọgụ nke leukocytes erughị 4 puku / μl, egosipụtara nyocha ọbara zuru oke, n'okpuru 1 puku / μl, ọgwụ ahụ na-akwụsị. Ọ bụrụ na ihe mgbaàmà mbụ nke ọrịa nke abụọ malitere megide myeloid hypoplasia, a ga-eme nyocha ọbara zuru ezu ozugbo.

Ọ dị mkpa wezuga ịkwụsị nnwere onwe nke ọgwụ ahụ yana nnwere onwe dị ịrịba ama na ịdị ukwuu nke mmega ahụ.

N'ụfọdụ, megidere ndabere nke iji ndị mgbochi ACE, gụnyere captopril, enwere mmụba nke mkpokọta K + na ọbara. Ihe ize ndụ nke ịmalite hyperkalemia na iji ACE inhibitors na-abawanye na ndị ọrịa nwere ọrịa akụrụ na mellitus ọrịa shuga, yana ị potassiumụ ọgwụ na-egbu ọgwụ, ọgwụ K + ma ọ bụ ọgwụ ndị ọzọ na-eme ka mmụba nke K + n'ọbara (dịka ọmụmaatụ, heparin). Ekwesịrị izere ịme ojiji nke potassium na-eme ka ọnụnọ na K + mee ya.

Mgbe ị na-eduzi usoro ịba ọcha n'anya na ndị ọrịa na-anata isi akwara, a ga-ezere ojiji nke membreses dialysis membranes (dịka. AN69), ebe ọ bụ na n'ọnọdụ ndị dị otu ahụ, ọ na-abawanye nsogbu nke ịmalite mmeghachi omume anaphylactoid.

N'ihe banyere mmepe nke angioedema, a na-akagbu ọgwụ ahụ ma na-ahụ maka nlekọta ahụike yana usoro ọgwụgwọ Symptomatic.

Mgbe ị na-ewere captopril, enwere ike ịhụ mmeghachi omume ụgha mgbe ị na-enyocha mmamịrị maka acetone.

Ndị ọrịa nwere obere nnu ma ọ bụ nnu nnu nwere ntakịrị ihe ize ndụ nke mbelata ọbara mgbali elu na mmepe nke hyperkalemia.

N'oge usoro ọgwụgwọ ahụ, a ga-akpachara anya mgbe ị na-anya ụgbọ ala ma na-etinye aka n'ihe omume ndị ọzọ nwere ike ịdị ize ndụ nke chọrọ nlebara anya na ọsọ nke mmeghachi omume psychomotor (ọgbụgba ga-ekwe omume, karịchaa mgbe ị theụchara ọgwụ mbụ).

Mmekorita

Ọ na-eme ka mmụba digoxin na plasma site na 15-20%.

Cimetidine, na-ebelata metabolism n'ime imeju, na-eme ka ịbawanye ụba nke captopril na plasma.

Mmetụta antihypertensive na-eme ka ike gwụ site na NSAIDs (njigide Na + na ibelata Pg njikọ), ọkachasị megide ndabere nke ntinye uche dị ala nke renin, yana estrogens (Na + igbu oge).

Njikọ ya na thiazide diuretics, vasodilators (minoxidil), verapamil, beta-mgbochi, tricyclic antidepressants, ethanol na-akwalite mmetụta hypotensive.

Ejikọtara ya na ọgwụ ndị na-eme ka ọnụnọ potassium na-eme nri, nhazi K +, cyclosporine, mmiri ara Na + dị ala (nwere ike ịnwe K + ruo 60 mmol / L), mgbakwunye potassium, nnọchi nnu (nwere nnukwu K +) nwere ike ịba ụba nke hyperkalemia.

Na-eme ka a ghara ị excụ ọgwụ Li +.

Clonidine na-ebelata ogo mmetụta hypotensive.

Site na nhọpụta nke captopril mgbe ị na-ewere allopurinol ma ọ bụ procainamide, ihe ize ndụ nke ịmalite ọrịa Stevens-Johnson syndrome na immunosuppressive ime ihe na-abawanye.

Ojiji nke captopril n’ime ndị ọrịa na-anata immunosuppressants (dịka ọmụmaatụ azathioprine ma ọ bụ cyclophosphamide) na-abawanye ohere nke ibute ọrịa ọgbaghara.

Utionsdọ aka na ntị maka ojiji

A na-eme ọgwụgwọ n'okpuru nlekọta ahụike mgbe niile. N'oge usoro ọgwụgwọ, nlebara anya nke ọbara ọgbụgba, usoro nke ịwa ahụ, ọkwa protein, plasma potassium, urea nitrogen, creatinine, ọrụ akụrụ, oke ahụ, na nri dị mkpa. Site na mmepe nke hyponatremia, akpịrị ịkpọ nkụ, ọ dị mkpa imezi usoro usoro usoro onunu ogwu. Ọ dị mkpa ịkpachara anya mgbe ị na - eme usoro ịwa ahụ (gụnyere eze), karịchaa mgbe ị na - eji ọgwụ na - agwọ ọrịa izugbe nwere mmetụta dị egwu. A na-atụ aro ịhapụ ị beụ mmanya na-egbu egbu n'oge ọgwụgwọ. Jiri ịkpachara anya na-arụ ọrụ maka ndị ọkwọ ụgbọ ala na ndị ọrụ ha jikọtara na itinye uche ha na nlebara anya. Ọ bụrụ na ọgwụ ahụ zoro, ọgwụ ndị na-esote ya abụghị okpukpu abụọ. Mgbe ị na-eme ule maka acetonuria, nsonaazụ dị mma ga-ekwe omume.

Nsonaazụ

Site n'akụkụ akụkụ akwara na akwara anụ ahụ: ike ọgwụgwụ, nkụda mmụọ, isi ọwụwa, nkụda mmụọ nke sistemụ ụbụrụ nke etiti, ụra, ọgba aghara, ịda mba, ataxia, nsị, ọnya ma ọ bụ mkpọtụ na njedebe, ọhụhụ ọhụhụ na / ma ọ bụ isi. Site na usoro obi na ọbara (hematopoiesis, hemostasis): hypotension, gụnyere orthostatic, angina pectoris, myocardial infarction, cardiac arrhythmias (atrial tachy ma ọ bụ bradycardia, atrial fibrillation), palpitations, nnukwu ọrịa ụbụrụ, oke akụkụ, isi ọwụwa, nhụjuanya, obi mgbu, pulmonary embolism, pulmonary embolism, pulmonary embolism, pulmonary embolism, pulmonary embolism, pulmonary embolism, pulmonary embolism, pulmonary embolism ya na ọrụ ezinaụlọ ya na - arụ ọrụ, na - emegide ihe ndabere), thrombocytopenia, eosinophilia Site na usoro iku ume: ụkwara ume ọkụ, mkpụmkpụ ume, ọnya ụbụrụ, ọnya afọ, ụkwara akọrọ akọrọ. Site na ngba nri: anorexia, aghara aghara, stomatitis, ọnya afọ nke mucous akpụkpọ ahụ nke oghere ọnụ na afọ, xerostomia, glossitis, ilo nri, ọgbụgbọ, ọgbụgbọ, dyspepsia, flatulence, mgbu afọ, afọ ntachi ma ọ bụ afọ ọsịsa, pancreatitis, imeju imeju (cholestasis) , cholestatic ịba ọcha n'anya, hepatocellular necrosis). Site na usoro mkpụrụ ndụ: arụ ọrụ ezughi oke, oliguria, proteinuria, enweghi ike. Site na anụ ahụ: ọbara ọbara nke ihu, ihe ọkụ ọkụ, itching, exfoliative dermatitis, toxic epidermal necrolysis, pemphigus, herpes zoster, alopecia, photodermatitis. Mmeghachi omume nrịanrịa: Stevens-Johnson syndrome, urticaria, ede ede Quincke, ụjọ anaphylactic, wdg ndị ọzọ: ahụ ọkụ, akpata oyi, sepsis, ọrịa arthralgia, hyperkalemia, gynecomastia, ọrịa ọbara, mụbara ọkwa ọbara nke enzymes imeju, urea nitrogen, acidosis, nke oma. mmeghachi omume mgbe a na-anwale ọgwụ mgbochi ọgwụ nje antijen.

Usoro onunu ogwu na nhazi

N'ime, 1 awa tupu nri. A na-edobe usoro usoro onunu ogwu ya iche iche.

Na obara mgbali elu - na onwa mbu nke 25 mg 2 ugboro kwa ubochi. Ọ bụrụ na ọ dị mkpa, a na-eji nwayọ were dose ahụ (na etiti oge izu 2-4) rue mgbe arụpụtara oke. Site n'ọbara mgbali elu dị nwayọ ma ọ bụ na-agabigaghị ókè, oge a na-ahụkarị bụ 25 mg ugboro abụọ n'ụbọchị. Oke kachasị bụ 50 mg ugboro abụọ n'ụbọchị. Na nnukwu ọbara ọgbụgba, ọnụọgụ kachasị bụ 50 mg ugboro atọ n'ụbọchị. Oke kachasị kwa ụbọchị bụ 150 mg.

Na nkụda obi na-adịghị ala ala, a na-edezi Angiopril n'ọnọdụ ebe iji ọgwụ ọgbụgba anaghị arụ ọrụ zuru oke. Nkezi mmezi ahụ bụ 25 mg 2-3 ugboro n'ụbọchị. N’ọdị n’ihu, ọ bụrụ na ọ dị mkpa, mụbaa dose ahụ (n’etiti ihe dịkarịa ala izu abụọ). Oke kachasị kwa ụbọchị bụ 150 mg.

Maka ndị ọrịa nwere obere obere akwara na-arụ ọrụ (Cl creatinine opekata mpe 30 ml / min), Angiopril ka enwere ike ịkọwa ya na ọgwụ dịka 75-100 mg / ụbọchị. Ọ nwere ọkwa akpọ aha kacha nta (Cl creatinine ® -25)

Ekwela ka ụmụaka ghara iru ya.

International Nonproprietary Aha

Aha mba ụwa na-akwadoghị maka ngwaahịa a bụ Captopril.

Maka ọgwụgwọ ha banyere arịa ọbara, a chọrọ ọgwụgwọ siri ike, nke gụnyere ị includesụ ọgwụ, nke gụnyere angiopril.

Ọgwụ nwere koodu ATX ndị a: C09AA01.

Weputara udi ya na ihe mebere ya

Ntọhapụ nke ọgwụ a na-arụ n'ụdị mbadamba ụzọ etinye na ibe nke PC 10 na PC 4. Ibe kaadiboodu nwere ike inwe mbadamba 1, 3, 10 nke mbadamba 10 ọ bụla ma ọ bụ 1 warara na mbadamba 4. Ngwakọta ọrụ nọ n'ọrụ bụ captopril - 25 mg. Ọzọkwa, a na-eji stearic acid, lactose, ọka ọka, colloidal silicon dioxide na microcrystalline cellulose eme ihe.

Mlọ ọgwụ

Mgbe iwere mbadamba nkume ndị ahụ, ọ na-abanye ngwa ngwa na eriri afọ n'ihi bioavailability nke 60-70%. A na-ahụta mbelata na-ejikwa nri nri nke achịcha ugboro ugboro. Ọkara ọkara nke ọgwụ ahụ ga-ewe awa 2-3. Ọkpụkpụ nke ihe na-arụ ọrụ dị na mmamịrị n'ụdị na-agbanweghi agbanwe.

Na-arịa ọrịa shuga

Ọ bụrụ na onye ọrịa ahụ nwere ọrịa mamịrị nephropathy, mgbe ahụ, a na-a medicineụ ọgwụ ahụ na 75-150 mg kwa ụbọchị. Usoro ogwu nwere ike igbanwe ogwu gi.