Amoxiclav - ntuziaka maka ojiji, nyocha, ụdị analogs na usoro onunu ogwu (mbadamba 125 mg, 250 mg, 500 mg, 875 mg, 1000 mg, nkwusioru) nke ọgwụ maka ọgwụgwọ nke ọrịa na-efe efe na ndị okenye, ụmụaka na ime.

N'isiokwu a, ị nwere ike gụọ ntuziaka maka iji ọgwụ Amoxiclav. Na-enye nzaghachi site n'aka ndị ọbịa na saịtị ahụ - ndị na-eri ọgwụ a, yana echiche nke ndị ọkachamara n'ịgwọ ọrịa gbasara iji Amoxiclav na omume ha. Nnukwu arịrịọ bụ ka ịgbakwunye nyocha gị gbasara ọgwụ ahụ: ọgwụ ahụ nyeere aka ma ọ bụ enyereghị aka iwepụ ọrịa ahụ, ihe nsogbu na nsonaazụ ndị a hụrụ, ikekwe ọ bụ ọkwa onye nrụpụta na nkọwapụta. Analogs nke Amoxiclav n'ihu ọnụnọ analogues dị n'ụdị dịnụ. Jiri maka ọgwụgwọ nke ọrịa dị iche iche na-efe efe na ndị okenye, ụmụaka, yana n'oge ime na lactation. Mmanya na-aba n'anya na nsonaazụ ya nwere ike ị Amoụchara Amoxiclav.

Amoxiclav - bụ ngwakọta nke amoxicillin - penisilini semisynthetic nwere ụdị nje dị iche iche na ọgwụ clavulanic na - egbochi ihe mgbochi beta-lactamase. Clavulanic acid na –eme ka ụlọ ọrụ enzymu ndị a sie ike ma nwekwaa ike iguzogide amoxicillin na beta-lactamases nke microorganisms mepụtara.

Clavulanic acid, nke dị n'otu n'ụdị ya na ọgwụ mgbochi beta-lactam, nwere ọrụ mgbochi nje na-adịghị ike.

Amoxiclav nwere ọgwụ mgbochi oke.

Ọ na-arụ ọrụ megide ụdị nsogbu amamịghe amoilillin, gụnyere ụdị na - eke beta-lactamases, incl. nje aerobic gram-nke ọma, nje aerobic gram-nke nje, anaerobic gram-positive bacteria, gram-negative anaerobes.

Mlọ ọgwụ

Ihe isi ọgwụ pharmacokinetic nke amoxicillin na clavulanic acid bụ otu ihe. Akụkụ abụọ a na-agbaso nke ọma mgbe ị theụsịrị ọgwụ n'ime, iri nri anaghị emetụta ogo nke mmịcha. Ejiri akụrụngwa abụọ gosipụtara site na ezigbo olu nke nkesa n'ime ahụ na akwara (akpa ume, ntị nke etiti, pleural na peritoneal fluid), akpanwa, ovaries, wdg. Amoxicillin na-abanyekwa n’ọbara synovial, imeju, gland prostate, herpes palatsine, muscle muscle, eriri afọ, secretion nke sinuses, salt, secretion nke bronchial. Amoxicillin na clavulanic acid anaghị abanye na BBB site na meninges na-enweghị mmerụ. Amoxicillin na clavulanic acid na-agafe ihe mgbochi placental na ichekwa ọnya na-apụ apụ na mmiri ara. A na-eji amamịgheillin na clavulanic acid n’etiti ejikọtara ya na protein ndị dị na plasma. Amoxicillin nwere metabolized obere akụkụ, acid dị ka clavulanic doro anya na-emetụta oke metabolism. Amoxicillin weputara site na akụrụ ya fọrọ nke nta ka ọ bụrụ na ọ naghị agbanwegharị site na tubular secretion na filmer glomerular. Clavulanic acid bupụrụ site na nzacha ikuku, nkebi n'ụdị metabolites.

Ihe na-egosi

Ọrịa ndị ọrịa microorganism na-akpata:

ofufe ọrịa nke akụkụ elu akụkụ okuku ume na akụkụ akụkụ ENT (nke gụnyere nnukwu ọrịa sinusitis na-adịghị ala ala, nnukwu ọrịa otitis media, ọrịa ụkwara ume ọkụ na-efe efe, tonsillitis, pharyngitis),
ofufe ọrịa nke ala akụkụ okuku ume na (gụnyere nnukwu bronchitis na nje superinfection, bronchitis na-adịghị ala ala, oyi baa),
urinary tract na-efe efe
ọrịa gynecological
anụ ahụ na anụ ahụ dị nro, gụnyere anụmanụ na ụmụ mmadụ,
Ọkpụkpụ na njikọ ọnya anụ ahụ,
ọrịa biliary tract (cholecystitis, cholangitis),
odontogenic na-efe efe.

Dị Mwepụta

Ntụ ntụ maka ịkwadebe ọgwụ maka ịgba ntụtụ maka nchịkwa ọbara (4) 500 mg, 1000 mg.

Ntụ ntụ maka ịkwadebe nkwusioru maka nchịkwa ọnụ nke 125 mg, 250 mg, 400 mg (ụdị dabara adaba maka ụmụaka).

Mbadamba ihe eji etinye ihe nkiri 250 mg, 500 mg, 875 mg.

Ntụziaka maka ojiji na usoro onunu ogwu

Ndị okenye na ụmụaka karịrị afọ 12 (ma ọ bụ karịa 40 n'arọ nke oke ahụ): usoro a na-ahụkarị maka ọrịa na-efe efe dị nwayọọ ruo ọkara bụ 1 mbadamba 250 + 125 mg kwa elekere 8 ọ bụla ma ọ bụ mbadamba mbadamba 500 + 125 na awa iri na abụọ ọ bụla, ma ọ bụrụ na nnukwu ọrịa na ọrịa akụkụ iku ume - 1 mbadamba 500 + 125 mg kwa elekere asatọ ọ bụla ma ọ bụ 1 mbadamba. Mkpokọta 875 + 125 mg kwa awa ọ bụla 12. Edebere mbadamba maka ụmụaka na-erubeghị afọ iri na abụọ (ihe na-erughị kilogram 40 nke ịdị ahụ).

Oke kachasị ụbọchị nke clavulanic acid (n'ụdị nnu nnu) bụ 600mg maka ndị okenye yana 10 mg / n'arọ nke anụ ahụ maka ụmụaka. Ogo kachasị nke amoxicillin bụ 6 g maka ndị okenye yana 45 mg / n'arọ nke ịdị arọ ahụ maka ụmụaka.

Usoro ọgwụgwọ ya bụ ụbọchị 5-14. Ọ bụ dibia bekee ga-ekpebi oge ọ ga-eji agwọ ọrịa. Ọgwụgwọ agaghị adị ihe karịrị ụbọchị iri na anọ na-enweghị nyocha ahụike nke abụọ.

Usoro onunu ogwu maka oria odontogenic: 1 tab. 250 +125 mg kwa elekere asatọ ọ bụla ma ọ bụ mbadamba 1 500 + 125 mg kwa elekere 12 ọ bụla maka ụbọchị 5.

Usoro ọgwụgwọ maka ọdịda akwara: maka ndị ọrịa nwere obere akwara na-ada ada (Cl creatinine - 10-30 ml / min), onyonyo ahụ bụ 1 tebụl. 500 + 125 mg kwa elekere 12 ọ bụla, maka ndị ọrịa nwere nnukwu akụrụ oke (creatinine Cl erughi 10 ml / min), dose ahụ bụ 1 tebụl. 500 + 125 mg kwa awa 24

Mmetụta akụkụ

Mmetụta ndị ọ na-enwekarị n'ọnọdụ dị nro ma dịkwa nwayọ.

agụụ
ọgbụgbọ, vomiting,
afọ ọsịsa
mgbu afọ
pruritus, urticaria, erythematous na onwu,
angioedema,
nsogbu anaphylactic,
nfụkasị vasculitis,
dermatitis na-efe efe,
Stevens-Johnson ọrịa
nlọghachi leukopenia (gụnyere neutropenia),
thrombocytopenia
hemolytic anaemia,
eosinophilia
anya isi, isi ọwụwa,
nkwarụ (nwere ike ibilite na ndị ọrịa nwere nsogbu gbasara akụrụ mgbe ha na-a takingụ ọgwụ ahụ elu),
obi uto
ehighi ura
intersitial nephritis,
kristalia
mmepe nke superinfection (gụnyere candidiasis).

Ihe ngbanwe

hypersensitivity na akụkụ nke ọgwụ,
hypersensitivity na akụkọ ihe mere eme nke penicillins, cephalosporins na ọgwụ mgbochi beta-lactam ndị ọzọ,
akụkọ ihe mere eme nke ọgbụgba ọkụ na-akpata cholestatic jaundice na / ma ọ bụ ọrụ imeju ndị ọzọ kpatara site na ị amoụ amoxicillin / clavulanic acid,
ọrịa mononucleosis na ọrịa leukemia.

Ime na lactation

Enwere ike ịkọwa Amoxiclav n'oge afọ ime ma ọ bụrụ na enwere ihe ngosi doro anya.

Amoxicillin na clavulanic acid na ntakịrị pere mpe nke mmiri ara.

Ntụziaka pụrụ iche

Site na usoro ọgwụgwọ, a ga-enyocha ọrụ nke ọbara, imeju na akụrụ.

N'ime ndị ọrịa nwere ezigbo ọrụ gbasara akụrụngwa, ịgbazigharị usoro usoro usoro onunu ogwu ma ọ bụ mmụba n’etiti etiti n’etiti dosing chọrọ.

Iji belata ihe ize ndụ nke mmeghachi omume ọjọọ site na eriri afọ, a ga-eji ọgwụ a theụọ ọgwụ ọgwụ.

Nnwale ụlọ nyocha: oke nke amoxicillin na-enye mmeghachi omume ziri ezi na glucose mmamịrị mgbe ị na-eji Benedict reagent ma ọ bụ ihe ngwọta Felling. A na-atụ aro ka mmeghachi omume enzymatic na glucosidase.

Amachibidoro ịxicomi Amoxiclav na ị alcoholụ mmanya n'otu oge n'ụdị ọ bụla, ebe ihe ọghọm nke nsogbu imeju na-ewere ha n'otu oge na-abawanye ụba.

Mmetụta ikike ịkwọ ụgbọ ala na usoro nchịkwa

Enweghị data na mmetụta ọjọọ nke Amoxiclav na usoro onyonyo a tụrụ aro na ike ịkwọ ụgbọ ala ma ọ bụ rụọ ọrụ.

Mkparịta ụka ọgwụ ọjọọ

Site n'otu oge iji ọgwụ ọjọọ ahụ nke Amoxiclav nwere antacids, glucosamine, laxatives, aminoglycosides, absorption na-agbada, yana ascorbic acid - na-abawanye.

Diuretics, allopurinol, phenylbutazone, NSAIDs na ọgwụ ndị ọzọ na-egbochi mmiri tubular na-eme ka ịbawanye ụba nke amoxicillin (clavulanic acid na-apụkarị site na nhicha ikuku).

Site na oge nke Amoxiclav na-abawanye toxicity nke methotrexate.

N'iji oge nke Amoxiclav na allopurinol, onodu nke exanthema na-abawanye.

A ga-ezere nchịkwa mkpuchi na disulfiram.

N'ọnọdụ ụfọdụ, ị theụ ọgwụ ahụ nwere ike ịgbatị oge prothrombin, n'akụkụ a, ọ kwesịrị ịkpachara anya mgbe ị na-ede ọgwụ anticoagulants na ọgwụ ọgwụ ahụ ọgwụ ọjọọ.

Nchikota nke amoxicillin na rifampicin bu ntughari (enwere nkwusi nke ngbanye ogwu).

Ekwesịrị iji Amoxiclav mee ihe n'otu oge yana ọgwụ nje bacteriostatic (macrolides, tetracyclines), sulfonamides n'ihi mbelata nke ike na Amoxiclav.

Probenecid na-ebelata excretion nke amoxicillin, na-eme ka ịta ahụhụ ọbara dịkwuo elu.

Ọgwụ nje na-ebelata ịdị irè nke ọgwụ mgbochi ọnụ.

Analogues nke ọgwụ mgbochi ọgwụ Antixiclav

Anakpụrụ nke analogues nke na-arụ ọrụ: