Mbelata Amoxicillin: ntuziaka maka ojiji > Ọgwụgwọ na mgbochi

Amoxicillin: ntuziaka maka ojiji na nyocha

Aha Latin: Amoxicillin

Koodu ATX: J01CA04

Ihe na-arụ ọrụ: amoxicillin (amoxicillin)

Onye na-emeputa ihe: Biochemist, OJSC (Russia), Dalhimpharm (Russia), Organka, OJSC (Russia), STI-MED-SORB (Russia), Hemofarm (Serbia)

Nkọwa na nwelite: 11.26.2018

Ahịa dị n'ụlọ ahịa ọgwụ: site na 30 rubles.

Amoxicillin bụ ọgwụ antibacterial, penisilini semisynthetic.

Mwepụta wepụtara ya na ihe mejupụtara

Usoro onunu ogwu echekwara:

mbadamba: ihe fọrọ nke nta ka ọ bụrụ ọcha ma ọ bụ na-acha ọcha, nke nwere oghere dị larịị, nke nwere akara nkerisi na chamfer (pcs 10 ma ọ bụ pcs 20 na blisters, na igbe kaadi nke 1, 2, 5, 10, 50 ma ọ bụ 100 ngwugwu, 24 PC. Mkpọ nke nwere agba gbara ọchịchịrị, na mbadamba nke 1 nwere ike, pcs 20. na iko ma ọ bụ karama, na mbadamba nke 1 nwere ike ma ọ bụ karama),
capsules: gelatinous, na dose nke 250 mg - size Nke 2, yana okpu na-acha akwụkwọ ndụ gbara ọchịchịrị na ọcha na anụ ahụ na-acha odo odo, na nha 500 mg - nha nke 0, nke nwere okpu uhie na ahụ na-acha odo odo, n'ime okpu ahụ bụ akwa ntụ ntụ nke nwere agba site na ya acha odo na-acha ọcha, a na-ahapụ idochi ọnụ ya (250 mg nke ọ bụla: 8 PC. n'ime blisters, na ngwungwu kaadiboodu 2 blisters 10, pọọsụ 10) na ngwungwu ogbe, na ngwungwu 1 ma ọ bụ 2 ngwugwu, 10 ma ọ bụ 20 PC. n'ime mbadamba, na kaadiboodu 1 nwere ike, 500 mg nke ọ bụla: PC asatọ. n'ime blisters, na ngwungwu 2 blisters, 8 PC. urnyh ọnya na a katọn ngwugwu 1 ma ọ bụ ngwugwu 2, 10 PC. na blisters na a katọn igbe 1, 2, 50 ma ọ bụ 100 ngwugwu)
nsogbu dị iche iche maka nkwusi okwu ọnụ: granular ntụ ntụ site na ọcha na ajị ajị na-acha ọcha, mgbe ọ ghasịrị na mmiri - nkwusioru na-acha odo odo nwere mkpụrụ mkpụrụ (40 g nke ọ bụla na karama iko gbara ọchịchịrị nke nwere 100 ml, na ngwugwu kaadiboodu 1 karama ya na ngaji ngaji nke nwere ihe di iche di milimita isii na milimita ise).

Otu mbadamba 1 nwere:

ihe na-arụ ọrụ: amoxicillin trihydrate (na usoro nke amoxicillin) - 250 mg ma ọ bụ 500 mg,
ihe inyeaka: stachi nduku, magnesium stearate, polysorbate-80 (tween-80), talc.

Otu capsule dị 1:

ihe na-arụ ọrụ: amoxicillin trihydrate - 286.9 mg ma ọ bụ 573.9 mg, nke kwekọrọ na ọdịnaya nke 250 mg ma ọ bụ 500 mg nke amoxicillin,
ihe inyeaka: microcrystalline cellulose PH 102, magnesium stearate, titanium dioxide (E171), gelatin.

Na mgbakwunye, dị ka akụkụ nke ihe mkpuchi Capsule:

oke 2: okpu - quinoline acha odo odo (E104), indigo carmine (E132), ikpe - quinoline edo edo (E104),
nha 0: okpu - acha odo odo na-acha odo odo na-acha odo odo (E110), daijiya Azorubine (E122), ahu - udiri iron oxide odo (E172).

N'ime 5 ml nke nkwusioru ahụ emechara (2 g nke oke).

ihe na-arụ ọrụ: amoxicillin trihydrate (na usoro nke amoxicillin) - 250 mg,
ngwa inye aka: sodium saccharinate dihydrate, sucrose, simethicone S184, sodium benzoate, guar gum, sodium citrate dihydrate, flarawberry, flapberi, ihe oriri na-aba n'anya.

Mlọ ọgwụ

Amoxicillin bụ ọgwụ penicillin gbara mkpị, ọgwụ nje na-egbochi nje bacteria na-egbochi ọtụtụ ihe. Usoro ihe a na-eme bụ n'ihi ike nke amoxicillin iji mee ka nyocha nke nje, na-egbochi transpeptidase na ịkpaghasị njikọ nke protein akwụkwọ ntụpọ nke mgbidi sel nke peptidoglycan n'oge nkewa na uto.

Gram-positive na gram-microorganisms microorganisms na-egosipụta uche na ọgwụ.

Amoxicillin na-arụ ọrụ n'ime nje ndị a:

nje aerobic gram-positive: Corynebacterium akọwapụtara (spp.), Staphylococcus spp. (ewezuga maka nsogbu na-ekepụta penisiliniin), Bacillus anthracis, Listeria monocytogenes, Enterococcus faecalis, Streptococcus spp. (gụnyere ume na ụkwara ume ọkụ Streptococcus),
nje aerobic gram-negative: Brucella spp., Bordetella pertussis, Shigella spp., Escherichia coli, Klebsiella spp., Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, Salmonella spp., Vibrio cholerae, Proteus mioterabiolaella, Proteus mioterabella
Ndị ọzọ: Leptospira spp., Clostridium spp., Borrelia burgdorferi, Helicobacter pylori.

Mpempe ọgwụ ndị na-emepụta penisiliniin na beta-lactamases ndị ahụ adịghị emetụta ọgwụ ahụ, ebe ọ bụ na beta-lactamases na-emebi amoxicillin.

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gasịrị, amoxicillin na-agbakarị ọsọ ọsọ (ọ fọrọ nke nta ka 93%) banye. Anakpo Absorption site na ịme nri n'otu oge, ọgwụ ahụ anaghị emebi na mpaghara acid nke afọ. A na-erute ntinye uche kachasị mgbe awa 1-2 gachara 0.0015-0.003 mg / ml mgbe ọgwụ mgmg nke 125 mg na 0.0035-0.005 mg / ml mgbe 250 mg gasịrị. Mmetụta ahụike na-amalite itolite na 1 / 1-2 / 2 awa ma dịruru 8 awa.

Ọ nwere nnukwu nkesa. Oke ịta ahụ na-abawanye na nha maka ọgwụ ọgwụ. A na-ahụta oke mmiri nke amoxicillin na plasma, pleural na peritoneal fluid, sputum, bronchial secretion, ngụgụ na anụ ahụ, mucosa eriri afọ, mmamịrị, gland prostate, akụkụ ahụ nwanyị, adipose anụ ahụ, mbupụ ntị nke etiti, yana ọnya anụ ahụ. Ọ banye n’ime anụ ahụ nwa ebu n’ukuku, ya na arụ ọrụ imeju nkịtị - n’ime eriri afọ, ebe ihe ndị dị n’ime ya nwere ike karịa ịta plasma site ugboro 2-4. Ekpuchichara purulent nke bronchi bu nke oma. Mgbe ejiri ya n’oge afọ ime, ihe dị n’ime amoxicillin n’ime arịa nke eriri nwa na mmiri amniotic bụ 25-30% nke ịta na plasma nke ahụ nwanyị.

Na mmiri ara ara, a na-ewepụta obere ego. A na - emeri ihe mgbochi ụbụrụ ọbara na - emezighị emezi, itinye uche na mmiri cerebrospinal mgbe ị na - eji amoxicillin maka ọgwụgwọ nke meningitis (mbufụt nke meninges) abụghị ihe karịrị 20%.

Na-ejikọ ndị na-edozi plasma - 17%.

A na-agwakọta ya na olu na-ezughi ezu na usoro nke metabolites na-adịghị arụ ọrụ.

Ọkara ndụ (T_1/2) bụ 1-1.5 awa. 50-70% ewepụtara site na akụrụ ya anaghị agbanwe agbanwe. N'ime ndị a, site na nzacha ụwa - 20%, tubular excretion - 80%. 10-20% weputara site na eriri afọ.

Ndi_1/2 ọ bụrụ na arụ ọrụ ezumike ezumike ya na ikike idozi creatinine (CC) nke 15 ml / min ma ọ bụ obere, ọ na-abawanye ruo awa 8.5.

Site na iji akụrụngwa anụ ahụ, a na-ewepụ amoxicillin.

Ihe ngosi maka ojiji

Dịka ntuziaka ahụ si gosipụta, a na-egosi Amoxicillin maka ọgwụgwọ nke ọrịa na-efe efe na mbufụt nke ụmụ nje na-akpata.

na akụkụ okuku ume na akwara na-efe efe - akwara akwara, ụkwara akwara nke na-arịa ụkwara ume ọkụ, bronchopneumonia, lobar pneumonia,
ofufe ọrịa nke akụkụ ENT - sinusitis, tonsillitis, pharyngitis, nnukwu otitis media,
Ọrịa nke anụ ahụ na anụ ahụ dị nro - nke abụọ akpịrị ọrịa akpịrị, erysipelas, impetigo,
ofufe ọrịa nke usoro mkpụrụ ndụ - cystitis, pyelonephritis, urethritis, gonorrhea,
ọrịa gynecological - endometritis, cervicitis,
nsia na-efe efe - ịba Ọrịa ịba, ahụ ọkụ paratyphoid, shigellosis (ọnyụnyụ ọbara), salmonellosis, salmonella ebu,
ọnya afọ nke afọ na duodenum (dịka akụkụ nke njikọta ọgwụgwọ),
afọ ime - enterocolitis, peritonitis, cholecystitis, cholangitis,
ọrịa meningococcal,
listeriosis (nnukwu na latent form),
leptospirosis,
Borreliosis (ọrịa Lyme)
sepsis
endocarditis (mgbochi n’oge ezé na obere nsogbu ịwa ahụ).

Ihe ngbanwe

imeju imeju
ụkwara ume ọkụ,
hay fever
lymphocytic leukemia
nje mononucleosis,
colitis n'ihi ịitisụ ọgwụ nje (gụnyere akụkọ gbasara ahụike),
inye ara
ọgwụ mgbochi ọgwụ beta-lactam, gụnyere penisiliniins, cephalosporins, carbapenems,
mmadụ inabata ya na ọgwụ ndị ahụ.

Ọzọ contraindications maka ụfọdụ n'ụdị amoxicillin:

mbadamba: ọrịa ọrịa (gụnyere ihe gbasara ahụike), afọ ruo afọ 10 na aru ya na-erughị 40 n'arọ,
capsules: atopic dermatitis, akụkọ banyere ọrịa eriri afọ, afọ ruru afọ ise,
nsogbu dị iche iche: ọrịa glucose-galactose malabsorption syndrome, ụkọ sucrose (isomaltase), ndidi fructose, atopic dermatitis, akụkọ ihe mere eme nke ọrịa eriri afọ.

Na-akpachapụ anya, a na-atụ aro ka ekenye Amoxicillin ka ndị ọrịa nwere ọrịa gbasara akụrụ, akụkọ banyere ọbara ọgbụgba, na-enwekarị mmeghachi omume nfụkasị (gụnyere akụkọ ihe mere eme), n'oge ime.

Na mgbakwunye, ekwesịrị ịkpachara anya mgbe ị na-eji mbadamba ọgwụ maka ọgwụgwọ ndị ọrịa nwere ọrịa eriri afọ.

Nsonaazụ

site na usoro nri: imebi echiche uto, ọgbụgbọ, vomiting, dysbiosis, afọ ọsịsa, stomatitis, pseudomembranous colitis, glossitis, ọrụ imeju na-arụ ọrụ, ịba ụba ọrụ nke transfeases hepatatic na-adịghị ala ala, cholestatic jaundice, nnukwu ịba ọcha n'anya cytolytic.
site na ụjọ usoro: ehighị ụra, nsogbu, isi ọwụwa, nchekasị, ọgba aghara, ọgbụgbọ, ataxia, mgbanwe omume, neuropathy akụkụ, obi erughị ala, mmeghachi omume nkwarụ,
nfụkasị Jeremaya: fever, urticaria, flushing nke anụ, rhinitis, conjunctivitis, erythema, eosinophilia, angioneurotic edema, ihe mgbu na nkwonkwo, exfoliative dermatitis, Stevens - Johnson poliformnaya (multiforme) erythema, anabata vasculitis, anaphylactic ujo Jeremaya mere yiri ọrịa ọbara
plọgum ụlọ nyocha: neutropenia, leukopenia, agranulocytosis, anaemia, thrombocytopenic purpura,
site na usoro urinary: kristal crystalluria, interstitial nephritis,
ndị ọzọ: tachycardia, mkpụmkpụ nke iku ume, candidiasis, na-ebu ibu (karịa mgbe ọ bụla na-agwọ ọrịa na-adịghị ala ala ma ọ bụ na ndị ọrịa nwere mmegide anụ ahụ).

Na mgbakwunye, enwere ike ịmepụta nsonaazụ ndị a na-esote nke akọọrọla mgbe ị na-ewere ụdị ụfọdụ nke Amoxicillin:

mbadamba: mmeghachi omume nfụkasị ahụ n'ụdị akpụkpọ ahụ ọkụ, itching, necrolysis na-egbu egbu, juputara na exusthematous pustulosis, hepatic cholestasis, eosinophilia,
okpu: afụ ọnụ, ire ntutu na-acha oji, candidiasis nke anụ ahụ na akpụkpọ ahụ mucous, mmụba na oge prothrombin na oge ịmịkọta ọbara, imechi enamel ezé na odo, agba aja aja ma ọ bụ isi awọ.
nsogbu dị iche iche: asụsụ ojii nwere ntutu ojii, ịkpụcha enamel ezé, ọbara ọgbụgba ọbara na-arịa, nnukwu ihe na-akpata exanthematous pustulosis.

Ntụziaka pụrụ iche

Nhọpụta nke Amoxicillin ga-ekwe omume naanị ma ọ bụrụ na enweghị ihe ngosi banyere akụkọ ntolite onye ọrịa banyere mmeghachi omume nfụkasị ọgwụ mgbochi beta-lactam (gụnyere penicillins, cephalosporins). Maka ebumnuche profilactic, a na-egosi na imekọ ihe mgbochi nke antihistamines.

Mgbe ị na-eji ọgwụ mgbochi estrogen nwere nje nwanyị, a ga-adụ ụmụ nwanyị ọdụ ka ha jiri ụzọ mgbochi mgbochi nke mgbochi n'oge ọgwụgwọ na amoxicillin.

N'iburu ọgwụgwọ anticoagulant concomitagulant, ekwesịrị ichebara etu esi ele ha anya belata.

Ọgwụ nje adịghị agwọ ọrịa maka ọgwụgwọ nke ọrịa nje na-efe efe dị oke njọ.

Ekwesighi ịkọ ọgwụ Amoxicillin maka ọgwụgwọ nke mononucleosis na-efe efe n'ihi ihe ize ndụ nke ịmalite ọrịa akpụkpọ ahụ erythematous na ka njọ mgbaàmà nke ọrịa ahụ.

Ọ na-atụ aro ya iji ụdị nke amoxicillin maka ọgwụgwọ nke ndị ọrịa nwere ọrịa eriri afọ, nke afọ ọsịsa ma ọ bụ ọgbụgbọ na-aga.

Ọ bụrụ na afọ ọsịsa na-apụta mgbe ị na-a amoụ amoxicillin, ịnwere ike iji ọgwụ antidiarrheal nke nwere kaolin ma ọ bụ attapulgite, na-ezere ị drugsụ ọgwụ na-egbu mgbu nke eriri afọ.

N'ọnọdụ akpịrị na-arịa oke ọnya, mmiri mmiri nke agba akwụkwọ ndụ akwụkwọ ndụ na -ewe ya ísì ụtọ puru iche, tinyere mmirichukwu nke ọbara tinyere ọnya na oke mgbu, ị kwesịrị ịkpọtụrụ dọkịta ozugbo. Ihe mgbaàmà ndị a nwere ike igosi nnukwu nsogbu nke ọgwụ nje n'ụdị mmepe nke clostridiosis pseudomembranous colitis.

Ime na lactation

N'ime oge mmegharị ahụ, ojiji nke Amoxicillin ga-ekwe omume naanị ma ọ bụrụ na atụmanya ọgwụgwọ nke nne dị ka nne, dị ka dọkịta si kwuo, gafere ihe egwu dị na nwa ebu n’afọ.

Ihe ọgwụ a na - eme n'oge a na - enye akwa ọgwụ. Ọ bụrụ na ọ dị mkpa ịde ọgwụ amoxicillin, a ga-akwụsị ịkwụsị inye ya ara.

Na arụ ọrụ ezumike ọrụ

Iji kpachara anya, ekwesịrị iji Amoxicillin gwọọ ndị ọrịa ọrịa ọdịda.

A na-eji usoro usoro ọgwụgwọ oge mbụ maka mbadamba nkume na granules na ndị ọrịa nwere CC karịa 40 ml / min, maka capsules nwere CC karịrị 30 ml / min.

Na nkwarụ siri ike gbasara akụrụ, achọrọ ịmegharị dose. Emepụtara ya na-elebanye anya n'ime CC site na ibelata otu ọgwụ ma ọ bụ nwekwuo etiti oge nke Amoxicillin.

Site na CC 15-40 ml / min, a na-enyekarị ọgwụ a na-agbakarị, mana oge dị n'etiti doses na-abawanye ruo awa iri na abụọ, ebe CC na-erughị 10 ml / min, a ga-belata dose ahụ site na 15%.

Oke kachasị kwa ụbọchị nke Amoxicillin na anuria bụ 2000 mg.

N'ọnọdụ arụmọrụ ezumike nká na ụmụaka nwere CC karịa 30 ml / min, a chọghị ndozi usoro usoro onunu ogwu. Site na CC nke 10-30 ml / min, a na-enye ụmụaka 2/3 nke ọgwụ a na-emekarị, na-abawanye oge dị n'etiti onunu ruo awa iri na abụọ. N'ime ụmụaka nwere CC ihe na-erughị 10 ml / min, ugboro ole nchịkwa ọgwụ bụ 1 oge kwa ụbọchị, ma ọ bụ na-edepụtara ha 1/3 nke ọgwụ ụmụaka na-emebu.

Mkparịta ụka ọgwụ ọjọọ

Site na nke imeghari nke amoxicillin:

ascorbic acid: na - ebute mmụba na ogo nke ọgwụ a,
aminoglycosides, antacids, laxatives, glucosamine: nyere aka belata ma belata absorption,
ethanol: na - ebelata oke oriri nke amoxicillin,
digoxin: na-eme ka mmụba ya belata,
probenecid, phenylbutazone, oxyphenbutazone, indomethacin, acetylsalicylic acid: na-eme ka mmụba nke amoxicillin na plasma ọbara, na-ebelata mkpochapu ya,
methotrexate: ihe ọghọm nke ibute nsị na bekee na-aba ụba,
anticoagulants na-apụtaghị ìhè na ọgwụ n'oge metabolism nke para-aminobenzoic acid guzobere: megide nzụlite nke mbelata nke njikọta vitamin K na prothrombin index n'ihi nrụgide nke microflora eriri afọ site na amoxicillin, ihe ize ndụ nke ọbara ọgbụgba na-abawanye,
allopurinol: na - ebulite ohere o nwere ibute mmeghachi omume nfụkasị anụ ahụ,
ogwu mgbochi: a na - emeghari osigharị nke estrogens n’ime eriri afọ, nke na - eduga n’ibelata ịdị irè nke mgbochi afọ,
ọgwụ nje na-akpata nje (cycloserine, vancomycin, aminoglycosides, cephalosporins, rifampicin): na-akpata mmetụta nje nje,
ọgwụ bacteriostatic (sulfonamides, macrolides, lincosamides, chloramphenicol, tetracyclines): na-enye aka na-eme ka ike gwụ mkpụrụ mmetụta nke amoxicillin,
metronidazole: ọrụ antibacterial nke amoxicillin na-abawanye.

Ihe analogues nke Amoxicillin bu: mbadamba - Amoxicillin Sandoz, Ecobol, Flemoxin Solutab, Ospamox, capsules - Hiconcil, Amosin, Ampioks, Hikontsil, Ampicillin Trihydrate.