Lozap 50 mg - ntuziaka maka ojiji > Ọgwụgwọ na mgbochi

Mbadamba mbadamba 50 mg

Otu mbadamba ihe

ihe na - arụ ọrụ - losartan potassium 50 mg,
ndị na - ahụkarị: mannitol - 50,00 mg, microcrystalline cellulose - 80,00 mg, crospovidone - 10.00 mg, anhydrous colloidal silicon dioxide - 2.00 mg, talc - 4.00 mg, magnesium stearate - 4.00 mg,
Ihe mejupụtara ọcha Septema 752: hydroxypropyl methylcellulose, microcrystalline cellulose, macrogol stearate 2000, titanium dioxide (E171), macrogol 6000

Mbadamba ụrọ dị mma, biconvex, halved, nke nwere ihe nkiri ịke na-acha ọcha ma ọ bụ nke fọrọ nke nta ka ọ bụrụ nke na-acha ọcha, ihe dịka 11.0 x 5.5 mm

Mlọ ọgwụ

Mgbe nchịkwa ọnụ gasịrị, losartan na-anabata nke ọma site na eriri afọ (GIT) ma na-enyocha usoro metabolism nke etolite metabolicl metabolite na metabolites ndị ọzọ na-adịghị arụ ọrụ. Akpụrụ bioav adị nke losartan n'ụdị mbadamba bụ ihe dịka 33%. A na-erukarị ogo nke losartan na metabolite na-arụ ọrụ ya mgbe elekere 1 na 3 ruo 4 gasịrị, n'otu n'otu.

Biotransformation

Ihe dịka 14% nke losartan, mgbe a na-eji ọnụ nye ya, na-agbanwe ka ọ bụrụ metabolite na-arụ ọrụ. Na mgbakwunye na metabolite na-arụ ọrụ, a na-akpụkwa metabolites na-adịghị eme ihe.

Mkpochapu plasma nke losartan na metabolite na-arụ ọrụ bụ 600 ml / nkeji na 50 ml / nkeji, n'otu n'otu. Nwepu nke losartan na metabolite ya na-arụ ọrụ bụ ihe dịka 74 ml / nkeji na 26 ml / nkeji, n'otu aka ahụ. Site na nchịkwa ọnụ nke losartan, ihe dị ka 4% nke dose ahụ adịkwaghị na mmamịrị ahụ, ihe dị ka 6% nke dose ahụ na-adị na mmamịrị ahụ dị ka metabolite na-arụ ọrụ. A na-ahụ ọgwụ ọgwụ nke losartan na metabolite na-arụ ọrụ na ya site na nchịkwa ọnụ nke potassium losartan na doses ruo 200 mg.

Mgbe nchịkwa ọnụ gasịrị, ihe ndị metụtara losartan na metabolite na-arụ ọrụ na-agbada nke ukwuu na ọkara ndụ ikpeazụ nke ihe dị ka awa 2 na awa 6 ruo 9, n'otu n'otu. Mgbe ejiri ya otu ugboro kwa ụbọchị na ọgwụ nke 100 mg, enweghi oke iko losartan na metabolite na-arụ ọrụ na plasma ọbara.

Losartan na metabolite na-arụ ọrụ ya bụ ihe dị na akwara na mmamịrị. Mgbe nchịkwa ọnụ gachara, ihe dị ka 35% na 43% ka etachara na mmamịrị ahụ, yana 58% na 50% nwere ọnya ndị ọzọ.

Usoro nke ime ihe

Losartan bụ antagonistin II receptor antagonist (ụdị AT1) maka ọnụ. Angiotensin II - vasoconstrictor dị ike - bụ hormone na-arụ ọrụ nke sistemụ renin-angiotensin na otu ihe dị mkpa na pathophysiology nke ọbara mgbali elu. Angiotensin II na-ejikọ ndị na-anabata AT1, nke dị na akwara olu nke arịa ọbara, na akwara adrenal, akụrụ na obi), na-ekpebi ọtụtụ mmetụta ndu dị mkpa, gụnyere vasoconstriction na mwepụta nke aldosterone. Angiotensin II na - akpalitekwa ịbawanye uru akwara dị mma.

Losartan na-egbochi ndị na - anabata AT1. Losartan na ogwu ya na - arụ ọrụ na - arụ ọrụ na - arụ ọrụ na - egbochi carbonlic acid (E-3174) na vitro na vivo ihe niile dị egwu nke angiotensin II, n'agbanyeghị isi mmalite ya na ụzọ njikọta ya.

Losartan enweghị mmetụta agonistic ma ọ dịghị egbochi ndị ọzọ na-anabata hormone ma ọ bụ ọsị ion na-etinye aka na nhazi nke sistem. Ọzọkwa, losartan anaghị egbochi ACE (kininase II), enzyme nke na-akwalite mbibi nke bradykinin. N'ihi nke a, a na-anaghị ahụ itepụ iche maka ihe ọ bụla ọ na-ebute site na bradykinin.

N'oge a na-eji losartan, iwepu mmeghachi omume na-adịghị mma nke angiotensin II na-ebugharị mmiri na-eduga n'ịba ụba na ọrụ renin plasma (ARP). Mmụba dị otú ahụ na-eduga n'ịba ụba nke angiotensin II na plasma ọbara. N'agbanyeghị mmụba a, ọrụ antihypertensive na mbelata nke ịhapụ aldosterone na plasma ọbara na-adịgide, nke na-egosi mmachi dị mma nke ndị na-anabata angiotensin II. Mgbe ịkwụsịsịrị losartan, ọrụ plasma renin na ọkwa angiotensin II n’ime ụbọchị atọ laghachiri na ntọala.

Ma losartan na isi metabolite ya nwere mmekọrịta dị elu maka ndị na-anabata AT1 karịa maka AT2. Metabolite nọ n'ọrụ bụ ugboro 10 ruo 40 karịa ike losartan (mgbe a gbanwere ya ka ọ bụrụ oke).

Lozap na-ebelata ngụkọta akwara vaskụla ọnụ (OPSS), mkpokọta adrenaline na aldosterone n'ọbara, mgbali ọbara, mgbali elu na akwara ọbara, belata mgbe ọ gachara, nwere mmetụta nke akwara Lozap na-egbochi mmepe nke hypertrophy myocardial, na-eme ka ndidi na-eme ka ndị ọrịa nwee nkụda mmụọ. Mgbe otu Lozap jiri otu, mmetụta antihypertensive (mbelata systolic na ọbara mgbali) ruru oke mgbe awa 6 gachara, jiri nwayọ belata n'ime awa 24. Mmetụta antihypertensive kachasị na-enweta izu 3-6 mgbe mmalite were Lozap.

Ihe omuma nke ogwu na-egosi na itinye uche nke losartan na plasma obara n’ime ndi oria nwere oria cirrhosis na-abawanye nke ukwuu.

Ihe ngosi maka ojiji

Ihe ngosiputa maka iji ogwu a bu:

ọgwụgwọ nke oke ọbara mgbali elu n’ime ndị okenye
ịgwọ ọrịa akụrụ na ndị okenye nwere ọria ọbara na arịa oke ọrịa shuga II nke nwere proteinuria ≥0.5 g / ụbọchị dịka akụkụ nke ọgwụgwọ antihypertensive
mgbochi nke mmepe nke ọrịa obi, gụnyere ọrịa ọnya na ndị ọrịa nwere ọbara mgbali elu na mgbali ventricular hypertrophy, nke nyocha nke ECG kwupụtara.
ọrịa obi na-adịghị ala ala (dịka akụkụ nke ọgwụgwọ njikọta, yana
enweghị ndidi ma ọ bụ adighi ike nke ọgwụgwọ na ACE inhibitors)

Usoro onunu ogwu na nhazi

A na -ekwu Lozap ọnụ, n'agbanyeghị nri ahụ, ugboro ole nchịkwa - oge 1 kwa ụbọchị.

Site n'ọbara mgbali elu, akwara ụbọchị bụ 50 mg otu ugboro n'ụbọchị. A na-enweta mmetụta antihypertensive kachasị elu izu 3-6 mgbe mmalite ọgwụgwọ. N'ime ụfọdụ ndị ọrịa, ịba ụba dose ahụ ruo 100 mg kwa ụbọchị (n'ụtụtụ) nwere ike ịdị irè karị.

Enwere ike ịnye Lozap ọgwụ ndị ọzọ antihypertensive, ọkachasị na nsị (dịka ọmụmaatụ, hydrochlorothiazide).

Ndị ọrịa nwere ọbara mgbali elu na ụdị ọrịa shuga II nke mellitus (proteinuria ≥0.5 g / day)

Ọgwụ mbụ a na-ebido bụ 50 mg otu ugboro kwa ụbọchị. Enwere ike ịbawanye ọgwụ ahụ na 100 mg otu ugboro kwa ụbọchị, dabere na ngosipụta nke ọbara mgbali otu ọnwa mgbe ịmalite ọgwụgwọ. Enwere ike iji Lozap na ọgwụ ndị ọzọ na - egbochi (dịka ọmụmaatụ, diuretics, ndị na - egbochi calcium, alpha ma ọ bụ beta receptor blockers, ọgwụ ndị a na - eme), yana insulin na ọgwụ hypoglycemic ndị ọzọ na - ejikarị (dịka sulfonylurea, glitazone na glucosidase inhibitors).

Usoro ọgwụgwọ nkụchi obi

Mkpụrụ mbụ nke losartan bụ 12.5 mg otu ugboro n'ụbọchị. A na-enyekarị ọgwụ ọgwụ mgbochi ahịrị oge izu (i.e. 12.5 mg otu ugboro kwa ụbọchị. 25 mg otu ugboro kwa ụbọchị. Mg mg 50 kwa ụbọchị, 100 mg otu ugboro kwa ụbọchị) ka a na-emezi ọgwụ mgbochi 50 mg otu oge. otu ugboro kwa ụbọchị dabere na ndidi.

Mbelata ihe ize ndụ nke ọrịa strok na ndị ọrịa nwere ọbara mgbali elu na akwara mgbali aka ekpe, nke ECG kwupụtara.

Ọgwụ mbụ a na-amalite bụ losap 50 mg otu ugboro kwa ụbọchị. Dabere na mbelata ọbara mgbali elu, ekwesịrị ịgbakwunye hydrochlorothiazide na ọgwụgwọ dị ala na ọgwụgwọ yana / ma ọ bụ itinye Lozap ka ọ ga-abawanye na 100 mg otu ugboro kwa ụbọchị.

Nsonaazụ

N'oge ọgwụgwọ Lozap, ndị ọrịa zụlitere ụfọdụ mmetụta n'ihi nnabata ihe mbadamba n'otu n'otu:

Mbufụt nke imeju, ụba ọrụ nke ọrịa hepatic,
Mmụba glucose ọbara
Ọkpụkpụ ụkọ anaemia,
Agụụ agụụ, ọgbụgbọ, ọnụ akọrọ, mgbe ụfọdụ ọgbụgbọ na ọgbụgba,
Site na sistemụ akwara - ura, iwe, isi ọwụwa, oke iwe iwe, na ndị ọrịa nwere ọnya akwara neurocirculatory, a na-abawanye na mwakpo ụjọ, nkụda mmụọ, oke nke oke ahụ,
Mmeghachi omume Allergic - ọdịdị nke ihe ọkụ na akpụkpọ ahụ, mmepe nke ụbụrụ Quincke ma ọ bụ anaphylaxis,
Ọhụhụ ụzọ, ntị ịnụ, tinnitus,
Site n'akụkụ akụkụ obi na arịa ọbara - mbelata nke ọbara mgbali elu, ọdịda, mkpụmkpụ ume, tachycardia, ọchịchịrị n'anya, ịda mba, nkụchi,
Na akụkụ nke akụkụ okuku ume - mmepe nke usoro mkpali nke akụkụ okuku ume na elu, ụkwara, bronchospasm, ịba ụba nke ụkwara ume ọkụ, mụbara ọgụ asthmatic,
Ọkpụkpọ anụ ahụ.

N'ọtụtụ oge, a na-anabata Lozap nke ọma, nsonaazụ ya na-agafe ma ọ chọghị ịkwụsị ọgwụ ahụ.

Ihe ngbanwe

Enwere ike ị drugụ ọgwụ ahụ naanị mgbe ịgachara ọkachamara. Tupu ịmalite usoro ọgwụgwọ, ị kwesịrị iji nlezianya mụọ ntuziaka maka mbadamba ihe ndị ahụ, ebe Lozap nwere contraindications ndị a:

hypersensitivity na ihe na-arụ ọrụ ma ọ bụ ndị nwe ọgwụ a
nnukwu ikeji imeju
ime na lactation
ụmụaka na ndị ntorobịa erubeghị afọ iri na asatọ
ngalaba na aliskiren na ndị ọrịa nwere ọrịa mellitus

Mkparịta ụka ọgwụ ọjọọ

Ọgwụ ndị ọzọ na - egbochi mmiri nwere ike ịkwalite mmetụta Lozap dị egwu. Ojiji nke oge a na ọgwụ ndị ọzọ nwere ike ime ka ọnọdụ nke hypotension bụrụ ihe na - akpata mmeghachi ike (tricyclic antidepressants, antipsychotics, baclofen na amifostine) nwere ike ịbawanye n'ihe ize ndụ nke hypotension.

Losartan bụ metabolized tumadi na ntinye nke sistemụ cytochrome P450 (CYP) 2C9 na metabolite acid na-arụ ọrụ. N'ime ọmụmụ ụlọ ọgwụ, achọpụtara na fluconazole (onye na-egbochi CYP2C9) belata ikpughe metabolite nọ n'ọrụ ka ihe ruru 50%. A chọpụtara na ọgwụgwọ n’otu oge na losartan na rifampicin (onye na - ewepụta enzymes metabolic) na - eduga na mbelata 40% na mkpokọta metabolites na - arụ ọrụ na plasma ọbara. Amaghi ihe banyere ogwu a nke amamịghe a. Enweghị ọdịiche na mkpughe n’otu oge iji Lozap nwere fluvastatin (inhibitor CYP2C9 na-adịghị ike).

Dịka ọgwụ ọjọọ ndị ọzọ na-egbochi angiotensin II ma ọ bụ nsonaazụ ya, ojiji nke ọgwụ ndị na-ejigide potassium na ahụ (dịka ọmụmaatụ potassium-sparing diuretics: spironolactone, triamteren, amiloride), ma ọ bụ nwekwuo ọkwa potassium (dịka ọmụmaatụ heparin) yana mgbakwunye nke potassium ma ọ bụ dochie nnu, nwere ike ibute oke ụba ọkwa potassium. A naghị atụ aro iji ụdị ego a n'otu oge.

Enweela mmụba dị ukwuu n'ọtụtụ lithium, yana ihe na-egbu egbu, ka ejiri mkpụkọ lithium ya na ndị na - egbochi ACE. Ọzọkwa, a kọchaghị akụkọ banyere iji angiotensin II receagonor antagonists. Ekwesịrị iji nlezianya kpachara anya na lithium na losartan. Ọ bụrụ n'iji ụdị ngwakọta a dị mkpa, a na-atụ aro ka ịlele ọkwa lithium n'oge a na-eme ya.

N'iji oge nke angagonensin II antagonists na ọgwụ mgbochi na - abụghị steroidal anti-inflammatory (dịka ọmụmaatụ, cyclooxygenase-2 inhibitors (COX-2), acetylsalicylic acid na doses nwere mmetụta mgbochi mkpali, NSAIDs na - abụghị nhọrọ), enwere ike ịkụda mmetụta antihypertensive. Ojiji nke antiotensin II antagonists ma ọ bụ ihe onodu na NSAID nwere ike ibulite ihe egwu dị na ọrụ na-akpata nsogbu, gụnyere mmepe enwere ike ịda ada, yana mmụba nke ọkwa potassium, karịchaa ndị ọrịa nwere nsogbu mgbazigharị dị adị. Ekwesịrị iji nlezianya tinye njikọta a, ọkachasị ndị agadi. Ndị ọrịa kwesịrị ị hydụ mmiri kwesịrị ekwesị, ha kwesịkwara ịtụle nlezianya ọrụ akụrụ mgbe mmalite nke ọgwụ oriri, yana oge ụfọdụ.

Hypersensitivity

Ọkpụkpụ Angioneurotic. A ga-enyochakarị ndị ọrịa nwere ọria angioneurotic ede (edema nke ihu, egbugbere ọnụ, akpịrị, na / ma ọ bụ ire).

Nnukwu ọbara ọgbụgba na mmiri elektrik

Symptomatic artpot hypotension, ọkachasị mgbe nke mbụ nke ọgwụ ma ọ bụ mgbe ịbawanye dose ahụ, nwere ike ịdakwasị ndị ọrịa nwere obere intravascular olu na / ma ọ bụ ụkọ sodium, kpatara site na iji ọgwụ mgbali siri ike, igbochi iri nri oriri, ịba ahụ ma ọ bụ vomiting. Tupu ịmalite ọgwụgwọ na Lozap, ekwesịrị ime mgbazi nke ọnọdụ ndị dị otú ahụ ma ọ bụ ka a ga-eji ọgwụ ahụ na ntakịrị ọgwụ mbụ.

Electrolyte ahaghioke

A na - ahụta enweghị elektrọn elektrọnte na ndị ọrịa nwere ọrụ mkpali na-arụ ọrụ (yana ọrịa mellitus ma ọ bụ na-enweghị ya), nke a kwesịrị iburu n'uche. N'ime ndị ọrịa nwere ụdị mellitus II nke ọrịa shuga na nephropathy, ọrịa hyperkalemia dị elu na ndị otu Lozap karịa na otu placebo. Yabụ, ị kwesịrị ị na-elele ntinye uche nke potassium na plasma ọbara na nwepu nke creatinine, ọkachasị ndị ọrịa nwere nkụda obi na mwepụ nke mkpụrụ osisi 30 - 50 ml / nkeji.

A naghị atụ aro ka ejikọtara ọgwụ Lozap na potassium na - egbochi ọgwụ, ọgwụ mgbakwunye na nnu ndị nwere potassium.

Mwepụta wepụtara ya na ihe mejupụtara

Emepụtara n'ụdị mbadamba, nke a na-eji ihe mkpuchi na-acha ọcha nke 12.5 mg, 50 mg na 100 mg. N'elu, mbadamba biconvex. Blisters nwere mbadamba 10 PC. rere ya na ngwugwu kaadi nke 30, 60, 90 PC.

Ngwakọta ọgwụ ọgwụ Lozap gụnyere losartan potassium (ihe na-arụ ọrụ), povidone, microcrystalline cellulose, croscarmellose sodium, mannitol, magnesium stearate, hypromellose, talc, macrogol, ihe odo na-acha odo odo, dimethicone (excipients).

Lozap gbakwunyere mbadamba (yana yana hydrochlorothiazide diuretic iji mee ka mmetụta ahụ dịkwuo elu), ihe ndị na-arụ ọrụ, losartan na hydrochlorothiazide.

Njirimara nke ogwu

Ọgwụ Antihypertensive - anaghị egbochi peptide nke ndị na-anabata AT2, na-asọmpi ndị na-anabata nke ụdị AT1. Site na igbochi ndị na-anabata ya, Lozap na-egbochi njikọ nke angiotensin 2 na AT1 ndị na-anabata ya, na-ebute nsonaazụ ndị na-esote nke AT2: ọbara mgbali akwara, mwepụta nke renin na aldosterone, catecholamines, vasopressin, na mmepe nke LVH. Ọgwụ ahụ anaghị egbochi enzyme angiotensin, nke pụtara na ọ naghị emetụta usoro kinin ma ọ dịghị eduga n'ịchịkọta bradykinin

Lozap na-ezo aka na prodrugs, ebe ọ bụ na metabolite ya na-arụ ọrụ (metabolite nke carboxylic acid), guzobere n'oge usoro biotransformation, nwere mmetụta antihypertensive.

Mgbe otu mkpụrụ ọgwụ gasịrị, mmetụta antihypertensive (mbelata systolic na ọbara mgbali) ruru oke mgbe awa 6 gachara, jiri nwayọ belata n'ime awa 24. Mmetụta antihypertensive kachasị na-enweta izu 3-6 mgbe mmalite ọgwụ.

Ntụziaka maka ojiji

Ejiri ọnụ na Lozap, ọnweghị nri ịdabere na nri. E kwesịrị iburu mbadamba otu ugboro n'ụbọchị. Ndị ọrịa nwere ọbara mgbali elu na-a medicineụ ọgwụ nke 50 mg kwa ụbọchị. Iji nweta nsonaazụ kachasị ama, a na-abawanye ọgwụ ahụ ruo 100 mg. Otu esi ewere Lozap na nke a, dọkịta ahụ na-enye ndụmọdụ n'otu n'otu.

Ntụziaka maka Lozap N na-enye ndị ọrịa nkụda obi na-a takeụ ọgwụ nke 12.5 mg otu ugboro n'ụbọchị. Nke nta nke nta, a na-eji okpukpu abụọ nke ọgwụ ahụ okpukpu abụọ otu nkeji ruo mgbe ahụ, ruo mgbe ọ ruru mgmịnta 50 otu ugboro n'ụbọchị.

Ntụziaka maka iji Lozap Plus gụnyere ị nweta otu mbadamba otu ugboro kwa ụbọchị. Uru kasịnụ nke ọgwụ ahụ bụ mbadamba abụọ kwa ụbọchị.

Ọ bụrụ na mmadụ were ọgwụ ọgwụ diuretic dị elu n'otu oge, a na-ebelata ọgwụ Lozap kwa ụbọchị na 25 mg.

Ndị agadi na ndị ọrịa nwere nsogbu gbasara akụrụngwa (gụnyere ndị nọ n'ọbara ha) adịghị ha ka ha dozie usoro a.

Nsonaazụ

Mmeghachi omume nfụkasị dị iche iche ga-ekwe omume: mmeghachi omume anụ ahụ, angioedema, ụjọ anaphylactic. Ọ ga - ekwe omume iweda ọbara mgbali elu, adịghị ike, ike ọgwụgwụ. Ọ dịkarịsịrị ala, ịba ọcha n'anya, migraine, myalgia, mgbaàmà nke iku ume, dyspepsia, nsị imeju.

Mgbaàmà nke ịdoụbiga ókè bụ hypotension, tachycardia, mana bradycardia nwekwara ike. Usoro ọgwụgwọ a chọrọ iwepu ọgwụ n’ahụ ma wepụsịa akara ngosi nke oke ịdoụbiga mmanya ókè.

Jiri n'oge ime na lactation

Emela Lozap n'oge ime. N'oge ọgwụgwọ n'ime oge nke abụọ na nke atọ yana ọgwụ ndị na-emetụta usoro renin-angiotensin, ntụpọ na mmepe nke nwa ebu n'afọ na ọbụna ọnwụ nwere ike ime. Ozugbo ime dị, nwa ahụ kwesịrị ịkwụsị ọgwụ ozugbo.

Ọ bụrụ na a ga-ewere Lozap n'oge a na-enye ya ara, a ga-akwụsị inye ya ara ozugbo.

Etu esi aru umuaka?

Emebeghị ịdị irè nke ikpughe na nchekwa nke iji ụmụaka, ya mere, ejighị ọgwụ ahụ na-emeso ụmụaka.

Ihe analogues zuru oke na ihe eji arụ ọrụ:

Ngọngọ
Brozaar
Vasotens,
Vero-Losartan,
Zisakar
Cardomin Sanovel,
Karzartan
Cozaar
Lakea
Lozarel
Losartan
Potassium Losartan,
Lorista
Losacor
Presartan
Nkọwapụta.

Mgbe ị na-ahọrọ analogues, ọ dị mkpa ịghọta na nkuzi maka iji Lozap, ọnụahịa na nyocha nke ọgwụ nwere otu mmetụta emetụtaghị ya. Ọ dị mkpa ịnweta ndụmọdụ nke dọkịta na ịghara ime mgbanwe ọgwụ ọ bụla.

Lozap ma ọ bụ Lorista - nke ka mma?

Ihe na-arụ ọrụ na ọgwụ Lorista bụ otu ihe ahụ na Lozap. Edere Lorista maka ndị ọrịa na-arịa ọbara mgbali elu na akwara obi na-adịghị ala ala. N'otu oge ahụ, ọnụ ahịa ọgwụ Lorista dị ala. Ọ bụrụ na ọnụahịa nke Lozap (30 PC.) Ruru 290 rubles, mgbe ahụ ọnụahịa nke mbadamba 30 nke ọgwụ Lorista bụ 140 rubles. Agbanyeghị, ịnwere ike itinye ntule ahụ naanị mgbe ịgachara dọkịta ma ọ bụrụ na ejirila nlezianya gụọ nkọwapụta ahụ.

Kedu ihe dị iche na Lozap na Lozap Plus?

Ọ bụrụ na ịchọrọ ị withụ ọgwụ a, ajụjụ a na-ebilitekarị, nke ka mma - Lozap ma ọ bụ Lozap Plus?

Mgbe ị na-ahọrọ ọgwụ, ekwesịrị iburu n'uche na n'ụkpụrụ nke Lozap Plus, a na-ejikọta losartan na hydrochlorothiazide, nke bụ diuretic ma nwee mmetụta diuretic na ahụ. Ya mere, ekwuputara mbadamba nkume ndị a maka ndị ọrịa chọrọ ọgwụgwọ ọgwụgwọ njikọta.

Ntụziaka pụrụ iche

N'ime ndị ọrịa nwere oke ọbara na-agagharị agagharị (nsonaazụ ugboro ugboro nke iji ọgwụ mgbatị ogologo), Lozap® nwere ike ịkpalite mmepe nke ọbara mgbali ala. Ya mere, tupu ịmalite ọgwụgwọ ọgwụ a, ọ dị mkpa iji kpochapụ mmebi ndị dị ugbu a, ma ọ bụ were ọgwụ ahụ na obere usoro.

Ndị ọrịa na-arịa ọrịa imeju (imeju ma ọ bụ agafeghị oke) mgbe ha jisịrị onye na-ahụ maka hypotensive, ntinye nke akụkụ ahụ na-arụ ọrụ na metabolite na-arụ ọrụ dị elu karịa na ndị nwere ahụ ike. Na nke a, n'ọnọdụ a, kwa na usoro ọgwụgwọ, achọrọ obere doses.

Ọ bụrụ na arụ ọrụ ezughi oke ọrụ, mmepe nke hyperkalemia (ịba ụba ịta potassium n'ime ọbara) ga-ekwe omume. Ya mere, n'oge usoro ọgwụgwọ, achọrọ ka ị nyochaa ọkwa nke microelement a mgbe niile.

Site na nlekọta nke ọgwụ ndị a na-eme n'otu oge na-emetụta usoro renin-angiotensin na ndị ọrịa nwere renal stenosis (otu ma ọ bụ nke nwere akụkụ abụọ), serum creatinine na urea nwere ike ịba ụba. Mgbe ịkwụsị ọgwụ ahụ, ọnọdụ ahụ na-agbanwekarị. N’ọnọdụ a, ọ dịkwa mkpa iji nleba anya nyocha nlele nyocha nke ọkwa kemịkaliki nke ọrụ akụrụ.

Achọpụtaghị ozi banyere mmetụta Lozap n'ikike ịnya ụgbọ ala ma ọ bụ rụọ ọrụ chọrọ achọ itinye uche ngwa ngwa na ọsọ nke mmeghachi omume psychomotor.

Mkparịta ụka ọgwụ ọjọọ

Enwere ike inye ọgwụ ndị ahụ ọgwụ ndị ọzọ na - alụ ọgụ. A na-ahụta mmekọrịta nke mmekọrịta nke beta-blockers na ọmịiko. N'iji ojiji nke losartan na diuretics, a na-ahụta ihe mmetụ.

Enweghị mkparịta ụka ọgwụ nke losartan nwere hydrochlorothiazide, digoxin, warfarin, cimetidine, phenobarbital, ketoconazole na erythromycin.

A kọwo Rifampicin na fluconazole belata mkpokọta metabolite na-arụ ọrụ nke losartan na plasma ọbara. Amabeghị mkpa ụlọ ọgwụ dị na mmekọrịta a.

Dịka ọ dị n'ihe ndị ọzọ na-egbochi angiotensin 2 ma ọ bụ mmetụta ya, ojiji nke losartan na potassium-sparing diuretics (dịka ọmụmaatụ, spironolactone, triamteren, amiloride), nkwado potassium na nnu nwere mmanụ potassium na-eme ka ohere nke hyperkalemia dịkwuo elu.

Ndị NSAID, gụnyere ndị na-egbochi COX-2 na-egbochi, nwere ike belata nsonaazụ diuretics na ọgwụ ndị ọzọ na-egbochi mmiri.

Site na iji angiotensin 2 na antagonists na lithium na-anabata ihe, enwere ike ịbawanye ụba na plasma lithium. Nyere nke a, odi nkpa itule uru na ọghọm dị n’otu nchịkwa nke losartan nwere nkwanye nnu nnu. Ọ bụrụ na nkwonkwo dị mkpa, a ga-enyocha ọkwa nke lithium na plasma ọbara.

Kedu ihe nyocha na-ekwu maka ya?

Nyocha na Lozap Plus na Lozap na-egosi na n'ọtụtụ oge, ọgwụ ọjọọ na-ebelata ọbara mgbali n'ụzọ dị irè ma nwee mmetụta dị mma na ọnọdụ ahụike nke ndị mmadụ nwere ọrịa nke usoro obi.

Ndị ọrịa na-aga nnọkọ ahụ pụrụ iche ịhapụ nzaghachi na Lozap 50 mg mara na ụkwara, akpịrị ịkpọ nkụ, na nkwarụ ntị bụ mgbe ụfọdụ ka a na-ahụta ya. Mana n’ozuzu, nyocha ndị ọrịa banyere ọgwụ a dị mma.

N'otu oge, nyocha ndị dọkịta na-egosi na ọgwụ nwere ike ọ gaghị adabara mmadụ niile na-arịa ọbara mgbali elu. Ya mere, na mbu, ekwesịrị ịdaba n'okpuru nlekọta nke ọkachamara.

Ọrụ imeju na-arụ ọrụ

N'iburu n'uche ọgwụ pharmacokinetic na-egosi mmụba dị ukwuu na mkpokọta Lozap na plasma ọbara na ndị ọrịa nwere ọrịa imeju, a ga-atụle akụkọ banyere ibelata ọgwụ nke ndị ọrịa nwere ọrụ imeju na-adịghị mma. Ekwesighi iji Lozap ọgwụ a mee ihe na ndị ọrịa nwere ọrụ imeju dị oke egwu n'ihi enweghị ahụmịhe.

Renrụ ọrụ na-arụ ọrụ na ụlọ

Mgbanwe na arụmọrụ gbasara akụrụ, gụnyere ọdịda akụrụ, metụtara mgbochi nke sistemụ renin-angiotensin (ọkachasị ndị ọrịa nwere akụrụngwa akwara-angiotensin-aldosterone, ya bụ ndị ọrịa nwere nnukwu ọrịa obi ma ọ bụ nwee nkwarụ dị na renal). Dịka ọgwụ ọjọọ ndị ọzọ na-emetụta sistemụ renin-angiotensin-aldosterone, a kọwo mmụba na urea ọbara na ọkwa serum creatinine na ndị ọrịa nwere akwara mkpụrụ ndụ akwara stenosis ma ọ bụ stenosis nke otu akụrụ akwara. Mgbanwe ndị a na arụ ọrụ akụrụ nwere ike ịgbanwere ya mgbe ọ kwụsịrị ọgwụgwọ. Ekwesịrị ịkpachara anya mgbe ị na-eji Lozap na ndị ọrịa nwere akwara akwara akwara ma ọ bụ stenosis nke akwara akwara.

Ojiji nke Lozap na ACE inhibitors na-emebi ọrụ akụrụngwa, yabụ akwadoghị nchikota a.

Obi ada mba

Dị ka ọgwụ ọjọọ ndị ọzọ na-emetụta sistemụ renin-angiotensin, n'ime ndị ọrịa nwere nkụda obi na / na-enweghị ọrụ na-arụ ọrụ na-enweghị nsogbu, enwere ihe ize ndụ nke hypotension arterial na (mgbe niile nnukwu ọrụ) na-arụ ọrụ ezumike.

Enweghi ahụmihe ọgwụgwọ na-ezughi oke iji ojiji Lozap n'ime ndị ọrịa nwere nkụda obi na nkwarụ akwara siri ike, n'ime ndị ọrịa nwere nnukwu obi (IV ọkwa dị ka NYHA), yana ndị ọrịa nwere nkụda obi na nrịanrịa ọrịa obi na-eyi ndụ egwu. Ya mere, ekwesiri iji Lozap mee ihe na otu ndi ọrịa a. A na-adụ ọdụ ịkpachara anya iji Lozap na beta-egbochi n'otu oge.

Stenosis nke aortic na mitral valves, ihe na-egbochi kadiochipic hypertrophic.

Dị ka ọ dị na ndị vasodilators ndị ọzọ, a na-eji ọgwụ pụrụ iche nye ndị ọrịa nwere ọrịa aortic na mitral valve stenosis ma ọ bụ ndị na-egbochi kadị hyperrophic cardiomyopathy.

Jiri n'oge ime na lactation

Ekwenyeghi Lozap n'oge di ime. Ọ bụrụ na ọgwụgwọ na losartan adịghị mkpa, mgbe ahụ ndị ọrịa na-eme atụmatụ ịtụrụ ime ka a ga-edepụtara ha ọgwụ ndị ọzọ na-alụ ọgụ maka mmiri dị mma n'oge afọ ime. N'ihe dị ime, a ga-akwụsị ọgwụgwọ Lozap ozugbo ma ekwesịrị iji usoro ọgwụgwọ ọzọ mee ihe iji chịkwaa ọbara mgbali.

Mgbe ị na-ede ọgwụ mgbe ị na-ara, a ga-eme mkpebi iji kwụsị ị breastụ ara ma ọ bụ ịkwụsị ọgwụgwọ na Lozap.

Oria puru iche nke ogwu a n’onye ugboala ma obu ihe ozo puru iche

Enweghị ọmụmụ ọ bụla emeghị na nsonaazụ ike nke ịnya ụgbọ ala ma jiri usoro rụọ ọrụ. Ka o sina dị, mgbe ị na-anya ụgbọ ala ma jiri usoro rụọ ọrụ, mmadụ ga-echeta na mgbe ị na-a drugsụ ọgwụ mgbochi ọgụ, dizzness ma ọ bụ iro ụra nwere ike ime mgbe ụfọdụ, ọkachasị na mbido ọgwụgwọ ma ọ bụ mgbe ọnụọgụ dị elu.

Dodoụbiga ya ókè

Site na mmụba nke ọgwụ a tụrụ aro ya ma ọ bụ ogologo oge ị ofụ ọgwụ ahụ, ndị ọrịa na-azụlite ihe ịrịba ama nke ịdoụbiga mmanya ókè, nke egosiri na mmụba nke nsonaazụ ndị akọwapụtara n'elu yana mbelata ọbara mgbali elu. Na mgbakwunye, n'ihi mmụba nke mmiri na microelements site n'ahụ ahụ, enweghị mmiri elektrik na-etolite.

Site na mmepe nke mgbaàmà ndị dị otú ahụ, a na-akwụsị ọgwụgwọ na Lozap ozugbo ma zigara onye ọrịa na dọkịta. A na-egosi onye ọrịa ahụ afọ na-egbu egbu (ọ dị mma ma ọ bụrụ na a recentlyụrụ ọgwụ ahụ n'oge na-adịbeghị anya), nchịkwa nke sorbents n'ime yana ọgwụgwọ Symptomatic - mkpochapu akpịrị mmiri, mweghachi ọkwa nnu na ahụ, normalization nke ọbara mgbali na ọrụ obi.