Hypothiazide: ntuziaka maka ojiji

N'isiokwu a, ị nwere ike gụọ ntuziaka maka iji ọgwụ Hypothiazide. Na-enye nzaghachi site n'aka ndị ọbịa na saịtị ahụ - ndị na-eri ọgwụ a, yana echiche nke ndị ọkachamara n'ịgwọ ọrịa gbasara ojiji Hypothiazide na omume ha. A nnukwu arịrịọ bụ ifịkwo tinye nyocha gị banyere diuretic ahụ: ọgwụ ahụ nyeere ma ọ bụ enyereghị aka iwepụ ọrịa ahụ, ihe nsogbu na nsonaazụ ndị a hụrụ, ikekwe ọ bụ ọkwa onye nrụpụta na nkọwapụta. Hypothiazide analogues na ọnụnọ nke usoro analogues dịnụ. Jiri maka ọgwụgwọ ọbara mgbali elu na ọrịa ọrịa edematous na ndị okenye, ụmụaka, yana n’oge ime na lactation.

Hypothiazide - diuretic (diuretic). Primaryzọ kachasị mma nke thiazide diuretics bụ ka iwelie diuresis site na igbochi ndọghachi nke sodium na ion nke chlorine na akụkụ mbụ nke tubules akụrụ. Nke a na - ebute ịba ụba nke sodium na chlorine na, yabụ, mmiri. Mmeghe nke electrolytes ndị ọzọ, ya bụ potassium na magnesium, na-abawanye. N’ime usoro ọgwụgwọ kachasị, mmetụta diuretic / natriuretic nke thiazides niile bụ ihe otu.

Natriuresis na diuresis na - apụta n'ime awa 2 wee rute ogo kachasị elu mgbe ihe dị ka elekere anọ gachara.

Thiazides belatara ọrụ carbon anhydrase site na ịbawanye ụba nke bicarbonate ion, mana mmetụta a na-esikarị ike ma gharakwa emetụta pH nke mmamịrị.

Hydrochlorothiazide (ihe na-arụ ọrụ nke ọgwụ Hypothiazide) nwekwara ihe antihypertensive. Ọrịa Thiazide anaghị emetụta ọbara nkịtị.

Ngwakọta

Hydrochlorothiazide + ndị anụ ọhịa.

Mlọ ọgwụ

Hypothiazide ezughi ezu, ma a na-etinye ya ngwa ngwa site na ngwara. Mmetụta a dịgide ruo awa 6-12. Hydrochlorothiazide na-agafe ihe mgbochi placental ma na-apụ apụ na mmiri ara. Routezọ mbụ mwepụ ahụ bụ site na akụrụ (filtration na secretion) n'ụdị agbanwebeghị.

Ihe na-egosi

• ọbara mgbali ọbara (ma maka monotherapy yana yana ọgwụ ndị ọzọ na - egbochi mmiri),
• ọrịa edema nke mmalite dị iche iche (obi na-adịghị ala ala, nephrotic syndrome, premenstrual tension syndrome, nnukwu glomerulonephritis, ọdịda akụrụ na-adịghị ala ala, ọbara mgbali portal, ọgwụgwọ na corticosteroids),
• nchịkwa nke polyuria, tumadi ya na insipidus nephrogenic,
• mgbochi nke ịkpụpụta okwute n’ime oghere ọnya n’arụ n’arụ ndị ọrịa na-arịa (belata hypercalciuria).

Dị Mwepụta

Mbadamba 25 mg na 100 mg.

Ntụziaka maka ojiji na usoro onunu ogwu

Ekwesịrị ịhọrọ dose ahụ n'otu n'otu. Site na nlekọta ahụike mgbe niile, etinyere obere ọgwụ dịkarịrị ala. Ekwesịrị iji ọgwụ a gwọ ya ọgwụ mgbe ị risịrị nri.

Site na ọbara mgbali elu, usoro izizi bụ 25-50 mg kwa ụbọchị otu ugboro, n'ụdị nke monotherapy ma ọ bụ na njikọta ya na ndị nnọchianya antihypertensive. Maka ụfọdụ ndị ọrịa, ọgwụ izizi nke 12.5 mg ezuru (ma dị ka monotherapy na njikọta). Ọ dị mkpa itinye obere opekempe ịba uru, ọ bụghị karịa 100 mg kwa ụbọchị. Mgbe ị na-ejikọ hypothiazide na ọgwụ ndị ọzọ na-egbochi mmiri, ọ nwere ike ịdị mkpa iji belata ọgwụ ọzọ iji gbochie mbelata ọbara mgbali elu.

A na-egosipụta mmetụta antihypertensive n'ime ụbọchị 3-4, mana ọ nwere ike were izu 3-4 iji nweta nsonaazụ kachasị mma. Mgbe usoro ọgwụgwọ ahụ gasịrị, mmetụta hypotensive na-adịgide ruo izu 1.

Site na ọrịa edematous nke mmalite dị iche iche, usoro izizi bụ 25-100 mg kwa ụbọchị otu ugboro ma ọ bụ otu oge n'ime ụbọchị 2. Dabere na nzaghachi ụlọ ọgwụ, enwere ike belata ọgwụ ahụ ruo 25-50 mg kwa ụbọchị otu ugboro ma ọ bụ otu ugboro kwa ụbọchị 2. N'ọnọdụ ụfọdụ siri ike, na mmalite ọgwụgwọ, enwere ike ịbawanye ụba nke ọgwụ ahụ ruo 200 mg kwa ụbọchị.

Prenwe ọgwụ mgbochi obia premenstrual, a na-enye ọgwụ ahụ ọgwụ na ọgwụ 25 mg kwa ụbọchị ma jiri ya malite mmalite nke mgbaàmà ruo mmalite nke oge nsọ.

Site na insipidus nephrogenic, a na-atụ aro ọgwụ kwa ụbọchị nke 50-150 mg (n'ọtụtụ usoro).

N'ihi ụba ụba nke ion potassium na magnesium ion n'oge ọgwụgwọ (ọkwa nke potassium nwere ike ịdị

Omume ọgwụ

Mmetụta diuretic hydrochlorothiazide bụ nke bụ isi maka mgbochi nke reabsorption nke Na + na SG na ọdụ taliles. N'okpuru mmetụta ya, a na-emeziwanye ntụpọ nke Na + na SG na, n'ihi nke a, mmiri mmiri, yana potassium na magnesium. Mmetụta diuretic nke hydrochlorothiazide na-ebelata olu nke inyefe plasma, na-eme ka ọrụ nke plasma renin dịkwuo elu, na-eme ka mkpụrụ ndụ nke aldosterone pụta, n'ihi nsị nke potassium na bicarbonate na mmamịrị na-abawanye na ntinye nke potassium na serum na-ebelata. Angiotensin-P na-achịkwa njikọ nke renin-aldosterone, yabụ, ijikọ ọnụ nke angiotensin-P receptor antagonist nwere ike ịgbanwe usoro excretion potassium na-ejikọ ya na nsị thiazide.

Ọgwụ ahụ nwekwara mmetụta mgbochi na-adịghị ike na carbon anhydrase, ruo n'ókè dị ala, si otú a na-eme ka mmịkọ nke bicarbonate dị, ebe enweghị mgbanwe dị ukwuu na pH.

Mlọ ọgwụ

Hydrochlorothiazide na-agbaso nke ọma mgbe nchịkwa ọnụ gasịrị, mmetụta ya diuretic na natriuretic na-apụta n'ime awa 2 mgbe nchịkwa ma rute oke ha mgbe ihe dị ka awa anọ gachara. Ihe omume a dịruru 6-12

N'ime ya site na akụrụ n'ụdị agbanweghị. Ọkara ọkara nke ndị ọrịa nwere ọrụ gbasara ezumike nkịtị bụ awa 6.4, maka ndị ọrịa nwere nnukwu akwara ezughị oke - awa 11.5, yana ọdịda akwara siri ike na mwepụ nke creatinine erughị 30 ml / min. - 20.7 awa. Hydrochlorothiazide na-agafe ihe mgbochi placental ma na-apụ apụ na mmiri ara ara obere obere.

Ihe ngosi maka ojiji

• Ọbara mgbali elu (n'ụdị dị nwayọ - ma n'ụdị monotherapy, yana yana ọgwụ ndị ọzọ na - egbochi mmiri).

• Edema nke gbasara obi, hepatic ma ọ bụ akụrụ etiology, edema premenstrual, edema na - eso ọgwụ, dịka corticosteroid.

• Na insipidus nephrogenic na-arịa ọrịa shuga iji belata polyuria (mmetụta dị iche iche)

• Iji belata hypercalciuria.

Ihe ngbanwe

• Akpachapụ anya na ọgwụ ma ọ bụ na sulfonamides ndị ọzọ

• gbasara akwara siri ike (mwepụ nke okike n'okpuru 30 ml / min) ma ọ bụ ọrịa imeju

• Na-eguzogide ọgwụ hypokalemia ma ọ bụ hypercalcemia

• Ọria hyperuricemia (gout)

Ekwuputaghi ọgwụ a maka iji ya eme ihe n’ebe ụmụaka gbara afọ 6.

Ime na lactation

Ahụmahụ hydrochlorothiazide n'oge afọ ime, ọkachasị n'oge ọnwa atọ. Ihe omuma enwetara na ule anumanu ezughi oke. Hydrochlorothiazide na-agafe ihe mgbochi placental. Ọ bụrụ na a na-eji hydrochlorothiazide na ọkara nke abụọ na nke atọ, ọ (n'ihi usoro ọgwụ ya) nwere ike ịkpaghasị mmanụ fetoplacental na-akpata ma ọ bụ nwee nsogbu nke nwa ebu n'afọ ma ọ bụ nwa amụrụ, ahaghị ntoputa nke electrolyte na thrombocytopenia.

Ekwesighi iji Hydrochlorothiazide n'oge afọ ime iji gwọọ edema, ọbara mgbali elu ma ọ bụ preeclampsia, n'ihi na kama ọ nwere mmetụta bara uru na ọrịa ahụ, ọ na - eme ka ihe dị egwu belata mbelata nke plasma na iyi egwu nke inye ọbara ọgbụgba na akpanwa na Plasenta.

Enweghị ike iji hydrochlorothiazide na-agwọ ọbara mgbali dị oke mkpa n'ime ụmụ nwanyị dị ime, ma e wezụga n'ọnọdụ ndị a na-adịghị ahụkebe mgbe ọgwụgwọ ndị ọzọ.

Ekwesighi iji mbadamba nkume Hydrochlorothiazide n'oge afọ ime - enwere ike iji ya naanị n'ọnọdụ ndị siri ike.

Hydrochlorothiazide na-abanye n'ime mmiri ara, a na-egbochi ya n'oge ara. Ọ bụrụ na ojiji ya enweghị atụ, ịhapụ ị breastụ ara.

Usoro onunu ogwu na nhazi

Ekwesịrị ịhọrọ usoro ọgwụgwọ ahụ n'otu n'otu ma chọọ nlekọta nlekọta ahụike mgbe niile. N'ihi mmụba na-aba ụba nke potassium na magnesium n'oge ọgwụgwọ (ọkwa nke serum nwere ike ịda n'okpuru 3.0 mmol / l), enwere mkpa maka nnọchi potassium na magnesium. Ekwesịrị ilebara anya na ndị ọrịa nwere nkụchi obi, ndị ọrịa nwere ọrụ imeju, ma ọ bụ na ndị ọrịa na-anata ọgwụgwọ gwọọgụ. Mbadamba kwesịrị iwere mgbe nri.

Dịka onye na-ahụ maka ọgwụ mgbochi, ọgwụ mbụ a na-eme kwa ụbọchị bụ 25-100 mg n'otu ọgwụ, n'ụdị monotherapy ma ọ bụ na ọgwụ ndị ọzọ antihypertensive. Maka ụfọdụ ndị ọrịa, ọgwụ izizi nke 12.5 mg ezuru, ma n'ụdị monotherapy yana njikọta. Ọ dị mkpa iji ntakịrị opekempe ọ bụla na-agaghị akarị 100 mg kwa ụbọchị. Ọ bụrụ na a jikọtara hypothiazide yana ọgwụ ndị ọzọ na-egbochi mmiri, ọ nwere ike ịdị mkpa iji belata ọgwụ ole otu iji gbochie ọnụego ọbara mgbali elu.

A na-egosipụta mmetụta antihypertensive n'ime ụbọchị 3-4, ka o sina dị, iji rụpụta oke kachasị mma, ọ nwere ike were izu 3-4. Mgbe ọ gwọchara ya, oke mmetụta na-adịgide ruo otu izu.

N’oge ọgwụgwọ edema otu esi ebido ya bụ ọgwụ 25-100 nke ọgwụ otu ugboro n'ụbọchị ma ọ bụ otu ugboro kwa ụbọchị abụọ. Dabere na nzaghachi ụlọ ọgwụ, a kwesịrị belata dose ahụ ruo 25-50 mg otu ugboro n'ụbọchị ma ọ bụ otu ugboro kwa ụbọchị abụọ. N'ụfọdụ nsogbu, enwere ike ịchọ ọgwụ were ruo 200 mg kwa ụbọchị.

Na premanstrual edema, ọgwụ a na-ahụkarị bụ 25mg kwa ụbọchị ma a na-eji ya site na mmalite nke ihe mgbaàmà ruo mmalite nke oge nsọ.

Na nephrogenic ọrịa shuga insipidus A na-atụ aro ị doseụ kwa ụbọchị nke 50-150 mg (n'ọtụtụ usoro).

Ekwesịrị ịhazi usoro ọgwụgwọ dabere na ịdị arọ nwata ahụ. A na-enyekarị ọgwụ ịchọrọ ahụ kwa ụbọchị, 1-2 mg / n'arọ nke ịdị arọ ahụ ma ọ bụ 30-60 mg kwa mpekere nke anụ ahụ dị elu, otu ugboro kwa ụbọchị. Ngụkọta ụbọchị kwa ụbọchị maka ụmụaka dị afọ 6 ruo afọ iri na atọ bụ 37.5-100 mg kwa ụbọchị.

Dodoụbiga ya ókè

Kpọọ dọkịta gị ma ọ bụ ụlọ ọnọdụ mberede ozugbo ọ bụrụ na ị doụbiga mmanya ókè!

Ngosiputa nke ngosiputa nke mmiri hydrochlorothiazide bu oke mmiri na electrolytes, nke ekwuputara n'ihe iriba ama na akara ndia.

Ọkpụkpụ akwara: Tachycardia, hypotension, ujo

Neuromuscular: adịghị ike, ọgba aghara, dizziness na cramps muscle, paresthesia, ọgụgụ isi, ike ọgwụgwụ.

Gastrointestinal: ọgbụgbọ, ọgbụgbọ, akpịrị ịkpọ nkụ,

Renal: polyuria, oliguria ma ọ bụ anuria.

Ndị na-egosi ụlọ nyocha - hypokalemia, hyponatremia, hypochloremia, alkalosis, ọkwa dị elu nke nitrogen n'ime ọbara (karịsịa na ndị ọrịa nwere akụrụ gbasara akwara).

Doụbiga mmanya ókè: Ngwọta doro anya maka ị .ụbiga mmanya ókè

Umịpụta ọgbụgbọ, ọnya afọ nwere ike ịbụ ụzọ iji wepụ ọgwụ ahụ. Enwere ike belata nnabata nke ọgwụ ahụ site na iji carbon na-arụ ọrụ. N'ọnọdụ hypotension ma ọ bụ ujo, a ga-akwụghachi olu nke inyefe plasma na electrolytes (potassium, sodium, magnesium).

Ekwesịrị inyocha mmiri mmiri elektrolyte (ọkachasị serum potassium) yana ọrụ akụrụ ruo mgbe etolitepụtara ụkpụrụ ọma.

Mmekọrịta na ọgwụ ndị ọzọ

Gbalịsie ike ịgwa onye na-ahụ maka ahụike banyere ọgwụ niile ị na-a ,ụ, ọbụlagodi na ọ bụrụ na ọ bụrụ na ọ dabere na ikpe.

Ikekwe mmekọrịta dị n'etiti thiazide diuretics na ọgwụ ndị na-eso ya na iji ha n'otu oge.

Mmanya na-egbu egbu, barbiturates, ọgwụ ndị na-egbu egbu na ọgwụ mgbochi:

Nwere ike ịkwalite hypotension orthostatic.

Ndị Antidiabetic (ọgwụ na insulin):

Ọgwụ nke Thiazide nwere ike belata nnabata glucose. May nwere ike ịgbanwe ọgwụ hypoglycemic ọgwụ. Ekwesịrị iji Metformin kpachara anya n'ihi ihe ize ndụ nke lactic acidosis n'ihi ọdịda akụrụngwa arụ ọrụ metụtara hydrochlorothiazide.

Ndị ọzọ na - arụ ọrụ antihypertensive:

Colestyramine na colestipol resins:

Na ọnụnọ ọnụnọ mgbanwe nke anion, nnabata hydrochlorothiazide site na ngụgụ nri. Otu ọgwụ colestyramine ma ọ bụ colestipole resins na-ejikọ hydrochlorothiazide ma belata mwepu ya na eriri afọ, dika 85% na 43%.

Amonia Pressor (dịka adrenaline):

O kwere omume na a kwụsịrị ime ihe ndị na-eme ka amị presser dị, mana ọ bụghị ruo n'ókè nke igbochi ojiji ha.

Ihe na - emegharị ahụ adịghị mma (dịka ọmụmaatụ tubocurarine):

Mmetụta izu ike akwara nwere ike ịba ụba.

Diuretics belata mkpochasị lithium na mmụba ma belata ihe egwu nke lithium. A naghị atụ aro iji ha n'otu oge ahụ. Ọgwụ maka ọgwụgwọ gout (probenicid, sulfinpyrazone na allopurinol):

Enwere ike ịchọ ndozi nke ọgwụ uricosuric, ebe hydrochlorothiazide nwere ike ịbawanye ọkwa seric uric acid. Enwere ike ịbawanye ụba nke ọgwụ probenicide ma ọ bụ sulfinpyrazone. Ojiji nke thiazides n’otu oge nwere ike ime ka onodu a pụtakarị n’arịa ọrịa allopurinol.

Anticholinergics (dịka ọmụmaatụ, atropine, biperiden):

N'ihi mbelata motility nke eriri afọ na ogo nke akpa afọ, bioavailability nke diuretic nke ụdị thiazide na-abawanye.

Ndị nnọchi anya nke cytotoxic (dịka ọmụmaatụ cyclophosphamide, methotrexate):

Thiazides nwere ike belata mkpụrụ ndụ akwara nke ọgwụ cytotoxic ma welie mmetụta myelosuppressive ha.

N'ihe banyere usoro ịgwọ ọrịa nke salicylates dị ukwuu, hydrochlorothiazide nwere ike ịkwalite nsonaazụ nke salicylates na sistemụ ụjọ.

N'ọnọdụ ụfọdụ, akwara hemolytic na iji otu oge hydrochlorothiazide na methyldopa.

Iji ọgwụ cyclosporine mee ihe nwere ike ịbawanye hyperuricemia na ihe ize ndụ nke ịmalite nsogbu dịka gout.

Hypokalemia ma ọ bụ hypomagnesemia nke thiazide nwere ike itinye aka na mmepe nke arrhythmias nke digitalis na-akpasu.

Ọgwụ na-emetụta mgbanwe nke serum potassium:

A na-atụ aro mkpebi oge oge nke ọkwa potassium na ndekọ nke electrocardiogram ma ọ bụrụ na ejiri hydrochlorothiazide eme ihe n'otu oge yana ọgwụ ndị na-emetụta mgbanwe na mkpo ọka serum (dịka ọmụmaatụ, glycosides dijitalụ na ọgwụ antiarrhythmic), yana ọgwụ ndị a na-esoro tachycardia ọgwụ (ventricular pirouette) tachycardia) (gụnyere ụfọdụ ọgwụ ọgwụ antiarrhythmic), n'ihi na hypokalemia bụ ihe na-eso akpata mmepe nke tachycardia dịka pirouette:

• ọgwụ antiarrhythmic nke klaasị 1a (dịka ọmụmaatụ, quinidine, hydroquinidine, viopyramide),

• ọgwụ III antiarrhythmic ọgwụ (wdg., Amiodarone, sotalol, dofetilide, ibutilide),

• ụfọdụ antipsychotics (dịka ọmụmaatụ, thioridazine, chlorpromazine, levomepromazine, trifluoperazin, cyamemazine, sulpiride, sultopride, amisulpride, tiapride, pimozide, haloperidol, droperidol),

• ọgwụ ndị ọzọ (dịka ọmụmaatụ, bepridil, cisapride, diphemanil, intrivenous erythromycin, halofantrine, misolastine, pentamidine, terfenadine, vincamine intravenous).

Thiazide diuretics na-abawanye ọkwa calcium n'ihi nkwụsịtụ belata. Ọ bụrụ na ọ dị mkpa maka nhọpụta nke ndị na-emezigharịrị ihe ndị dị na calcium, ọ dị mkpa ijikwa ọkwa nke kalsel dị n'ọbara ahụ, ma, dabere na ya, họrọ otu nke calcium.

Mkparịta ụka dị n'etiti ọgwụ na ule ụlọ nyocha: N'ihi nsonaazụ metabolism, thiazides nwere ike imegharị nsonaazụ nke ule ọrụ parathyroid.

Njirimara ngwa

Ileba anya na nlebara anya na ndu di nkpa n'ihi ihe egwu nke hyponatremia symptomatic.

Iodine-nwere iche iche:

N'ihe banyere mmiri akpịrị na - eme ka ọnya na-egbu mmiri, ihe ọghọm nke akụrụngwa akwara na-abawanye, ọkachasị mgbe ejiri ọgwụ iodine nwere nnukwu ọgwụ. Tupu ị na-eji ayodiin, ọ dị mkpa imegharị mmiri mmiri ahụ n’ahụ ndị ọrịa.

Amphotericin B (parenteral), corticosteroids, ACTH na ọgwụ ndị na-akpali akpali:

Hydrochlorothiazide nwere ike itinye aka na echiche elektrolyte, tumadi mmepe nke hypokalemia.

Mwepụta wepụtara ya na ihe mejupụtara

Mpempe usoro onodu ogwu: mbadamba nkume di okirikiri, lari, ya na akara nkewa di na akuku ya na ihe osise “H” n’akụkụ nke ozo, ocha ma obu nke di ocha (pcs iri abuo. Na blisters, n’ime kaadiboodu 1 blister na ntuziaka maka iji Hypothiazide).

Ngwakọta ọrụ na-arụ ọrụ bụ hydrochlorothiazide, ọdịnaya ya na mbadamba 1 bụ 25 ma ọ bụ 100 mg.

Ihe ntinye aka: gelatin, steeti magnesium, ọka ọka, talc, lactose monohydrate.

Mlọ ọgwụ

Ihe Hypothiazide dị n'ọrụ bụ thiazide diuretic hydrochlorothiazide, ihe bụ isi usoro nke ime ya bụ iwelie diuresis site na igbochi reabsorption nke sodium na ion chlorine na akụkụ mbụ nke tubules renal. N'ihi ya, mwepu sodium, chlorine, na, ya mere, mmiri na-abawanye. Na mgbakwunye, excretion nke electrolytes ndị ọzọ - potassium na magnesium - na-eto. Nsonaazụ diuretic / natriuretic nke thiazides niile mgbe ewere ya na usoro ọgwụgwọ kachasi ike dịka otu.

Omume Natiruretic na mmetụta diuretic na-apụta na awa 2, rute ogo kachasị elu mgbe ihe dị ka awa anọ gachara.

Thiazide diuretics, na mgbakwunye, site na ịbawanye ụba nke bicarbonate ion belata ọrụ carbon anhydrase, mana a na - egosipụta ike a na - anaghị enwe mmetụta mmamịrị pH.

Hydrochlorothiazide nwere ihe antihypertensive. Ọrịa Thiazide anaghị emetụta ọbara nkịtị (BP).

Hypothiazide, ntuziaka maka ojiji: usoro na usoro onunu ogwu

A na-ewere ọnụ Hypothiazide n'ọnụ mgbe nri gasịrị.

A na-ahọrọ dose ahụ n'otu n'otu n'oge ọgwụgwọ. Na-enyocha ọnọdụ a na-adakarị onye ọrịa, dọkịta ahụ depụtara obere opekempe ọgwụ hypothiazide.

Singzọ ịtụrụ ndị okenye maka mbụ:

• Ọrịa ecdematous nke etiologies dị iche iche: 25-100 mg 1 oge kwa ụbọchị ma ọ bụ oge 1 n'ime ụbọchị 2, n'ọnọdụ ndị siri ike - 200 mg kwa ụbọchị. Nyere mmeghachi omume ụlọ ọgwụ, ọ ga-ekwe omume belata ọgwụ ahụ ruo 25-50 mg kwa ụbọchị otu ugboro ma ọ bụ otu ugboro kwa ụbọchị 2.
• Ọrịa ọgbụgba obara: 25 mg otu ugboro n'ụbọchị, nchịkwa na - amalite site na mgbe mgbaàmà mbụ pụtara tupu mmalite nke nsọ nwanyị,
• Ọbara ọgbụgba (jikọtara ya na monotherapy): 25-50 mg otu ugboro n'ụbọchị, maka ụfọdụ ndị ọrịa 12.5 mg ezuru. Obere kachasị dị aro agaghị agafe 100 mg kwa ụbọchị. A na-egosipụta mmetụta ọgwụgwọ ahụ n’ime ụbọchị 3-4, maka imeziwanye ọbara mgbali elu (BP) ọ nwere ike were izu 3-4. Mgbe iwepu hypothiazide, mmetụta hypotensive ahụ na-ewe otu izu. Iji gbochie mbelata ọbara mgbali elu n'oge usoro njikọta, enwere ike ịchọ Mbelata nke ọgwụ ndị ọzọ na - egbochi ọgwụ,
• Insipidus nke Nehrogenic na-arịa: 50-150 mg kwa ụbọchị n'ọtụtụ usoro.

A na-agbakọ usoro ọgwụ Hypothiazide maka ụmụaka na-eburu ibu nke nwatakịrị. Ọgwụ ụmụaka kwa ụbọchị na-abụkarị 1-2 mg kwa 1 n'arọ nke nwatakịrị ahụ ma ọ bụ 30-60 mg kwa 1 square. Ahụ dị elu 1 oge kwa ụbọchị, maka ụmụaka site na afọ 3 ruo afọ 12 - 37.5-100 mg kwa ụbọchị.

Nsonaazụ

Ojiji nke hypothiazide nwere ike ibute nsogbu ndị a:

• Usoro nri: nri nri, afọ ọsịsa ma ọ bụ afọ ntachi, cholecystitis, cholestatic jaundice, pancreatitis, sialadenitis,
• Metabolism: nkụda mmụọ, ọgba aghara, nke na-ebelata usoro iche echiche, nkwarụ, ahụ erughị ala, ike ọgwụgwụ, nhụjuanya akwara na hypercalcemia, hypomagnesemia, hypokalemia, hyponatremia. Oge ụbụrụ na-adịghị ala ala, akpịrị ịkpọ nkụ, akpịrị ịkpọ nkụ, ike ọgwụgwụ pụrụ iche ma ọ bụ adịghị ike, mgbanwe na psyche ma ọ bụ ọnọdụ, nhụjuanya na olu mgbu, ọgbụgbọ, vomiting n'ihi hypochloremic alkalosis (na mgbakwunye, hypochloremic alkalosis nwere ike ime ka hepatic encephalopathy ma ọ bụ coma). Glycosuria, hyperuricemia na mmepe nke ọgụ nke gout. Hyperglycemia, nke nwere ike kpalite mmepe nke ọrịa shuga mellitus n'oge gara aga. Ọgwụgwọ dị elu nwere ike ịba ụba liumids
• Usoro obi: arrhythmia, vasculitis, hyperension orthostatic,
• Sistem Hematopoietic: ọ dịkarịghị - thrombocytopenia, leukopenia, hemolytic anaemia, agranulocytosis, aplastic anemia,
• Usoro ụjọ: ọhụhụ na-adị nwa oge, isi ọwụwa, isi nri, paresthesia,
• Sistem na urin: akwara nephritis di iche-iche, akwara akari irighiri akwara,
• Mmeghachi omume nfụkasị: urticaria, photoensitivity, necrotic vasculitis, purpura, Stevens-Johnson syndrome, mmeghachi omume anaphylactic ruo ujo. Ọrịa mgbu nke akụkụ iku ume, gụnyere ọrịa oyi baa na ụkwara ume ọkụ na-abụghị nke obi,
• Ndị ọzọ: nwere ikike belatara.

Ntụziaka pụrụ iche

N'oge ọgwụgwọ ogologo oge, ọ dị mkpa ijikwa akara ngosi nke nsogbu mmiri-electrolyte nrụgide, ọkachasị ndị ọrịa nwere ọrụ imeju arụ ọrụ, ọrịa nke sistem.

Ojiji nke hypothiazide na-akwalite excretion nke magnesium na potassium ion, yabụ, na usoro ọgwụgwọ, a ga-emerịrị ihe iji kpochapụ erughi ha.

N'ime ndị ọrịa nwere nsogbu gbasara akụrụngwa, a ga-enyocha nhazi nke creatinine; ma ọ bụrụ na oliguria, a ga-aza ajụjụ banyere iwepụ hypothiazide.

N'ime ndị ọrịa nwere ọrụ imeju na-egbu egbu, a ga-eji thiazides jiri nlezianya mee ihe, ebe ọ bụ na obere mgbanwe na mmiri-electrolyte nguzo na ọkwa serum amonia nwere ike ibute ọrịa hepatic.

Ojiji nke hypothiazide n'ime ndị ọrịa nwere nnukwu akwara na ọrịa sclerosis chọrọ nlekọta pụrụ iche.

Ogologo oge ọgwụgwọ maka latent na ọrịa shuga mellitus ga-esonyere ya na nhazi usoro nke carbohydrate metabolism na mmezi nke ọgwụ hypoglycemic.

Oge nyocha nke ọnọdụ chọrọ ndị ọrịa nwere metabolic uric acid metabolism.

Ogologo oge ọgwụgwọ, n'ọnọdụ ndị a na - adịghị ahụkebe, nwere ike ibute mgbanwe ọrịa na glands parathyroid.

Ime na lactation

Hydrochlorothiazide na-agafe ihe mgbochi placental, yabụ enwere ihe ize ndụ nke nwa ebu n'afọ / jaundice, thrombocytopenia, na mmeghachi omume ndị ọzọ na-adịghị mma.

Iji hypothiazide n'oge ọnwa atọ mbụ dị ime bụ nke a machibidoro iwu. N’ime usoro nke abụọ nke III - III, a na-enye ọgwụ ahụ ka ọ bụrụ na ọ dị mkpa, mgbe uru a tụrụ anya na nne ga-aba karịa ihe nwere ike ibute nwa ebu n’afọ.

Hydrochlorothiazide dị na mmiri ara ehi ara. Ọ bụrụ n’ịchọrọ iji ya n’oge a, ị ga-akwụsị ị breastụ ara.

Ngwakọta na ụdị ntọhapụ

na plọg 20.., n'ime igbe kaadiboodu 1 ọnya.

Ihe ngosi Hypothiazide ®

ọbara mgbali elu (ejiri ya na monotherapy yana yana ọgwụ ndị ọzọ na - egbochi mmiri),

ọrịa edema nke mmalite dị iche iche (obi na-adịghị ala ala, nephrotic syndrome, ọrịa premenstrual, nnukwu glomerulonephritis, ọrịa gbasara akwara na-adịghị ala ala, ọbara mgbali elu, ọgwụgwọ na corticosteroids),

nchịkwa nke polyuria, tumadi ya na insipidus nephrogenic,

mgbochi nke imepụta okwute na ọnya ọnya mkpụrụ ndụ na ndị ọrịa nwere nsogbu (mbelata hypercalciuria).

Ime na lactation

Hydrochlorothiazide na-agafe ihe mgbochi placental. N'ime ọgwụ ọnwa mbụ nke afọ ime ka a machibidoro ya iwu. N'ime usoro nke afọ nke II na III nke afọ ime, a ga - edenye ọgwụ ahụ naanị mgbe enwere mkpa ngwa ngwa, mgbe uru nne gafere karịa ihe nwere ike ibute nwa ebu n’afọ na / ma ọ bụ nwa. Enwere ihe ọghọm nke ibute jaundice nke nwa ebu n’afọ ma ọ bụ nwa amụrụ ọhụrụ, thrombocytopenia na nsonaazụ ndị ọzọ.

Ọgwụ ahụ na-abanye na mmiri ara ara, yabụ, ọ bụrụ n’ị ofụ ọgwụ dị oke mkpa, a ga-akwụsị ịhapụ inye ụmụaka ara.

Hypothiazide

Hypothiazide bụ ọgwụ ịba ọcha n'anya nke sitere na ndị otu benzothiadiazine. Mmetụta diuretic hypothiazide bụ n'ihi mbelata nke mmịpụta nke chlorine, sodium ion na tubules renal. Mmụba nke sodium si n'ahụ mmadụ na-eme ka mmiri ghara ịdịkwa. N'ihi iwepu mmiri, olu nke na-ekesa ọbara na-ebelata, nke na-eduga n'ịbelata ọbara mgbali elu (ọ bụrụ na e buliri ya elu, ọbara mgbede nkịtị adịghị agbadata). Ọgwụ ahụ na-akwalitekwa mmịpụta nke potassium, bicarbonates na magnesium ion site n'ahụ ya, mana ruo ntakịrị.

Mmetụta diuretic (diuretic) na-amalite 1-2 awa mgbe ị takingụsịrị ọgwụ ahụ, ruru oke mgbe awa 4 gachara wee ruo awa 6-12. Iji hypothiazide ogologo oge anaghị ebelata mmetụta diuretic ya. Kwụsịlata iji nnu eji nri eme ihe na-eme ka ọgwụ a ghara ịba ụba ike.

Ntinye intraocular na-ebelata na Hypothiazide. Ọgwụ nwere ike ịgafe ihe mgbochi placental. Ara na mmamịrị na ara ara. Na ọdịda akụrụ, ịhapụ ọgwụ ka ejiri nwayọ nwayọ nwayọ.

Ihe dị n’ọrụ ọgwụ ahụ bụ hydrochlorothiazide.

Ọgwụ Hypothiazide

Site na oke ibu, enwere ikike ichekwa mmiri n'ime ahụ n'ihi ụba hydrophilicity anụ ahụ. Na mgbakwunye, na-emegidekarị oke ibu, akwara na-etolite etolite, na-eme ka njigide mmiri dịgide. Mgbe ahụ enwere mkpa itinye n'ọrụ na ọgwụgwọ nke ọ bụghị naanị ọgwụ obi, kamakwa diuretics. N'ime ọgwụ ndị ahụ, a na-ejikarị hypothiazide, nye ya ezigbo nsị, ọ na-enwekarịkwa nsogbu na-adịghị mma.

Agbanyeghị, iji hypothiazide maka ịbelata ibu kwesịrị ịkpachapụ anya ma bụrụ naanị dọkịta nyere ya ndụmọdụ. Ojiji nke diuretic a n’enweghi ezigbo ihe kpatara ya nwere ike ibute nsonaazụ dị ukwuu - ụdị oke edematous nke oke ibu ga-aghọ edematous maka ihe kpatara ogologo oge iji ọgwụ mgbatị ahụ na-akpata nsonaazụ: mmiri n'ime akwara na-agbakọ ngwa ngwa.

Ọ dị mfe ma ka mma iji wepụ ihe ndị dị mmiri n'ahụ site na iji decoctions na infusions nke ọgwụ ọgwụ (bearberry, horsetail, wdg).
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