Finlepsin: ntuziaka maka ojiji

Ntuziaka dị na Finlepsin, ngosipụta maka ojiji a bụ:

• Akwụkwụ na-adọ (gụnyere ọnụnọ, akpa ume, ihe ọdịdọ nke myoclonic),
• idiopathic trigeminal neuralgia,
• neuralgia nke na - ahụkarị na nke na - efe efe nke na - akpata otutu sclerosis,
• idiopathic neuralgia nke akwara glossopharyngeal,
• Ọnọdụ nnukwu manic (n'ụdị monotherapy ma ọ bụ ọgwụgwọ njikọta),
• usoro na - emetụta nsogbu
• ọrịa mmanya na-egbu egbu,
• ọrịa shuga na-esite na etiti sitere,
• polydipsia na polyuria nke neurohormonal sitere.

Contraindications Finlepsin

Ntuziaka maka Finlepsin na-akọwa ụdị contraindications maka ojiji a:

• hypersensitivity na carbamazepine,
• imebi ụmị ọkpụkpụ,
• nnukwu nsogbu porphyria,
• ojiji nke MAO inhibitors,
• Ihe mgbochi AV.

Ekwesịrị iji Finlepsin na ịkpachara anya na nkụda mmụọ obi mebiri emebi, ADH hypersecretion syndrome, hypopituitarism, adrenal cortex insufficiency, hypothyroidism, mmanya na-arụ ọrụ, ịka nká, ọdịda imeju, ụba ọbara intraocular.

Mmetụta akụkụ nke finlepsin

A na-akọpụta mmetụta ndị ọzọ na-esote mgbe a na-eji Finlepsin:

• site na Mgbakọ Mba: ọgbụgbọ, isi ọwụwa, echiche na-adịghị mma, nsụhọ, ihe ndọghachi azụ, paresthesias, hyperkinesis, oke iwe,
• site na akwara afọ: vomiting, ọgbụgbọ, ụba transminases ịba ọcha n'anya,
• site na CCC: mmụba ma ọ bụ ibelata ọbara mgbali elu, mbelata obi, mebie AV,
• sitere na usoro hematopoietic: mbelata ọnụ ọgụgụ nke neutrophils, sel ọbara, platelet,
• site na akụrụ: oliguria, hematuria, nephritis, edema, ọdịda akụrụ,
• site na iku ume: pulmonitis,
• site na usoro endocrine: mmụba nke ọkwa prolactin, yana galactorrhea, gynecomastia, mgbanwe nke ọkwa homonụ thyroid,
• ndị ọzọ: mmeghachi omume nfụkasị ahụ, gụnyere ọrịa Stevens-Johnson.

Ọnụ ọgụgụ dị ukwuu nke nsonaazụ na-akpata nyocha na-adịghị mma nke Finlepsin site n'aka ndị ọrịa. Iji gbochie ọdịdị ha ma ọ bụ iji belata ogo, ị nwere ike iji Finlepsin dịka ntuziaka dị na usoro ọgwụgwọ zuru oke yana n'okpuru nlekọta ahụike siri ike.

Usoro nke ngwa, usoro onunu ogwu nke finlepsin

Finlepsin bụ maka ọnụ. Uzo eji ebido ndi okenye bu 0.2-0.3 g kwa ubochi. Nwayọọ nwayọ, usoro onodu a na-erute 1.2 g Obere usoro a na-eme kwa ụbọchị bụ 1.6 g. A na-atụkwa ọgwụ kwa ụbọchị na usoro atọ ruo anọ, n'ụdị ogologo oge - na otu ụzọ abụọ.

Usoro nke Finlepsin maka ụmụaka bụ 20 mg / kg. Ruo afọ 6, a naghị eji Finlepsin mbadamba ihe.

Mmekọrịta nke Finlepsin yana ọgwụ ndị ọzọ

Ojiji nke Finlepsin na MAO inhibitors anaghị anabata ya. Anticonvulsants ndị ọzọ nwere ike belata mmetụta anticonvulsant nke Finlepsin. Site na nhazi nke ọgwụ a n'otu oge na valproic acid, ọ ga-ekwe omume ịmalite nsogbu nke nsụhọ, coma. Finlepsin na - abawanye nsị nke ịkwado lithium. N'iji oge nke macrolides, ndị na-egbochi calcium, isoniazid, cimetidine na Finlepsin, ịta ọkwa nke ikpeazụ na-abawanye. Finlepsin belata ọrụ anticoagulants na mgbochi.

Dodoụbiga ya ókè

Site na mmụba nke Finlepsin, mmebi nke nsụhọ, nkụda mmụọ nke akụkụ okuku ume na akwara, imebi ọbara na-emebi, yana mmebi akụrụ. Usoro ọgwụgwọ akọwapụtabeghị: lavage gastric, ojiji nke laxatives na enterosorbents. N'ihi ike dị ukwuu nke ọgwụ nwere ike iji kegide protein ndị dị na plasma, nnweta a na-emegharị ya na ị Finụ ọgwụ Finlepsin adịghị arụ ọrụ. Hemosorption na sọrel unere ka eme. N'ime ụmụaka, enwere ike inye mmịnye ọbara.

N'ihi ịdị ike dị elu nke ọgwụ a, enwere ike ịkọ akwụkwọ n'ọnọdụ dị iche iche, nyocha nke Finlepsin dị mma. Ọgwụ ahụ nwere mmetụta antiepileptik dị irè, mmetụta analgesic maka neuralgia.

Ntụziaka pụrụ iche

Tupu iji ọgwụ a, ọ dị mkpa ịmụ ntuziaka maka Finlepsin n'ụzọ zuru ezu.

Mgbe ị na-ahọrọ ezigbo usoro onunu ogwu, odi nkpebi ikpebi mkpokoro plasma nke carbamazepine. Mwepu ọgwụ a na mberede nwere ike ịkpalite ọdịkwụkwụ. Ọ dịkwa mkpa iji nyochaa usoro ịgwọ ọrịa hepatic mgbe ị na-ede Finlepsin. Dabere na ngosipụta siri ike, enwere ike iji Finlepsin ndị ọrịa nwere mgbali intraocular karịa, mana a ga-enyocha ihe ngosi a.

Mwepụta wepụtara ya na ihe mejupụtara

Finlepsin dị n'ụdị mbadamba: gburugburu, ya na bevel, ọcha, convex n'otu akụkụ yana ihe iyi egwu ga-agbanwe ya - n'akụkụ nke ọzọ (pcs 10. N'ime blisters, na ngwungwu kaadiboodu 3, 4 ma ọ bụ 5 blisters).

Nchikota kwa otu mbadamba 1:

• ihe na-arụ ọrụ: carbamazepine - 200 mg,
• ihe inyeaka: gelatin, steeti magnesium, cellulose microcrystalline, shịum croscarmellose.

Mlọ ọgwụ

Finlepsin bụ ọgwụ antiepileptik. O nwekwara ọgwụ antipsychotic, antidiuretic na antidepressant. N'ime ndị ọrịa nwere neuralgia, ọ na-egosipụta mmetụta analgesic.

Usoro nke carbamazepine bụ n'ihi ihe mgbochi nke sodium voltaji na-adabere, nke na-enyere aka imezi membranes nke neurons na-enweghị oke, na-eduga na nkwụsị nke mkpụrụ ndụ akwara na-ebelata mmechi nke ihe ndị dị na synapses. Ihe nke carbamazepine na-egbochi ịmaliteghachi ikike nke ihe dị na mkpụrụ ndụ neuronal depola, na-ebelata ntọhapụ nke glutamate (amino acid neurotransmitter na-akpali akpali), na-eme ka nbibi nke sistemụ akwara Central na, n'ihi nke a, na-ebelata ihe ize ndụ nke njakịrị ọdịdọ. Mmetụta anticonvulsant nke Finlepsin bụkwa n'ihi ngbanwe nke ọwa mmiri 2 2 na-agba ọkụ na mmụba na arụ ọrụ K +.

Carbamazepine dị mma na akụkụ ọdịdọ akụkụ dị mfe ma sie ike (yana ma ọ bụ na-enweghị usoro nke abụọ), yana ọdịdọ nke tonic-clinical n'ọgwụ ọdịdọ, yana mgbe ị na-ejikọkwa ụdị ọdịdọ ndị edepụtara. Ọgwụ anaghị adịkarị mma ma ọ bụ na ọ nweghị ọrụ maka obere ihe ọdịdọ (ọnụnọ, myoclonic ọdịdọ, petit mal).

N'ime ndị ọrịa nwere ọrịa akwụkwụ (ọkachasị na nwata na ntorobịa), ọgwụ ahụ na-emetụta ihe mgbaàmà nke ịda mba na nchegbu, na-ebelata iwe na oke iwe.

Mmetụta Finlepsin na arụmọrụ psychomotor na ịrụ ọrụ cogniti dabere na dose.

Mmetụta anticonvulsant nke ọgwụ na-amalite site na ọtụtụ awa ruo ọtụtụ ụbọchị, ma mgbe ụfọdụ ruo otu ọnwa.

N'ime ndị ọrịa nwere trigeminal neuralgia, Finlepsin, dịka iwu, na-egbochi nhụjuanya mgbu. A na-achọpụta mmebi nke ọrịa mgbu n'ọtụtụ site na 8 ruo 72 awa mgbe ị theụsịrị ọgwụ.

Site n'ịkagbu mmanya, carbamazepine na -ewelata ọnụ ụzọ mbata maka ịdị njikere, ma na-ebelata ogo mgbaàmà ọrịa dịka oke ịma jijiji, iwe iwe na uru ọfụma.

Mmetụta antipsychotic nke ọgwụ na-etolite mgbe ụbọchị 7-10 gasịrị, nke enwere ike jikọta ya na mgbochi nke metabolism nke norepinephrine na dopamine.

Mlọ ọgwụ

Carbamazepine ji nwayọ nwayọ ma etinye uche gị dum. Iri nri adịghị emetụta ogo na ọsọ nke absorption. Nleta plasma kachasị ruru ka awa iri na abụọ gachara ị .ụ otu ọgwụ. Ekwesịrị itinye uche plasma plasma mgbe izu 1-2 gachara, nke dabere na njirimara nke metabolism, yana usoro nke ọgwụ ahụ, ọnọdụ onye ọrịa na oge ọgwụgwọ.

N'ime ụmụaka, carbamazepine na-ejikọ protein protein plasma site na 55-55%, na ndị okenye - site na 70-80%. Ogo o doro anya na nkesa ọgwụ bụ 0.8-1.9 l / n'arọ. Carbamazepine na-agafe ihe mgbochi placental ma na-arahụ na mmiri ara ara (nsonye ya n'ime mmiri ara nke nwanyị na-enye nwa ara bụ 25-60% nke ịta ahụhụ carbamazepine na plasma).

Metabolism nke ọgwụ na-eme na imeju, tumadi tinyere ụzọ epoxy. N'ihi ya, etolite metabolites isi na - esote: metabolite nọ n'ọrụ - carbamazepine-10,11-epoxide, metabolite na - adịghị arụ ọrụ - conjugate na glucuronic acid. N'ihi mmeghachi omume metabolic, ịmepụta metabolite na-adịghị arụ ọrụ, 9-hydroxymethyl-10-carbamoylacridane, ga-ekwe omume. Theta ahụ metabolite nọ n'ọrụ bụ 30% nke ịta ahụhụ nke carbamazepine.

Mgbe ị takingụsịrị otu ọgwụ ọgwụ ahụ, ọkara ndụ ahụ bụ awa 25-65, mgbe iji ugboro ugboro - awa 12 24 (dabere na oge ọgwụgwọ). N'ime ndị ọrịa na-anabatakwa anticonvulsants ndị ọzọ (dịka ọmụmaatụ, phenobarbital ma ọ bụ phenytoin), ọkara ndụ ahụ belata ka awa 9-10.

Mgbe otu ọgwụ Finlepsin na-agbago, ihe dị ka 28% nke ọgwụ a isụbara dị na feces na 72% na mmamịrị.

Na umuaka, n'ihi mkpochapu nke carbamazepine, enwere ike icho ibu nke ogwu kwa kilogram nke aru aru.

Enweghị data maka mgbanwe na ọgwụ ọgwụ nke Finlepsin na ndị ọrịa agadi.

Usoro onunu ogwu na nhazi

A na -ewere Finlepsin ọnụ site na mmiri zuru oke ma ọ bụ mmiri mmiri ọzọ. E kwesịrị iburu mbadamba na nri ma ọ bụ mgbe nri gasịrị.

N’oge àkwụkwụ na-adọ, ọ bụ ihe amamihe dị na ya ịkọ ọgwụ a n'ụdị monotherapy. Mgbe ị na-esonye na Finlepsin na ọgwụgwọ na-aga n'ihu, a ga-ahụ anya ma kpachara anya, ma ọ bụrụ na ọ dị mkpa, na-edozigharị ọgwụ ole eji eme ihe.

Mgbe ị na-egwufe ọgwụ ọzọ, ị ga-ewere mbadamba ihe echefuru ozugbo onye ọrịa chetara nke a. Can nweghị ike ị takeụ okpukpu abụọ nke carbamazepine.

Maka ọgwụgwọ Akwụkwụ, ọgwụ mbụ nke Finlepsin maka ndị okenye na ndị ntorobịa karịrị afọ 15 bụ 200-400 mg kwa ụbọchị. Mgbe nke a gasịrị, a na-abawanye ọgwụ ahụ ruo mgbe a ga-enweta nsonaazụ ọgwụgwọ kacha mma. Ogologo nlekọta mmezi nke ọgwụ ahụ sitere na 800 ruo 1200 mg kwa ụbọchị na usoro 1-3. Oke kachasị maka ndị okenye bụ 1600-2000 mg kwa ụbọchị.

Maka umuaka ndi oria n’akwara, ka edere ogwu ahu na ogwu ndia:

• ụmụaka gbara afọ 1-5: 100-200 mg kwa ụbọchị na mbido ọgwụgwọ, n'ọdịniihu a ga-eji nwayọ belata 100 mg kwa ụbọchị ruo mgbe a ga-enweta nsonaazụ ahụ chọrọ chọrọ, usoro mmezi ahụ bụ 200-400 mg kwa ụbọchị n'ọtụtụ usoro,
• ụmụaka dị afọ 6-10: 200 mg kwa ụbọchị, n'ọdịniihu, a ga-eji nwayọọ nwayọọ mụbaa ọgwụ ahụ site na 100 mg kwa ụbọchị ruo mgbe a ga-enweta nsonaazụ ahụ achọrọ, usoro mmezi bụ 400-600 mg kwa ụbọchị na 2-3 usoro,
• ụmụaka na ndị nọ n'afọ iri na otu nọ n’agbata afọ 11 ruo 15: 100-300 mg kwa ụbọchị, na-esochi mmụba nke ọgwụ na 100mgg kwa ụbọchị ruo mgbe a ga-enweta nsonaazụ achọrọ, usoro nlekọta ahụ bụ 600-1000 mg kwa ụbọchị na 2-3 usoro.

Ọ bụrụ na nwa ahụ enweghị ike ilo ihe dị na Finlepsin mbadamba, ọ ga-egwepịa ya, rie ya ma ọ bụ maa jijiji na mmiri ma drinkụọ ihe ga-esi na ya pụta.

Ogologo oge ọgwụ ahụ maka akwụkwụtọ na-adabere n'ihe ngosipụta na nzaghachi onye ọrịa n'otu n'otu na ọgwụgwọ. Dọkịta kpebiri oge ọ ga-eji gwọọ ọrịa ma ọ bụ mwepu nke Finlepsin dị iche iche maka onye ọrịa ọ bụla. A na-atụle ajụjụ nke belata dose ma ọ bụ ịkwụsị ọgwụ ahụ mgbe ọgwụgwọ afọ 2-3 gasịrị, n'oge ọdịdọ ahụ na-anọghị ya.

A na-eji nwayọ belata Finlepsin ihe karịrị afọ 1-2, na-elegide electroencephalogram oge niile. Site na mbelata nke ubochi ubochi n'ime umuaka, odi nkpa iburu n'uche mmụba nke afọ n’arụ n’arụ.

Na idiopathic glossopharyngeal neuralgia na trigeminal neuralgia, usoro mbụ nke ọgwụ ahụ bụ 200-400 mg kwa ụbọchị. N'ọdịnihu, ọ na-abawanye ruo 400-800 mg na 1-2 doses. Ọga n'ihu ruo mgbe ihe mgbu kwụsị kpamkpam. N'ime ụfọdụ ndị ọrịa, ọ ga-ekwe omume iji carbamazepine na usoro mmezi dị ala - 200 mg ugboro abụọ n'ụbọchị.

N'ime ndị ọrịa agadi na ndị nwere oke mmachi na Finlepsin, a na-enye ọgwụ ahụ na ọgwụ mbido, nke bụ 200 mg kwa ụbọchị na usoro abụọ kewara.

Ọ bụ n'ụlọ ọgwụ ka a na-ahụ maka ị withdrawalụ mmanya na-aba n'anya. Edere ọgwụ a na nkezi kwa ụbọchị dose nke 600 mg na usoro 3 kewara. N'okwu kachasị njọ, ịba ụba carbamazepine na-abawanye ruo 1200 mg kwa ụbọchị na usoro onwa atọ. Ọ bụrụ na ọ dị mkpa, a ga-eji ọgwụ ahụ otu oge na ọgwụ ndị ọzọ maka ọgwụgwọ nke ọrịa nkwụsị mmanya. Ọgwụgwọ kwụsịrị nwayọọ nwayọọ na oge nke 7-10 ụbọchị. N’oge ahụ niile, a ga-enyocha onye ọrịa ahụ anya maka mmepe mmepe nke nsonaazụ ya site na sistem ụjọ.

Maka mgbu na-esite na neuropathy na-arịa ọrịa mamịrị, a na-edenye Finlepsin na nkezi kwa ụbọchị nke 600 mg na usoro atọ kewara. N'ọnọdụ ndị na-adịghị ahụkebe, ọnụọgụ ahụ na-abawanye ruo 1200 mg kwa ụbọchị na usoro 3 kewara.

Maka ọgwụgwọ na mgbochi nke psychosis, a na-enye carbamazepine ọgwụ kwa ụbọchị nke 200-400 mg yana mmụba nke dose, ma ọ bụrụ na ọ dị mkpa, ka 800 mg kwa ụbọchị na usoro onwa abụọ.

Site na nkwarụ akwụkwụ na-emetụta ọtụtụ ọrịa sclerosis, a na-ede Finlepsin na ọnụọgụ 400-800 mg na nha abụọ kewara.

Nsonaazụ

Nsonaazụ nke ọgwụ sitere na sistemụ akwara na-esite na ya nwere ike ịbụ nsonaazụ nnyefere nke carbamazepine ma ọ bụ mgbanwe dị ukwuu na ịta ọgwụ a n'ọbara.

N'oge ọgwụgwọ Finlepsin, mmetụta ndị sitere na sistem na akụkụ ndị a nwere ike ime:

• sistem nri: oge ​​nile akpọnwụ akpịrị, ọgbụgbọ, ọgbụgbọ, mmụba nke ọrụ alkaline phosphatase na gamma glutamyl transferase, mgbe ụfọdụ afọ ntachi ma ọ bụ afọ ọsịsa, ihe mgbu n’ime afọ, ịba ụba ọrụ enzymes imeju, obere oge stomatitis, gingivitis, glossitis, parenchymal na cholestatic ịba ọcha n'anya, ịba ọcha n'anya, ịba ọcha n'anya, ọrịa nke imeju,
• sisitemu obi: ike - mmụba ma ọ bụ mbelata ọbara mgbali, mmepe ma ọ bụ na-akawanye njọ na nkụchi obi, bradycardia, nsogbu nke ọrịa obi na akwara, thromboembolic syndrome, isi ọwara intracardiac, ngọngọ nke ihe agha, yana mgbakasị ahụ, thrombophlebitis, ida,
• sistemụ akwara: isi ọwụwa, ụra, obi ọgbụgba, paresis nke ebe obibi, ataxia, adịghị ike izugbe, mgbe ụfọdụ nystagmus, mmeghari ahụ na - adịghị ala ala, adịkarịghị - enweghị agụụ, ụkọ okwu, nchekasị, ike akwara, ụbụrụ psychomotor, nkụda mmụọ, paresthesia, mgbaàmà paresis, auditory ma ọ bụ ihe ngosi nke ihe nlere anya, ọgba aghara nke oculomotor, disorientation, neuritis ọgụ, omume ike, ịgbalite mkpali, nsogbu nke choreoathetoid,
• akwara anụ ahụ: adịkarịghị - conjunctivitis, ígwé ojii nke oghere, ọgba aghara na uto, nkwarụ ntị, nsogbu intraocular mụbara,
• Usoro mkpụrụ ndụ: adịkarịghị - njigide nke urinary, ugboro ugboro urination, ọrụ na-arụ ọrụ na-arụ ọrụ nke ọma, nsogbu nephritis, mbelata ikike, ọdịda akụrụngwa,
• sistem: olu: olu mgbu, akwara na nkwonkwo,
• sistemụ metabolism na usoro endocrine: ọtụtụ mgbe - ịba ụba n’arụ ahụ, edema, hyponatremia, njigide mmiri, adịkarịghị - mmụba na mkpokọta thyroid na-akpali akpali na prolactin, mbelata nke ịta L-thyroxine, calcium na phosphorus metabolism na anụ ahụ, hypertriglyceridemia, hypercholesterolemia, osteomala, osteomala toba oke akpụ akpụ
• sisitemu hematopoietic: oge ​​- eosinophilia, thrombocytopenia, leukopenia, adịkarịghị - agranulocytosis, leukocytosis, reticulocytosis, hemolytic, megaloblastic na aplastic anaemia, lymphadenopathy, splenomegaly, folic acid deficiency, ezi erythrocyte aram,
• mmeghachi omume nfụkasị: oge ​​ụfọdụ - ọnya ọgbụgba, oge ụfọdụ - ụdị hypersensitivity na-egbu oge, mmeghachi omume anaphylactoid, nfụkasị ahụ nfụkasị, ọnya Quincke, aseptic meningitis, eosinophilic pneumonia, adịkarịghị - akpụkpọ ahụ mgbu, necrolysis na-egbu egbu, lupus-like syndrome, photoensitivity, multiform
• mmeghachi omume ndị ọzọ: ọnya, ntutu na-egbu egbu, purpura, ọsụsọ gabigara ókè, ụcha akpụkpọ ahụ.

Ime na lactation

Ọ ka mma ka ụmụ nwanyị ịmụ nwa depụta Finlepsin n'ụdị ọgwụgwọ monotherapy yana n'ọtụtụ kachasị dị irè, ebe ọ bụ na ugboro ugboro nke ajọ ọrịa ụmụaka na - amụ amụ, nke nne ya natara ọgwụ antiepileptik karịrị nke ụmụ ọhụrụ ndị nne ha natara naanị carbamazepine.

Womenmụ nwanyị dị ime, karịchaa na oge mbụ, a na-eji ọgwụ elebara ọgwụ anya, na-eburu uru ndị a tụrụ anya ya na nsogbu ndị ọ ga-ekwe omume. Finlepsin nwere ike ịbawanye ohere nke nsogbu ịmụba intrauterine n'ime ụmụ amụrụ ọhụrụ ndị nne ha na-arịa Akwụkwụ na-adọ.

Ọgwụ antiepileptik na - eme ka enweghi nri folic acid ka njọ, nke a na - ahụkarị na ụmụ nwanyị dị ime, yabụ mgbe ị na - eme atụmatụ ịtụrụ ime na mgbe ọ mere, a na - atụ aro ka a na - akwado prophylactic management nke folic acid. Iji gbochie nsogbu ọbara ọgbụgba n'ime ụmụ ọhụrụ, a na-atụ aro ụmụ nwanyị na njedebe afọ ime na ụmụ amụrụ ọhụrụ ịkọ vitamin K₁.

Finlepsin na-abanye na mmiri ara ara, yabụ na a ga-eleba ya anya mgbe a na-a breastụ ara, a ga-enyocha uru ndị a tụrụ anya ya maka nne na ihe nwere ike ibute nwata nwa ahụ.

Mkparịta ụka ọgwụ ọjọọ

Ntinye uche nke carbamazepine n'ime ọbara na-abawanye site na ojiji nke Finlepsin na ihe ndị na-esonụ na nhazi (mgbazi nke usoro onunu ogwu nke carbamazepine ma ọ bụ nlebara anya nke ịta ya na plasma chọrọ): felodipine, viloxazine, fluvoxamine, acetazolamide, desipramine, verapampoji, verapamiligaline, naanị na ndị okenye na oke onunu ogwu), diltiazem, azoles, macrolides, loratadine, isoniazid, nje protease inhibitors, terfenadine, propoxyphene, juice grape.

Ntinye uche nke carbamazepine na ọbara na-ebelata site na ojiji nke Finlepsin na ihe ndị a na-eso: phenytoin, metsuximide, theophylline, cisplatin, phenobarbital, primidone, rifampicin, doxorubicin, fensuximide, ikekwe valproic acid, clonazepazppaprolon, oxnaze oxon, mkpara 387

Carbamazepine pụrụ ibelata plasma kasịnụ nke ndị na-esonụ ọgwụ ọjọọ: clonazepam, ethosuximide, valproic acid, dexamethasone, prednisolone, tetracycline, methadone, theophylline, lamotrigine, tricyclic antidepressants, clobazam, digoxin, primidone, alprazolam, cyclosporine, haloperidol, onu anticoagulants, topiramate, felbamate, clozapine , Ndị na-egbochi nje HIV, nkwadebe ọnụ nwere progesterone na / ma ọ bụ estrogens, ndị na-egbochi calcium channel, tiagabine, levothyroxine, olazapine, risperidone, ciprasidone, oxcarbazepi n, praziquantel, tramadol, itraconazole, midazolam.

Site na iji Finlepsin na nkwadebe lithium, enwere ike ịkwalite mmetụta neurotoxic nke ọgwụ abụọ ahụ, yana tetracyclines - enwere ike ịbelata mmetụta ọgwụgwọ nke carbamazepine, na paracetamol - ihe egwu nke nsị nke paracetamol na imeju na-abawanye na ịdị irè ya belata, ya na diuretics, hyponatremia nwere ike, belata etinyere ya, belata ya, etinyere etinyere ya, belata ya, belata ya, belata ya, belata ya, belata ya, belata ya. ethanol, ya na isoniazid - a na-eme ka mmetụta hepatotoxic nke isoniazid dịkwuo mma, yana nkwarụ na-enweghị depolarizing - mmetụta ahụ na-akụda mmụọ. muscle relaxants, na myelotoxic ọgwụ - carbamazepine enwekwukwa haematotoxicity.

Mmetụta anticonvulsant nke Finlepsin na-agbada site na iji ya n'otu oge na pimozide, haloperidol, clozapine, phenothiazine, molindone, maprotiline, thioxanthenes na antidepressants tricyclic.

Carbamazepine na-eme ka metabolism nke mgbochi mgbochi homonụ, anticoagulants na-apụtakarị, ọgwụ na-egbu egbu, praziquantel na folic acid, ọ nwekwara ike ịkwalite secretion nke homonụ thyroid.

Ihe analogues nke Finlepsin bụ: Zeptol, Carbamazepine, Carbamazepine-Akrikhin, Carbamazepin-Ferein, Carbamazepine retard-Akrikhin, Tegretol TsR, Tegretol, Finlepsin retard.

Nyocha maka Finlepsin

Ndị ọrịa na-a takingụ ọgwụ ahụ ruo ọtụtụ afọ, yana ndị ikwu ha, na-ahapụ nyocha dị mma maka Finlepsin, ebe ọ bụ na ọgwụgwọ nke àkwụkwụ na-apụ n'anya n'ezie n'ihi ọgwụgwọ. N'otu oge ahụ, ụfọdụ ndị ọrịa na-achọpụta mmetụta ọjọọ nke ọgwụ ahụ na ọrụ ọgụgụ isi. Karịsịa, ha chọpụtara mmebi nke nkwukọrịta mmekọrịta yana mpụta nke enweghị mmasị.

Achọpụtara Finlepsin ka ọ bụrụ ọgwụgwọ dị mma maka mwakpo egwu, mana enweghị nkwụsi ike na ụfọdụ ndị ọrịa.

Omume ọgwụ

Ọgwụ antiepileptik (a dibunzigine ọgwụ), nke nwekwara ọgwụ antidepressant, antipsychotic na antidiuretic, nwere mmetụta analgesic na ndị ọrịa nwere neuralgia.

A na - ejikọta usoro nke ime ihe na mgbochi nke ọwa mmiri sodium voltaji, nke na - eduga na nkwụghachi nke akpụkpọ ahụ nke neurons nke na - ejedebe, na - egbochi ọdịdị nke mwepụ nke neurons yana mbelata nke usoro ihe ọgbụgba synaptik. Na-egbochi iwezigharị ike nke Na + na-arụ ọrụ ike na neurons. Na-ebelata ntọhapụ nke amino acid neurotransmitter na-akpali akpali - glutamate, na-eme ka ọnụ ala nhụchasị nke sistemụ akwara na-eme ka ọ dịkwuo ala, ma, si otú a, belata ihe ize ndụ nke ịmalite ịmịtọ ihe ọdịdọ. Ọ na - eme ka K + dịkwuo arụmọrụ, gbanwee modulu Ca 2+ nke voltaji, nke nwekwara ike itinye aka na mmetụta anticonvulsant nke ọgwụ.

Ọ dị mma maka ọdịdọ ọdịdọ (akụkụ dị mfe), yana ma ọ bụ enweghị ngwụcha jikọtara ya, maka ngwụsị nke tonic-clonic jikọtara ọnụ, yana maka njikọta ụdị ihe ọdịdọ ndị a (anaghị adịkarị mma maka obere ọdịdọ - petit mal, ọnụnọ na ọdịdọ myoclonic). Ndị ọrịa nwere akpa akwụkwụ (ọkachasị na ụmụaka na ndị nọ n’afọ iri na ụma) nwere mmetụta dị mma na mgbaàmà nke nchegbu na nkụda mmụọ, yana mbelata mgbakasị ahụ na oke iwe. Mmetụta na arụmọrụ cognitive na arụmọrụ psychomotor bụ dabere na ntanetị. Mmalite nke mmetụta anticonvulsant dịgasị site na ọtụtụ awa ruo ọtụtụ ụbọchị (mgbe ụfọdụ ruo ọnwa 1 n'ihi nhiwe nke metabolism).

Site na neuralgia trigeminal dị mkpa na nke abụọ, carbamazepine n'ọtụtụ oge na-egbochi mmalite nke mgbu mgbu. Ahụhụ ihe mgbu na trigeminal neuralgia bụ ama ama awa 8-72 gachara.

Site na ọrịa ịwepụ mmanya na-egbu egbu, ọ na-eme ka ọnụ ụzọ dị njikere maka ịdịrị njikere, nke a na-ebelata na ọnọdụ a, ma na-ebelata ogo ngosipụta nke ọrịa ahụ (oke iwe, oke ụjọ, ọgba aghara).

Ihe omume antipsychotic (antimaniacal) na-amalite mgbe ụbọchị 7-10 gasịrị, nwere ike ịbụ n'ihi mgbochi nke metabolism nke dopamine na norepinephrine.

Formdị usoro ịsụ ọgwụ ogologo oge na-eme ka enwekwu ohere ịgwọ ọrịa carbamazepine n'ọbara mgbe a na-ewere ya 1-2 ugboro n'ụbọchị.

Ime na lactation

Mgbe ọ bụla enwere ike, a na-enye Finlepsin ® retard ndị nwanyị oge ọmụmụ dịka monotherapy, na obere oge, Ugboro ugboro nke mmerụ ịmụ nwa site n'aka ndị nne bụ ndị jikọtara ọgwụ antiepileptik karịrị nke monotherapy.

Mgbe ime dị, ọ dị mkpa ịtụle uru a tụrụ anya na ọgwụgwọ na nsogbu ndị ọ ga-ekwe omume, ọkachasị n'oge ọnwa atọ mbụ nke ịtụrụ ime. A maara na ụmụaka nke nne na-arịa ọrịa akwụkwụ na-emerịrị ọrịa intrauterine development, tinyere mmejọ. Finlepsin ardard nwere ike iwelite ohere nke nsogbu ndị a. Enwere akụkọ dịpụrụ adịpụ nke ọrịa nke agbụrụ na arụrụ arụ, gụnyere na-enweghị mmechi nke oghere vertebral (spina bifida).

Ọgwụ Antiepileptic na-abawanye ụkọ folic acid, nke a na-ahụkarị n’oge afọ ime, nke nwere ike ime ka mmerụ ahụ dị n’etiti ụmụaka mụọ, yabụ na-atụ aro ị takingụ folic acid n’ihu ịtụrụ ime na n’oge ime. Iji gbochie nsogbu ọbara ọgbụgba n'ime ụmụ amụrụ ọhụrụ, a na-atụ aro ka ụmụ nwanyị ruzie izu ikpeazụ nke ime afọ, yana ụmụ amụrụ ọhụrụ, ka ha depụtara vitamin K.

Carbamazepine na-abanye n'ime mmiri ara, yabụ uru na mmetụta ndị ọ na-agaghị ekwe omume nke ị breastụ ara kwesịrị iji ya tụnyere usoro ọgwụgwọ na-aga n'ihu. Site n’ịnọgide na-a breastụ ara mgbe ị na-a theụ ọgwụ ahụ, ịkwesịrị igosipụta nlezianya maka nwatakịrị ahụ na o nwere ike ịmalite mmeghachi omume ọjọọ (dịka ọmụmaatụ, ụra ụra siri ike, mmeghachi ahụ anụ ahụ).

Usoro onunu ogwu na nhazi

N'imen'oge ma ọ bụ mgbe nri gị nwere ọtụtụ mmiri mmiri. Maka ịdị mfe nke iji ya, mbadamba (yana ọkara ya ma ọ bụ nkeji iri na ise) nwere ike ibula mmiri na mmiri ma ọ bụ ihe ọ juiceụ juiceụ, n'ihi a ga-edowe ihe nke ogologo oge ewepụtara nke ihe na-arụ ọrụ mgbe ịfesịrị mbadamba ihe na mmiri. Usoro onunu ogwu eji mee ihe bu 400-100 mg / ubochi, nke kewara 1-2 na ubochi.

Ogo kachasị kwa ụbọchị ekwesịghị ịgabiga 1600 mg.

N'ọnọdụ ebe enwere ike, ekwesịrị ịkọwa Finlepsin ard retard dị ka monotherapy. Ọgwụgwọ na-amalite site n'iji obere ọgwụ kwa ụbọchị, nke na-eji nwayọ nwayọ nwayọ ruo mgbe a ga-enweta nsonaazụ kachasị mma. Ekwesịrị iji mgbakwunye Finlepsin ard retard na ọgwụ na-aga n'ihu na-aga n'ihu iji nwayọọ nwayọọ, mgbe usoro ịsesụ ọgwụ ndị a na-eji agbanwe agbanwe ma ọ bụ, ọ bụrụ na ọ dị mkpa. Ọ bụrụ na onye ọrịa echefuru ị doseụ ọgwụ ọzọ na oge a, a ga-ewere ọgwụ ahụ echefuara ozugbo ozugbo achọpụtala, ma ị nweghị ike ị takeụ ọgwụ okpukpu abụọ.

Ndị okenye Usoro izizi bụ 200-400 mg / ụbọchị, mgbe ahụ, a ga-eji nwayọ were ọgwụ mee ihe ruo mgbe arụpụtara ezigbo ya. Ọkwa mmezi bụ 800- 1200 mg / ụbọchị, nke ekesara n'ime 1-2 awa kwa ụbọchị.

Childrenmụaka. Usoro izizi maka ụmụaka site na afọ 6 ruo 15 bụ 200 mg / ụbọchị, mgbe ahụ, a ga-eji nwayọọ nwayọọ mụbaa ọgwụ ahụ site na 100 mg / ụbọchị ruo mgbe a ga-enweta nsonaazụ kachasị mma. Kwado doses maka ụmụaka 6-10 afọ bụ 400-600 mg / ụbọchị (na 2 doses), maka ụmụaka 11-15 afọ - 600-1000 mg / day (na 2 onunu).

Ogologo oge eji na-adabere na ngosipụta na nzaghachi nke onye ọrịa na ọgwụgwọ. Mkpebi ịbufe onye ọrịa na Finlepsin ard retard, oge ọ ga-eji na kagbuo ọgwụgwọ ahụ bụ nke dọkịta. A na-atụle ohere ị belata ọgwụ ma ọ bụ ịkwụsị ọgwụgwọ mgbe afọ 2-3 gasịrị nke enweghị ọdịdọ zuru ezu.

A kwụsịrị ọgwụgwọ, jiri nwayọ belata ọgwụ nke 1-2 ruo afọ, n'okpuru nchịkwa EEG. N’aka umuaka, tinyere mbelata nke ubochi ubochi, a ga-atule uto nke aru ya na ndi agadi.

Trigeminal neuralgia, idiopathic glossopharyngeal neuralgia

Ọgwụ nke mbụ bụ 200-400 mg / ụbọchị, nke kewara abụọ. Ọbara mbụ ebido ruo mgbe ihe mgbu kwụsịrị kpamkpam, na nkezi ruo 400-800 mg / ụbọchị. Mgbe nke ahụ gasị, n'otu akụkụ nke ndị ọrịa, enwere ike ịga n'ihu na ọgwụgwọ nlekọta dị ala nke 400 mg.

Edere Finlepsin ardardard na ndị ọrịa agadi na ndị ọrịa nwere Karabamazepine na ntinye ọgwụ nke 200 mg otu ugboro n'ụbọchị.

Mgbu na neuropathy mamịrị

Ihe nkezi ubochi kwa ụbọchị bụ 200 mg n'ụtụtụ yana 400 mg na mgbede. N'ọnọdụ ndị pụrụ iche, enwere ike ịkọwa Finlepsin ® retard na dose 600 mg ugboro abụọ n'ụbọchị.

Ọgwụ n'ụlọ ọgwụ na-a withdrawalụ mmanya

Ihe nkezi ubochi kwa ụbọchị bụ mg mg (200 mg n'ụtụtụ na 400 mg na mgbede). N'okwu ndị siri ike, na ụbọchị mbụ, enwere ike ịbawanye ọgwụ ahụ ruo 1200 mg / ụbọchị, nke kewara abụọ.

Ọ bụrụ na ọ dị mkpa, enwere ike ijikọ Finlepsin ard retardps na ihe ndị ọzọ eji eme ihe maka ị withdrawalụbiga mmanya ókè, na mgbakwunye na ọgwụ ọgbụgba.

N'oge ọgwụgwọ, ọ dị mkpa iji nlezianya nyochaa ọdịnaya nke carbamazepine na plasma ọbara.

N'ihe banyere mmepe omume nke nsonaazụ ndị sitere na sistemụ akwara na akwara autonomic, a na-elezi ndị ọrịa anya n'ụlọ ọgwụ.

Akwụkwụ na-adọ adọ n'ime otutu sclerosis

Ihe nkezi ubochi kwa ụbọchị bụ 200-400 mg ugboro abụọ kwa ụbọchị.

Ọgwụgwọ na mgbochi nke psychosis

Usoro ọgwụgwọ na usoro mmezi na-abụkarị otu - 200-400 mg / ụbọchị. Ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye dose ahụ ruo 400 mg ugboro abụọ kwa ụbọchị.

Mmekọrịta na ọgwụ ndị ọzọ

Nlekọta oge nke carbamazepine na ndị na - egbochi CYP3A4 nwere ike ibute mmụba na plasma ọbara ma mee ka mmeghachi omume ọjọọ. Nchikota ojiji nke CYP3A4 inducers nwere ike iduga na mmeba nke metabolb nke carbamazepine, mbelata nke mkpocha nke carbamazepine na plasma obara na mbelata na ogwugwo ogwu, nke ozo, iwepu ha nwere ike belata onodu biotransformation nke carbamazepine ma duga mmụba na mkpo ya.

Mkpoko nke carbamazepine na plasma abawanyele site na verapamil, diltiazem, felodipine, dextropropoxyphene, viloxazine, fluoxetine, fluvoxamine, cimetidine, acetazolamide, danazole, desipramine, nicotinamide (na okenye, naanị na ha, a ga-eji ya, ya na ya, ya na ya, ya na ya, ya na ya, ya na ya, ya na ya, ya na ya, ya na ya, ya na ya, ya na ya, ya na ya,), ya na ya, ya, ya, ya, ya, ya, na ya, (itraconazole, ketoconazole, fluconazole), terfenadine, loratadine, isoniazid, propoxyphene, ihe ọ juiceụ ,ụ mkpụrụ osisi, inhibitors viral nke eji mee ihe na ọgwụgwọ nje HIV (dịka ọmụmaatụ ritonavir) - a chọrọ ndozi nhazi usoro onunu ogwu. na nlekota plasma nke carbamazepine.

Felbamate na-ebelata ịta nke carbamazepine na plasma ma na-eme ka ịta ahụhụ nke carbamazepine-10,11-epoxide pụta, ebe mbelata nke oge n'otu na nchịkọta nke felbamate ga-ekwe omume.

A na-ebelata mkpụkọ nke carbamazepine site na phenobarbital, phenytoin, primidone, metsuximide, fensuximide, theophylline, rifampicin, cisplatin, doxorubicin, enwere ike clonazepam, valpromide, valproic acid, oxcarbazepine na ngwaahịa herbal nwere St John's wort. (Hypericum perforatum). Enwere ohere nke mkpocha nke carbamazepine site na valproic acid na primidone site na njikọta na protein protein na mmụba nke mkpokọta ọgwụ na-arụ ọrụ (carbamazepine-10,11-epoxide). Site na ijiri finlepsin na valproic acid, n'ọnọdụ dị iche, coma na ọgba aghara nwere ike ime. Isotretinoin gbanwere bioavailability na / ma ọ bụ nhichapụ nke carbamazepine na carbamazepine-10,11-epoxide (nyochaa nlebara anya nke carbamazepine na plasma dị mkpa).

Carbamazepine nwere ike belata mkpokọta plasma (belata ma ọ bụ ọbụna wepu mmetụta kpamkpam) ma chọọ ndozi nke ọgwụ ndị a: clobazam, clonazepam, digoxin, ethosuximide, primidone, valproic acid, alprazolam, corticosteroids (prednisolone, dexamethasone, cyclospinin cylin, cyclospinin cylin, cyclospinin cylin, cyclosporin cyclin, cyclospinin cylin, cyclospin, cyclospinin cylin, cyclospin, cyclospin, cyclospin, cyclospinin cyto cylin, cyclospin, cyclospin, cyclospinin cyto cylin, cyclospin, cyclospinin, cyclosporin, cyclospin, cyclospinin, cyclospinin, cyclospinin, cyclospinin, cyclospinin, cyclospin, cyclosplin haloperidol, methadone, nkwadebe ọnụ nwere estrogens na / ma ọ bụ progesterone (nhọrọ nke usoro ọgwụgwọ igbochi ọzọ dị mkpa), theophylline, ọgwụ anticoagulants (warfarin, fenprocoumone, dicumar) la), lamotrigine, topiramate, tricyclic antidepressants (imipramine, amitriptyline, northriptyline, clomipramine), clozapine, felbamate, tiagabine, oxcarbazepine, ndị na-egbochi nchebe na-eji ọgwụgwọ nke nje HIV (indinavir, ritonavir, saquidine, saquidine, saquidine felodipine), itraconazole, levothyroxine, midazolam, olanzapine, praziquantel, risperidone, tramadol, ziprasidone.

Enwere ohere ịbawanye ma ọ bụ ibelata phenytoin na plasma ọbara megide ndabere nke carbamazepine ma nwekwuo ọkwa nke mefenytoin. N'iji oge nke carbamazepine na njikere lithium, enwere ike ịkwalite mmetụta neurotoxic nke ma ihe na-arụ ọrụ.

Tetracyclines nwere ike belata ọgwụgwọ ọgwụgwọ carbamazepine. Mgbe ejikọtara ya na paracetamol, ihe ọghọm nke nsí ya na imeju na-abawanye ma ọ ga-agbake ma na-agwọ ya.

Nlekọta oge nke carbamazepine nwere phenothiazine, pimozide, thioxanthenes, mindindone, haloperidol, maprotiline, clozapine na tricyclic antidepressants na-eduga na mmụba nke mmetụta inhibitory na sistemụ akwara na ụkọ nke anticonvulsant mmetụta nke carbamazepine.

Ndị na - egbochi MAO na - ebute nsogbu nke ịba ụba ọrịa hyperpyrethmic, ọdụdọ nke ọbara mgbali elu, ọdịdọ, na nsonaazụ (a ga - ewepụ ndị gbochiri MAO ma ọ dịkarịa ala izu abụọ tupu ma ọ bụ mgbe enyere carbamazepine ọgwụ, ma ọ bụ ọ bụrụ ọnọdụ ụlọ ọgwụ na - enye ohere, ọbụlagodi ogologo oge).

Nlekọta nke imekotaotu oge ya na diuretics (hydrochlorothiazide, furosemide) nwere ike ibute hyponatremia, ya na ngosipụta nke ulo ogwu.

Ọ na –emepụta nsonaazụ nke ndị na - anaghị eme ka ahụ dị jụụ (pancuronium). N'ihe banyere iji ụdị ngwakọta a, ọ nwere ike ịdị mkpa ka iwelie ọnya na-eme ka ahụ ghara izu ike, ebe ịlele ọnọdụ onye ọrịa anya dị mkpa n'ihi ekwe omume ịkwụsịtụ ngwangwa ngwa ngwa.

Carbamazepine na-ebelata nnabata ethanol.

Ọgwụ Myelotoxic na-abawanye hematotoxicity nke ọgwụ.

Ọ na - eme ka metabolism nke anticoagulants na - apụtaghị ìhè, mgbochi nke homonụ, folic acid, praziquantel, ma nwee ike ịkwalite mkpochapụ homonụ thyroid.

Ọ na - eme ka metabolism nke ọgwụ na - agwọ ọrịa na - egbochi ọgwụ na - eme ka ọ bụrụ nke na - eme ka ọ bụrụ ihe na - eme ka ọ na - eme ka metabolism nke metabolic nephrotoxic nke methoxyflurane. Na-eme ka mmetụta hepatotoxic nke isoniazid dị.

Njirimara ngwa

Monotherapy nke Akwụkwụ na-amalite site na nhọpụta nke obere mmalite mbụ, jiri nwayọ na-abawanye ya ruo mgbe a ga-enweta nsonaazụ ọgwụgwọ chọrọ.

Mgbe ị na-ahọrọ oke kachasị mma, ọ bụ ihe amamihe dị na ya ikpebi itinye uche nke carbamazepine na plasma ọbara, ọkachasị yana usoro ọgwụgwọ. N'ọnọdụ ụfọdụ, oke kachasị mma nwere ike ịhapụ ụzọ dị iche iche a tụrụ aro ya na usoro mmezi, dịka ọmụmaatụ, n'ihe metụtara ntinye nke enzymes imeju microsomal ma ọ bụ n'ihi mmekọrịta na usoro njikọta.

Ekwesighi ijikọ Carbamazepine yana ọgwụ ogwugwo. Ọ bụrụ na ọ dị mkpa, a ga-ejikọ Finlepsin ardardard na ihe ndị ọzọ eji eme ka mmanya kwụsị. N'oge ọgwụgwọ, ọ dị mkpa iji nlezianya nyochaa ọdịnaya nke carbamazepine na plasma ọbara. Na njikọ mmepe nke mmetụta ndị sitere na sistemụ akwara na akwara autonomic, a na-elezi ndị ọrịa anya n'ụlọ ọgwụ. Mgbe ị na-ebufe onye ọrịa ahụ na carbamazepine, a ga-eji nwayọ belata ọgwụ nke ọgwụ antiepileptik nke edere ruo mgbe ọ ga-akagbu kpamkpam. Contkwụsị carbamazepine na mberede nwere ike ịkpalite ọdịdọ. Ọ bụrụ na ọ dị mkpa ịkwụsịtụ ọgwụgwọ ngwa ngwa, a ga-ebufe onye ọrịa ahụ na ọgwụ ọgwụ antiepileptik ọzọ n'okpuru aghụghọ nke ọgwụ egosipụtara na ụdị ndị ahụ (dịka ọmụmaatụ, diazepam nyere iv ma ọ bụ n'ụzọ anọ, ma ọ bụ phenytoin inv iv).

Enwere otutu okwu ọgbụgbọ, afọ ọsịsa na / ma ọ bụ belata nri, ụkwara ume ọkụ na / ma ọ bụ nkụda mmụọ na ụmụ amụrụ ọhụrụ ndị nne ha buru carbamazepine n’otu oge na anticonvulsants ndị ọzọ (ikekwe mmeghachi omume ndị a bụ ngosipụta nke ọrịa mbugharị na ụmụ amụrụ ọhụrụ). Tupu ịkọwa carbamazepine na n'oge ọgwụgwọ, ịmụ banyere ọrụ imeju dị mkpa, karịsịa na ndị ọrịa nwere akụkọ banyere ọrịa imeju, yana ndị ọrịa agadi. N'ihe banyere mmụba nke nsị imeju dị adị ma ọ bụ mgbe ọrịa imeju na-arụ ọrụ mere, a ga-akwụsị ọgwụ ozugbo. Tupu ịmalite ọgwụgwọ, ọ dị mkpa ịmụ banyere foto ọbara (gụnyere ịgụta platelet, reticulocytes), ọkwa nke iron n'ọbara ọbara, ule mmamịrị n'ozuzu, ọkwa urea n'ọbara, otu electroencephalogram, mkpebi siri ike nke mkpokọta electrolytes n'ọbara ọbara (na kwa oge n'oge ọgwụgwọ, n'ihi enwere ike mmepe nke hyponatremia). Na-esote, ekwesịrị inyocha akara ndị a n'oge ọnwa mbụ nke ọgwụgwọ kwa izu, yana kwa ọnwa.

N'ọnọdụ ka ukwuu, mbelata nke na-ebugharị nwa oge na platelet na / ma ọ bụ ọnụ ọgụgụ ọbara ọcha abụghị ihe ọjọọ na mmalite nke anaemia ma ọ bụ agranulocytosis. Ka o sina dị, tupu ịmalite ọgwụgwọ, yana oge ụfọdụ n'oge usoro ọgwụgwọ ahụ, a ga-enyocha ọbara nyocha nke ụlọ ọgwụ, gụnyere ịgụta ọnụ ọgụgụ platelet na ikekwe reticulocytes, yana ikpebi ọkwa nke iron n'ọbara ọbara. Ọrịa leukopenia na-anaghị enwe ọganihu anaghị achọ ịdọrọ, Otú ọ dị, a ga-akwụsị ọgwụgwọ ma ọ bụrụ na leukopenia na-aga n'ihu ma ọ bụ leukopenia, tinyere akara ngosipụta nke ọrịa na-efe efe.

Ekwesịrị ịwepụ Carbamazepine ozugbo ma ọ bụrụ na mmeghachi omume hypersensitivity ma ọ bụ ihe mgbaàmà pụtara, na-atụ aro mmepe nke Stevens-Johnson syndrome ma ọ bụ ọrịa Lyell. Mmeghachi omume anụ ahụ (nke dịpụrụ adịpụ macularpapular exquhema) na-apụkarị n'ime ụbọchị ole na ole ma ọ bụ izu ole na ole, ọbụlagodi mgbe ọ na-aga n'ihu ma ọ bụ mgbe mbelata ọgwụ (dọkịta kwesịrị ilebara onye ọrịa ahụ anya n'oge a).

Ekwesịrị iburu ime ka mmuta uche na-eme n'oge na-adịghị anya pụta ìhè, na ndị ọrịa mere agadi, enwere ike ịmalite mkpaghasị uche ma ọ bụ mkpasu iwe psychomotor.

N'ọnọdụ ụfọdụ, omume nke iji ọgwụ igbu onwe ya yana ihe omume na igbu onwe onye na ebumnuche igbu onwe ya. Egosiputara nke a site na iji usoro nyocha nke ọnwụnwa nyocha ụlọ ọgwụ site na iji ọgwụ antiepileptik. Ebe ọ bụ na amabeghị usoro ihe omume nke igbu onwe onye mgbe ị na-eji ọgwụ antiepileptik, isi ya enweghị ike ịhapụ ịkọwa ya na usoro ndị ọrịa nwere Finlepsin ® retard. A ga-adọ ndị ọrịa (na ndị ọrụ) aka na ntị gbasara mkpa ọ dị ịcheba anya ntopute nke echiche igbu onwe / omume igbu onwe ya, ma enwere ihe mgbaàmà, chọọ nlekọta ahụike ozugbo.

Enwere ike ịmịpụta nwoke ọmụmụ yana / ma ọ bụ nwee nsogbu spermatogenesis, agbanyeghị, mmekọrịta nke nsogbu ndị a na carbamazepine enwebeghị ike. Ngosipụta nke ọbara ọgbụgba n'etiti mmadụ na - ejikwa ọgwụ mgbochi ọnụ ọnụ n'otu oge ga-ekwe omume. Carbamazepine nwere ike imetụta ntụkwasị obi nke mgbochi afọ, yabụ, ụmụ nwanyị nke afọ omumu kwesịrị iji usoro ndị ọzọ nke nchebe ime n’oge ọgwụgwọ. Ekwesịrị iji Carbamazepine naanị n'okpuru nlekọta ahụike.

Ọ dị mkpa iji mee ka ndị ọrịa mara banyere ihe ịrịba ama nke mmalite nke egbu egbu, yana ihe mgbaàmà sitere na anụ ahụ na imeju. A gwa onye ọrịa banyere mkpa ọ dị ịkpọtụrụ dọkịta ozugbo ma ọ bụrụ na mmeghachi omume na-adịghị mma dịka ahụ ọkụ, akpịrị, ọnya, ọnya ọnya ọnụ, enweghị ọnya ọgbụgba, ọbara ọgbụgba n'ụdị petechiae ma ọ bụ purpura.

Tupu ịmalite ọgwụgwọ, a na-atụ aro maka nyocha nke ophthalmic, gụnyere nyocha nke fundus na tụọ mgbali intraocular. N'ihe banyere idegara ndị ọrịa ọgwụ mgbali intraocular ọgwụ, ọ dị mkpa ileba anya n'ihe ngosipụta a oge niile.

Ndị ọrịa nwere ajọ ọrịa obi, mmebi imeju na akụrụ, yana ndị agadi ka edepụtara ọgwụ oke. Ọ bụ ezie na njikọ dị n'etiti dose nke carbamazepine, ntinye ya na nrụpụta ọrụ ya ma ọ bụ ịnagide ya dị obere, agbanyeghị, mkpebi siri ike nke larịị nke carbamazepine nwere ike ịba uru n'ọnọdụ ndị a: iji mmụba dị ukwuu na ugboro ugboro nke ọgụ, iji chọpụta ma onye ọrịa ahụ na-a isụ ọgwụ ahụ nke ọma. n'oge afọ ime, n'ọgwụgwọ ụmụaka ma ọ bụ ndị na-eto eto, site na ịgwọ ọrịa ịgwọ ọrịa ọgwụ na-enyo enyo, ya na mmepe nke mmeghachi omume nsi ma ọ bụrụ na onye ọrịa ahụ ewere ya. ultiple ọgwụ ọjọọ.

N'oge ọgwụgwọ Finlepsin ardardard, a na-atụ aro ka ọ hapụ ị alcoholụ mmanya.

Nkọwa nke usoro onunu ogwu, ihe mejupụtara

Mpempe akwụkwọ Finlepsin nwere akụkụ gbara ya gburugburu, ihu nwere ihu abụọ, akụkụ ya dị okirikiri, yana agba ọcha. Ihe kachasị dị mkpa nke ọgwụ ahụ bụ carbamazepine, ọdịnaya ya na otu mbadamba bụ 200 mg. Ọzọkwa, ihe mejupụtara ya gụnyere ihe ndị ọzọ inyeaka, nke gụnyere:

• Stereta magnesium.
• Gelatin
• Microcrystalline cellulose.
• Croscarmellose sodium.

Mpempe akwụkwọ Finlepsin na-etinye na ngwungwu na-acha uhie uhie 10. Otu mkpọ kaadi nwere blisters 5 (mbadamba 50), yana ntuziaka maka iji ọgwụ ahụ.

Iji ya n'ụzọ kwesịrị ekwesị, usoro onunu ogwu

A na-eche mbadamba Finlepsin maka nchịkwa ọnụ (nchịkwa ọnụ) n'oge nri ma ọ bụ mgbe nri gasịrị. A areụchaghị mmiri ma sachaa ha. Ofzọ njikwa ọgwụ ahụ na usoro onunu ogwu si dabere na ngosipụta na afọ onye ọrịa:

• Akwụkwụ na-adọ - a na-atụ aro iji ọgwụ ahụ dịka monotherapy. N'ihe omume nke iji ọgwụ anticonvulsants ndị ọzọ ejiri ọgwụ ọgwụ eme ihe ma ọ bụ na-eji ya n'oge edepụta mbadamba Finlepsin, usoro a ga-amalite na nke kacha nta. Ọ bụrụ na imafere usoro a ga-enye gị, kwesịrị iwere ya ngwa ngwa o kwere mee, ebe ị na-enweghị ike okpukpu abụọ nke usoro onunu ogwu. Maka ndị okenye, usoro ọgwụgwọ mbụ bụ 200-400 mg (mbadamba 1-2), mgbe ahụ ọ na-amụba nwayọ iji nweta nsonaazụ ọgwụgwọ achọrọ. Ọgwụ mmezi bụ 800-1200 mg kwa ụbọchị, kewara 2-3 usoro. Usoro kachasị elu kwa ụbọchị ekwesịghị gafere 1.6-2 g. Maka ụmụaka, usoro onunu ogwu dabere na afọ. Maka ụmụaka gbara afọ 1-5 - 100-200 mg jiri mmụba nke 100 mg kwa ụbọchị ruo mgbe arụpụtara ezigbo ọgwụgwọ, na-abụkarị 400 mg, afọ 6-12 - usoro ọgwụgwọ mbụ bụ 200 mg kwa ụbọchị yana mmụba nwayọ nwayọ ruo 400- 600 mg, afọ 12-15 - 200-400 mg na mmụba nwayọ ruo 600-1200 mg.
• Trigeminal neuralgia - usoro ọgwụgwọ mbụ bụ 200-400 mg, a na-eji nwayọọ nwayọọ abawanye na 400-800 mg. N'ọnọdụ ụfọdụ, 400 mg ezuru iji belata ogo ihe mgbu.
• Mwepụ mmanya na-egbu egbu, ọgwụgwọ nke a na-eme na ọnọdụ ụlọ ọgwụ - usoro ọgwụgwọ mbụ bụ 600 mg kwa ụbọchị, nke kewara n'ime usoro 3. Ọ bụrụ na ọ dị mkpa, enwere ike ịbawanye ya ruo 1200 mg kwa ụbọchị. Is Tụ ọgwụ ahụ ga-eji nwayọ kwụsị. Ekwesịrị iji ọgwụ ndị ọzọ maka oge nke ọgwụgwọ mgbapụta na-ahapụ n'otu oge.
• Ọrịa mgbu na neuropathy mamịrị - nkezi usoro ọgwụ kwa ụbọchị bụ 600 mg, n'ọnọdụ dị iche, ọ na-agbago na 1200 mg kwa ụbọchị.
• Akwụkwụ na-adọ akụkụ ya, nzụlite nke a na-akpasu iwe site na otutu sclerosis - 400-800 mg otu ugboro n'ụbọchị.
• Mgbochi na ọgwụgwọ nke psychosis - usoro ọgwụgwọ mbụ na mmezi bụ 200-400 mg kwa ụbọchị, ọ bụrụ na ọ dị mkpa, ọ nwere ike ịbawanye 800 mg kwa ụbọchị.

Mkpebi nke oge ọgwụ na mbadamba Finlepsin na-ekpebi n'otu n'otu site na dọkịta na-aga ya.

Atụmatụ eji

Tupu o dee mbadamba Finlepsin, dọkịta ahụ ejiri nlezianya gụọ ntuziaka maka ọgwụ ahụ wee dọta uche gaa n'ọtụtụ atụmatụ nke ojiji eji ya.

• Monotherapy nwere ọgwụ bidoro na obere usoro mmalite dị ntakịrị, nke a na-eji nwayọ nwayọ rue mgbe a ga-enweta nsonaazụ ọgwụgwọ.
• Site na nhọrọ nke usoro ọgwụgwọ ahụ n'otu n'otu, a na-atụ aro ka a chọpụta mkpebi ụlọ nyocha nke ịba ụba nke carbamazepine n'ime ọbara.
• Mgbe ị na-ewere mbadamba Finlepsin, ọdịdị nke mmadụ igbu onwe ya na onye ọrịa apụtaghị, nke chọrọ dọkịta nyochara ya nke ọma.
• Agaghị akwado ka ịgwakọta ọgwụ ahụ na ọgwụ ịra ụra na ọgwụ mgbochi, ewezuga ojiji ha maka ọgwụgwọ mgbaàmà nkwụsị na mmanya na-adịghị ala ala.
• Mgbe ị na-ede mbadamba ihe ndị dị na Finlepsin ka ị na-eji ọgwụ ndị ọzọ anticonvulsants, ha kwesịrị iji belata ọgwụ ha.
• Na-agbaso usoro ọgwụgwọ ọgwụ, ịlele ụlọ nyocha oge nke ọrụ akụrụ, imeju, na ọbara na-agafe agafe.
• Tupu i detuo mbadamba ihe ndị dị na Finlepsin, a na-atụ aro ka ọ mụọ ọmụmụ ụlọ nyocha zuru oke na nyocha ọbara (biochemistry, nyocha ụlọ ọgwụ), mmamịrị A na-eme nyocha ndị dị otú ahụ kwa oge.
• Ọ dị mkpa ijikwa ọnụ ọgụgụ ọbara nha nke mkpụrụ ndụ megide ndabere nke usoro ọgwụgwọ ọgwụ ogologo oge.
• N'ime ndị ọrịa agadi, mgbe ịmalitechara mbadamba Finlepsin, ihe ize ndụ nke ngosipụta nke latent (latent) psychosis na-abawanye.
• Anaghị egbochi ime nwoke ọmụmụ nwa nwoke na - anaghị enwe nwa oge n'ihi ọgwụ a, n'ime ụmụ nwanyị - ọhụụ nke ọbara ọgbụgba n'etiti nwoke.
• Na mmalite nke usoro ọgwụgwọ na ọgwụ ahụ, yana oge ụfọdụ n'oge ọ na-aga n'ihu, a ga-eme ọmụmụ banyere ọrụ nke akụkụ nke ọhụụ.
• Mgbe ị na-eji mbadamba Finlepsin, a naghị atụ aro ị alcoholụ mmanya.
• Ojiji nke ọgwụ dịịrị ụmụ nwanyị dị ime ga-ekwe omume naanị mgbe a họpụtara dọkịta maka ihe ahụike siri ike.
• Akụkụ ahụ na-arụ ọrụ nke ọgwụ ahụ nwere ike ịmekọrịta ọgwụ nke otu ọgwụ ọgwụ ndị ọzọ, nke dọkịta aghaghị iburu n'uche tupu nhọpụta ya.
• Ebe ọgwụ ahụ nwere mmetụta ọfụma na ọrụ sistemụ akwara, yabụ, megide usoro a na-eji eme ya, ọ gaghị ekwe omume itinye aka n'ihe omume ndị dị ize ndụ, yana mkpa maka ọsọ ọsọ nke mmeghachi omume psychomotor na ntinye uche.

Mpempe akwụkwọ Finlepsin dị na ahịa ọgwụ dị na ndenye ọgwụ. Iji gbochie mmepe nke nsogbu na nsonaazụ ahụike na-adịghị mma, a naghị atụ aro ya iji ha na onwe ha.